DAY 1 AT TRAINING AT TRAINING

DEPARTMENT Tableting department

INCHARGE Shantanu Ro
INTR!D"CTI!N There are three #a$ o% tabletting
1& dire't 'ompre$$ion
(& )et granulation
*& dr granulation +$lugging,
THE PR!CESS !- TA./ET MA0ING
The pro'e$$ o% tablet ma1ing ha$ the %ollo#ing $tep$&
1& A'2uiring the ra# material$
(& Sie3ing o% the po#dered ra# material$
*& #eighing o% the ra# material$ %or adding in de4nite
proportion$
5& Mi6ing o% the ra# material$
7& Preparation o% mu'ilage
8& Mi6ing o% the mu'ilage #ith the mi6ed ra# material %or
binding
9& Dring
:& Granulation or $i;e redu'tion in order to get granule$ o%
de$ired $i;e
<& Addition o% lubri'ation i% ne'e$$ar
1=& Compre$$ion in a rotar 'ompre$$or in order to get tablet$ o%
de$ired $hape $i;e and #eight
11& Tablet 'oating i% ne'e$$ar
1(& tablet $tripping
1*& Pa'1aging and retailing
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TA./ETTING PR!CESS -/!)SHEET
-ig&1 .a$i' -lo# $heet o% the Tblet ma1ing Pro'e$$$
THE DETAI/ED PR!CESS
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A #ell made 'ompre$$ed tablet ha$ the %ollo#ing 2ualitie$&
1& Abilit to #ith$tand the rigor$ o% me'hani'al treatment
in3ol3ed in produ'tion> pa'1aging> $hipment and
di$pen$ing&
(& -reedom %rom de%e't$ $u'h a$ 'ra'1$> 'hipped edge$>
'ontamination&
*& Rea$onable ph$i'al and 'hemi'al $tabilit during a3erage
$torage 'ondition$&
5& Abilit to relea$e the medi'ament in a reprodu'ible and
predi'table manner&
A tablet i$ a 3ehi'le %or 'arring medi'ation to the patient& In
addition to the drug it i$ al$o 'ompo$ed o% 3ariou$ other material$ that
ma1e it 'ompre$$ible> ta$t and tough> the$e are ne'e$$ar be'au$e
the tablet i$ %ormed on a $tamping ma'hine> 'alled pre$$e$& Hen'e the
limitation$ and the $en$iti3it o% the ra# material$ and the ma'hine$
$hould be ta1en 'are o% during the %ormulation&
He ma'hine$ built to 'ompre$$ the tablet$ 'ontain
1& A hopper %or $toring the material&
(& -eed %rame %or di$tributing the material$ into the die$&
*& Die$ %or 'ontrolling the $hape$ and $i;e o% the tablet$&
5& Pun'he$ %or 'ompa'ting the material$ in the die$&
7& Cam$ %or guarding the pun'he$&
"pper and lo#er pun'h in a R!TARY TA./ET C!MPRESSI!N ma'hine
THE R!TARY C!MPRESS!R
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In a rotar tablet 'ompre$$or the granulation i$ $tored in a
hopper that emptie$ in a %eed %rame> #hi'h ha$ $e3eral
inter'onne'ted 'ompartment$& The$e 'ompartment$ $pread the
granulation o3er a #ide area in order to pro3ide time %or the die$
to get 4lled& The pull do#n 'am guide$ the lo#er pun'he$ to the
bottom o% their 3erti'al tra3el allo#ing the die$ to o3er4ll& The
pun'he$ then pa$$ o3er a #eight 'ontrol 'am> #hi'h redu'e$ the
4ll in the die$ to the de$ired amount& A #ipe o? blade at the right
end o% the %eed %rame remo3e$ the e6'e$$ granulation and
dire't$ it around the turret and ba'1 into the %ront o% the %eed
%rame& The pun'he$ e6ert a 46ed di$tan'e into the die$> #hile the
lo#er pun'he$ are rai$ed to $2uee;e and 'ompa't the granule$
#ithin the die$& The upper pun'he$ are #ithdra#n a$ the %ollo#
the upper ri$ing 'am> the lo#er pun'he$ ride up the 'am #hi'h
bring$ the tablet @u$h #ith or $lightl abo3e the $ur%a'e o% the
die$& The e6a't po$ition i$ determined b a threaded bolt 'alled
the eAe'tor 1nob& The tablet$ $tri1e a $#eep o? blade aB6ed to
the %ront o% the %eed %rame and $lide do#n a 'hute into the
re'epta'le&

The material$ intended %or 'ompre$$ion mu$t po$$e$$ t#o
e$$ential 'hara'teri$ti'$&
1& -luidit
(& Compre$$ibilit
1& Fluidity i$ ne'e$$ar %or the tran$port o% the material %rom
the hopper to the %eed %rame&
(& Compressibility Thi$ propert i$ re2uired in order to ma1e a
'ompa't ma$$ #hen pre$$ure i$ applied&
The granulation $hould ha3e the %ollo#ing propertie$ that #ill
gi3e @uidit and 'ompre$$ibilit to it& A''ordingl good tablet
granulation $hould
1& Contain parti'le$ #hi'h approa'h $pheri'al $hape&
(& Pre$ent a range o% parti'le$ that re$emble a normal
di$tribution 'ur3e #ith a $mall per'entage o% 'oar$e
and 4ne&
*& Ha3e a uni%orm di$tribution o% all the ingredient$ in the
%ormulation&
ADDITICES AND C!MP!NENTS !- TA./ET MA0ING
Tablet$ generall 'on$i$t o% $e3eral material$ in addition to the
drug$ that the 'on3e to the patient&
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1& Dilutants The prin'iple $ub$tan'e added a$ a bul1ing agent
i$ la'to$e& It i$ relati3el ine6pen$i3e and i$ a3ailable
'ommer'iall a$ 'oar$e granule$ o% regular $hape& Star'he$
deri3ed %rom #heat> 'orn> ri'e> and potato are al$o u$ed a$
bul1ing agent> binder> and di$integrator$& The are a3ailable
a$ 4nel di3ided po#der&
TA./ET C!MPRESSI!N
Tablet 'ompre$$ion i$ done in order to ha3e proper $hape and
$i;e a$ #ell a$ #eight o% the tablet$& Se3eral in pro'e$$ te$t$ are
'arried out on the 'ompre$$ed tablet$ in order to 'he'1 it$ 2ualit&
1& Tablet thi'1ne$$ te$t
(& Tablet Hardne$$ te$t
*& Di$integration te$t
5& )eight 3ariation te$t
7& -riabilit te$t
-riabilit te$ter
DAY (
5
CHARGE PREPERATI!N Charge prepared b mi6ing the ra# material$ in a
planetar mi6er& The preparation o% the 'harge %or
Horn o tablet$ #a$ ob$er3ed& The 'harge i$ dr
'harge& The ingredient$ areDD
1& !rnid$ole
(& !Eo6a'in
*& Star'h
5& Dr /a'to$e
7& Magne$ium $tearate
8& Sili'on di o6ide
9& ai3'el
:& deprogel
Horn o tablet i$ prepared b dire't 'ompre$$ion pro'e$$& In thi$
pro'e$$ th ingredient$ are 4r$t mi6ed in dr 'ondition& Then the mi6ed
ingredient$ $re $ent to the 'ompre$$ion unit #here initial 'ompre$$ed
tablet$ are made& The$e tablet$ are then $ent to the granulation unit&
Here the tablet$ are again granulated to de$irable $i;e& Again
'ompre$$ion in 'arried out on the$e granule$& Thi$ dire't 'ompre$$ion
method i$ per%ormed on the $ub$tan'e$ #hi'h are $en$iti3e to #ater&
DRYERS
T#o di?erent dre$ are there in thi$ pla'e&
1& tra drer$
(& -luidi;ed bed drer$
Detail$ about tra drer$ and @uidi;ed bed drer$&+to be #ritten,
TA./ET C!ATING
Tablet 'oating here i$ done b a ma'hine 'alled "NIC!ATA *8&
The $'hemati' diagram o% the tablet 'oating ''le i$ $ho#n in the
4gure belo#&
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S'hemati' diagram o% the tablet 'oating pro'e$$
The Tablet Coating Material
1& Hdro6 methl propl 'hloride
(& Ethl 'ellulo$e
*& Pol 3enl proledon
5& Pol ethlene gl'ol
7& Titanium di o6ide
8& Cellulo$e
9& Erithro$ine
:& Proplene gl'ol
<& Methlene 'hloride
1=& I$opropl al'ohol
The Coating i$ done in order to
1& Sa3e the tablet %rom moi$ture
(& Ma1e the $ur%a'e $moth %or ea$ $#alloeing
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*& To ma1e it good and glo$$ loo1ing
5& -or ta$te enhan'ing&
TA./ET PAC0AIGING
There are t#o method$ o% tablet pa'1aging
1& .li$ter pa'1aging
(& Strip pa'1aging
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