Systemic lupus erythematosus (SLE) is an autoimmune disease, which means the body's immune system mistakenly attacks healthy tissue. This leads to long-term (chronic) inflammation.
The underlying cause of autoimmune diseases is not fully known.
SLE is much more common in women than men. It may occur at any age, but appears most often in people between the ages of 10 and 50. African Americans and Asians are affected more often than people from other races.
Systemic lupus erythematosus (SLE) is an autoimmune disease, which means the body's immune system mistakenly attacks healthy tissue. This leads to long-term (chronic) inflammation.
The underlying cause of autoimmune diseases is not fully known.
SLE is much more common in women than men. It may occur at any age, but appears most often in people between the ages of 10 and 50. African Americans and Asians are affected more often than people from other races.
Systemic lupus erythematosus (SLE) is an autoimmune disease, which means the body's immune system mistakenly attacks healthy tissue. This leads to long-term (chronic) inflammation.
The underlying cause of autoimmune diseases is not fully known.
SLE is much more common in women than men. It may occur at any age, but appears most often in people between the ages of 10 and 50. African Americans and Asians are affected more often than people from other races.
lupus Last reviewed: February 14, 211! Systemic lupus erythematosus "SLE# is a lon$%term autoimmune disorder that may a&ect the s'in, (oints, 'idneys, brain, and other or$ans! )auses, incidence, and ris' *actors Systemic lupus erythematosus "SLE# is an autoimmune disease, which means the body+s immune system mista'enly attac's healthy tissue! ,his leads to lon$%term "chronic# in-ammation! ,he underlyin$ cause o* autoimmune diseases is not *ully 'nown! SLE is much more common in women than men! .t may occur at any a$e, but appears most o*ten in people between the a$es o* 1 and /! 0*rican 0mericans and 0sians are a&ected more o*ten than people *rom other races! SLE may also be caused by certain dru$s! For in*ormation on this cause, see Dru$% induced lupus erythematosus Symptoms Symptoms vary *rom person to person, and may come and $o! 0lmost everyone with SLE has (oint pain and swellin$! Some develop arthritis! Fre1uently a&ected (oints are the 2n$ers, hands, wrists, and 'nees! 3ther common symptoms include: )hest pain when ta'in$ a deep breath Fati$ue Fever with no other cause 4eneral discom*ort, uneasiness, or ill *eelin$ "malaise# 5air loss 6outh sores Sensitivity to sunli$ht S'in rash %% a 7butter-y7 rash over the chee's and brid$e o* the nose a&ects about hal* o* people with SLE! ,he rash $ets worse in sunli$ht! ,he rash may also be widespread! Swollen lymph nodes 3ther symptoms depend on what part o* the body is a&ected: 8rain and nervous system: headaches, numbness, tin$lin$, sei9ures, vision problems, personality chan$es Di$estive tract: abdominal pain, nausea, and vomitin$ 5eart: abnormal heart rhythms "arrhythmias# Lun$: cou$hin$ up blood and di:culty breathin$ S'in: patchy s'in color, 2n$ers that chan$e color when cold ";aynaud+s phenomenon# Some patients only have s'in symptoms! ,his is called discoid lupus! Si$ns and tests ,o be dia$nosed with lupus, you must have 4 out o* 11 typical si$ns o* the disease! <our doctor will per*orm a physical e=am and listen to your chest with a stethoscope! 0n abnormal sound called a heart *riction rub or pleural *riction rub may be heard! 0 nervous system e=am will also be done! ,ests used to dia$nose SLE may include: 0ntibody tests, includin$ antinuclear antibody "0>0# panel )8) )hest =%ray ?idney biopsy @rinalysis ,his disease may also alter the results o* the *ollowin$ tests: 0ntithyro$lobulin antibody 0ntithyroid microsomal antibody )omplement components ")A and )4# )oombs+ test % direct )ryo$lobulins ES; ?idney *unction blood tests Liver *unction blood tests ;heumatoid *actor ,his list is not all inclusive! ,reatment ,here is no cure *or SLE! ,he $oal o* treatment is to control symptoms! 6ild disease may be treated with: >onsteroidal anti%in-ammatory medications ">S0.Ds# treat arthritis and pleurisy )orticosteroid creams to treat s'in rashes 0n antimalaria dru$ "hydro=ychloro1uine# and low%dose corticosteroids *or s'in and arthritis symptoms <ou should wear protective clothin$, sun$lasses, and sunscreen when in the sun! Severe or li*e%threatenin$ symptoms "such as hemolytic anemia, e=tensive heart or lun$ involvement, 'idney disease, or central nervous system involvement# o*ten re1uire more a$$ressive treatment by doctor specialists! ,reatment *or more severe lupus may include: 5i$h%dose corticosteroids or medications to decrease the immune system response )ytoto=ic dru$s "dru$s that bloc' cell $rowth# i* you do not $et better with corticosteroids, or whose symptoms $et worse when the stop ta'in$ them! ,hese medicine have serious, severe side e&ects! <ou should be closely monitored by your doctor! .* you have lupus, it is also important to have: Breventive heart care @p%to%date immuni9ations ,ests to screen *or thinnin$ o* the bones "osteoporosis# ,al' therapy and support $roups may help relieve depression and mood chan$es that may occur in patients with this disease! Support 4roups See: Lupus resources E=pectations "pro$nosis# 5ow well a person does depends on the severity o* the disease! ,he outcome *or people with SLE has improved in recent years! 6any people with SLE have mild symptoms! Comen with SLE who become pre$nant are o*ten able to carry sa*ely to term and deliver a healthy in*ant, as lon$ as they do not have severe 'idney or heart disease and the SLE is bein$ treated appropriately! 5owever, the presence o* SLE antibodies may increase the ris' o* pre$nancy loss! )omplications Some people with SLE have abnormal deposits in the 'idney cells! ,his leads to a condition called lupus nephritis! Batients with this condition may eventually develop 'idney *ailure and need dialysis or a 'idney transplant! SLE causes dama$e to many di&erent parts o* the body, includin$: 8lood clots in the le$s "deep vein thrombosis# or lun$s "pulmonary embolism# Destruction o* red blood cells "hemolytic anemia# or anemia o* chronic disease Fluid around the heart "pericarditis#, endocarditis, or in-ammation o* the heart "myocarditis# Fluid around the lun$s "pleural e&usions# and dama$e to lun$ tissue Bre$nancy complications, includin$ miscarria$e Stro'e Severely low blood platelets "thrombocytopenia# .n-ammation o* the blood vessels )allin$ your health care provider )all your health care provider i* you have symptoms o* SLE! 0lso, call i* you have this disease and your symptoms $et worse or a new one occurs! ;e*erences ;ui9%.rastor9a 4, ;amos%)asals 6, 8rito%Deron B, ?hamashta 60! )linical e:cacy and side e&ects o* antimalarials in systemic lupus erythematosus: a systematic review! 0nn ;heum Dis! 21;EF:2%2G! HBub6edI 5ahn 85, ,sao 8B! Batho$enesis o* systemic lupus erythematosus! .n: Firestein 4S, 8udd ;), 5arris ED Jr!, et al!, eds! ?elley+s ,e=tboo' o* ;heumatolo$y! Gth ed! Bhiladelphia, Ba: Saunders Elsevier; 2G:chap K4! ;eview Date: 2L14L211! ;eviewed by: 6ichael E! 6a'over, 6D is a pro*essor and attendin$ in rheumatolo$y at the >ew <or' @niversity 6edical )enter, >ew <or', ><! ;eview provided by Meri6ed 5ealthcare >etwor'! 0lso reviewed by David Dieve, 6D, 650, 6edical Director, 0!D!0!6!, .nc!