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Cerebellum
OUTLINE
I. CEREBELLUM
A. Gross
B. Function
II. DIVISIONS AND ORGANIZATION
A. Lobes (Transverse Division)
B. Longitudinal Zones (Sagittal Division)
C. Organization
III. CEREBELAR CORTEX: CELL LAYERS
A. Molecular Layer
B. Purkinje Layer
C. Granular Layer
D. Inner White Matter
IV. IMPORTANT SYNAPSES AND CIRCUITRY
A. Synaptic Organization
B. Patterns of Excitation
V. NEURONS AND FIBERS OF THE CEREBELLUM
A. Three Highways
B. Three Inputs
C. Three Outputs
VI. CEREBELLAR AFFERENT FIBERS
A. From the Cortex
B. From the Spinal Cord
C. From the Vestibular Nerve
VII. CEREBELLAR EFFERENT FIBERS
VIII. SUMMARY (CEREBELLAR CORTICAL CIRCUITRY)
IX. CLINICAL CORRELATIONS
Objectives:
Name the major lobes of the cerebellum and give the function of each
lobe.
Describe the division of the cerebellum into a midline vermis and lateral
cerebellar hemispheres.
Describe the histology of the cerebellar cortex.
Name the deep cerebellar nuclei and their general connections.
Name the types of afferent fibers to the cerebellar cortex and identify
their source.
Name the afferent fibers from the cerebellar cortex.
Trace the various circuitries within the cerebellar cortex.
Name the cerebellar peduncles and the fiber tracts (afferent and efferent)
that constitute them.
Describe the cerebellar connections of the vestibular system.
References
Snells Neuroanatomy
Lansangs Neuroananatomy Notes
Dr. Deriadas Slide Lecture
Legends
Text in Times New Roman are from reference books and 2014B trans
Text in Arial Narrow are from the recorded lecture of Dr. Deriada
Text in Calibri are from the powerpoint presentation of the lectures
I. CEREBELLUM
A. GROSS
Located in the posterior cranial fossa
roof over by a vault of dura matter separating from occipital lobe of
cerebrum (tentorium cerebelli)
lies posterior to the pons and medulla oblongata
Group 3A |Cy, CARA, Cring, Kenji
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Anatomic
Division
ANTERIOR
POSTERIOR OR
MIDDLE
(Largest)
FLOCCULONODULAR
Functional
Division
Phylogenetic
Division
Gross Location
Spinocerebellum
Cerebrocerebellum
Vestibulocerebellum
Paleocerebellum
Neocerebellum
Archicerebellum
(oldest)
With a pair of flocculus
and at the vermis there
is a nodulus (pl. Flocculi
and noduli)
Situated anterior to
primary fissure and
terminates at rostral
end of cerebellum
Posterior to the
primary fissure and
anterior lobe.
Limited by the
posterolateral fissure
Input
Function
Posterolateral
Fissure- separate
posterior lobe from
flocculonodular lobe
Spinocerebellar
and
trigeminocerebella
r pathways
Stance and gait
Cerebral cortex
Vestibular nuclei
Speech and
coordinated
movement
Equilibrium (balance,
posture and eye
movements)
Function
Control of
posture, muscle
tone,
locomotion and
equilibrium
Coordination of
ipsilateral
somatic motor
activity
Planning of
movements
Assessment of
errors
Damage/
Disease/
Lesion
Ataxiauncoordinated
voluntary
muscular
movements
Wide-based stance
Stagger walking
Cerebellar
incoordination
(asynergia- lack
of coordination.
Ergo
incoordination )
Dysmetria- refers
to a lack of
coordination of
movement typified
by the undershoot
or overshoot of
intended position
with the hand, arm,
leg, or eye.
Inability to judge
distance or scale
Past-pointing
Tremors
Dysdiadochokine
sis- inability to
perform regular/
rapidly
alternating
movements
Rebound
phenomenon
In the neocerebellum there is a pair of tonsils (located at both side of the midline).
When ICP increase like of tumor may cause herniation through the foramen
magnum because it immediately lies to it, compressing the brainstem which is
essential for breathing and blood pressure
INTERMEDIATE
Medial
VERMAL
PARAVERMAL
FLOCCULONOD
ULAR ZONE
To spinal cord
To cerebral
hemisphere
[efferent fibers:
[includes anterior
fastigial
lobe and the anterior
nucleussynaps part of vermis]
eaxon to
vestibular
[singals/ information
nucleiSC
from cereberal
long axis of the
cortext to emboliform
body]
and globose nuclei or
nucleus interposidus
axons
terminated
contralateral red
nucleus crossing
the other side of the
spinal cord]
LATERAL
Lateral
[MOSTLY
POSTERIOR part]
[cerebral cortex
dendate nuclei
thalamus motor
cortex pontine
nuclei and anterior
horn of spinal
cord]
C. Organization
Outer layer of gray matter- cortex
Inner core of white matter
o Fold in cerebellum or folia would contain outer cortex and inner core
white matter
Deep in the white matter are four pairs of masses of gray matter
or the intracerebellar nuclei:
o Large, multipolar neurons; simple branching dendrites; and
Axons
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1.
2.
3.
4.
Middle
3. Granular layer
Internal
The cell body of the purkinje cells lie in the purkinje cell layer
while the dendrites pass into the molecular layer where they
undergo profuse branching
The primary and secondary branches of the dendrites are
smooth
Dendritic spines- short and thick spines that cover the
subsequent branches which form synaptic contacts with the
parallel fibers derived from granule cell axons
Axons of the purkinje cells will project into the granular layer
and will acquire myelin sheath and terminate by synapsing with
the cells of one of the intracerebellar nuclei which will form the
cerebellar peduncle.
Collateral branches synapse with dendrites of the basket and
stellate cells.
Some pass directly to the end in the vestibular nuclei of the
brainstem. They by-pass the intracerebellar nuclei.
The axons of these cells are the ENTIRE OUTPUT FIBERS of the
cerebellar cortex.
Purkinje cells form the center of a functional unit of the
cerebellar cortex
C. Granular Layer
Found between purkinje cell layer and the cerebellar white matter.
Axons pass into the molecular layer where it bifurcates in a Tjunction forming parallel fibers that run at right angles and
synapse with dendritic processes of the purkinje cells
A. Molecular Layer
Contains two types of neurons: (1) outer: stellate cell (2) inner:
basket cell that are scattered among dendritic arborizations
and numerous thin axons running parallel to the folia.
Neuroglial cells are found in between
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A.
o
o
SYNAPTIC ORGANIZATION
PURKINJIE CELLS
Output cells of the cortex inhibit neurons of the
underlying deep cerebellar nuclei.
The inhibitory control of Purkinje cells over the
excitability of the deep cerebellar nuclei is a key aspect
of cerebellar function.
EXCITATORY
1. Mossy fibers: enter the cerebellum from the spinal cord,
pontine nuclei, vestibular ganglia and nuclei, trigeminal
nuclei, and reticular formation nuclei
o Glutamate (except those from the pedunculopontine
nucleus and some of the vestibular nuclei Ach)
2. Climbing fibers: originate exclusively in the inferior olive
o Glutamate and Aspartate (excite the purkinje cell
dendrites on which they synapse)
o GABA: inhibit the deep cerebellar nuclei
Inhibitory: noradrenergic (locus ceruleus superior
cerebellar peduncle), dopaminergic (substantia nigra
& ventral mesencephalic tegmentum nucleus
interpositus and dentate nuclei), and serotonergic
(raphe nuclei all parts of the cerebelar nuclei and
cortex
OTHER CELLS: INHIBITORY
1. Basket cells
o Inhibit the Purkinje neurons; synapse with climbing
fibers and purkinje dendrites
2. Stellate cells
o inhibit the Purkinje neurons; synapse with climbing
fibers and purkinje dendrites
o Golgi inhibits granule cell
B.
PATTERNS OF EXCITATION
1.
Purkinje
Golgi Type II
Basket cells
Stellate cells
CLIMBING FIBERS CIRCUITRY:
Climbing fiber (+) Dendrites of Purkinje cell axon to (-)
Dentate nucleus
o Dendrite of Purkinje cell Axon to (-) Deep
cerebellar nuclei
o Dendrite of Basket cell Axon to (-) Purkinje cell at
axon hillock
o Dendrite of Stellate cell Axon to (-) Purkinje cell
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Small
granules
Cells
Granular
layer
Golgi
Type II
cells
Granular
layer
climbing fibers
Granular layer and
synapse with axons
of Golgi type II and
mossy fibers
THREE HGHWAYS
1.
Afferent:
o Ventral spinocerebellar Tract (unconscious)
o Some trigeminocerebellar Fibers
2.
Fig. 7 Cerebellar Cortex Circuitry
*Excitatory climbing and mossy fibers use GLUTAMATE as excitatory
transmitter on the dendrites of the Purkinje cells. Other afferent
fibers entering the cortex liberate NOREPINEPHRINE AND
SEROTONIN at their endings that possibly modify the action of the
glutamate on the Purkinje cells.
3.
Mossy Fibers
- Terminal fibers of all other cerebellar afferent fibers
- synapses with golgi neurons
- influence the degree of purkinje cell stimulation
produced by climbing and mossy fiber input
Efferent Fibers: neuron location and synapses
Neuron
Purkinje
Fibers
Cell body
Location
Purkinje
layer
Dendrites Location
Axons Location
Molecular layer
synapsing with
parallel fiber/axons
of granule cell and
Granular layer
extending to white
matter and synapse
with deep cerebellar
B.
Afferent ONLY:
o Pontocerebellar Tract (Cross tract / Contralateral)
Inferior Peduncle
Medulla (Lentiform bodies)
Mainly afferent
Afferent:
o Dorsal Spinocerebellar Tract
o Cuneocerebellar Tract
o Reticulocerebelllar Tract
o Olivocerebellar Tract (important)
o Trigeminocerebellar Fibers (some)
o Vestibulocerebellar Fibers
Efferent:
o
Fastigiobulbar Tract
THREE INPUTS
1.
Mossy Fibers
Spinocerebellar pathways
o Ends in the granular layer
2.
Climbing Fibers
From the inferior olive
Ends in the molecular layer
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3.
C.
Flocculonodular
Cortex
Vestibular Nuclei
Inferior
(juxtarestiform)
Inferior
(juxtarestiform)
THREE OUTPUTS
1.
2.
3.
Fastigial Nuclei
Concerned with balance; sends information mainly to
the vestibular and reticular nuclei (Medial)
Receives purkinje cell output from the vermal zone,
send efferent fibers to the reticular and vestibular nuclei
of the brainstem project into the spinal cord
control of posture and balance
Interposed Nuclei
Same as dentate nucleus; Globose + Emboliform
Receives input from purkinje cell in the paravermal and
vermal zone magnocellular division of the red
nucleus rubrospinal tract crosses midline and
descend into the SC. locomotion and coordinated
movements of the extremities
Dentate Nuclei
Concerned more with voluntary movement and send
axons mainly to the thalamus and red nucleus (lateral &
biggest)
OTHER EFFERENTS
o Lateral zone
Lateral part of the posterior lobe send purkinje cell
axon dentate and interposed nucleus
Fibers from the dentate nucleus terminate in the
parvocellular division of the red nucleus rubro-olivary
tract descend ipsilaterally terminate in the inferior
olivary complex feedback to the dentate and lateral
zone
o Thalamocortical fibers
Ventral lateral thalamic nucleus motor regions of the
ipsilateral frontal lobe
o Intralaminar nuclei
Prefrontal cortex executive functioning
Parietal lobe visuospatial processing
Frontal lobe linguistic activity
Cingulate and parahippocampal region affective and
motivational phenomena
SOURCE
Dentate Nucleus
-voluntary movt
Nucleus
Interpositus
Fastigial Nucleus
-balance
and
sends info
TERMINATION
VL Thalamic nucleus
Red nucleus
Reticular Formation
VL thalamic nucleus
Red nucleus
Reticular Formation
Vestibular Nuclei
Reticular Formation
Corticopontocerebellar Pathway
o Information from cerebral cortex particularly primary
motor and sensory areas and associative areas
(different lobes of the cerebrum)
o Info descend through the corona radiata and internal
capsule
o Terminate on the pontine nuclei (corticopontine fibers)
o The pontine nuclei give rise to the transverse fibers of
the pons
PEDUNCLE USED
Superior
Superior
Superior
(Uncinate
fasciculus)
Inferior
(juxtarestiform)
Superior
(Uncinate
fasciculus)
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Cerebro-olivocerebellar Pathway
o Descend through the corona radiata and internal
capsule to terminate bilaterally on the inferior olivary
nuclei.
o The inferior olivary nuclei give rise to fibers that cross
the midline and enter the opposite cerebellar
hemisphere through the inferior cerebellar peduncle.
o Information: motor area
**Fibers that arise from inferior olivary nuclei terminate as
the climbing fibers in the cerebellar cortex, the rest will
terminate as mossy fibers
Cerebroreticulocerebellar Pathway
o Descend to terminate in the reticular formation on the
same side and on the opposite side in the pons and
medulla
o Cells in the reticular formation give rise to the
reticulocerebellar fibers that enter the cerebellar
hemisphere on the same side through the inferior and
middle cerebellar peduncles.
o Information: motor areas
Cuneocerebellar Tract
o Originate in the nucleus cuneatus
o Enter the cerebellar hemisphere on the same side
through the inferior cerebellar peduncle
o The fibers terminate as mossy fibers in the cerebellar
cortex
o Collateral branches that end in the deep cerebellar
nuclei
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Vestibulocerebellar
o receives information from the inner ear
o Project axons directly to cerebellum
o Directly synapse with neurons in cerebral cortex through
inferior cerebellar peduncle
o All the afferent fibers from the inner ear terminate as
mossy fibers in the flocculonodular lobe of the cerebellum.
*All afferent fibers terminate in flocculonodular lobe
*Other Afferent Fibers
1.
Globose-Emboliform-Rubral Pathway
Contained in the intracerebellar nuclei (via Globose and
Emboliform or Nucleus interpositus) to the red nucleus/-i.
Axons travel through the superior cerebellar peduncle and
cross the midline to the opposite side in the decussation of
the superior cerebellar peduncles
Fibers end by synapsing with cells of the contralateral red
nucleus, which give rise to axons of the rubrospinal tract
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Dentothalamic Pathway
Axons travel through the superior cerebellar peduncle
Cross the midline to the opposite side in the decussation of
the superior cerebellar peduncle
Fibers end by synapsing with cells in the contralateral
ventrolateral nucleus of the thalamus
Axons of the thalamic neurons ascend through the internal
capsule and corona radiata and terminate in the primary
motor area of the cerebral cortex.
Influence motor activity by acting on the motor neurons of
the opposite cerebral cortex
Impulses from the motor cortex are transmitted to spinal
segmental levels through the corticospinal tract.
Deccusation of pyramid
4.
3.
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Brainstem-nuclei-cerebellar Loop
Olivocerebral and Reticulocerebral enters thru the inferior
middle peduncle to the cortex (Lateral/Posterior) then go to
Purkinje cells to the Nucleus Interpositus / Dentate Nuclei
then to the Red / Reticulospinal then finally the spinal cord
Also follow Double Decussation
Dentate Nucleus and Interposed Nucleus
Red Nucleus
Reticular Nucleus
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Origin:
o cerebral cortex
o muscles, tendons, and joints
o vestibular nerve
Cerebellum
o NO DIRECT neuronal connections with LMNs (indirect)
o coordinator of precise movements, bring about the
necessary adjustments
o influence activity of LMNs Cerebellum
o send back information -> inhibit agonist muscles
o stimulate antagonist ms. -> limits voluntary movement
B.
COMMON DISEASES
1. Acute Alcohol Poisoning
Alcohol acting on GABA receptors of the
cerebellar neurons
2. Alcohol Cerebellar Degeneration
Severe chronic alcoholism with malnutrition
Vermal degenerative changes
o Ataxia of gait but with normal speech and muscle
coordination of upper extremities
3. Tumors
Vermis Syndrome = Medulloblastoma (in Children)
Cerebellar Hemisphere Syndrome
o Ataxia is very noticeable
C.
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