PLASMA HALF- LIFE

TIME FOR PLASMA CONCENTRATION OF A DRUG

TO DECREASE BY HALF OF ITS INITIAL LEVEL
AFTER THE PEAK HAS BEEN ACHIEVED

PLASMA HALF LIFE

PROFILE OF SOME DRUGS
ESMOLOL

09 MIN

ASPIRIN

15 MIN

RANITIDINE

02 HOURS

PRAZOSIN

03 HOURS

PROPRANOLOL

04 HOURS

MINOCYCLINE

18 HOURS

LITHIUM CARBONATE

22 HOURS

DIGOXIN

39 HOURS

DIGITOXIN

168 HOURS

FACTORS
PLASMA PROTEIN BINDING
PHARMACOKINETIC PATTERN *
RENAL/HEPATIC DISEASE
ACTIVE METABOLITES
ENTERO-HEPATIC CIRCULATION

DRUG FOLLOWING
IST ORDER KINETICS

DRUG FOLLOWING
ZERO ORDER KINETICS

TIME

AMOUNT
ELIMINATED

AMOUNT IN
PLASMA

TIME

AMOUNT
ELIMINATED

AMOUNT IN
PLASMA

0 hr

100mg

0hr

10 mg

100 mg

1st hr

10 mg

90 mg

1st hr

10 mg

90 mg

2nd hr

9 mg

81 mg

2nd hr 10 mg

80 mg

3rd hr

8.1 mg

72.9 mg

3rd hr

10 mg

70 mg

4th hr

7.3 mg

65.6 mg

4th hr

10 mg

60 mg

5th hr

6.6 mg

59 mg

5th hr

10 mg

50 mg

6th hr

5.9 mg

53.1 mg

6th hr 10 mg

40 mg

0 hr

200 mg

0 hr

200 mg

1st hr

20 mg

180 mg

1st hr

10 mg

190 mg

2nd hr

18 mg

162 mg

2nd hr

10 mg

180 mg

3rd hr

16.2 mg

145 mg

3rd hr

10 mg

170 mg

4th hr

14.6 mg

131.2 mg

4th hr

10 mg

160 mg

5th hr

13.2 mg

118.0 mg

5th hr

10 mg

150 mg

6th hr

11.8 mg

106.2 mg

6th hr

10 mg

140 mg

7th hr

10 mg

130 mg

8th hr

10 mg

120 mg

9th hr

10 mg

110 mg

10th hr

10 mg

100 mg

SIGNIFICANCE

RATE OF ELIMINATION

DURATION OF ACTION

INTERVAL BETWEEN DOSES

TIME FOR STEADY STATE

TIME FOR COMPLETE ELIMINATION