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(1)
h = 6.626 10
34
J s = 4.14 10
15
eV s (2)
c = 3 10
8
m/s(speedoight) (3)
E(eV) =
1.24 10
6
(m)
eV (4)
1.24 10
6
(m)
=
1240
(nm)
eV (5)
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 7 / 89
Photons (EM waves) (cont.)
Recall human body is opaque to visible light
Cosmic Rays (10
11
Ato 10
16
A) human
body is transparent
Energy is 10
15
10
20
eV
1 eV = 1.6 10
12
erg = 1.6 10
19
joules
Charge on an electron is 1.6 10
19
C
X-rays (energy 0.1 123 keV, 0.1
A 100
(x,y,z)dz
+
E(E
s
, )E
s
S(x, y, E
s
, )ddE
s
(6)
I(x,y): image at the receptor
N: # of incident x-ray photons per unit area
(assumed single energy E)
(x, y, z): attenuation coecient (i.e. YOU)
S(x, y, E
s
, ): # scatter photons arrived at (x,y) from
solid angle (i.e. d = sin d d)
with energy range dE
s
E(E, ): energy absorption coecient
for energy E, solid angle
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 19 / 89
Lambert-Beer Law of Photon Absorption
I (x, y) NE(E, 0)Ee
(x,y,z)dz
+
S
E(E)E = NE(E, 0)Ee
(x,y,z)dz
(1+R)
(7)
R: Scattered to primary ratio
If we now make the substitution
C =
I
1
I
2
I
1
(8)
where C is the contrast, we have
I
1
= NE(E, 0)Ee
1
t
1
+
S
E(E)E (9)
I
2
= NE(E, 0)Ee
[
1
(t
1
t
2
)
2
t
2
]
+
S
E(E)E (10)
C =
e
1
t
1
e
[
1
(t
1
t
2
)
2
t
2
]
e
1
t
1
(1 + R)
(11)
=
1 e
(
2
1
)t
2
1 + R
(12)
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 20 / 89
Contrast Integral
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 21 / 89
Contrast and SNR
So, when scatter R C
The change in intensity between two regions is given by
I = I
1
I
2
= CI
1
So, the signal over area A = I A = I
1
C A
Signal
area
= C A N E E e
1
t
1
(1 + R) (13)
But what is the noise over the adjacent area?
Assume E is the same for primary and secondary photons and a
Poisson process for X-Ray photon arrival at area A.
Noise
area
= E
I
1
A
E
= E
NEAe
1
t
1
(1 + R) (14)
So
SNR
area
= C
NEAe
1
t
1
(1 + R) = [1e
(
2
1
)t
2
]
NEAe
1
t
1
1 + R
(15)
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 22 / 89
Dose
Given the minimal acceptable SNR (typically 5 (units are dB but
more on this later)), what is the required dose to see a cube of
t
2
t
2
t
2
? The required # of incident X-Ray photons is derived
from
SNR = k = [1 e
(
2
1
)t
2
]
NEAe
1
t
1
1 + R
(16)
which is approximately equal to
SNR = k = [1 [1 (
2
1
)t
2
]]
NEAe
1
t
1
1 + R
(17)
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 23 / 89
Dose
Rearrange terms and clear the radical
(1 + R)k
2
(
2
1
)
2
= NEAt
2
2
e
1
t
1
(18)
N =
k
2
(1 + R)e
1
t
1
E(
2
1
)
2
t
4
2
(19)
This is the number of photons per unit area (thats why the A
went away). To get surface dose, we have
Dose
surf
= N(
EN
)E =
EN
Ek
2
(1 + R)e
1
t
1
E(
2
1
)
2
t
4
2
(20)
Where N is the number of incident photons per unit area,
EN
is
the mass energy absorption coecient for tissue, and E is the
photon energy.
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 24 / 89
Quantum Mottle
Exposure (X) due to scatter
1
2
.
Recall, D = 0.434
x
x
D
Q
= 0.434(AEN)
1
2
, which is the
optical density due to quantum mottle (*proportional to lm
gamma)
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 25 / 89
Film Granularity
Recall, D
G
= 0.434
gA
A
, where is the cross-sectional area of a
silver speck resulting from a sensitized AgBr grain.
Nuttings Law gives D = 0.434g D
G
=
0.434D
A
(*proportional to
D)
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 26 / 89
Film Granularity
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 27 / 89
Detective Quantum Eciency
DQE =
SNR
out
SNR
in
2
DQE
total
= DQE
1
DQE
2
. . . DQE
n
In other words, the total DQE is the
product of each individual DQE
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 28 / 89
Geometric Unsharpness
Image blurring B =
ad
2
d
1
= a(m 1), where m is the image
magnication, i.e. m =
d
1
+d
2
d
1
(divide both sides by m)
U
g
=
B
m
= a(1
1
m
) (21)
Directly proportional to focal spot size, a, i.e. m U
g
.
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 29 / 89
Receptor Unsharpness
Caused by lateral spread of photons. Let F be the intrinsic receptor
unsharpness, i.e. the thickness of the image of an object which has
NO thickness. Imagine a photograph. The reason you can hold it is
because the paper and the ink have thickness - the image has zero
thickness. The receptor has thickness, but the image does not.
U
r
=
F
m
(22)
Inversely proportional to magnication, m, i.e. m U
r
.
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 30 / 89
Total Unsharpness
Ignore motion unsharpness (patient movement), making total
unsharpness the geometric mean of U
g
and U
r
U =
U
2
g
+ U
2
r
(23)
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 31 / 89
General Radiography
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 32 / 89
Xeroradiogram
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 33 / 89
Image Intensier
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 34 / 89
Photo Multiplier Tube
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 35 / 89
Digital Angiography
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 36 / 89
Digital Angiography
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 37 / 89
Four Generations of CT
Actually 5, though the fth is just a derivative of the fourth
All modern CT scans can be traced to the rst 1973 model
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 38 / 89
First Generation CT
Single X-Ray source,
single detector (180
rotate
and shift)
Small angle fan beam
(10
)
20 seconds per slice
(240 seconds per
slice/average 12
detectors)
Wedge size
determines the
eciency of the slice
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 40 / 89
Third Generation CT (Fan beam reconstruction)
Single X-Ray source,
multiple (128-600)
detectors (360
rotation only)
Wide angle fan beam
(pulsed)
5 seconds per slice
(240 seconds per
slice/average 48
detectors)
Zenon gas detector
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 41 / 89
Fourth Generation CT
Single X-Ray source,
multiple ( 1000)
detectors (360
rotation only)
Wide angle fan beam
(continuous)
2 seconds per slice
(240 seconds per
slice/average 120
detectors)
Zenon gas detector
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 42 / 89
Fifth Generation
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 43 / 89
Classical Tomography
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 44 / 89
Computed Tomography
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 45 / 89
Computed Tomography
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 46 / 89
Projection
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 47 / 89
Back Projection
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 48 / 89
Back Projection
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 49 / 89
Algebraic Reconstruction Technique
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 50 / 89
Convolution, Backprojection, and Radon Transform
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 51 / 89
Dose vs. Resolution
Recall N =
SNR
2
(1+R)e
1
t
(
2
1
)t
4
2
Now
=
k
1
(SNR)
2
t
3
(k
2
t)
, where
: DQE
: x-ray dose (related to N)
k
1
: constant related to E
t: dimension of the smallest object
visible
k
2
t: thickness of the slice
(k
2
= 2 5 t)
dose
1
(spatial resolution)
4
Values for diagnostic CT
resolution: less than 1
mm
discrimination: 1% in
image density (related
to SNR)
dose: 10 100mGy
(compare to 1 mGy for
mammogram)
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 52 / 89
Beam Hardening
Low energy x-rays are attenuated
rst
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 53 / 89
Radioisotope Imaging
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 54 / 89
Ways to Detect -rays
Scintillation Crystal
NaI (Tl doping)
-ray visible light voltage (NaI PMT)
Gas-lled, multi-wire chamber
Xe
-ray charge voltage (wires)
Semiconductor
Si, Ge with doping (HPGe, CdTe, HgI
2
-ray charge voltage
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 55 / 89
Radioisotope Imaging
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 56 / 89
Gamma Camera
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 57 / 89
Gamma Camera
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 58 / 89
Position Determination
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 59 / 89
Spatial Resolution
Geometric Unsharpness: determined by the -ray energy and
the collimator design (R
c
< 10mm)
Intrinsic Unsharpness: determined by the thickness of the NaI
crystal, the number of PMTs and the position calculation
network (R
i
< 4mm)
Total Unsharpness (Spatial Resolution): R =
R
2
c
+ R
2
i
(R < 10mm)
At least an order of magnitude LESS than other modalities (CT,
MRI) Advantage of radioactive isotopes
Functional Imaging: Not just anatomical but physiological
information (metabolism)
Strong signal from small amount of tracer (nanograms)
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 60 / 89
Production of Radionuclides
Neutron Capture: Place target in a eld of thermal neutrons
(nuclear reactor)
98
42
Mo + n
99
42
Mo +
Nuclear Fission (nuclear reactor)
235
92
U + n
236
92
U
99
42
Mo +
99
42
Sn+
Charged Particle Bombardment: H
+
(p), H
, D
+
,
He
+
,
3
He
++
,
4
He
++
() (Cyclotron)
68
30
Zn + p
67
31
Mo + n
Radioactive Decay: Metastable
99
42
Mo
99
43
Tc
Isomeric Trans
99
43
Tc + (140 keV)
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 61 / 89
Decay of Radionuclides
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 62 / 89
Two Most Used Decays
Single Photon Emission
(
99
Mo
2.7 day
)
99
43
Tc
m
99
43
Tc + (140 keV) (Technetium
half-life 6.02 hours)
Positron Emission
(
68
Ge ) +
68
31
Ga
68
30
Zn+e
+
+ (Gallium half-life 68 minutes)
Annihilation produces two photons, each with energy 511 keV
(E = mc
2
)
Detect both, reduces scatter, increases spatial resolution ( 5
mm)
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 63 / 89
Compton -Camera Refraction
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 64 / 89
Dynamic Imaging
MUGA - Multiple Uptake Gate Acquisition
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 65 / 89
Dodges Area Length Formula
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 66 / 89
Diagnostic Ultrasound
Pulse Echo Imaging
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 67 / 89
Diagnostic Ultrasound
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 68 / 89
Pulse Echo Display Modes
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 69 / 89
Sound Speed (velocity), Bulk Modulus, Density, and
Impedance
Sound Velocity (speed): c =
=
dP
d
=
dP
d
(g cm
1
s
1
) (g
1
cm
3
) =
cm
2
s
2
cm
s
, i.e. velocity
Acoustic characteristic impedance: z = c =
K
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 70 / 89
Fluid Mechanical Analogue
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 71 / 89
Reection/Refraction of Sound Waves at Interface
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 72 / 89
Pulsed Doppler System
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 73 / 89
Beamforming, Dynamic and Geometric Focusing
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 74 / 89
Duplex Scanning
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 75 / 89
Future Directions
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 76 / 89
Magnetic Resonance Imaging
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 77 / 89
Magnetic Resonance Imaging
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 78 / 89
Magnetic Resonance Imaging
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 79 / 89
Magnetic Resonance Imaging
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 80 / 89
RF Sequences
Saturation Recovery
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 81 / 89
RF Sequences
Inversion Recovery
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 82 / 89
RF Sequences
Spin Echo
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 83 / 89
RF Sequences
180 Rephasing
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 84 / 89
RF Sequences
Carr-Purcell and Carr-Purcell-Meiboom-Gill
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 85 / 89
Coils
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 86 / 89
Coils
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 87 / 89
Coils
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 88 / 89
References
[1]
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 89 / 89
S. Webb, The Physics of Medical Imaging.
Taylor and Francis, 1988.
John DiCecco, PhD BME464: Medical Imaging September 25, 2014 89 / 89