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and Pauling pre-empted the recent study by several decades. Some may be reminded of the description of Linus Pauling being consistently 20 years ahead of other scientists.[6] Over the past decade it was shown that vitamin C inhibits hyaluronidase and related breakdown enzymes.[7,8] Once again this is not a new finding as it was determined by Edmond Reppert and colleagues back in 1951.[9] The recent mole-rat study is a confirmation of the core ideas of Cameron, Pauling, and others. It supports an important anticancer mechanism of high-dose vitamin C. Over the last several decades, additional ways that vitamin C attacks cancer have been established.[10-13]
Summary
Although we welcome the recent mole-rat paper, our enthusiasm is tempered by the lack of references to the far earlier work of Pauling, Cameron, and other orthomolecular researchers. The paper presents old ideas as new. Orthomolecular medicine should not be ignored when its findings are confirmed. Vitamin C provides an effective basis for the safe treatment of cancer, an important implication that the recent paper and the worldwide media coverage failed to mention.
References:
1. Tian X, Azpurua J, Hine C. Vaidya A, Myakishev-Rempel M, Ablaeva J, Mao Z, Nevo E. Gorbunova V. Seluanov A. (2013) High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat, Nature, Jun 19, doi: 10.1038/nature12234. 2. Cameron E. (1966) Hyaluronidase and Cancer, Pergamon Press. 3. Cameron E. and Pauling L. (1973) Ascorbic acid and the glycosaminoglycans: an orthomolecular approach to cancer and other diseases. Oncology, 27, 181-192. 4. Cameron E, Pauling L, Leibovitz B. (1979) Ascorbic acid and cancer: a review, Cancer Res., 39(3), 663-681. 5. Gonz lez MJ, Miranda-Massari JR, Mora EM, Guzm n A, Riordan NH, Riordan HD, Casciari JJ, Jackson JA, Rom n-Franco A. (2005) Orthomolecular oncology review: ascorbic acid and cancer 25 years later, Integr Cancer Ther., 4(1), 32-44. 6. Roberts H. (2004) Vitamin C, Linus Pauling was right all along. A doctor's opinion, Medical News Today, Aug 17. http://www.medicalnewstoday.com/releases/12154.php 7. Okorukwu ON, Vercruysse KP. (2003) Effects of ascorbic acid and analogs on the activity of testicular hyaluronidase and hyaluronan lyase on hyaluronan, J Enzyme Inhib Med Chem., 18(4), 377-382.
8. Spickenreither M, Braun S, Bernhardt G, Dove S, Buschauer A. (2006) Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases, Bioorg Med Chem Lett., 16(20), 5313-5316. 9. Reppert E, Donegan J, Hines LE. (1951) Ascorbic acid and the hyaluronidase hyaluronic acid reaction, Exp Biol Med., 77(2), 318-320. 10. Hickey S (2013) Antioxidants may prevent cancer and some may even cure it. http://www.orthomolecular.org/resources/omns/v09n02.shtml 11. OMNS (2011) Intravenous vitamin C as cancer therapy. http://www.orthomolecular.org/resources/omns/v07n03.shtml 12. OMNS (2010) Cancer and vitamin C: Evidence-based censorship. http://www.orthomolecular.org/resources/omns/v06n23.shtml 13. OMNS (2008) Vitamin C slows cancer down. And, doctors say, can reverse it as well. http://www.orthomolecular.org/resources/omns/v04n19.shtml