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APPLICATION FORM
YSP-Travel Fellowships for 13th FAOBMB Congress, Bangkok, 23'29 Novembet'2012.
Name of Applicant:

Dr. Atlu Shadat Mohammod Noman

& Research X'ellow (Bangladesh Council for Scientific

position:
&

Associate Professor Industrial Research)

Address of Applicant: (Normally this will be your institutional or office address) Principal Investigator Laboratory of Eukaryotic Gene Expression & Function &, Associate Professor Department of Biochemistry & Molecular Biology University of Chittagong Chittagong-4331
Bangladesh Mobile: +88-0172-7 7 7 37 67 Land Phone: +88-03 l-2606068

Fax: +88-031-726310

Email address: asmnomancubd@gmail.som Membership of FAOBMB Constituent Society: (lndicate the Constituent Society of FAOBMB in your country/region of residence which you are a membet'). Please see Societies profile under i'About FAOBMB: Constituent Member" on the webpage at:
http://faobmb.net
Bangladesh Society for Biochemistry

& Molecular Biology

Date of Birth: December 15,1978

Applicants must be no more than 35 years of age at the closing date for application: (31 July, 2012).

Page 1 of 11

Proof of Age: (Certification by the Head of your Institution or Department is required)

I certify on the basis of official documentation which I have seen (e.g. passport, birth certificate or driver's licence) that the date of birth of the applicant Dr. Abu Shadat Mohammod Noman is ...15/.. .12...[978....., &S shown above. (DD/MonthNear)
Signed:

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.

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Position: Chairman Department of Biochemistry University of Chittagong Chittagong-4331

Bangladesh

& Molecular Biology

Page 2 of 8

Curriculum Vitae Provide a brief CV showing education and research training, including any prizes or awards: (no more than one page)
NAME POSITION TITLE

Abu Shadat Mohammod Noman, Ph.

ERA COMMONS USER NAME

D.

Noman

Associate Professor University of Chittagong, Bangladesh &, Research Fellow, BCSIR, Bangladesh

EDUCATIONiTRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) UTURTT/ INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY Trainino

University of Rajshahi, Bangladesh University of Rajshahi, Bangladesh

B.Sc. Master

999 2000
1

Aichi Medical University, Japan University of Massachusetts Medical School, MA (ln collaboration with Hollings Cancer Center) Bangladesh Council for Scientific & lndustrial Research

PhD
Postdoc Research Fellow

2010
2011 2012

Biochemistry Biochemistry and Molecular Biology lnnate lmmunity and Cancer lnnate lmmunity and Cancer lnnate lmmunity and Cancer

A.
19992000-

Research Traininq
Master Level Research with Dr. Rezaul Karim in Rajshahi University Post Master Level Research with Dr. Rezaul Karim in Rajshahi University Higher Research on Protein Engineering in Chemico Laboratories,
Bangladesh

2000 2002

2002-2004 2004-2006

Higher Research on arsenic toxicity in Chittagong University, Bangladesh 2007Higher Research on arsenic toxicity with Dr. Yoshiyuki Kawamoto, Chubu University, Japan 2007- 2010 Graduate Research with Professor Dr. Takashi Yokochi, Department of Microbiology and lmmunology, Aichi Medical University, Japan 2010- 2011 Postdoctoral research with Michael Brodsky at University of Massachusetts Medical School and, in collaboration with Dr. Zihai at Hollings Cancer Canter. 2012-Continue Research Fellow of Bangladesh Councilfor Scientific and lndustrial
Research.

B. Academic Awards:
1

Bangladesh Council of Scientific and lndustrial Research Scholar Aikikai Foundation Scholarship, Japan Honors Scholarship by Japan Student Services Organization Japan Medical Association Memorial Scholarship National lnstitute of Health Fund, USA Best Poster Award in Bangladesh Society for Biochemistry & Molecular 2012 Biology 2012-Continue Fellow Bangladesh Council for Scientific and lndustrial Research 999- 2000 2007-2010 2009-2010 2009- 2010 2010-2011

Page 3 of 11

List of Publications in International Journals* Selected peer-reviewed publications (from a total of 27).
1. S. Wu, K. Dole, F. Hong, A. S. Noman, J. Issacs, B. Liu andZ. Li. Chaperone gp96-independent Inhibition

of Endotoxin

Response

by Chaperone-based

Peptide

Inhibitors. Journal of Biological Chemistry 287, 19896-19903 (2012) (IF 5.328)

2. A. Haque, A. S. M. Noman, N. Koide, E. Odkhuu, Y. Naiki, S. Hashimoto, T.

Komatsu, T. Yoshida and T. Yokochi. An ADP ribosylation factor-GTPase activating

protein negatively regulates the production of proinflammatory mediators in response to lipopolysaccharide. Cancer Immunolopy and Immunotherapy 60, 1439-1446 (2Oll)
(rF 3.7e)

3. A. Haque, N. Koide, I. I.-E-Khuda, A. S. M. Noman,

E,.

Odkhuu, B. Badamtseren,

Y. Naiki, T.

Komatsu,

T.

Yoshida and

r.

Yokochi. Flavopiridol inhibits

pathway.

lipopolysaccharide-induced TNF-a production through inactivation of nuclear factor-

rcB and mitogen-activated protein kinases

in the MyD88-dependent

Microbiolog,, and Immunolog,,55, 160-l 67 (2011) (lF 1.304)

4. A. S. M. Noman, N. Koide, F. Hassan, II-E-Khuda, J. Dagvadorj, G.Tumurkhuu,

S. Islam, Y. Naiki, T. Komatsu, T. Yoshida and T. Yokochi. Retinoblastoma protein-

interacting zinc finger 1 (RIZI) regulates the proliferation of monocytic leukemia

cells via activation of p53. Caner Investigation 28, 806-812 (2010) (IF 2.390)

5.

A. S. M. Noman, N. Koide, II-E-Khuda, J. Dagvadorj, G. Tumurkhuu, Y. Naiki, T.

Komatsu, T. Yoshida and T. Yokochi. Retinoblastoma protein-interacting zinc finger

l, a

tumor suppressor, augments lipopolysaccharide-induced proinflammatory

c1'tokine production

via enhancing nuclear factor-kappaB activation.

Cellular

Immunolog,t 264, 114-1 I 8 (201 0) (lF 2.265)

6. A. S. Noman, N. Koide, II-E-Khuda, J. Dagvadorj, G.Tumurkhuu, Y. Naiki, T.

Komatsu, T. Yoshida and T. Yokochi. Retinoblastoma protein-interacting zinc finger
Page 4 of 11

1 (RlZl) participates in RANKL-induced

osteoclast formation

via regulation of

NFATcI expression. Immunology Letters 131,166-169 (2010) (IF 2.526)

7. I. I.-E-Khuda, N. Koide, A. S. Noman, J. Dagvadorj, G. Tumurkhuu, Y. Naiki, T.
Komatsu, T. Yoshida and T. Yokochi. Seladin-1 is a novel lipopolysaccharide (LPS)-

responsive gene and inhibits the tumour necrosis factor-alpha production and
osteoclast formation in response to LPS. Immunology 131,59-66 (2010) (IF 3.39S)

8. J. Dagvadorj, Y. Naiki, G. Tumurkhuu, A. S. Noman, I. t.-E-Khuda, N. Koide, T.

Komatsu,

T. Yoshida and T. Yokochi. Tumor necrosis factor (TNF)-o augments

lipopolysaccharide (LPS)-induced SOCS-3 protein expression via preventing the

degradation (p). Immunology 129,97-104 (2010) (IF 3.398)

9. G. Tumurkhuu, N. Koide, J. Dagvadorj, A. S.Noman, l. I.-E-Khuda, Y. Naiki, T.

Komatsu, T. Yoshida and T. Yokochi. series 2.26s)

Bl

cells produce nitric oxide in response to a

of toll-like receptor ligands. Cellular Immunologt 261, 122-127 (2010) (IF

10. G. Tumurkhuu, N. Koide, T. Hiwasa, M. Ookoshi, J. Dagvadorj,

A. S.Noman, I.
a

I.-E-Khuda,

Y. Naiki, T. Komatsu, T. Yoshida and T. Yokochi. ONO 3403,

synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis

factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic
shock. Innate Immunity17,97-105 (2011) (IF 4.00)

l.

J. Dagvadod, G. Tumurkhuu, Y. Naiki,

A.

S. Noman,

I. I.-E-Khuda, B. Badamtseren,

T. Komatsu, N. Koide, T. Yoshida and T. Yokochi. Endotoxin-induced lung injury in ogalactosylceramide-sensitized mice is caused by failure of interleukin-4 production in lung

natural killer T cells. Clinical and Experimental Immunology 162, 169-177 (2010) (lF
3.36)

12.

N. Koide, Y. Naiki, A. Morikawa, G. Tumurkhuu, J. Dagvadorj, A.S. Noman, I.

I.-E-Khuda, T. Komatsu, T. Yoshida and T. Yokochi. Nystatin-induced nitric oxide

production

in mouse macrophage-like cell line

RAW264.7. Microbiolog,t and

Immunologt 53,295-300 (2009) (lF 1.304)

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A. s. M. Noman, I.I.-E-Khuda, y. Naiki, T. Komatsu, T. Yoshida, M. oda, M. Nagahama, J. Sakurai and T. yokochi. The
13. G. Tumurkhuu, N. Koide, J. Dagvadorj,

inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production by Clostridium perfringens alpha-toxin and its relation to alpha-toxin-

induced intracellular ceramide generation. International Journal

Microbiolog,,299, 554-562 (2009) (lF 4.173)
14. J. Dagvadorj, Y. Naiki, G. Tumurkhuu,

of

Medical

A.

S. Noman,

I. I.-E-Khuda, N. Koide, T.
attenuates

Komatsu,

T.

Yoshida and

T.

Yokochi. Interleukin (IL)-10

lipopolysaccharide-induced

lL-6 production via inhibition of I{kappa}B-{zeta}

activity by Bcl-3. Innate Immunity 15,217-224 (2009) (IF 4.00)

A. S. Noman, N. Koide, I. I.-E-Khuda, J. Dagvadorj, G. Tumurkhuu, y. Naiki, T. Komatsu, T. Yoshida and T. Yokochi. Thalidomide inhibits lipopolysaccharide15.

induced tumor necrosis factor-o production

via

down-regulation

of

MyD8B

expression. Innate Immunity 15, 33-41 (2009) (IF 4.00)

16.

A.

S. Noman, N. Koide, F. Hassan,

I. I.-E-Khuda, J. Dagvadorj, G. Tumurkhuu,

S. lslam, Y. Naiki, T. Komatsu, T. Yoshida and T. Yokochi. Thalidomide inhibits

lipopolysaccharide (LPS)-induced nitric oxide production and prevents LPS-mediated

lethality in mice. FEMS Immunolog,, and Medical Microbiology 56,204-211 (2009)

(tF 2.441)

17. I. I.-E-Khuda, N. Koide,

A.

S. Noman, J. Dagvadorj, G. Tumurkhuu,

y. Naiki, T.

Komatsu, T. Yoshida and T. Yokochi. Astrocyte elevated gene-1 (AEG-1) is induced

by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and

signalling. Imntunology 128,700-706 (2009) (lF 3.321)

augments TLR4

18.

I. I.-E-Khuda, N. Koide, F.

Hassan,

A.

S. Noman, J. Dagvadorj, G. Tumurkhuu,

Y. Naiki, T. Komatsu, T. Yoshida and

r.

Yokochi T. Novelmechanism of Ul8666A-

induced tumor necrosis factor (TNF)- o production in RAW 264.7 macrophage cells.

Clinical and Experimental Immunologgt l55,552-558 (2009) (IF 3.36)

Page 6 of 11

19.

A. S. Noman, N. Koide, II-E-Khuda, J. Dagvadorj, G. Tumurkhuu, Y. Naiki,

T.

Komatsu, T. Yoshida and T. Yokochi. Thalidomide inhibits epidermal growth factor

(EGF)-induced cell growth in mouse and human monocl,tic leukemia cells via Ras inactivation. Biochemical and Biophysical Research Commnnications 374,683-687
(2008) (rF 2.s23)

20. M. Kato, Y, Goto, N. Ohgami, Y. Kawamoto, K. Hossain and A. S. M. Noman.

Prevention against environmental factor-induced diseases. Annual report of Research

Institute of Lfe and Health Sciences 4,29-32 (2008)

21. A. S. M. Noman, M. A. Hoque, M. M. Haque, F. Pervin and M. R. Karim.

Nutritional and anti-nutritional components in Pachyrhizus erosus L. tuber. Food

Chemistry

102,1112-lll8 (2007) (fF 4.268)

22. A. S. M. Noman, M. R. Karim, M.

A.

Hoque and P.

K.

Sen. Purification and

some properties of amylase from post harvest yam bean (Pachyrhizus erosus L.)
tuber. Food Chemistry 99, 444-449 (2006) (IF 4.268)

23.

A. S. M. Noman, M.

S. Islam, N.

A. Siddique and K. Hossain. High

Frequency

Induction of Multiple Shoots from Nodal Explants of Vitex negundo using Silver
Nitrate. International Journal of Agriculture & Biology 10, 633-637 (2008)

24.

M. R. Islam, S. M. R. Islam, A. S. M. Noman, J. A. Khanam, S. M. M. Ali,

-29 (IF
2. I 33)

S.

Alam and M. W. Lee. (2007) Biological Screening of a Novel Nickel (ll) Tyrosine
Complex. Mycolog,t 35,
25

25. M. E. Haque, M. F. Hossen, M. S. Islam, and A. S. M. Noman. Biological

screening

of

some ferrocene derivative metal complexes. International Journttl

of

Agriculture & Biology 8,774- 777 (2006)

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Page 7 of 11

Abstract Indicate below the abstract that is submitted by you for presentation at the ySp and the FAOBMB Congress in Bangkok (include all authors, affiliation(s) and the text of the abstract)

Title: Novel Regulators of rLR4 for Tuning LpS Responses

Abu shudur Mohammod Nomanl*,Takahashi yokochi2, & Zihai

Lil

1.

Department of Biochemistry
Chittagong-43
3

& Molecular Biology, University of Chittagong,

2. 3.

1, Bangladesh.

Department of Microbiology & Immunology, Aichi Medicaluniversity School of Medicine, Nagakute, Aichi 480-1195, Japan. Department of Microbiology & Immunology, Medical university of South Carolina, Charleston, SC 29425, USA

*correspondence: asmnomancubd@smail.com, Tel: 88-031-2606001 (Ext. 4334), Cell: 88-0172-7773767.

Abstract

Toll like receptor (TLR.) 4 is essential for

sensing gran'l negative bacterial cell wall

component LPS (lipopolysaccharide). Heat shock protein gp96 is important in the innate function of macrophages. Function of TLR4 is abrogated in gp96

Ko

mice.

Hence, we used gp96 null or over expressed RAW264.7 ceil lines to explore novel

LPS responsive genes. We compared the pattern of genes expression between these

two types of cells in presence of LPS. A series of genes, RIZI, AEG1, ASAPi,
expressed in RAW254.7 cells" RIZ1 and

ancl

SELADIN1 has been found to be down regulated in gp96 null cells whereas over

AEGI regulated TLR4 signalling positively

whereas ASAP1, and SELADIN-1 are negative regulators. LPS induced production

of

NO, TNF-alpha, IL-6, and osteoclast formation were regulated by these factors. Therefore, RIZ1, AEGI, ASAPI, and SELADIN-I are instrumental to tune TLR4
pathway for sensing LFS.

Key words: TLR4, LPS, gp96, RIZI, AEG1, ASAPI, and SELADINl.

Page 8 of 11

Personal Statement Indicate briefly here your Research Interests and Career Goals, why you are interested to participate in the YSP Program (including what you will bring to the YSP and what you hope to gain from it): (no more than one page)
Research Interest

& Career Goals

Last several years we are interested on understanding the molecular mechanism by

which inflammation and cancer are interconnected with each other. To understand the
mechanism we have focused on Toll like receptors (TLRs). TI-Rs are important in the

innate function and cancer. These receptors are essential for sensing micretbial
components and have critical role in onco-inflammation. We have fixed our goals on answering two questions: First, who are the regulators inside TLR pathways? Second, how entire TLR pathway is regulated? Now we are interested to understand the role

of

TLRs during environmental stress especially on arsenic exposure. Arsenic contamination causes an environmental tragedy in the some pafts of the world especially in Bangladesh. Arsenic has been reported to be associated with several
complications including cardiovascular diseases, lung, renal dysfunctions and cancers.

However, still there is no therapeutic strategy against arsenic mediated toxicity.

Earlier, we and others have been observed that a number of toll-like receptors (TLRs),
and several cytokines and their receptors were significantly altered in arsenic-exposed

mice. We, therefore believe that TLRs and its regulator gp96 would be instrumental to
understand the mechanism

of arsenic mediated inflammatory

responses and cancer.

Now we are aiming to investigate the status of TLR and gp96 in the arsenic exposed
people in Bangladesh. We hope, our effort

will be helpful to

create a therapeutic

strategy against arsenic mediated onco-inflammation.

In YSP, I will present our previous research findings on novel regulators of TLR4
signalling for sensing LPS and response. In YSP, we will get an open platform to
discuss our findings with the scientists and experts in the conference. Definitely, we

will

get effective suggestions from the conference. We believe these suggestions

will

tune our work. The out come will be helpful for the better understanding of the
pathogenesis

of

LPS-related diseases, such as systemic inflammatory response

syndrome and septic shock. Finally, the total out come

therapeutic strategy bgainst LPS-related diseases.

will help us to design

Page 9 of 11

Attachments:

Letters of recommendation from two referees.

Page 10 of 11

Aichi Medical University School of Medicine Department of Microbiology and Immunology Nagakute, Aichi 480-1195, Japan. Tel: +81-561-62-3317 Fax: +81-561-639787 E-mail : )zokochi@aichi-med-u.ac jp January 1,5,2010

lrtter of Recommendation for Mr. Abu

Shadat Mohammod Noman

The aim of this letter is to recommend Mr. Abu Shadat Mohammod Noman who has

been

completed a Ph.D. course from my department. He has successfully completed the PhD course as one of the best students in the third students, which is originally the four years course. As a Ph.D. student, he has shown an outstanding performance in our school. He has achieved A grade in all the courses and published several excellent scientific paired review papers in renowned PubMed journals.

He has investigated the mechanism of thalidomide in regulating cell growth and inflammatory responses. Later he has elucidated new function and mechanism of tomor suppressor retinoblastoma protein interacting gene finger (RIZ) 1. He successfully find out the interaction of RIZ1 and another tumor suppressor p53 in regulating inflammatory property and cell cycle arrest. Identification of role of new gene in p53 pathway has potential to understand DNA damage responses and apoptosis to develop therapeutic strategy against several human complications. His current study is very much important in this respect. He knows all the basic biochemical, molecular biological and genetic approaches to study cell cycle check point. He is author and coauthor of a remarkable original scientific PubMed articles. In my department he was guided to
become an independent researcher, and now he is capable to run a project independently.

am sure that his knowledge on regulation and function of signal transduction pathways and experiences on all the basic biochemical, molecular biological and genetic approaches will soon make him a young promising researcher.
that his dedication to research, sincerity, dignity, hardworking capability, well manner, cooperative approach, and independent judgment skill will assist him to contribute science at a remarked level. I am confident he will provide an admirable service to any where he deserve to join as an expert of Biology. His expertise knowledge and technological know how will assist him for setting up specific research area and supervision as well.

I strongly believe

I would like to wish Mr. Noman all the very best with his future pursuits and I will gladly furnish any additional information should it be desired.

#,, ,L l- /'
Takahashi Yokochi, MD.; PhD Professor and Chair Department of Microbiology & Immunology

/---,

/ /-

/.

Dr. Md. Khaled Hossain

M.Sc. (Biochemistry), University of Rajshahi, Bangladesh Ph.D, Nagoya University, Japan

Associate Professor
Department of Biochemistry & Molecular Biology University of Rajshahi, Rajshahi 6205, Bangladesh

Recommendation Letter for Abu Shadat Mohammod Noman

for Mr. Abu Shadat Mohammod Noman who has completed his undergradriate and master level education with brilliant academic records from the Department of Biochemistry & Molecular Biology, University of Rajshahi, Bangladesh. He is well known to me since 1998 when he got admission in the Department.
a recommendation letter

It is my great pleasure to write

As my student, I found him to be very much diligent and devoted to academic works. I am highly impressed by his performance in carrying his research. Presently he is doing ph.D. level study in Aichi Medical University School of Medicine, Japan under an optimistic supervision of Professor Dr. Takashi Yokochi. As a Ph.D. student, he has shown an outstanding performance and published some scientific papers in reputed journals. His working habits are impeccable. He is punctual, extremely weil prepared and very well acquainted with scientific topics. He has a keen interest in the different fields of biological
sciences that is evident to me by his enthusiasm to read scientific papers of other fields. find anv major rveak point of Mr. Noman in his research which can be mentioned here.

I did not

Sincerely yours,

(Md. Khaled Hossain)

Phone: +BB0-12I-150041-9lExt. 4109 (Dept.). Fax: +88-0127-150064, E-mail: khossain69@yahoo.com

Submission methods: You can apply in either of two ways:

by sending an email with scanned attachments to the Chair of the FAOBMB Fellowship Committee, Prof. Piamsook Pongsawasdi: piamsook.p@chula.as.tb or piamsook.p@gmail This is the preferred method. If using this method, please assemble the Application Form and the Attachments into a single PDF file.

by sending a hard copy of the application form and supporting documents to:
Professor Piamsook Pongsawasdi,

Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.

Closing Date: Applications must be received by 31 July, 2012 (Bangkok time, GMT + 7 Hours). Applicants will be notified by email of the decision of the Committee by no later than 1 5 September, 2012.

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