SBD2013

TUTORIAL CHAPTER 1: INTRODUCTION TO BASIC PATHOLOGY 1. Define the followings: (a) Histopathology (b) Forensic Pathology (c) Familial Disease (d) Congenital Disease (e) Pathogenesis (f) Pathologic changes (g) Prognosis (h) Diagnosis (i) Autopsy (j) Biopsy CHAPTER 2: TISSUE RESPONSE TO INJURY 1. Normal cell will adapts or change their shape and number whenever there is an increased in functional demand. Define the FIVE (5) principal adaptation responses of cell. 2. State the THREE (3) components of extracellular matrix (ECM). 3. State the SIX (6) categories of cytokines. 4. Hypoxia is the most common cause of cell injury. Define hypoxia and state its causes. 5. State the examples of immunologic agents that can injure the cell. 6. Briefly explain nutritional derangements as etiology of cell injury. 7. Explain briefly the functional and its morphological changes to the cell following injury. 8. State TWO (2) phenomena that distinguish irreversible from reversible cell injury. 9. Describe on FOUR (4) morphologies of cell injury. 10. State the cellular mechanisms of aging. 11. State the factors that may affect aging process. CHAPTER 3: INFLAMMATION 1. Compare on different features of acute and chronic inflammations. 2. Briefly explain on haemodynamic changes. 3. Briefly explain the Lewis triple response. 4. State FIVE (5) mechanisms of increased vascular permeability. 5. Explain briefly on what happens during cellular events. 6. List THREE (3) outcomes for acute inflammation. 7. Identify THREE (3) inflammatory cells associated with chronic inflammation. 8. Define granulomatous inflammation. 9. Discuss on granuloma characteristics and formation. 10. Describe briefly on morphologic patterns of inflammation. 11. State the TWO (2) types of mediators of inflammation. 12. State TWO (2) common vasoactive amines and give their function. 13. Name the cell that can release reactive oxygen intermediates (mediators of inflammation). 14. State the function of platelet activating factor (mediators of inflammation). 15. Distinguish the THREE (3) groups of cell based on their regenerative ability. 16. Granulation tissue formation in healing process is further divided into three phases. Explain briefly on all phases. 17. Dscribe process of wound contraction. 18. Differentiate the characteristics of wound in healing by first and second intention.

SBD2013 BASIC PATHOLOGY / TUTORIAL 1

SBD2013

CHAPTER 4: DEGENERATION & REGENERATION 1. Define the followings: (a) Degeneration (b) Resolution (c) Repair (d) Regeneration 2. Identify whether the following components is metabolite or storage overload. (a) Carbon (b) Amyloidosis (c) Lipidosis (d) Hyaline change (e) Lipofuscin (f) Fatty change (g) Bilirubin (h) Calcification (i) Pigments 3. State FOUR (4) causes of impaired energy production in the mechanism of cellular degeneration. 4. State THREE (3) effects of defective energy production. 5. State the factors that interfere with healing process. 6. State the factors of regeneration to occur. CHAPTER 5: NECROSIS 1. Distiguish the features of necrosis and apoptosis. 2. Describe on nuclear changes of necrotic cell. 3. Describe in general on morphology of necrotic cell. 4. Identify the etiology and explain the pathogenesis for different types of necrosis. 5. Differentiate the etiopathogenesis between dry, wet and gas gangrene. 6. Describe the gross and microscopic appearance for different types of necrosis.

SBD2013 BASIC PATHOLOGY / TUTORIAL 1