ALIQUOT CALCULATION INVOLVING VERY SMALL QUANTITIES (ALTERNATIVE METHOD)

alternative method*
Solid liquid aliquot
Steps;
Example 1:
1. Calculate the least volume of
Drug A 20 mg solvent required;
𝑀𝑊𝑄
𝑀𝑖𝑛 𝑉 =
Distilled water to 50 ml 𝑆
S = solubility  in BPC under
Steps; solubility of the drug
1. MWQ? 2. Decide on the convenient
200mg volume of water to be used.
2. Solubility of drug A? 3. Calculate the volume of the
Say it`s 1:4 vs. 1:100 solution to be taken for
3. Aliquot? compounding;
𝑄𝑟 × 𝑉𝑢
MWQ/Drug = 200mg/20mg = 10 𝑉𝑟 =
𝑄𝑢
4. Dissolve Drug A in convenient volume of water
Vr = volume to be taken from
the solid liquid aliquot solution.
Qr = quantity of drug required
If the solubility of drug A is 1 in 4 (1:4), then in the prescription.
Vu = volume of solvent used in
0.2 g drug can dissolve in 0.8 ml water (minimum volume needed),
the solid liquid aliquot.
And 0.08 ml of the solution will contain 20mg Drug A. Qr = quantity of drug used in
the solid liquid aliquot.

However it is more convenient to dissolve 0.2 g in a volume bigger than Example 1;

Step 1
0.8 ml. We can use 10ml, 20ml etc 𝑀𝑊𝑄
𝑀𝑖𝑛 𝑉 =
𝑆
0.2 g in 10 ml  1 ml of solution contain 20mg drug A 0.2𝑔
𝑀𝑖𝑛 𝑉 = = 0.8 𝑚𝑙
1𝑔
0.2 g in 20 ml  2 ml of solution also contain 20 mg Drug A 4𝑚𝑙
Step 2
If the solubility is 1 in 400 (1:400) then Use 10 ml
Step 3
0.2g in 80ml (min. vol.)  8 ml 𝑄𝑟 × 𝑉𝑢
𝑉𝑟 =
𝑄𝑢
0.2g in 100ml  10 ml
20𝑚𝑔 × 10𝑚𝑙
𝑉𝑟 = = 1 𝑚𝑙
0.2g in 200ml 20 ml 200𝑚𝑔

~mlk~ | 1