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Alcohol
Breast feeding
Driving
Over 60
Over 60
Pregnancy
Tobacco
Asthma and severe respiratory problems combined * Effect of drug enhanced by cimetidine,
with bronchopneumonia erythromycin, influenza virus vaccine among
others.
Dosage
* Drug enhances effect of ephedrine.
Adults: By slow injection - (13 to 15 mg/kg/day
divided in 3 doses) * It decreases effect of phenytoin.
By Mouth - (100-300 mg) 3 - 4 times daily after food Patient Information
* If GI upset occurs, take with food.
Precaution
Safety Contra- Increased
* Do not chew or crush enteric coated/ sustained
not
established
indicated risk of
adverse
release tablets.
effects
* Take every 6 hrs (round the clock) or as directed
Can
continue
Increased
risk of
by the physician.
use of adverse
medicine Over 60 effects * Notify physician if adverse effects occur.
Others * Avoid drinking large amounts of caffeine
containing beverages such as tea, coffee, cocoa,
Use with caution in cases of severecardiac disease, cola drinks and chocolates, which enhance the
severe renal or hepatic (liver related) disease, acute adverse effects of the drug.
heart injury, heart failure, peptic ulcer.
Adverse Effects
Gastrointestinal irritation, nausea, vomiting,
gastrointestinal bleeding.
Continue the drug and inform your doctor
* Stimulation of CNS: anxiety, headache,
confusion, restlessness, vertigo and palpitations
(increased activity of heart).
Rational Therapy Tips
Continue the drug and inform your doctor.
Q. Which type of cough syrup should be
* Overdosage is especially dangerous in children.
prescribed to the children below the
age of one year, expectorant or
suppressant?
Ans. Usually no cough syrup should be given to
children below the age of one year. Water
Contraindicated Contraindicated
* May produce drowsiness, dizziness, light- Irritation of nasal passages and fungal infection of
headedness, blurred vision. Hence caution while mouth and throat.
driving or similar job requiring alertness. Discontinue and call the doctor immediately.
* Diabetics - may mask signs of low blood sugar or Additional Information
other blood glucose levels.
Patient Information
* May be taken without regard to meals.
* Rinse mouth with water or mouth wash after each
use to help reduce dry mouth and hoarseness.
* Allow at least one minute between inhalations.
Adults: Rheumatic fever: 0.72 gm every 4 weeks or Hypersensitivity reactions to benzyl salicylate has
12-24 lakh units every 3 weeks IM. been reported. Skin reactions seen for sensitive
skins.
Syphilis: initial stage 1.44 gm as single dose,
later 4.2 gm twice at 7 day intervals.
Pharyngitis: 0.72 gm as single dose, 1.44 gm daily.
Children: Syphilis: upto 2 yrs: 0.03 gm/kg
(1 dose). 2-12 yrs: Adult dose.
P h a r y n g i t i s : u p t o 2 7 . 3 k g b o d y we i g h t :
0.18 gm - 0.36 gm
Body weight more than 27.3 kg: 0.54 gm
(1 dose). Rational Therapy Tips
Precaution Q. What is the role of antibiotic skin
Contraindicated Contraindicated
ointment?
Ans. Very little. Most skin infections in
childen would need oral antibiotics.
Further there is a risk of sensitisation
Others with ointments.
* Allergy to penicillin and cephalosporins
* Kidney and heart problems
* It should be administered by IM route only and
no other route.
* Administer slowly after sensitivity testing.
Adverse Effects
On high doses - lethargy, confusion, convulsions,
liver problems, allergic reactions like skin rashes,
sudden severe allergic reactions (anaphylaxis).
Discontinue and call the doctor immediately.
Over 60
Others
* Liver problems
* Blood disorders
* Glaucoma Rational Therapy Tips
* Heart problems Q. What is the best treatment for anemia
* Kidney problems in children?
Ans. Most of the time it is iron deficiency
* Bone marrow depression anemia. Iron syrup or drops should be
* Psychotic problems used in the dose given below:
Adverse Effects Elemental Iron: 6 mg/kg/day. Most Iron
syrups in the market, with notable
Dizziness, drowsiness, confusion, headache, exceptions, contain around 30 mg of
fatigue, blurred vision, anemia, abnormal liver elemental iron per 5 ml.
function, acuteurinar y retention paralysis,
pneumonia rashes, abdominal pain dryness of
mouth, hypertension, congestive heart failure,
muscle and joint pain, fever and chills.
Continue the drug and inform doctor.
Contraindications: Kidney or liver problems, * May cause drowsimess. Avoid during day tasks
epilepsy, heart problems, glaucoma, Parkinson’s requiring alertness.
disease. * Avoid alcohol and other depressants.
Adverse Effects * Avoid prolonged exposure to sunlight.
* Sudden death. * Avoid changing posture frequently.
* Liver damage resulting in jaundice. * Caution while climbing stairs.
* Blood disorders.
* Caution in case of hot weather.
* Alteration in blood pressure, increased heart
beat, cardiac arrest, irregularities in rhythm of * Avoid phenobarbitone.
heart beats
* Exposure to sunlight may lead to skin reactions
* Allergic reactions as skin rashes.
* Hormonal disorders.
Overdosage : Fatal or leading to coma. In general, CNS
depression.
Adults: 400 mg (2-4 times daily) by mouth. * Decreases effective levels of digoxin in blood.
Contraindications
Liver or kidney problems.
Adverse Effects
* Gynaecomastia (excessive development of male
mammary glands, sometimes secreting milk).
* Irregular heart beats.
* Fever. Headache. Rational Therapy Tips
* Decrease in white blood cells. Q. Is there any need for routine use
of antiinflammatory drugs while
* Liver toxicity. treating acute infections, e.g., tonsilitis
Continue the drug and inform your doctor. and pharyngitis?
Ans. No, they are of no added advantage.
Additional Information
Drug Interactions
* Prolongs action of warfarin type
a n t i c o a g u l a n t s, p h e n y t o i n , p r o p a n o l o l ,
lidocaine, theophylline and benzodiazepine
derivatives (e.g. diazepam).
* Antacids if needed should preferably be taken at
spaced intervals from time of taking this drug.
* Interferes with action of ketoconazole.
Precaution Others
Can
continue
Contra-
indicated
Increased
risk of
* Stop drug slowly.
use of adverse
medicine effects * Low blood pressure
Others Adverse Effects
Patients with problems of stomach and intestine, Dry mouth, drowsiness, sedation, consti-pation,
liver problems. headache and fatigue abnormalities in liver
Early pregnancy. function, weight gain, congestive heart failure,
rashes, burning of eyes and dryness of nasal
Adverse Effects mucosa.
Bowel obstruction, water retention, stomach upset Should not be withdrawn.
and pain.
Additional Information
Reversible brown to pink discoloration of skin and
Drug Interactions
discoloration of hair, sweat, tears, faeces and urine.
Clonidine may enhance the CNS depressant effects
Additional Information
of alcohol, barbiturates (like phenobarbitone) and
* Rush to the doctor in case of loss of vision, sedatives.
bloody black stools, yellow eyes and vomiting.
Patient Information
* If discoloration of skin occurs, one should not
* Abrupt withdrawal may cause rapid rise in BP.
get frightened.
* Avoid cough cold or allergy medications.
Drug Interactions
* If dizziness occurs, avoid sudden changes in
Not known.
posture.
Dosage Dosage
Adults: Use 20% solution (or dilute with three parts of Organ Transplantation: Used alone (10-15 mg/kg) as 1
water) on the affected areas of the skin, one to three dose 4-12 hrs. before trans-plantation followed by
times a day. 10-15 mg/kg daily for 1-2 weeks and then reduced to
2-6 mg/kg.
For use on scalp: Dilute 20% 10 times with water.
Bone Marrow Transplantation: 3-5 mg/kg by IV
For bath: Add 100 ml of 20% solution to the bath and
soak in it for 5 minutes. infusion over 2-hrs from day before transplantation
to 2 weeks post operatively, then 12.5 mg/kg by
Children: Dose not established. mouth for 3-6 months.
Precaution Precaution
Safety Contra- Contra-
not indicated indicated
Safety Safety
established
not not
established established
Others
Adverse Effects
* Open wounds, inflammed skin, infected skin.
Liver dysfunction, fatigue, gastro-intestinal
* Patients intolerant to tars may be intolerant to coal disturbances, burning sensation in hands and feet,
tars also.
headache, rash, anemia, weight increase,
Adverse Effects convulsions, muscle cramps, inflammation of
Induction of acne type skin eruptions and sensitivity pancreas, kidney damage, mild tremor, abnormal
to sun. growth of gum.
Discontinue and call the doctor immediately.
Additional Information
Drug Interactions
* Amphotericin B, erythromycin or ketoconazole
should not be coadmin-istered since it increases
cyclosporin toxicity.
* Phenobarbitol, phenytoin, rifampicin and
trimethoprim sulphamethaxole should not be
given.
Over 60
Others
Peptic ulcer, glaucoma, TB, herpes infection, mental
illness.
Rational Therapy Tips
Not to be stopped suddenly if used for a Q. For calculating dose per kg for a
prolonged duration. malnourished child should the actual
Adverse Effects weight be considered or is the
expected weight required?
Abdominal stretching, nausea, vomiting, weight
gain, peptic ulcer, impaired wound-healing, skin Ans. Actual weight.
rashes, thin fragile skin, convulsions, insomnia,
hiccups, menstr ual irregularities, increased
sweating, cataracts, glaucoma, irregular heart
beat, cardiac arrest, muscle weakness and loss of
muscle mass.
Additional Information
Drug Interactions
Phenytoin, phenobarbitone, rifampcin and
ephedrine increase drug clearance.
Aspirin, isoniazid should not be given as also
aminophylline.
Avoid Can
continue Others
use of
medicine
* Antimalarial therapy.
Adverse Effects
* Impaired kidney functions.
Pain may occur at the injection site, hemoglobin
Adverse Effects
biosynthesis affected, redness of skin, itching,
oedema, jaundice, nausea, vomiting. Typical Mazotti reactions: skin rash, fever joint
pain, aches, headache, eye and vision problems and
Continue the drug and inform your doctor.
decrease in BP.
* Risks of GI side-effects.
Continue to use the drug and inform the doctor.
* Unsafe in acute porphyria (a rare inherited, blood
Additional Information
disease).
Patient Information
Additional Information
* Take satisfactory food and fluid.
Drug Interactions
* Increase dose slowly.
* Reduces excretion of lithium and also that of
methotrexate (an anticancer drug).
* Typical NSAID (non-steroidal anti-inflammtory
drug) reactions.
Others
Long term kidney problems, abnormal heart
Adverse Effects
rhythms.
In most cases well tolerated. Mild side-effects
Adverse Effects
include flatulence, vomiting and itching.
Rashes and other allergic reactions reported.
Do not discontinue the drug. Contact your doctor.
Prolactin effects like enlargement of breasts and
Additional Information
milk secretion.
Ineffective when administered alone in the
Continue the drug and inform your doctor.
treatment of extra-intestinal amoebiasis.
Additional Information
Drug Interactions
* Antipsychotic drugs and analgesics (opioids)
should not be given.
Contra- Reduced
indicated dose to be
given
Over 60
Others
* Allergy to tetracycline.
* Liver, kidney problems.
* Surgery under general anaesthesia. Rational Therapy Tips
Pregnancy: take only in first four months. Q. What is the role of liver tonics in
Adverse Effects hepatitis?
Ans. Most liver tonics available in the market
Nausea, vomiting, diarrhoea, black tongue, ulcers, have no proven value in case of jaundice in
rashes, fatty liver, anemia, discoloration of thyroid newborn or viral hepatitis in children.
gland, abnormal pigmentation of conjuctiva of eye. Only drug manufacturers tell that they are
Continue the drug and inform the doctor. useful but no authentic literature or
Additional Information authority agrees with them.
Drug Interactions
* Antacids, iron and alkali should not be given
since they impair the absorption of the drug.
Over 60
Others
* Narrow angle glaucoma
* High BP
* Diabetes
* Overactive thyroid
Rational Therapy Tips
* Heart problems
Q. Is it rational to use steroids as a
* Never give intravenously
‘WONDER' drug during any type of
Adverse Effects ailment?
Cerebral haemor rhag e (serious bleeding), Ans. It is not. Steroids have very specific
hallucination, impairment of memory, panic, indications. They are dangerous in
suicidal tendencies. ordinary fevers or nonspecific ailments.
Palpitations, changes in blood pressure, irregular Two good examples of their rational use
heart beat, decreased urine formation and and are asthma and nephrotic syndrome. Two
painful urination. Heart burn, haemorrhage at site common examples of misuse are hepatitis
of injection. and high fever.
Respiratory difficulties.
Additional Information
Drug Interactions
* P h e n o t h i a z i n e s ( e. g. , c h l o r p r o m a z i n e ,
prochlorperazine, etc. — a class of drugs used in
Adults: 10 micrograms (400 units) is given by * Very important to comply with dosage
intramuscular injection or gelatin capules instructions, diet and calcium supplemen-tation.
containing 25,000 to 50,000 units orally. * Notify physician if any of adverse effects persist
for long or become serious.
Precaution
Can Can Can
* Avoid use of magnesium containing antacids/
continue continue continue laxatives while taking this drug.
use of use of use of
medicine medicine medicine
Others
Monitoring of plasma calcium in high dosages, and
in kidney disorders, is necessary.
Adverse Effects
Weakness, headache, sleep disturbances, nausea,
vomiting, dry mouth, constipation, muscle pain,
bone pain and metallic taste.
Later, excessive urination, excessive thirst, loss of Rational Therapy Tips
appetite, weight loss, conjunctivitis, inflammation
Q. How safe is aspirin in childhood
of pancreas, inability to face light, excessive nasal
fevers?
discharge, itching, fever, decreased vigor, increased
blood pressure, irregular heart beats. Ans. It is best avoided. It has possible
etiologic links with Rye's Syndrome
Additional Information (coma + liver damage), a serious
Drug Interactions disease. Its use for treatment of
fever in children below 12 years is not
* Use of magnesium containing antacid may cause recommended, specially in cases of
increased magnesium levels in blood. chickenpox and influenza.
* Cholestyramine interferes with absorption of
Vit D
* If patient is treated simultaneously with Vit D
and thiazide diuretics (like fr usemide,
hydrochlothiazide), elevated calcium levels in
blood may result.
Contra- Avoid
Eye ointment: 0.1 - 0.3% every 6-12 hours.
indicated
Eye/ear drops: 0.1 - 0.3% every 4-8 hours.
Precaution
Others Contra- Contra- Contra-
indicated indicated indicated
G6PD Deficiency
Adverse Effects Can Can Increased
continue continue risk of
* Mild toxic symptoms (headache, nausea) use of
medicine
use of
medicine Over 60
adverse
effects
* Measle-like rashes
Others
* Changes in blood
* Must be stopped before you have general
* When used for vaginal infections may anaesthesia
occasionaly cause swelling of vulva or itching.
* Should not be given for longer than ten days
Additional Information usually.
Patient Information * Reduce dose if kidney problems.
* Foods with high tyramine content (cheese, beer,
red wine) and alcohol should be avoided during
and for short time after treatment.
Grisactin FP, Grisofil FP, Idifulvin, * It decreases the efficacy of warfarin, phenytoin
Walavin 250 and barbiturates (e.g., pheno-barbitone).
Contra- Contra-
indicated indicated
Others
* Porphyria (rare, inherited blood disease)
* Pregnancy
* Sensitivity to sunlight Rational Therapy Tips
* Pencillin sensitivity Q. If temperature is high inspite of
paracetamol, what should be done?
* Systemic Lupus Erythematosus (a chronic,
inflammatory disease affecting the skin and Ans. Tepid water sponge.
various internal organs)
Adverse Effects
Skin rashes, edema, oral thrush, nausea, vomiting,
diarrhoea, headache, fatigue, mental confusion,
photo allergy.
Continue the drug and inform your doctor.
Adolescents: 30 mg
Contra- Contra- Reduced
Precaution indicated indicated dose to be
given
Safety Contra- Reduced Over 60
not indicated dose to be
established given
Others
Contra- Contra- Reduced * Kidney or liver problems.
indicated indicated dose to be
given
Over 60 * Heart problems
Others * Old age.
For liver and kidney problems, epilepsy, lung Adverse Effects
disorder, Parkinson's disease Headache, nausea, vomiting, fast heart beat,
Adverse Effects numbness and tingling, rashes, fever, difficulty in
urination, fluid accumulation, loss of appetite.
Abnormal movements of face and limbs, lethargy, Redness of eyes, nasal stiffness.
weight gain, dizziness, rash.
Continue the drug and inform your doctor.
Additional Information
Additional Information
Patient Information
Patient Information
* Notify physician if impaired vision, jaundice,
tremors or muscle twitching occur. * Take with meals
* Do not discontinue this medication suddenly.
* Avoid cold, cough or allergy medication.
* If dizziness occurs, avoid sudden changes in
posture.
Diuretic, used to reduce fluid retention, treat kidney * Will increase urination early during the day, may
disorders, heart problems and high BP. increase blood sugar levels in diabetes so notify
the physician.
Dosage
* Eat food rich in potassium.
Adults : 25-200 mg daily
Children : 2 mg/kg/day every 12 hours.
Precaution
Contra- Contra- Contra-
indicated indicated indicated
Contra- Increased
indicated risk of
adverse
Over 60 effects
Others
Kidney diseases, liver diseases, gout, diabetes.
Adverse Effects
Rational Therapy Tips
Cramps, abdominal bloating, constipation,
jaundice, frequent urination, impotence, headache, Q. Which are the commonly used drugs
weakness, lethargy, fatigue, muscle cramps, in which dose should be calculated on
nervousness, agitation, anemia, chest pain, skin the basis of active base and not on the
rashes, blurred vision, chills, flushing. actual strength of the salt?
Continue the drug and inform your doctor. Ans.
1. Chloroquine for treatment of malaria.
Additional Information Most chloroquine tablets containing 250
Drug Interactions mg of phosphate salt (150 mg of base).
Most liquid preparations have 50 mg of
Barbiturates (like phenobarbitone) and narcotics chloroquine base per 5 ml.
(eg. opium, morphine, pethidine) aggravate adverse
effects and decreases the efficacy of thiazides (a 2. Theophyline preparations in use for
class of drugs used as diuretics, eg., frusemide, bronchial asthma. Different preparations
hydro-chlorthiazide) and so does indomethacin have different strengths of the base. Find
and other NSAIDS (non-steroidal anti- it out from the manufacturer.
inflammatory drugs, like ibuprofen, aspirin,
diclofenac, phenylbutazone).
Others
* History of GI lesions.
* If headache persists
* Impaired kidney function.
* Presence of infection
* Eye complaints
* Hypertension
* Impaired liver function
* Low blood counts
* Parkinson's.
* Epileptic fits.
Adverse Effects
Source : VHAI
Others
* Patients with thyroid gland disorders.
* If irritation occurs in superficial wounds without
infection.
Rational Therapy Tips Adverse Effects
Q. Which is the safest and most effective Irritation, running nose, sore weeping eyes, fever,
antipyretic and analgesic to be used in headache, coughing and pain and swelling over the
children? angle of the jaw.
Ans. Common ones which can be used are:
Additional Information
1. Paracetamol - (Dose 10-15 mg/kg/dose
every 4-6 hrs) * Store in glass or earthen ware container with a
well waxed stopper.
2. Mefenamic acid - (Dose 6 mg/kgm/dose
every 6 hrs) * Do not use metal bowls.
3. Ibuprofen - (Dose 20 mg/kg/day divided * Accidental ingestion causes vomiting, diarrhoea,
into 3 doses) stomach pain.
Give milk/starch mucilage (sticky, viscous
preparation) before inducing vomiting and then give
activated charcoal.
Others
Liver damage, high risk of adverse effects on
nervous disorders in malnourished, anemics and
those with seizure disorders
Adverse Effects
INH allergic reaction can cause serious liver damage Rational Therapy Tips
especially in people over 35 years and regular alcohol
Q. Which antitubercular drugs are not
consumers.
hepatotoxic?
INH causes deficiency of Vitamin B 6 leading to Ans. Streptomycin
nerve pain and tenderness in hands, feet.
Ethambutol
Blurred vision/changes in vision.
Damage to the nervous system.
Allergic reaction to thiacetazone can be fatal. If
there is allergy/itching, discontinue and call the doctor
immediately.
Others
Allergy to nitrates
Adverse Effects Rational Therapy Tips
* Most serious could be excessively lowered BP Q. Which drug should be avoided in a
Overdose: Bluish lips, finger nails, fainting, dizziness, patient having G-6PD deficiency?
unusually seizures, blurred vision and skin rash. Ans. A number of drugs lead to severe
* Headache is a common untoward effect, it does intravascular hemolysis in a known patient
not require discontinuation. of G-6PD deficiency. The drugs known to
cause significant hemolysis in G-6PD
Additional Information
deficient children include antimalarials
Patient information (primaquine, quinine chloroquine),
* In case chest pain persists after taking nitrofurantoin, fuzazoladone,
sulfonamide, nalidix acid, aspirin, analgin
and naphtalene which is used in moth
balls.
Contra- Contra-
5-25 mg per dose. However, dosage may vary from
indicated indicated individual to individual.
Over 60
Administered as tablets or injections.
Others
Precaution
Kidney and liver problems, patients with epilepsy Contra- Contra- Contra-
indicated indicated indicated
Adverse Effects
Muscle dystonias (abnormal muscle contractions).
Contra- Contra- Reduced
* CNS: drowsiness restlessness, fatigue, loss of sleep, indicated indicated dose to be
taken
depression. Over 60
Additional Information
Drug Interactions
Oral Neomycin therapy
* Should not be administered with penicillin V
potassium.
* Decreases effect of digitalis. Space the intervals
between intake of the two drugs.
* Enhances effects of oral anticoagulants by causing
malabsorption of Vitamin K.
* Avoid concurrent use of diuretics to reduce risks
of adverse effects.
* Avoid concurrent use of other nephrotoxic and
ototoxic agents (kidney and ear toxic).
Patient Information
Oral therapy
* Complete full course of therapy.
* Notify physician if ringing in ears, hearing
Source : Medical Ethics Vol.3, No.4 impairment or dizziness occur.
October - December 1995
Topical application
* Cleanse affected area prior to application unless
otherwise directed.
established
* Rifampicin (antibacterial)
* Phenytoin (antiepileptic) Avoid Avoid Avoid
Others
* Intestinal obstruction
* Pneumothorax (air in pleural cavity of lungs)
* Head injury
* High doses in prolonged delivery.
Adverse Effects
Diffusion, lack of oxygen, drug induced high fever,
delirium, irregular heart beats, inability to walk, loss
of bladder and bowel control, mental changes,
n u m b n e s s i n h a n d s , l e g s
or feet or unsteadiness, breathing problems, nausea,
vomiting, sore throat, blood disorders.
Others.
* Test for pregnancy
* Carcinoma of breast or reproductive organs.
* Liver problems
* Undiagnosed vaginal bleeding
* Missed abortion
* Asthma
* Heart problems
Contra-
indicated
Over 60
Others
History of sensitivity to nystatin
Adverse Effects
Occasionally : nausea, vomiting and diarrhoea may
result.
* Following topical use allergic reaction may be
seen.
Contra-
indicated
Over 60
Others
Kidney, liver, heart problems, stomach problems
Rational Therapy Tips Adverse Effects
Q. What is rational about anti-convulsant Blood disorders, skin reactions, serum sickness,
therapy? stomach upset, fever, kidney problems.
Ans. Use one drug at a time and try to use the
second one only if a fair trial of about 4 to Discontinue and call the doctor immediately.
8 weeks has been tried with the first drug Additional Information
with adequate dosage and g ood
compliance. It is better to change in case Patient Information
of failure rather than adding one more Have good potassium, sodium, calcium intake.
anti-convulsant.
Others
* Heart problems
* IV administration not greater than 50 mg per Rational Therapy Tips
min.
Q. D o e s p h e n o b a r b i t o n e a f f e c t
Adverse Effects performance of a child?
Slurred speech, mental confusion, dizziness, Ans. Yes. In quite a few children it causes
insomnia, ner vousness, motor twitchings, hyperactivity and reduces their attention
headache, tremors, drowsiness, seizures, nausea, span.
vomiting, diarrhoea / constipation, skin rashes,
anemia, liver damage, problems with gums,
hirsutism (excessive body hair), acute inflammation
of lungs (pneumonitis).
Continue to take the drug and inform the doctor.
Additional Information
Drug Interactions
* Drugs affecting phenytoin, barbiturates,
carbamazepine, folic acid, calcium gluconate,
antacid, cloxacillin, dietary calciuam reduce
phenytoin availability.
Adverse Effects
* Friable bleeding or recently biopsied warts.
Avoid application on
* Mole or birthmarks
* To small areas of intact skin
* Avoid contact with mouth or eyes
* Do not use near heat, open flame or smoking
Additional Information
System toxicity: Death can occur if amount as small
as 300 mg is ingested. Kidney and liver failure,
cerebral toxicity. System toxicity includes stomach
pain, clumsiness, unsteadiness, vomiting,
confusion, diarrhoea, weakness, sore throat,
unusual bleeding.
Others
* High potassium levels especially in case of
impaired kidney function.
* Extensive tissue damage (e.g.burns)
Adverse Effects
* Decreased excretion.
Others
* Parkinson’s disease treated with Levodopa.
* Doses greater than 200 mg/day for 30 days cause
dependency.
* Doses greater than 2 - 6 gm cause serious side-
effects.
* Liver and kidney problems.
* In use as substitute for balance diet.
Others
* Heart block
* Allergy to drug
* Patient should be monitored closely
R. K. Laxman in The Times of India
Adverse Effects
* Some individuals are very sensitive and can
experience blurred vision, dizziness, severe
headache, ringing in the ears, rashes or other
forms of allergic reactions.
* Diarrhoea is common.
* Anemia and other blood disorders.
* In some cases, the drug itself can cause
irregularities in rhythm of heart beats
Is there anybody in the house not affected by malaria ?
Continue the drug and inform your doctor.
Upto 5 tabs a day providing Rifampicin 600 mg, INH * Antacids reduce absorption of INH and
400 mg and Pyrazinamide 1250 mg. Given as a single rifampicin.
dose one hour before food in the morning. * Pyridoxine supplementation should be taken by
Precaution patients taking this drug especially those prone
Contra- Avoid Reduced
to pyridoxine (B 6) deficiency.
indicated dose to be
taken * Foods like cheese should be avoided.
Othersiven
* Individuals allergic to any of the compo-nents of
the combination.
* Liver disease
* Jaundice
* Gout
* To be administered with caution in patients with Rational Therapy Tips
liver damage, alcoholics, potential pyridoxine (B Q. Which antitubercular drug should not
6) deficients. be used under 3 years of age?
Adverse Effects Ans. Ethambutol has ocular (eye related)
toxicity, which is difficult to assess under 3
* Generally well tolerated. years of age.
* May cause liver damage, gout, uric acid
accumulation, disturbances of nervous system.
* Photosensitivity
Do not stop the drug therapy on your own.
Others
Others
* Apart from osmotic disturbances, it is relatively
* Patients with high BP
non-toxic.
* Coagulation defects
* Large doses by mouth have a purgative action.
* Recent peptic ulcers
Adverse Effects
* Excessive bleeding
* Fever
* Rashes and allergic reactions to the enzyme
may be triggered.
Additional Information
Drug Interactions
* Interacts with antiblood coagulants and
antiplatelet drugs to increase the risk of bleeding
(platelets are disc-shaped structures in blood that
perform several functions related to blood clotting).
Others Over 60
Others
* Liver and pancreas problems
* Blood disorders
* Severe epilepsy
* Mental retardation
Adverse Effects
Rational Therapy Tips Loss of control, seizure, general uneasiness,
Q. What is the best way to administer oral weakness, lethargy, loss of appetite, vomiting,
jaundice, water retention, liver function, weight
iron? gain, hair loss, tremor, drowsiness, lack of muscular
Ans: Ascorbic acid (Vitamin C) increases the coordination.
iron absorption from intestines. Phytates Additional Information
in food (cereals), phosphates in milk and
avidin in raw egg decreases iron Drug Interactions
absorption. Hence oral iron should be * Phenobarbitone and phenytoin should not be
taken between the meals on an empty given with the drug.
stomach - preferably with Vitamin C. Patient Information
* Take with food.
* Do not chew tabs or capsules. Swallow whole to
avoid local irritation of mouth.
vinblastine) Others
Continue the drug and inform your doctor.
Even minor bumps/bruises may bleed excessively.
Additional Information
Contraindicated in :
Patient Information
* Adequate amount of fluid intake is very * Severe increase in BP
essential. * Severe to moderate problems of liver or kidney
* In case of severe constipation, laxatives may be * Bleeding tendencies
used after proper medical advice.
Adverse Effects
* Doctor should be informed if suffering from
chickenpox, gout, kidney stones, liver disease, Major risk: Loss of blood from almost any organ of
nerve or muscle disease. the body.
* Doctor should be informed if probencid and * When consumed orally during pregnancy, can
sulfinpyrazine are also being taken at the time of cause birth defects in the growing
treatment.
Source: Abhay Shukla and Anant Phadke. Swathya Sathi. Part 1, CEHAT, Pune, 2000.
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