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ACYCLOVIR CREAM

Claim

Strength Category

5 % w/w Antiviral

2 Manufacturing Formula (Batch Size : 30.00 Kg) Sr. No Composition Overage % Qty/Batch (kg/lit)

1 2 3 4 5 6 7 8 9 10

Acyclovir Benzyl alcohol Emulsifying Wax Liquid Paraffin Polyethylene glycol 499 Cetomacragol 1000 Potassium Dihydrogen Phosphate Cetyl alcohol Isopropyl palmitate Purified Water

1.500 0.030 3.000 3.000 1.605 0.900 0.035 3.800 2,200 17

3. Manufacturing Process

1. 2. 3. 4. 5. 6. 7.

Boil 7.4 kg of purified water and allow it to cool down to 75C. Melt Cetyl alcohol, Cetomacragol 1000, Emulsifying wax in 25 lit capacity S.S vessels. Add polyethylene Glycol in the hot molten mass and keep it aside so that 75 C. temperature is maintained. Disperse Acyclovir in Liquid paraffin and mix well. Charge the hot purified water in the bowl of 25 kg capacity planetary mixer through muslin cloth. Dissolve Potassium Dihydrogen phosphate in it. Add the molten oil phase to the water phase slowly in a thin stream through

3. Manufacturing Process

muslin cloth while stirring. 8. 9. 10. Add the Acyclovir mass into the bulk. Add benzyl alcohol. Next day scrap the side valves of the bowl to remove the residues and mix the mass for 5 minutes in the mixer. Check the pH of the cream and record. The limit is between 4.0to 4.5