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- My opinion
Author - Mr. Pushparaj Ghodke praj_gh@yahoo.co.in
Consequences of ageing
The concise encyclopedia defines old age as “ the sum of changes
in an organism occurring with years . In animals and humans , these
are atrophic muscles , fragile bones , flaccid skin , hardened blood
vessels ( sclerosis ) , and weakened nervous activity . “
Let's discus some very important consequences of ageing . As we age
, concentration of water in the tissues decreases . To be more
precise , the extra-cellular water in the tissues decreases , but the
intra-cellular water in the tissues remain practically the same . A
higher content of total water in the newborns is observed primarily
due to the extracellular water ; with maturation , the total water
decreases , i.e. as if the organism has become somewhat drier .
the water loss is effected at the expense of extracellular fluids .
Newborns 75 35 35 5
Under 1 year 70 35 30 5
Newborns 34 70
During cellular respiration , toxic free radicals are formed . These free radicals
damage mitochondrial DNA and cellular bio-membrane . Damaged mitochondria
produce less ATP and more free radicals , most of them destroyed by lysosomes.
Mitochondria of old cell are especially subjected to an attack of free radicals .
Many authors blame the free radical damage as the reason for age-related
pathological changes such as " greying of hairs " and formation of "cataract" in
crystalline lens .
It is appropriate here to quote here lines from the article on ageing on Internet .
“It was found that the ability of mitochondria to generate energy decreases with age. This
situation prompted to begin the study contained in the mitochondria DNA, which
encodes a dozen proteins necessary for their functioning. It is assumed that the
mitochondrial DNA being attacked by free radicals, since these organelles are the main
source of free radicals in the body, and mtDNA is particularly susceptible to oxidation.
The rate of oxidation of DNA in mitochondria is significantly higher than in the nucleus. A
special vulnerability of mitochondrial DNA due to the fact that it does not contain histone
proteins that bind to nuclear DNA and protect it. In addition, mitochondrial genes are
only minimally served by enzymes, "cut" and substituting the oxidized regions of DNA in
the cell nucleus.
These observations suggest the possibility that the oxidative attack on unhindered
mitochondrial DNA can slowly disrupt the mitochondria in the ageing organism. When in
a cell large number of these organelles is severely damaged, cell begins to suffer from
lack of energy. And when the body breaks down a large number of cells, its activity is at
decline.
In the elderly people , mitochondrial DNA in cells of the heart and the brain is defective,
but , this defect is not detected in embryonic tissues.
Some common for elderly chronic disease, including senile diabetes, Parkinson's
disease and Alzheimer's disease, associated with damage to the mitochondria . “
Crystalline lens of the eye - while all the others have nerves and
vessels , this is simply a jelly-like prism whose key function is to
remain transparent and let light reach the retina .Crystalline lens is
also affected by age-related pathological changes . Currently prevailing
scientific explanations about cataract formation still retains their "
hypothetical " status . Some authors have claimed that cause of age-
related opacity of crystalline lens is free radical damage in the form
of lipid peroxidation . According to authors , with age , the content
of natural protein antioxidant “ L-carnosine “ contained in the
crystalline lens decreases . This results in opacity of crystalline lens . “
L- carnosine “ based eyedrops have already appeared in international
market . In the opinion of authors , L- carnosine based eyedrops will
avert the formation of cataract in the crystalline lens .
It is known that gastric juices , saliva , urine and other biological fluids in the
human and animals change their chemical composition if the body develops any
deviation from normal . Research has shown that the drying of these fluids forms
crystals of the substances which enter into their composition , the crystals
changing their shapes depending on the character of the disturbances in the
organism .
In this regard , the lines from the book of some authors are worth
quoting .
“The human brain differs from the animal brain both in quantity
and quality . The ratio of the brain’s weight to that of the organism
as a whole is known o have changed during evolution . The weight
of the whale’s brain is 1/1000th of that of its body , the lion’s brain
1/545th , the elephant’s brain 1/500th , the ape’s brain 1/150th and the
human brain , 1/46th .The human brain is thus more than three times
as heavy as that of an ape .
In absolute weight the human brain is smaller than that of large
animals . The average human brain weighs anywhere from 1100 to
2000 g ( 1500 g on the average ) compared with that of anthropoid
apes ( 400-500 g ), dolphins ( 1800 g ) , elephants ( 5200 g ) , and
whales ( 7000 g )
The square index of the brain to that of the body , can be
determines by multiplying the absolute weight of the brain by its
relative weight . This index which distinguishes humans from the
whole animal world is 0.19 in rodents , 1.14 in carnivores , 6.27 in
cetaceans ( dolphins ) , 7.35 in anthropoid apes , 9.82 in elephants ,
and , finally , 32.0 in humans “
In conclusion
In conclusion , to summarize , I want to say that - the first step of
research would be to find out the correct biological reason at
molecular level for greying of hairs and the reduction in the
concentration of water in the tissues with age . And only then there
will occur a strategical breakthrough regarding implementation of
ageing retarding factors ( biological or non-biological )
I give a lot of importance to a reduction in the concentration of
water in tissues with age. To be more precise , the extra-cellular
water in the tissues decreases with age .