Professional Documents
Culture Documents
S O
structure
O
O S O
OH
OH
O OH O OH
O
HO O
OH O O
O
RO O
RO
HO S
O
O
toxicological properties
The evaluation of the Poly Suga®Nate Series of products shows these products to be very mild when compared to other traditional primary personal
care surfactants.
f t t These
Th ttests
t were performed
f d bby C
Consumer P
Product
d tT Testing
ti C Co. off F
Fairfi
i field,
ld NJ
NJ.
Eye
Poly Suga®Nate 160P is an extremely mild product receiving a score of only 5.5. This product is very suitable for baby and mild cleansing applications.
Poly Suga®Nate 100P had a score of 19.0 making it milder than alpha olefin sulfonate. Traditional surfactants used in personal care products like
SLES-2, which scores a 25.5, and SLS which scores a 30.0, are much less attractive.
The evaluation of the Poly Suga®Nate Series as an eye irritant was performed using the chorioallantoic membrane technique. The test was performed
with Poly Suga®Nate 100P and Poly Suga®Nate 160P diluted to 5 % activity. This test utilizes the inner membrane of a hen’s egg to gauge the irritation
potential of a compound by visual observation of injurious changes in the membrane.
Skin
To evaluate the potential irritation to skin, a study was performed adhering to ICH Guideline E6 and 21 CFR parts 50 and 56. Fifty-three (53)
volunteers, males and females, ranging in age from 16 to 79 were subjected to a “patch test”. The “patch test” was performed with the Poly Suga®Nate
100P and Poly Suga®Nate 160P diluted to 1.0 % activity. A 1″ X 1″ absorbent pad was moistened with 0.2 ml of liquid and applied to the backs of
the subjects between the scapulae. The patch sites were inspected at 48 hours for gross changes. It was observed that there was a complete absence
of skin change. The test sites were evaluated again at 72 hours. Once again the observation was negative skin changes. Under the conditions of this
test, Poly Suga®Nate 100P and Poly Suga®Nate 160P did not indicate a potential for dermal irritation.
We conclude all Poly Suga®Nate products are mild to eye and skin at moderate use levels as tested.
21.75
Ross-Miles Foam Height (1% active), mm Alpha Olefin Sulfonate
f o r m u l a t i o n s
moisturizing shampoo
featuring Poly Suga® products COLONIAL CHEMICAL, INC.
COMPOUND Wt. %
225 Colonial Drive
Water 55.00 South Pittsburg, TN 37380
Poly Suga®Nate 160P 10.00
Poly Suga®Nate 100P 15.00 Phone: 423-837-8800
Cola®Teric LMB 5.00
Cola®Liqid DC 2.00 Fax: 423-837-3888
Cola®Mate DSLS
Glucamate 120
5.00
2.00
www.colonialchem.com
Poly Suga®Quat L-1010P 3.00 WARRANTY
No warranties beyond the guarantee that Colonial Chemical products are
Cola®Moist 300P 3.00 manufactured to specs are expressed or implied, since the use of material is
TOTAL 100.00 beyond our control.
Technical information contained herein is believed to be accurate. However,
Viscosity 3,480 cps it is furnished without charge or obligation and is given and accepted at
pH (10% aqueous) 6.08 the recipient’s sole risk. No guarantee of the accuracy of the information is
made and the products discussed are sold without conditions or warranties
expressed or implied. Purchasers should make their own tests and determine
PROCEDURE: suitability of the product for their particular purposes. Nothing contained
Mix ingredients 1 through 6 in the order listed with sufficient mixing until clear. Heat the herein shall be considered a recommendation for any use that may infringe
mixture to about 50°C while adding Glucamate 120.Once the mixture is clear, cool to room upon patent rights.
COLONIAL CHEMICAL, INC. • 225 Colonial Drive • South Pittsburg, TN 37380
temperature and add ingredients 8 and 9. Adjust viscosity with NaCl. Adjust pH with 50% Phone: 423-837-8800 • Fax: 423-837-3888
citric acid. © Copyright 2007, Colonial Chemical, Inc. All rights reserved.