Cebu Normal University

College of Nursing
Osmenia Blvd. Cebu City 6000

NAS III – Pharmacology, Therapeutics and Diagnostics

DRUG STUDY

Name of Patient - Age - Height -

Diagnosis - Sex - Weight -
Doctor - Date of Admission - Body Build -

Classi
Mechanism Nursing
Drug Data ficati Indication Contraindications Adverse Reaction
of Action Responsibilities
on
Generic Non- Confirmed or suspected ectopic pregnancy Body as a whole – Drug is
Name Thera Softens the ectopic Aches/pains, extensively
peuti cervix and pregnanc Allergy to misoprostol asthenia, fatigue, absorbed and
misoprostol c stimulates y of ≤ 63 fever, chills, distributed
uterine
Class:
contractions.
days’ Presence of IUD rigors, weight – Drug is de-
Trade Name Endo gestation changes esterified to
crine- Women with uterine infections, severe anemia, misoprostol
Pharma
Cytotec Meta For the cardiovascular and cerebrovascular diseases, Skin acid, then to
cokineti
bolic treatment coagulopathy, and hypertension Rash, dermatitis, prostaglandin F
cs
Patients Agent and alopecia, pallor, analogs
Dose preventio breast pain – Excretion of
Onset
n of Drug interaction drug: Renal
pregnancies Phar
8
NSAID- – Drug interaction studies between misoprostol Special senses 80%, Fecal15%
through nine macol induced and several nonsteroidal anti-inflammatory Abnormal taste, – Inform patient
minutes
weeks is the ogic gastroduo drugs showed no effect on the kinetics of abnormal vision, about drug’s
vaginal Class: denal ibuprofen or diclofenac, and a 20% decrease in conjunctivitis, mechanism of
Peak
administrati Prost ulcers. aspirin AUC, not thought to be clinically deafness, action and
on of 800µg aglan significant. Studies also showed a lack of drug tinnitus, earache effect to the
30
of din interaction with antipyrine and propranolol baby.
minutes
misoprostol
followed 24 Also when these drugs were given with misoprostol. – Monitor vital
hours later Duratio indicated Misoprostol given for 1 week had no effect on Respiratory signs, compare
with the n for the the steady state pharmacokinetics of diazepam Upper with patient’s
vaginal treatment when the two drugs were administered 2 hours respiratory tract normal or
administrati 120 of apart. infection, previous
on of a minutes duodenal bronchitis, readings.
second ulcers Mean ± SD Cmax(pg/ AUC(0-4) Tmax(mi bronchospasm, – Take blood
800µg dose Drug caused by ml) (pg·hr/ml n) dyspnea, pressure when
of Half Life Peptic ) pneumonia, possible.
misoprostol Fasting 811 ± 317 417 ± 14 ± 8 epistaxis
Ulcer – Note patient’s
135
(2 x 800µg) 20 to 40 Disease individual
With Antacid 689 ± 315 349 ± 20 ± 14
minutes (PUD). 108* Cardiovascular physiological
Availability With High Fat 303 ± 373 ± 64 ± 79* Chest pain, response to
and color Breakfast 176* 111 edema, bleeding such
* Comparisons with fasting results statistically significant, diaphoresis, as changes in
200 µg , 400 p < 0.05. hypotension, menstruation,
µg and 800 hypertension, weakness,
µg tablets, arrhythmia, restlessness,
white phlebitis, and pallor.
increased – Monitor intake
cardiac enzymes, and output
syncope, (I&O), and
myocardial correlate with
Routes of infarction (some weight changes.
administrati fatal), – Maintain bed
on thromboembolic rest. Schedule
events activities to
Intravaginal provide
Gastrointestinal undisturbed rest
diarrhea and periods.
abdominal pain, – Increase oral
nausea, fluid intake to
flatulence, prevent
dyspepsia, occurrence UTI.
vomiting and – Administer with
constipation, GI food to prevent
bleeding, GI GI upset.
inflammation/inf – Advise against
ection, rectal doing activities
disorder, requiring mental
abnormal alertness.
hepatobiliary
function,
gingivitis, reflux,
dysphagia,
amylase increase
Hypersensitivity
Anaphylaxis

Metabolic
Glycosuria, gout,
increased
nitrogen,
increased
alkaline
phosphatase

Genitourinary
Polyuria, dysuria,
hematuria,
urinary tract
infection

Nervous
System/Psychiatr
ic
Anxiety, change
in appetite,
depression,
drowsiness,
dizziness, thirst,
impotence, loss
 of libido,
sweating
increase,
neuropathy,
neurosis,
confusion,
headache

Musculoskeletal
Arthralgia,
myalgia, muscle
cramps,
stiffness, back
pain

Blood/Coagulatio
n
Anemia,
abnormal
differential,
thrombocytopeni
a, purpura, ESR
increased

Source: Sourc Source: Source: Source: Source: Source:

http://www.medi e http://www. http://www.rx http://www.rxlist.com/cytotec-drug.htm#. http://www.drugs http://en.wikipedia.org
cationabortion.c http:/ misoprostol med.com/b.m .com/pro/misopr /wiki/Misoprostol.
om/misoprostol/i /www .org/File/IJG ain/b2.pharm ostol.html.
ndex.html .drug O_pharm_T aceutical/b2.
s.com ang.pdf. 1.monograph
/cons/ s/CPS-
misop %20Monogra
rostol phs/CPS-
.html %20(General
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