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When considering potential endogenous microbes in bovine Model viruses were also used in the SER-TAIN™ validation.
serum, viruses are a main concern. Several viruses that can Consistently propagating Bovine Leukemia Virus (BLV) in vitro
affect cattle are listed in Table 1, all of which are represented is nearly impossible. By using Feline Leukemia Virus (FeLV),
in the SER-TAIN™ validation. a virus that is physically similar and considerably less fastidious,
the amount of protection gamma radiation provides against
BVD, PI3, IBR, BTV and BLV are all bovine viral species of contamination by BLV can be accurately assessed. Based on
significant industrial importance. Although Porcine Parvovirus the information gathered about PI 3 (of the family
(PPV) does not cause disease in cattle under natural conditions, Paramyxoviridea), assessments can be made about the
it has been isolated from bovine herds2. MvM was intended inactivation of other paramyxoviruses, such as Bovine
as a potential environmental contaminate. Respiratory Syncytial Virus (BRSV). Similarly, the use of PPV
as a model provides confirmation of protection against Bovine
Viruses of the same type and similar physical characteristics Parvovirus (BPV).
show comparable vulnerability to inactivation by gamma
Table 1
Viruses Used in the SER-TAINTM Gamma Irradiation Serum Validation
Virus Family Characteristics Validation Virus
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