Ambroxol, hydrochloride is a mucoactive and surfactant-stimulatory antioxidant that inhibits the release of arachidonic acid cell membrane phospholipids. Acts as a scavenger of hypochlorous and hydroxyl radicals. Blocks nitric oxide-stimulated activation of guanylate cyclase (IC 50 2 - 4 uM)
Ambroxol, hydrochloride is a mucoactive and surfactant-stimulatory antioxidant that inhibits the release of arachidonic acid cell membrane phospholipids. Acts as a scavenger of hypochlorous and hydroxyl radicals. Blocks nitric oxide-stimulated activation of guanylate cyclase (IC 50 2 - 4 uM)
Ambroxol, hydrochloride is a mucoactive and surfactant-stimulatory antioxidant that inhibits the release of arachidonic acid cell membrane phospholipids. Acts as a scavenger of hypochlorous and hydroxyl radicals. Blocks nitric oxide-stimulated activation of guanylate cyclase (IC 50 2 - 4 uM)
USA & Canada Tel (800) 628-8470 United Kingdom Tel 0115 9430 840 E-mail address for technical inquiries: technical@calbiochem.com Find our current product data sheets on the web: http://www.calbiochem.com Revised: 04-January-02 Ambroxol, Hydrochloride Size Cat. No. 129870 1 g Synonym: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol, hydrochloride Description: A mucoactive and surfactant-stimulatory antioxidant that inhibits the release of arachidonic acid cell membrane phospholipids. Stimulates the release of surfactant by pneumocytes type II. Acts as a scavenger of hypochlorous and hydroxyl radicals. Blocks nitric oxide-stimulated activation of guanylate cyclase (IC 50 ~2 - 4 M). Form: White to yellowish solid. Packaged under inert gas. CAS Number: 15942-05-9 RTECS number: GV8425000 Molecular Weight: 414.6 Molecular Formula: C 13 H 18 Br 2 N 2 O HCl Structure: Purity: 98.5% by HPLC Solubility: DMSO or water (25 mg/ml) Storage: Freezer (-20C). Protect from light. Following reconstitution, aliquot and freeze at -20C. This product is stable for 2 years as supplied. Stock solutions are stable for 4 months at -20C. Toxicity: MSDS available upon request. Merck Index 12: 401 CN: 129870 References: Severina, I.S., et al. 2000. Eur. J. Pharmacol. 407, 61. Nowak, D., et al. 1994. Free Radic. Biol. Med. 16, 517. FOR RESEARCH USE ONLY. NOT FOR HUMAN OR DRUG USE.