You are on page 1of 2

ProClin Datasheet.

qxd 10/7/07 16:29 Page 1

SAFC Supply Solutions


3050 Spruce Street
Saint Louis, MO 63103
Tel: 800-244-1173 (US Toll Free)
+44 161 232 5500 (Europe)
+1-314-534-4900 (International)
Global Email: safcglobal@sial.com

ProClin®
Preservative

ProClin preservatives are an excellent choice


for replacing thimerosal, sodium azide and
gentamicin preservatives. In addition they are
highly effective, broad-spectrum biocides for
controlling microorganisms in reagents and
products intended for in vitro diagnostics use.
At concentrations as low as 0.02%, these
preservatives eradicate bacteria, fungi and
yeast for extended periods of time.

For further information or to obtain a


preservative efficacy study performed by
an independent laboratory contact your
SAFC representative.

Key features of ProClin preservatives:

• Compatibility with key enzymes and


assay indicators

• Will not inhibit antibody binding


Mechanism of Action
• Easy-to-use water-soluble liquid, effective
The active components of ProClin are two
at very low concentrations (6-20ppm)
isothiazolones, 2-methyl-4-isothiazolin-3-one
• Excellent stability over a wide pH range and 5-chloro-2-methyl-4-isothiazolin-3-one.
(2 to 8.5) Within minutes of contacting a
microorganism, the active components
• Level of active ingredients assayable by
penetrate the cell wall and inhibit specific
HPLC (Inquire for a HPLC standard)
enzymes (at the points noted in red in the
• At recommended usage levels, ProClin Krebs Cycle). Growth, macromolecule
presents no health hazards, toxological synthesis and respiration are inhibited,
problems or disposal issues ultimately leading to cell death.

www.safcsupplysolutions.com
ProClin Datasheet.qxd 10/7/07 16:29 Page 2

ProClin®
Packaging
ProClin Evaluation Kits are available for determining the suitability of ProClin products in new
product development. Each evaluation kit contains three different manufactured lots of ProClin
for testing performance consistency from lot to lot.

To determine the appropriate ProClin product for a specific application, ProClin variety kits are
also available. Each kit contains 5 ml of Proclin 150, 200, 300 and 950.

ProClin Evaluation Kits

48121 ProClin 150 – 3 x 5ml (3 lot numbers)

49381-U ProClin 150 – 3 x 400ml (3 lot numbers)

48911-U ProClin 300 – 3 x 5ml (3 lot numbers)

48119-U ProClin Variety Kit – 5ml each of ProClin 150, 200, 300 & 950 as an aid to select
the appropriate ProClin product for a specific application

Features ProClin 150 ProClin 200 ProClin 300 ProClin 950

Active (A.I.) CMIT/MIT CMIT/MIT CMIT/MIT MIT

% total A.I. 1.5 1.5 3 9.5

Salt Stabilizers 23 – 25% Mg salts 3% Mg salts Alkyl Carboxylate none

Matrix Water Water Propylene glycol Water

Working pH Range 2.5 – 8.5 2.5 – 8.5 2.5 – 8.5 2 – 12

Typical
0.05 – 0.10% 0.05 – 0.10% 0.02 – 0.07% 0.05 – 0.10%
Dosage Levels

Shelf Life 3 years 3 years 3 years 24 months

ProClin Preservatives ProClin Preservatives

Catalog No. Description Catalog No. Description

33360-U ProClin Reference Standard-1ml ProClin 300

ProClin 150 48912-U 50ml

49376-U 50ml 48914-U 400ml

49377-U 400ml 48915-U 2.0L

49378-U 3.6L 48916-U 2.8L

49379-U 15L (Pail) 48917-U 3.6L

49380-U 110kg (106.8L) 48918-U 18L (Pail)

ProClin 200 48919-U 110kg (106.8L)

48171-U 50ml ProClin 950

500380 400ml 46885-U 5ml

500399 3.6L 46878-U 50ml

500402 15L (Pail) 46879-U 400ml

46883-U 3.6L

46884 17L (Pail)

SAFC Supply Solutions™


Tel: 800-244-1173 (US Toll Free)
+44 161 232 5500 (Europe)
+1-314-534-4900 (International)
Email: safcglobal@sial.com
© 2007 SAFC
All rights reserved. Reproduction forbidden without permission.
ProClin is a registered trademark of the Rohm & Haas Company.
SAFC Supply Solutions is a trademark of Sigma-Aldrich Biotechnology LP.
02758-504321
JRG
0077 www.safcsupplysolutions.com

You might also like