Subjective experience can be described as an ainner feelingo that a patient perceives of his or her body, mind, relationships toward others, disease, and medication. A number of studies indicate that an increase in a patient's adherence to treatment may improve the outcome of schizophrenia.
Subjective experience can be described as an ainner feelingo that a patient perceives of his or her body, mind, relationships toward others, disease, and medication. A number of studies indicate that an increase in a patient's adherence to treatment may improve the outcome of schizophrenia.
Subjective experience can be described as an ainner feelingo that a patient perceives of his or her body, mind, relationships toward others, disease, and medication. A number of studies indicate that an increase in a patient's adherence to treatment may improve the outcome of schizophrenia.
The outcome studies of schizophrenic patients treated with anti-
psychotic drugs (APs) have traditionally been focused on the eval- uation of positive and/or negative symptoms through the admin- istration of classical rating scales such as BPRS, PANSS, and CGI, while symptoms such as the subjective experience toward the illness and its drug treatment have been considerably neglected. Subjective experience can be described as an inner feeling that a patient perceives of his or her body, mind, relationships toward others, disease, and medication. In a comprehensive evaluation of the drug treatment of schizophrenia, the assessment of the subjective experience of the patient toward the drug adminis- tered should be considered an important tool to measure the quality of treatment [4, 8]. A number of studies indicate that a patient's subjective experi- ence to APs and the adherence to treatment are key factors in en- suring a smooth recovery from illness [26], as it has been docu- mented that an increase in a patient's adherence may improve the outcome of schizophrenia [3]. Although there has been interest in the study of the subjective experience of schizophrenic patients since the 1950 s, it was not until the 1980 s that the majority of studies on the assessment of subjective experience were published [22]. In addition, a number of studies comparing first-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs) found a more favorable subjective experience in those who were taking SGAs [13,15]. Nowadays the following scales measuring subjective experien- ces and attitudes toward treatments are available: Performance of the Italian Version of the Subjective Well-being Under Neuroleptic (SWN) Scale in Schizophrenic Outpatients M. Balestrieri 1 G. Giaroli 2 M. Mazzi 2 C. Bellantuono 2 Affiliation 1 Centro InterUniversitario di Neuroscienze Comportamentali, Dipartimento di Patologia e Medicina Clinica e Sperimentale, University of Udine 2 Sezione di Psichiatria e Psicologia Clinica, Dipartimento di Medicina e Sanit Pubblica, University of Verona Correspondence Prof. Cesario Bellantuono Sezione di Psichiatria e Psicologia Clinica Dipartimento di Medicina e Sanit Pubblica Universit di Verona Policlinico G. Rossi Piazza L. Scuro 37134 VERONA Italy Phone: +39.045.8074.442 Fax: +39.3387004577 E-Mail: cesario.bellantuono@univr.it Received 13.6.2005 Revised 15.10.2005 Accepted 1.11.2005 Bibliography Pharmacopsychiatry 2006; 39: 14 Georg Thieme Verlag KG Stuttgart New York DOI n ISSN 0176-3679 Background: Several studies indicate that subjective experience toward antipsychotic drugs (APs) in schizophrenic patients is a key factor in ensuring a smooth recovery fromthe illness. Objec- tive: The principal aim of this study was to establish the psycho- metric performance of the Subjective Well-being Under Neuro- leptic (SWN) scale in its Italian version and to assess, through the SWN scale, the subjective experience of stabilized psychotic outpatients in maintenance with APs. Methods: The original short version of SWN, consisting of 20 items, was back translat- ed, and a focus group was also conducted to better improve the comprehension of the scale. Results: The results showed a good performance of the Italian version of the SWN as documented by the internal consistency (Cronbach's alpha; 0.85). A satisfactory subjective experience was reported in the sample of schizophre- nic outpatients interviewed (SWN mean total score: 84.95, SD: 17.5). Conclusions: The performance of the SWN scale in the present study was very similar to that reported by Naber et al. [18] in the original validation study. Large multi-center studies are needed to better establish differences in the subjective ex- perience of schizophrenic patients treated with first- and sec- ond-generation APs. Pharmaco 2033/2005/422, 9.1.06 Druckerei Sommer O r i g i n a l P a p e r 1 the Neuroleptic Dysphoria Scale (NDS) [25]; the Drug Attitude Inventory, available in a long and a short ver- sion (DAI 30 items, DAI 10 items) [9,10]; the Rating of Medication Influence (ROMI) [27]; the Attitude Toward Medication Treatment (ANT) [11]; the Personal Evaluation of Transitions in Treatment (PETiT) [26]; and the Subjective Well Being Under Neuroleptics, available in a long and a short version (SWN 38 items, SWN 20 items) [16,18]. Of these instruments, only the DAI-30, in its Italian version, has been validated and used in an outpatient setting [23]. The first aim of this study was to assess, in a sample of schizo- phrenic outpatients, the psychometric performance of the Italian version of the SWN scale (20 items). In previous validation stud- ies, this scale has shown a good performance in terms of reliabil- ity and sensitivity [12,16]. Secondary aims of the study were to evaluate the subjective ex- perience of schizophrenic patients and to establish whether there were differences between patients treated with FGAs ver- sus SGAs. Methods The SWN scale The SWN scale was originally designed by Naber [14] in a 38- itemversion, with the aimof exploring the subjective experience of psychotic patients towards their illness and medication; a short version of 20 items was further validated in 2001 [18]. The SWN scale contains five subscales consisting of four items each: 1. mental functioning (MF), 2. self-control (SC), 3. emotional regulation (ER), 4. social integration (SI), and 5. physical functioning (PF). Items have to be endorsed on a six-point Likert scale [18]. The to- tal score ranges from a minimum of 20 (poor subjective experi- ence) to a maximum of 120 (excellent subjective experience). To be able to calculate the total score and the sub-scores, some items have to be reversed [18]. Translation and focus group on the SWN In this study, the SWN scale was translated into Italian from the English version by an Italian trainee in psychiatry (G.G.) and was translated back to English [22] by an English-speaking benefit counselor (A.C.). The two versions have been compared and cor- rected to be as faithful as possible to the original English version. Then a focus group [14] consisting of two trainees in psychiatry (P.C. and S.T., conductor of the group), two psychiatric nurses (R.L and R.C.), one psychologist (C.P.), two parents of psychotic pa- tients (B.C. and F. F.), and two fully remitted schizophrenic pa- tients (T.B. and M.P.) was carried out. Only a few difficulties were observed in the comprehension of items 2, 5, 8, 15, 17, 18, and 19. However, these problems were overcome after minor changes to the Italian translation. Recruitment and inclusion criteria The Italian version of the SWB was administrated to consecutive schizophrenic outpatients attending two Community Psychiatric Services (CPS) located in the Friuli-Venezia-Giulia and Veneto re- gions, run by the Academic Departments of Psychiatry of Udine and Verona, respectively. Inclusion criteria for patients enrolled in the study were (1) being 1865 years old and (2) being on a stabilized antipsychotic drug treatment (with a first- or second-generation AP) during the last month; the combination of AP monotherapy with other psychotropic drugs (antidepressants, benzodiazepines, and a mood stabilizers) was allowed. Patients were adequately in- formed about the aims of the study and all gave their written consent to participate to the survey. Statistical Analysis Cronbach's alpha was utilized to analyze the internal consisten- cy. To investigate differences in SWN scores by gender and by type of Aps, a t-Student test for independent analysis was used. A nonparametric statistic was used to compare SWN scores by age groups. ANOVA analysis was also performed for investigating the co-therapy. All statistical analysis was performed using SPSS 11.5. Results The sample consisted of 98 patients, 52 recruited in the Verona CPS and 46 in the Udine CPS. The diagnoses of the patients were, according to DSM IV-TR [1], schizophrenia for 86 patients, schizoaffective disorder for 9 patients, and delusional disorder for 3 patients. The mean age of the patients was 42.7 (11 DS), and the gender distribution showed a significant majority of males over females (54.1% vs. 45.9%, respectively). On the whole, 55% of the total sample were taking a monother- apy (22 patients with a FGA, 32 with a SGA), while 45% were treated with a psychotropic drug combination. About 40% of the sample were in treatment with a FGA; of this, 22% were receiving a long-acting medication (as fluphenazine or haloperidol long-acting). About 60% of patients were on SGA: 21 with olanzapine, 12 with clozapine, 18 with risperidone, and 8 with quetiapine. The psychometric performance of the SWN Table 1 shows the performance of the SWN scale. The mean total score was 84.95 (SD 17.5), which can be interpreted, according to the scoring, as a satisfactory level of subjective well-being. The mean scores for the subscales were as follows: MF = 16.96 (SD 4.52), SC = 16.87 (SD 3.91), ER = 17.54 (SD 3.76), SI = 16.78 (SD 3.98), and PF = 16.81 (SD 4.39). The internal consistency, as measured with the Cronbach's alpha, for the whole scale was 0.85, while for the subscales the coeffi- Balestrieri M et al. Performance of the Pharmacopsychiatry 2006; 39: 14 O r i g i n a l P a p e r Pharmaco 2033/2005/422, 9.1.06 Druckerei Sommer 2 cients were as follows: MF = 0.76, SC = 0.53, ER = 0.54, SI = 0.50, and PF = 0.67. The SWN according to age, sex, and drug treatment Treatment with FGA and SGA by age and gender was evenly dis- tributed. No differences were evident in SWN total score by gen- der (t = 0.27, df = 96, P = 0.97) or age group (1829, 3039, 40 49, 5065) (F = 0.41 P = 0.626). Table 2 shows that there were no differences in SWN total scores (as well as single sub-scores; not shown) between patients treat- ed with FGAs versus SGAs (t = 1.6, df = 96, P = 0.12). Even when we performed the same exercise on selected samples of patients in monotherapy, we could not find any significant statistical dif- ferences in SWN total scores between patients taking FGAs ver- sus SGAs (t = 0.5, df = 52, P = 0.65). Discussion This is the first study carried out with the aim to establish the psychometric performance of the SWN scale in an Italian sample of stabilized schizophrenic patients taking AP drugs. The study presents the following limitations: (1) we did not per- form a testretest reliability, and (2) the Italian version was translated and back translated from the English 20-item version published by Naber et al. [18] and not from the original German version. It is of interest to note that our study presents some differences as compared with Naber's original study [16]. 1. Our patients were recruited among those in contact with out- patient services, while Naber's original sample included only inpatients. Even taking into account that in the Italian mental health system the use of hospital admissions is quite infre- quent, it is probable that the psychopathology of our sample was less severe than that observed in the original sample. 2. Our study included older patients (mean age 42.7) as compar- ed with Naber's sample (mean age 36.6). Notwithstanding these differences, it is remarkable that the per- formance of the SWN scale was so similar in the two samples. In both studies neither age nor gender distribution were signifi- cantly associated with the SWN scores. At discharge, the patients studied by Naber reported a positive subjective experience, which was similar to that observed in the patients of our CPS. However, even if the mean scores were quite similar, in our sam- ple the SWN showed a worse internal consistency in all the measures, and in particular in the subscales of self-control, emo- tional regulation, and social integration. Although it is difficult to understand the reasons for such differences, we must underline that even in the original sample these measures showed a lower performance. Despite this outcome, our results emphasize the impression that the measures of emotional regulation, self-con- trol, and social integration may require a better assessment. We suggest considering conservatively the general measure of SWN as an excellent measure of the subjective well-being during treatment with APs, without considering the single subscales. Even though in our sample we were unable to find any statisti- cally significant difference between FGAs and SGAs, it should be noted that this could have been determined by the fact that we did not assess the psychopathology of the patients treated with different APs. Table 1 Psychometric characteristics of the Italian version of the SWN compared with the Naber study [16] Our sample (n = 98) Naber study (n = 212) Mean (SD) Internal consistency (Cronbach's alpha) Mean (SD) at discharge Internal consistency (Cronbach's alpha) SWN total score 84.95 (17.5) 0.89 84.79 (16.5) 0.92 Mental functioning 16.96 (4.5) 0.76 16.24 (4.3) 0.80 Self-control 16.87 (3.9) 0.53 16.44 (3.9) 0.63 Emotional regulation 17.54 (3.7) 0.54 17.94 (3.9) 0.73 Social integration 16.78 (4.0) 0.50 16.90 (4.4) 0.74 Physical functioning 16.81 (4.4) 0.67 17.28 (3.4) 0.82 Table 2 Mean score of the SWN total score and use of antipsychotic drugs Mean SD t-Student P SWN total score for individuals treated with FGAs (n = 39) 88.31 15.04 1.6 0.12 SWN total score for individuals treated with SGAs (n = 59) 82.73 18.69 SWN total score for individuals treated with FGAs in monotherapy (n = 22) 85.86 15.86 0.5 0.65 SWN total score for individuals treated with SGAs in monotherapy (n = 32) 83.59 19.35 Balestrieri M et al. Performance of the Pharmacopsychiatry 2006; 39: 14 Pharmaco 2033/2005/422, 9.1.06 Druckerei Sommer O r i g i n a l P a p e r 3 Moreover, our sample was too small to allowthe detection of any significant difference in the subjective well-being of patients treated with each SGA. However, it is reasonable to think that, because of the different pharmacological profiles of these drugs, such differences may exist. It has been documented that negative subjective response to APs could be caused by the inhibition of the dopaminergic system of reward [2, 5, 6]. Recently, De Haan et al. [7] studied, through single-photon emission tomography, D2 receptor occupancy in the striatum of patients affected by schizophrenia and treated with APs. They found that receptor oc- cupancy between 60% and 70% was correlated with a good sub- jective experience as measured with the SWN scale [18]. 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