DRUG AND CLASSIFICATION

PHARMACOTHERAPEUTIC (INDICATION)

PHARMACOKINETICS (Peak Serum levels, Half Life , % to protein Bound like excretion)

NURSING MANAGEMENT

NAME : PENICILLIN G Penicillin G benzathine CLASSIFICATION: Pregnancy

Category: B

To treat: Group A Streptococcal Respiratory Infections Rheumatic Fever Prophylaxis Syphilis Yaw, Bejel, & Pinta Renal Impairment

Peak Plasma Concentration: 0.030.05 units/mL; levels persist for 514 days depending on dose Protein Bound: 60% Metabolism: ~30% in liver Excretion: urine (6090%)

NAME : PENICILLIN V Phenoxymeth ylpenicillin CLASSIFICATION: Penicillin , Natural Therapeutic class: Anti-infective

To treat: Streptococcal Pharyngitis Actinomycosis Erysipelas Periodontal Infections Renal Impairment Recurrent Rheumatic Fever Prosthetic Joint Infection (Off-label)

Peak Plasma time: 0.5-1 hr Half-life: 0.5-0.6 hr Protein bound: 80% Excretion: urine

Before administrating this medication, make sure the patient is not allergic to penicillin or cephalosporin antibiotics; Administered through IM and dosage depends on age and weight of patient Pain at the injection site, nausea, or vomiting may occur. SIDE EFFECTS: Upset stomach, nausea, vomiting, diarrhea Confirm no allergies Shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. This medication may be taken with or without food. However, penicillin is best absorbed when taken on an empty stomach (1 hour before or 2 hours after meals). SIDE EFFECTS: Upset stomach, nausea, vomiting, diarrhea, and mouth sores may occur.

NAME : Ampicillin CLASSIFICATION:

Penicillins, Natural,

To treat: Endocarditis Prophylaxis Genitourinary Tract Infections (Excluding Gonorrhea Respiratory Tract Infections

Half-Life: 1-1.8 hr Protein Bound: 1525% Peak Plasma Time: Oral 1-2 hr Absorption: oral 50% Distribution: bile, blister & tissue fluids, CSF with inflamed meninges Metabolism: liver Excretion: urine

NAME: Amoxocillin

To treat: Ear, Nose, & Throat Infections Genitourinary Tract Infections Skin & Skin Structure Infections Lower Respiratory Tract Infections Gonorrhea Anthrax

Absorption Rapidly absorbed Bioavailability: 7492% Peak plasma time: 12hr Distribution Most body fluids and bone, CSF <1% Protein bound: 1720% Metabolism Hepatic Half-life: 61.3 minutes Elimination Excretion: Urine

No drug allergies Take this medication by mouth usually 4 times a day (every 6 hours), or as directed by your doctor. Take ampicillin on an empty stomach (1 hour before or 2 hours after a meal) with a full glass of water. Drink plenty of fluids while using this medication unless your doctor tells you otherwise. Nausea, vomiting, diarrhea, or mouth/tongue sores may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Ampicillin can commonly cause a mild rash that is usually not serious. Give in oral preparations only; amoxicillin is not affected by food Continue therapy for at least 2 days after signs of infection have disappeared; continuation for 10 full days is recommended. Use corticosteroids or antihistamines for skin reaction. Report any side effects If GI upset occurs, take with meals

Name: Timentin

To treat : Septicemia Lower Respiratory Infections Skin & Skin Structure Infections Urinary Tract Infections Intra-abdominal Infections Gynecologic Infections

Absorption Absorption: 86% (IM) Peak Plasma Time: 30-75 min (IM) Peak Plasma Concentration: 324 mcg/mL (immediately after 30 min IV infusion of 3.1 g) AUC: 485 mcghr/mL (ticarcillin); 8.2 mcghr/mL (clavulanic acid) Distribution Protein Bound: 45 (ticarcillin); 25% (Clavulanate) Distributed into bile, low concentrations in CSF Metabolism Liver Elimination Half-life: 1.1 hr adults; 4.4 hr neonates; 1 hr infants/children Excretion: 60-70% urine (ticarcillin), 35-45% (clavulainic acid), excreted unchanged in first 6 hr after administration Plasma Protein Binding 2960%.b Elimination Metabolism Elimination Route -Urine Half-life 0.781 hour.b Serum half-life ranges from 9.4 23.4 hours in

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding problems, cystic fibrosis, kidney disease, seizures, severe loss of body This medication is given by injection into a vein as directed by your doctor, usually every 4 to 6 hours. It should be slowly injected over at least 30 minutes. The dosage is based on your medical condition, age, weight, and response to treatment. water/minerals (dehydration). Side effects will be swelling, redness, pain, or soreness at the injection site may occur.

Drug: Carbenicillin (Geocillin)

This medication is a penicillin antibiotic, prescribed for certain bacterial infections. It blocks the bacterial growth. Urinary Tract Infections (UTIs) Prostatitis

Confirm no drug allergy and administer oral Advise patients that should only be used to treat bacterial infections and not used to treat viral infections Advise patients that skipping doses or not completing the full course of therapy may decrease

effectiveness and increase the likelihood that bacteria will develop resistance and will not be treatable with carbenicillin or other antibacterials in the future.a Importance of discontinuing therapy and informing clinician if an allergic reaction occurs.a