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Mrunal [Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3) Print
- Mrunal - http://mrunal.org -
[Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3)
1. Universal Immunization program (UIP)
India Declared Polio-Free Acute flaccid paralysis (AFP) Polio Virologist dead BIBCOL Integrated Vaccine Complex Penta-valent Vaccine JEEV Vector control Blindness control Leprosy Iodine AIDS control NACO NACP phases One Two Three Four Bridge Population Mother to Child AIDS: 12th FYP Goal Truvada Truvada: Issues/concerns OraQuick Home Red Ribbon Express (RRE) Anti-retro viral drugs Two types of HIV TB control Risorin GeneXpert/ CBNAAT? Crystal TB Confirm Misc TB tests Project Axshya/ Mr.Sputum Swine Flu, Avian Flu Tamiflu, Relenza Non Communicable diseases Heart related Hydrogel Statin
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Mrunal [Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3) Print
12.
Omega-3 Fatty Acids HDL vs LDL Lupifio, Klotbuster Cancer related No Touch BreastScan (NTBS) Dermoscope Magic Shotgun Glivec, Novartis Patent Evergreening Zimmerman / Imatinib Novartiss side of story Gardasil and Cervarix Kinesio tape VitaVallis Instruments Neurostimulator Emmident Toothbrush Vomiting Larry Handheld Dental X-ray SAR Virtopsy Electronic nose BIONIC EYE OraQuick Home Surgeries Femtosecond Cataract Surgery Ex-Vivo Lung Perfusion Nobel Prizes G-proteincoupled receptors (GPCRs) Blank Slate Cells / Reprograming Cells / Disease in Dish Misc. ENCODE project Telomer Memory Enhancer/ BESEB Radioimmunoassay (RIA) IRMA Bhabhatron PACT ISOMED Linear No Threshold (LNT) concept Drugs from Sea
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Mrunal [Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3) Print
2. 3. 4. 5. 6. 7.
Measels Childhood TB Hepatitis B Tetanus Diphtheria Pertussis (whooping cough) Govt. also declared year 2012-13, as Year of Intensification of Routine Immunization.
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Mrunal [Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3) Print
Jonas Salk had developed the known as the inactivated polio-virus vaccine (IPV) in the 50s. But before that, Hilary Koprowski had invented the live-virus oral vaccine. Hilary Koprowski is in news, because he died in April 2013.
BIBCOL
Name of public sector undertaking (PSU) It manufactures Oral polio vaccine for Universal immunization program.
Penta-valent Vaccine
Penta=five. So penta-valent vaccine=five vaccines in one. 1. 2. 3. 4. 5. Diphtheria Pertussis Tetanus, Hepatitis-B Hib. (Hib Haemophilus Influenzae Type B). It is Responsible For Pneumonia, Meningitis And Epiglottitis) This is an injection (and not oral drops like polio vaccine.) In India, pentavalent vaccine was introduced in Tamil Nadu and Kerala in December 2011, under the Universal immunization program. Recently Delhi and Jammu and Kashmir, Haryana, Puducherry, Goa and Gujarat also started using it.
Benefits
Pentavalent vaccine helps in reducing the number of shots a child receives from nine to three. Convenient in storage space and transport because five vaccines are combined in a single vial.
JEEV
Indias first vaccine for Japanese Encephalitis. Company: Biological E Ltd. (BEL)
Vector control
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Mrunal [Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3) Print
National Vector borne diseases control program (NVBDCP) This is under National rural health mission. Directorate @Delhi gives cash and commodity to state Governments for implementing this. Government plans to eliminate kala-azar and filariasis by 2015. Comprehensive program against vector borne diseases such as By Notes Via female Anopheles mosquitoes. 3 stages 1) cold 2) hot 3) sweating. World Malaria day = 25th April 12th FYP wants Annual Malaria Incidence of <1/1000.
Disease
Synriam
Piperaquine (trade name Synriam): this was launched on World Malaria day in 2012 Synriam =First Indian anti-malarial drug. Ranbaxy produced it, with help of Dept. of Science and Technology + ICMR. Protozoa (parasite)
Malaria
ELQ-300
New anti-malarial drug. Undergoing trials.
Humanized Mice
It is engrafted with human liver cells. Itll help research liver-to-blood stage infection of Malaria. Via female sand fly Leads to skin darkening, therefore called kala Azar= black sickness. Target is to eliminate Kala Azar by 2015 Via Culex mosquitos Pigs to mosquito to man. More details given in old article click me 12th FYP wants to reduce JE deaths by 30%
Kala Azar
Japanese Encephalitis
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Mrunal [Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3) Print
Dengue Virus
Real time PCR essay: this will help detect dengue on first day. In the recent past Dengue has been reported from almost all the states and UTs except Lakshadweep. Via Mosquito: aedes Aegypti ELISA blood test needed for diagnosis symptoms similar to dengue fever Swahili word: that which bends up, because it leads to severe pain in joints. 12th FYP wants to Containment of outbreaks of Chikungunya. Via black flies and mosquitoes. target is to eliminate this by 2015.
Chikungunya
Via mosquitos It makes the skin and tissues around leg very thickmakes it look like elephants legs.
Continuing to more programs under NRHM National program for control of blindness (NPCB) 100% centrally sponsored Goal: reduce blindness to 0.3% by year 2020 Free eye checkup and spectacles to school kids This disease is caused by bacteria 100% centrally sponsored (the scheme, not the disease hahaha) It uses Multi-drug therapy (MDT). 12th FYP wants to reduce new cases to 0 for all districts. Iodine Deficiency => goiter, retardation (mental, physical), cretinism, squint etc.
Blindness control
Leprosy
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Mrunal [Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3) Print
National AIDS Control Organization It is a division of the Ministry of Health and Family Welfare NACO implements the national aids control program (NACP)
NACP phases
Phase Year What? 1986: first AIDS case in India detected, in Chennai, TN. First phase to control the spread of HIV infection. Treatment of sexually transmitted diseases in district hospitals and medical colleges Establishing AIDS surveillance system condom promotion. The School AIDS Education Programme National AIDS Prevention and Control Policy National Blood Policy NGOs involvement focus on High Risk Groups (HRGs) 1. 2. 3. 4. prostitutes gays drug addicts bridge populations (truckers and single male migrants) halt and reverse the epidemic in India over the next five years. promote district-level network of people living with HIV/AIDS income generation and other welfare activities for HIV positive people. reach zero infection, zero stigma and zero deaths. Prevent new infections Prevent Parent-to-Child Transmission Reduce stigma and discrimination of AIDS Increase partnership with NGO and civil society. Social protection and insurance mechanism for HIV positive people. Provide comprehensive care, support and treatment to all.
One
19921999
Two
19992006
Three 12
2007-
Four
20122017
Bridge Population
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Mrunal [Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3) Print
HIV first appears among most vulnerable (e.g. prostitutes and drug addicts) and. Bridge population means those people who acts as Bridge for transferring HIV virus from 1. high risk group (prostitutes, drug addicts, gays) to low risk groups/general population (housewives, future kids) 2. Urban to rural areas. Example of bridge population = single male migrant, truck drivers, bisexual men.
Mother to Child
If a pregnant woman is HIV positive, there are now drugs that can reduce the risk of her passing HIV virus on to her baby in the womb or at birth. Caesarean Delivery also reduces the risk of a baby becoming infected. if a mother is HIV positive, beast-feeding will increase the risk of her baby becoming infected. (because some HIV transmission can occur through breast milk.)
Truvada
Worlds first Oral pill to prevent HIV Developed by: Gilead Sciences. Made of two anti-reteroviral drugs: 1) Tenofovir and 2) Emtricitabine Given approval by US FDA.
Truvada: Issues/concerns
This drug only lowers the amount of HIV virus in blood. It doesnt make a person totally immune to HIV virus. But Some idiots will think they have become totally immune against HIV, and then indulge in unprotected sex- further spreading AIDS. Experts also believe that same idiots (described above), will not take the medicine regularly, and HIV virus will become resistant to Truvada. Then another billion dollars and 10-12 years will be required to design a new drug. In one clinical study, some prostitutes were given Truvada, yet it did not prevent the spread of HIV. Hence critiques are not entirely convinced about the efficiency of this drug.
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Mrunal [Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3) Print
OraQuick Home
Its the first Do It Yourself testkit for detecting HIVthe same one that health professionals use but without the trip to a doctors office or the need to wait days for results. Oral kit for HIV Test can detect antibodies developed within 1-3 months after getting infected. It cannot pick up acute or recent infection.
TB control
TB shortens the survival of patients with HIV infection. Revised TB control program, Under National Rural Health Mission (NRHM) Provide DOTS therapy. DOTS= directly observed treatment short course. It could drastically reduce the TB treatment duration. More on details, given in earlier article click me 12th FYP wants to reduce annual TB cases and deaths by 50%
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Mrunal [Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3) Print
Risorin
CSIR is developing this new Anti-TB drug.
GeneXpert/ CBNAAT?
Problem with MDR-TB= it takes almost 8 weeks, for doctor to diagnose this disease. GeneXpert/ CBNAAT is the latest device that can diagnose this MDR-TB in just two hours. Fastest detection of TB. can be installed at any place and can be used by paramedical staff. In India, itll be provided at subsidized rate (less than Rs.2000)
Crystal TB Confirm
Another TB detection test. Based on chromatography. Designed by Scientists @Delhi university. Provides result within twenty minutes. (given in Indian yearbook, hence listed.)
Misc TB tests
1. MGIT Liquid Culture 2. Hain Genotype (there may be five dozen more TB tests in the world, but these two were given in Hindus S&T edition hence listed hahaha)
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Mrunal [Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3) Print
Tamiflu, Relenza
Antiviral drug. Tamiflu=trade name for the drug Oseltamivir=generic name for the drug. Used for swine and bird flu. Another drug is: Relenza (Zanamivir) Concern: report suggest that the swine flu virus (H1N1) is becoming resistant to this drug. Antiflu= this is the cheaper version of Tamiflu, produced by Cipla. Vaxiflu-S= Indias first indigenously manufactured vaccine to combat swine flu (Cadila).
Statin
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Mrunal [Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3) Print
Theyre drugs used for cholesterol control. But new research indicates these Statins pose heath risks.
HDL vs LDL
HDL LDL High Density low-density lipoprotein Good cholesterol Bad Decreases heart riskIncreases
Lupifio, Klotbuster
CSIR developed it It can dissolve the blood clots and save heart attack patient.
Dermoscope
Melanoma=Skin cancer. To Detect Melanoma, earlier dermatologists had to put incision (cut) on the skin, take sample, and observe It under microscope. Dermoscope is a new handheld device for skin-cancer (Melanoma) detection. The device uses imaging technology that, in less than one minute, visualizes the micro-vessel structure of just below the skins surface. So Cancer can be detected without incision.
Magic Shotgun
US researchers are using this approach for developing more effective anticancer drugs.
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Mrunal [Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3) Print
Evergreening
As long as a company has patent for xyz drug, others cannot manufacture it. (for 20 years). But when the patent is about to expire, the company just slightly modifies the original drug formula to create a new drug and seeks patent for that new drug. This practice is known as everygreening Indian patent act prohibits Evergreening. (under Section 3(d)). In case of Norvatis, when their Glivec patent was about to expire, they had sought patent for similar new anti-cancer drug (Imatinib Mesylate), but lost patent case. They approached Supreme Now Indian companies can produce generic version of this anti cancer drug, and patient will get it at cheaper price. one-month dose of Glivec costs around Rs 1.2 lakh, while generic Indian drugs can do it at Rs 8,000.
Zimmerman / Imatinib
Imatinib Mesylate= a drug molecule to fight cancer. It was patented under Zimmarman patent. Now, this Glivec contains a beta crystalline form of a drug molecule imatinib mesylate. (therefore, Glivec is not really a new drug but a typical case of Evergreening, where company merely made some chances in the old drug molecule to file new patent.)
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Mrunal [Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3) Print
4. After the defeat in supreme court, Novartis said they will not invest in drug research in India anymore.
Kinesio tape
VitaVallis
Instruments Neurostimulator
New therapy for Migraine (type of Headache). Migraine is a chronic disease (long-term disease, unlike Common fever.) It is placed in the upper gum of patients mouth, through a small surgical incision. When a patient feels a headache or Migraine coming, the device delivers stimulation to block the headache pain.
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Mrunal [Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3) Print
MALDI It is a new Mass-Spectroscopy technique to detect Bacterial infection in blood, sputum, tissue etc. MALDI=Matrix assisted laser desorption/ionization. MALDI can accurately identify bacteria in minutes, which allows doctors to more quickly and appropriately treat infections.
Emmident Toothbrush
Worlds first no-brushing toothbrush. There is no need to actually brush your teeth abrasively, because It uses ultrasound waves to clean the teeth. Launched in UK.
Vomiting Larry
Larry is a humanoid simulated vomiting system designed by British scientists. It is being use to how norovirus spreads.
SAR
specific and absorption rate it is a measure of the amount of radio frequency energy absorbed by the human body while using a mobile phone) so that radiation does not affect human health. Presently, Indias SAR limit is 2 watt per kg The Inter-ministerial Committee wants SAR to be 1.6 watts per kg.
Virtopsy
Autopsy=examination and dissection of a dead body to determine cause of death. Previously, doctors would use scalpel, cut the chest open and examine tissues. Often, relatives of the dead donot agree for autopsies because of the disfigurement caused by such cutting and incisions. Now scientists have come up with a non-invasive technique for conducting autopsy. This is called Virtopsy(=virtual autopsy). Here, doctor examines the corpse in 3-D via computer screens.
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Mrunal [Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3) Print
Virtopsy combine the images from high-powered magnetic resonance imaging (MRI), computed tomography (CT) and surface scans of dead bodies. Combined, the devices are referred to as a virtobot. The technique allows the detection of injuries such as lesions and blows often undetectable during a traditional autopsy, as well as air pockets, heart attacks and even cancer. The method has already allowed the discovery of haemorrhages and fractures that were not picked up during conventional autopsies.
Electronic nose
Prototype electronic instrument. It can detect small quantities of harmful airborne substances. can be used for Batch to batch consistency during production. (perfumes, food) Detection of contamination, spoilage, adulteration
BIONIC EYE
The implants are said to be capable of completely restoring sight to blind patients, but only if their blindness was caused by a faulty retina
OraQuick Home
Its the first Do It Yourself testkit for detecting HIVthe same one that health professionals use but without the trip to a doctors office or the need to wait days for results. Oral kit for HIV Test can detect antibodies developed within 1-3 months after getting infected. It cannot pick up acute or recent infection.
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Mrunal [Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3) Print
donor friendly. In this technique, a special chemical solution is injected into dead-persons lungs and then he is kept on a ventilator for 4-6 hours. This can reverse lung injury and dry out excess fluid. Then lungs can be removed and transplanted to the patient.
Telomer
They are situated at the ends of chromosomes and protect the DNA from damage. Longer the size of telomer, means person will have longer life expectancy.
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Mrunal [Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3) Print
technique to measure hormones, vitamins, drugs etc. in vitro (outside body). Immuno radiometry Assay. same application like RIA. Bhabhatron, the indigenous telecobalt machine for cancer treatment. developed by Bhabha Atomic Research Centre, Mumbai Program of action for cancer therapy. Launched by IAEA. Under this PACT program, we donated one Bhabhatron machine to Vietnam These plant located in Trombay, Delhi, Banglore etc. provides radiation sterilization for medical and surgical instruments. In rural areas, midwifery kits and delivery packs are given after doing radiation sterilization here. It reduces chances of infection during delivery. means that harmful effects of radiation increase with radiation dose and even small radiation doses can cause some finite harm. Some scientists challenge the validity of LNT concept. They say, in low dose radiation we would be fine, and would not have any cellular damage. Program to harness the bioactive
Bhabhatron
PACT
ISOMED
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Mrunal [Public Health] Current Affairs 2012-13: Diseases, Drugs and Research (Part 2 of 3) Print
compounds from marine organisms for therapeutic uses e.g. anti HIV, cancer, malaria etc.
In the third and last part, well see the mock questions from part 1 and 2. click me to see the third part For more science-tech, public health, space tech and defense related current affairs, visit Mrunal.org/snt
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