[Sodium monochloroacetate]

[Denak Co., Ltd.]

[Reference No. 005]

[Last updated 2013/7/29]

[Page 1/10]

SAFETY DATA SHEET

1. Chemical Product and Company Identification Product name : Company name : Address : Responsible person : Phone number : FAX number : E-mail address : Emergency contact : Emergency phone number : Reference number : 2. Hazards Identification GHS classification : Physical and chemical hazards : Health hazards Acute toxicity (Oral) Acute toxicity (Dermal) Acute toxicity (Inhalation/vapour) Acute toxicity (Inhalation/mist) Skin corrosion/irritation Serious eye damage/irritation Respiratory sensitization Skin sensitization Germ cell mutagenicity Carcinogenicity Reproductive toxicity Specific target organ toxicity (Single exposure) Specific target organ toxicity (Repeated exposure) Aspiration hazard Environmental hazards Hazards to the aquatic environment - acute hazard Hazards to the aquatic environment - chronic hazard Classification not possible Category 3 Category 5 Not applicable Classification not possible Category 2 Category 2B Classification not possible Classification not possible Classification not possible Classification not possible Category 2 Category 2 (central nerves, heart, kidney) Category 3 (Respiratory tract irritation) Category 2 (liver, kidney) Classification not possible Sodium chloroacetate (synonym: Sodium monochloroacetate) Denak Co., Ltd. Bancho Kaikan 4F, 12-1 Goban-cho, Chiyoda-ku, Tokyo, 102-0076 Japan Marketing manager +81-3-5215-7701 (main phone number) +81-3-5215-7705 Junji.otsuka@akzonobel.com Denak Co., Ltd., Omi plant, MLMCA section (Inside DENKA DENKI KAGAKU KOGYO KABUSHIKI KAISHA) +81-25-562-6451 (office), or -6466 (control room) 005

Category 1 Not classified

[Sodium monochloroacetate]

[Denak Co., Ltd.]

[Reference No. 005]

[Last updated 2013/7/29]

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GHS label elements Pictogram

Danger Signal words: Danger Hazard statements Harmful if swallowed May be harmful in contact with skin Causes skin irritation Causes eye irritation Suspected of damaging fertility or the unborn child May cause damage to organs (central nerves, heart, kidney) May cause damage to organs (liver, kidney) through prolonged or repeated exposure Very toxic to aquatic life Precautionary statements
Precautionary statements Category Prevention Response IF SWALLOWED: Immediately call a doctor. Rinse mouth. (if immediate administration of antidote is required) Specific treatment (Reference to supplemental first aid instruction ... on this label). Storage Store locked up. Disposal Dispose of contents /container to ... (in accordance with local /regional /national /international regulations). Do not eat, drink or smoke when using this product. Wash hands 3 thoroughly after handling.

Hazard Acute toxicity - Oral

Acute toxicity - Dermal Skin corrosion /irritation

5 Wear protective gloves. (Manufacturer /supplier or the competent authority to specify type of 2 equipment.) Wash hands thoroughly after handling.

Call a doctor if you feel unwell. IF ON SKIN: Wash with plenty water and soap. Take off contaminated clothing and wash it before reuse. If skin irritation occurs: Get medical advice/attention. Specific treatment (Reference to supplemental first aid instruction ... on this label). (Manufacturer/supplier or competent authority may specify a cleansing agent if

[Sodium monochloroacetate]

[Denak Co., Ltd.]

[Reference No. 005]

[Last updated 2013/7/29]

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appropriate.) Serious eye damage /irritation IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present 2B and easy to do. continue rinsing. If eye irritation persists: Get medical advice/attention. Wash hands thoroughly

after handling Reproductive toxicity Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Avoid contact during pregnancy /while 2 nursing. Do not eat, drink or smoke when using this product. Do not breathe dusts or mists (if inhalable particles of dusts or mists may occur during use). Wear the personal protective equipment specified. Specific target organ toxicity (Single exposure) 2 3 Do not eat, drink or smoke when using this product. Wash hands thoroughly after handling. Do not breathe dust /fume /gas /mist /vapours /spray. IF exposed or concerned: Call a doctor if you feel unwell. IF INHALED: Remove person to fresh air and keep comfortable for breathing. Store locked up. Store in a well-ventilated place. Keep container tightly closed (if product is volatile so as to generate hazardous atmosphere). Dispose of contents /container to ... (in accordance with local /regional /national /international regulations). IF exposed or concerned: Get medical advice /attention. Store locked up. Dispose of contents /container to ... (in accordance with local /regional /national /international regulations).

[Sodium monochloroacetate]

[Denak Co., Ltd.]

[Reference No. 005]

[Last updated 2013/7/29]

[Page 4/10]

Specific target organ toxicity (Repeated exposure) Hazards to the aquatic environment - acute hazard 1 2

Do not breathe dust /fume /gas /mist /vapours /spray.

Get medical advice /attention if you feel unwell.

Dispose of contents /container to ... (in accordance with local /regional /national /international regulations).

Avoid release to the environment (if this is not the intended use).

Collect spillage

Dispose of contents /container to ... (in accordance with local /regional /national /international regulations).

Other hazards which do not result in GHS classification, important signs, expected emergency overview : Acute toxic material Most important hazard : If on skin, causes inflammation. Hazards : If in eyes, causes inflammation to the cornea. If inhaled, causes inflammation to the respiratory tract. Skin irritation Specific hazard : Japan; Acute toxic material Country / regional information :

3. Composition/Information on Ingredients Single chemical substance/mixture : Chemical name : Synonym : Ingredients and contents Chemical property : Serial no. of government gazette : CAS No : Hazardous components : Hazardous impurities : 4. First-aid Measures Upon hospital treatment, please hand this SDS to the doctor. If there is concern that touched or ingested or was exposed to the vapor to the sodium monochloroacetate, or if the symptoms are observed, please get medical advice by a doctor always. In addition, since it may appear effect delayed, you must take Medical observation. If inhaled : Wrap the patient in blanket and keep at rest, and remove to fresh air immediately. Transport to the hospital by symptoms. If the breathing is difficult, or if the breathing has stopped, to use artificial respiration or artificial resuscitation equipment immediately. If on skin : If sodium monochloroacetate is contacted on the skin, since these may feel the irritation to the skin and make the chemical burn, wash for at least 15 minutes with Single chemical substance Sodium chloroacetate Sodium monochloroacetate Sodium chloroacetate 98% C2H2ClCO2Na, molecular weight 116.5 (2)-1146 3926-62-3 Sodium chloroacetate Not applicable

[Sodium monochloroacetate]

[Denak Co., Ltd.]

[Reference No. 005]

[Last updated 2013/7/29]

[Page 5/10]

If in eyes :

If swallowed :

Most important sign and symptom : Protection for first-aiders :

Special note to doctor : 5. Fire Fighting Measures Extinguishing media : Unsuitable extinguishing media : Special riskhazard

plenty of water. Remove/Take off immediately contaminated clothing with take action above. Wash with plenty 0.9% saline water or clean water for at least 15 minutes and get medical attention by an ophthalmologist. Eyewash is effective that performed spread the eyelids with thumb and index finger. If using a contact lenses, wash by removing unless it is fixed. Rinse the mouth thoroughly, and drink a water. (however, do not induce vomiting.) Keep at rest, and breathe fresh air, and keep the posture as leaning against the object, and transport to the hospital. Pain of the skin, ocular pain, pain of respiratory tract. If to rescue the victims, wear dust mask, acid-resistant clothing, boots, goggles or full face shield, rubber or PVC gloves. Take a symptomatic treatment.

Special firefighting method :

Protection for fire fighters :

To extinguish use alcohol resistant foam, carbon dioxide, dry chemical, water. It is not specifically, but avoid water spray to the product directly. In case of fire or explosion, do not breathe fumes. When combustion or decomposition of the product, generate hydrogen chloride gas, carbon dioxide, formaldehyde, and carbon monoxide. Move container to a safe place immediately. If the container cannot be moved, it is cooled by water spray in and around the container to prevent damage container. Since the product is soluble in water, avoid water spray to the product directly. Prevent from entering of the spillages to the drainage pipe, drainage ditch or waterway. It must be cleaned thoroughly after use facilities. Warning to the fire brigades, convey the hazards and properties. As fire-fighting gloves that made by Kevlar fibers is passed through the water, wear rubber gloves when working removal. Protective clothing, respirator, dust mask, rubber boots, rubber or PVC gloves, goggles or full face shield.

[Sodium monochloroacetate]

[Denak Co., Ltd.]

[Reference No. 005]

[Last updated 2013/7/29]

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6. Accidental Release Measures Personal precautions, protective equipment and emergency measures : Avoid contact with skin and eyes. Do not breathe dust. As corrosive is very strong, in the case of work, wear protective equipment (protective clothing, respirator, closed-circuit oxygen respirator, rubber boots, rubber or PVC gloves, goggles or full face shield, etc.) to avoid direct contact or inhalation of the product. If necessary, prohibit the entry of people to the around the leakage area by put a rope, etc. Warning to the fire brigades, convey the hazards and properties. Prevent from discharge of the spillage into the rivers. By any chance if mixed or concerned mixing, contact immediately to relevant organizations. Enclose soil, sand, etc., so that it does not spread, and then prohibit the entry of unauthorized person to the around the leakage area by put a rope, etc. Wipe off the spillage as much as possible, and collect in a container and then dispose it. Remove the residue by washing with plenty of water.

Precautions for the environment :

Method and Equipment for recovery, neutralization, containment, clean-up :

7. Handling and Storage Handling : Technical measures : Avoid overheating to prevent explosion or fire. (refer to Section 5) Wear protective equipment always when handling. Described in Section 8 for personal protective equipment. Handle in a well-ventilated area, and avoid eating and drinking in a handling area. Do not contact with strong oxidizing agents. Keep away from direct sunlight, water leaks, moisture, and heat to prevent deterioration (or deformation), and store at room temperature. (Less than 40% relative humidity is desirable) Keep away from fire, heat source, sources of ignition to prevent fire. Because there is corrosive, use the storage container made by SUS316, SUS316L, PVC FRP, polyethylene FRP, or Glass Lining.

Precaution : Precaution for safe handling : Storage : Proper storage condition :

Safe container and packaging material :

8. Exposure Controls and Personal Protective Equipment Engineering controls : Make a structure to reduce dust generation as much

[Sodium monochloroacetate]

[Denak Co., Ltd.]

[Reference No. 005]

[Last updated 2013/7/29]

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Permissible exposure level :

as possible by local exhaust ventilation, etc. Provide an appropriate ventilation equipment. Provide eye wash and hand wash facilities near the work place where the product is handled, and display clearly the location. The Japan Society for Occupational Health : Not established ACGIH TLV-TWA : Not established

Personal protective equipment : Respiratory protection : Dust mask, respirator Hand protection : PVC protective gloves Eye protection : Safety glasses with side shield or full face shield Skin and body protection : Acid-resistant clothing, protective boots 9. Physical and Chemical properties Physical state Form : Color : Odor : pH : Temperature/temperature range of specific physical state changes Boiling point : Melting point : Flash point : Ignition point : Explosive limits : Vapor pressure : Vapor density : Relative density : Bulk density : Solubility : Partition coefficient (n-octanol/water) : Decomposition temperature : Powder White Pungent odor of acetic acid type 4.5~7.0 (10wt%) None 3) 150~200C 269C Not applicable Not applicable 3) Very few (25C) Not applicable 3 1,850kg/m (20C) 3 800~1,200kg/m Insoluble 3) log Pow=-3.47 No data

10. Stability and Reactivity Stability : Incompatible materials : Hazardous decomposition products : When temperature exceeds 150C, it pyrolytically decomposes. (also refer to Section 7) Do not overheat to avoid thermal decomposition. Generate hydrogen chloride gas, formaldehyde. (also refer to Section 5)

11. Toxicological Information Acute toxicity : Oral Oral Intraabdominal Rats LD50 Mice LD50 Guinea pigs LD50 95mg/kg 2) 165mg/kg 2) 115mg/kg
2)

[Sodium monochloroacetate]

[Denak Co., Ltd.]

[Reference No. 005]

[Last updated 2013/7/29]

[Page 8/10]

Skin corrosion/irritation :

Serious eye damage/eye irritation :

Carcinogenicity : Reproductive toxicity :

Specific target organ toxicity/systemic toxicity (Single exposure) : Specific target organ toxicity/systemic toxicity (Repeated exposure) : Hazards to aquatic environment : Aspiration hazard :

Dermal Rats LD50 >2000mg/kg There is a report that is not observed skin irritation in rabbits in SIDS (1996), but it have been skin irritation (Xi;R38) in the EU-Annex I (2006). In the eye irritation test in rabbits, there are one by one reports of positive and negative in SIDS, but there is a description that is irritating to the eyes (redness, pain, blurred vision) in ICSC(J) (2003). Not observed carcinogenicity. In a teratogenicity study in rats in SIDS (1996) that is a Priority 1 document, malformation of fetal heart has increased significantly in dose that is observed general toxicity (suppression of body weight gain) in the dams. In ICSC(J) (2003) that is a Priority 2 document, there is a description effects on the central nervous system, heart, kidneys of humans, and irritating to the respiratory tract. In repeated oral administration study in rats in SIDS (1996) and RTECS (1997), the effect was observed in the liver and kidney. 5) 24-hr LC50 = 427mg/L in crustacean (Daphnia magna), 5) 72-hour EC50 = 0.025mg/L in algae (Scenedesmus). A person with disorder of the respiratory system, airway disease and a disease such as chronic bronchitis and emphysema, may suffer a disorder further by aspiration in high concentration particles.

4)

12. Ecological Information Persistence/Degradability : Other information : 13. Precautions for Disposal See Section 8 for personal protective equipment. Follow the standard that relates to methods of disposal in poisonous and deleterious substances. Disposal of the product : When performing the incineration, to take measures processing for incineration exhaust gas because the hazardous gas (hydrogen chloride gas, carbon dioxide, formaldehyde, carbon monoxide) is generated. Residual waste : Dispose with plenty of water after collecting as much as possible. Disposal of contaminated containers and Dispose after collecting as much as possible. packaging : 14. Transport Information International regulation : IMDG Code(International Maritime Dangerous Goods Code) : Class 6.1 Packing group III It is easy to be degraded by micro-organisms in water. Prevent from discharge into the sewage.

[Sodium monochloroacetate]

[Denak Co., Ltd.]

[Reference No. 005]

[Last updated 2013/7/29]

[Page 9/10]

ICAO-TI (International Civil Aviation Organization Technical Instructions) / IATA-DGR (International Air Transport Association Dangerous Goods Regulations) : Class 6.1 Packing group III UN classification : Class 6.1 Packing group III UN number : 2659 Domestic regulation : Poisonous and Deleterious Substances Control Act : Cabinet Order Article 2 Deleterious Substances Road Act : Enforcement Order Article 19-13 No.1 Poisonous and Deleterious Substances (Restriction of vehicular traffic) Specific safety measure and condition of By the Poisonous and Deleterious Substances transport : Control Act, the container follows "standards for transport container of poisonous and deleterious substances". The container label is required 'non-medical', 'Deleterious Substances (red letter on white) ', ingredient name and its contents (requires the name and address of the manufacturer in the case of sale by the container). If transport by a vehicle etc., to make carry the transport note or yellow card to the transporter. 15. Regulatory Information Poisonous and Deleterious Substances Control Act : Cabinet Order Article 2 Deleterious Substances Civil Aeronautics Act : Enforcement regulations Article 194, Dangerous Goods Notification Appended Table 1, Toxic substances: Poisonous Substances Act on the Control of Import, Export, etc. of Specified Hazardous Wastes and Other Wastes : Article 2 paragraph 1, 1- / Notification of three ministries Regulations for the Carriage and Storage of Dangerous Goods in Ships : Article 2, 3, Dangerous Goods Notification Appended Table 1, Toxic substances Road Act : Enforcement Order Article 19-13 No.1 Poisonous and Deleterious Substances (Restriction of vehicular traffic) Act on Control of Household Products Containing Harmful Substances : Article 2, harmful substances Industrial Safety and Health Act : Article 57-2, notifiable substances: Not applicable Act on Confirmation, etc.of Release Amounts of Specific Chemical Substances in the Environment and Promotion of Improvements to the Management Thereof : Not applicable Foreign Exchange and Foreign Trade Act : Export Trade Control Order Article 1 Appended table 1, No. 16 (organic chemicals H.S29-1540) Export Trade Control Order Appended table 2 (Export approval)

[Sodium monochloroacetate]

[Denak Co., Ltd.]

[Reference No. 005]

[Last updated 2013/7/29]

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16. Other Information This information is accurate in the full extent of the knowledge of the author, but it is not complete about absolute accuracy of its contents and the comprehensiveness of the information collection. In addition, this information is concerned with ingredients and products. We do not assume that a case in which this material is processed or combined with other materials. Especially please do not use it in medical use. Responsibility for the final decision to the proper use of this material, and this information adapt to own handling and to be completely satisfactory is located in the user. Since all materials have unknown hazards, care must be taken when handling. In this MSDS, it is mentioned about the specific dangers, but it does not mean that the other risk does not exist. Before using, make the pre-test by yourself always, please check in your responsibility whether conform to the intended use or safety. Please note that the contents of this document is a case to change without notice by the new knowledge. Contact information about contents of description : Denak Co., Ltd. Phone number : +81-3-5215-7701 FAX number : +81-3-5215-7705 Reference : 1) Poisonous and Deleterious Substances Control Act statute book Yakumu kohosha (2000) 2) Chemical safety management data book (2nd revised edition) The Chemical Daily Co., Ltd. (2000) 3) International Chemical Safety Cards (ICSC) 4) SIDS, (1996) 5) IRPTC, (1996)