Drug Data Generic Name flupentixol Trade Name Fluanxol, Navane, Depixol Patients Dose

Classification Therapeutic! antip#y$%oti$# Pharmacologic &%ioxant%ene de'ivative# antip#y$%oti$# Pregnanc Categor C

Mechanism of Action Flupentixol i# a t%ioxant%ene antip#y$%oti$ t%at in%i(it# dopamine) mediated effe$t# (y (lo$*ing po#t#ynapti$ dopamine 'e$epto'# in t%e +N,. Pharmaco#inetics A! -eadily a(#o'(ed f'om t%e .I t'a$t. ,lo/ly a(#o'(ed f'om t%e in0e$tion #ite, D! +'o##e# t%e (lood) ('ain (a''ie' and pla$enta1 ente'# ('ea#t mil*. 2354 (ound to pla#ma p'otein#. M$%! 5xten#ively %epati$ via #ulfoxidation, #ide) $%ain N)deal*ylation and glu$u'oni$ a$id $on0ugation. &nset !"6 un*no/n I 6 24)72%'#. Pea# !"6 3)8%'#. I 6 4)7 day# Duration !"6 un*no/n I 6 2)4 /ee*# Drug 'alf (ife 9n*no/n

Indication General Indications !#y$%o#e#1 Dep'e##ion /it% o' /it%out anxiety Patients Actual Indication

Contraindications :ype'#en#itivity. 5xt'emely ex$ita(le and ove'a$tive patient#1 mania1 po'p%y'ia1 $oma1 p'eexi#ting +N, dep'e##ion1 (one)ma''o/ #up'e##ion1 p%aeo$%'omo$ytoma. La$tation. Precaution .e'iat'i$ and ve'y young patient# ;in$'ea#ed 'i#* of adve'#e 'ea$tion#<1 Inte#tinal o(#t'u$tion o' infe$tion1 !'o#tati$ %ype'pla#ia1 +%'oni$ 'enal, %epati$, pulmona'y, o' $a'dia$ di#ea#e1 !'egnan$y, la$tation, o' $%ild'en ;#afety not e#ta(li#%ed< .Drug interaction )drug to drug ay potentiate t%e adve'#e effe$t# of d'ug# /it% antimu#$a'ini$ effe$t# e.g. &+=#. -edu$ed effi$a$y of levodopa. In$'ea#e# adve'#e ext'apy'amidal #ymptom# /it% dopamine antagoni#t# ;meto$lop'amide and p'o$%lo'pe'a>ine<. Potentiall *atal! ay potentiate t%e adve'#e effe$t# of d'ug# /it% antimu#$a'ini$ effe$t# e.g. &+=#. -edu$ed effi$a$y of levodopa. In$'ea#e# adve'#e ext'apy'amidal #ymptom# /it% dopamine antagoni#t# ;meto$lop'amide and p'o$%lo'pe'a>ine<

Adverse Reaction -igidity, t'emo'#, 'e#tle##ne##, ta'dive dy#*ine#ia, in#omnia, d'yne## of mout%, /t gain, #exual dy#fun$tion, gala$to''%oea and men#t'ual di#tu'(an$e#. Potentiall *atal! Neu'olepti $ malignant #ynd'ome ;%ype't%e'mia, %ype'toni$ity of #*eletal mu#$le#, un$on#$iou#ne## and autonomi$ ne'vou# #y#tem in#ta(ility<.

Nursing Responsibilities +efore 1. =##e# patient?# diagno#i#. 2. =##e## patient?# mental #tatu#. 3. =##e## patient?# mood. 4. +onfi'm medi$ation f'om do$to'?# o'de'#. 5. "(tain p'e#$'i(ed do#e. During 1. +onfi'm patient?# identity. 2. =dmini#te' medi$ation at t%e 'ig%t p'e#$'i(ed 'oute. 3. Do not go ove' t%e 'e$ommended do#e. 4. !'a$ti$e a#epti$ te$%ni@ue. 5. ay admini#te' medi$ation /it% meal#. After 1. "(#e've p'ope' do$umentation of admini#te'ed medi$ation. 2. 5n#u'e t%at patient %a# fully #/allo/ed o'al fo'm of medi$ation. 3. "(#e've patient?# (e%avio' $lo#ely fo' atlea#t 15)30 minute# afte' admini#t'ation. 4. onito' patient?# A/, t%'oug%out t%e t%e'apy. 5. In#t'u$t patient to 'e#t to de$'ea#e 'i#* of fall#.

Minimum Dose 2mg/day Maximum Dose 20mg/day Contents flupentixol Availabilit and color Ampules! 20mg/1mL, 40mg/2mL "ials!200n g/10mL, 500mg/5mL Tablets!0. 5mg, 3mg Routes of administra tion I , !"

,ource!

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