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Antagonism between catalase and ascorbic acid in control of normal and neoplastic cell Related Articles
multiplication.
Different behaviour of normal and neoplastic cells cultured in
[Int JCancer.1987]
vitro in the presence of catalase and superoxide dismutase.
Liotti FS, Bodo M, Menghini AR, Guerrieri P, Pezzetti F.
Effects of ascorbic and dehydroascorbic acid on the
The authors studied the effects of a treatment with ascorbic acid on in vitro multiplication of [JCancerResClinOncol.1984]
multiplication of tumor ascites cells in vitro.
ascites tumour cells (ATP C+), of fibroblast-like cells and of hepatocytes from chick embryos, by Hydrogen peroxide mediates the killing of U937 tumor cells
measuring [3H]thymidine incorporation into DNA. The results obtained show that the ATP C+ [JPharmacol Exp
elicited by pharmacologically attainable concentrations of Ther.1996]
cells are the most sensitive to the toxic effects of the experimental treatment, while the
Review Ascorbic acid, cell proliferation, and cell differentiation
hepatocytes are the most resistant cell population. A treatment with catalase was able to greatly
in culture. [Subcell Biochem.1996]
reduce the damage caused by ascorbic acid on the ATP C+ cells. It is hypothesized that ascorbic
acid inhibits cell multiplication by the H2O2 formed by its oxidation and that the cells having the Review [Vitamin C and cell growth: use of L-ascorbic acid
highest level of catalase are more resistant to its toxic effects. [Seikagaku.1988]
2-phosphate in culture for construction of three-dimensional
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