PH Info Exam

Group 7
Caringal, Rizzalaine Parallag Diane

Dueas, Angelica Ranjo, Johanna Marie
Pagkalinawan, Erikka Marie Semilla, Jean Darlene

ANESTHETICS

Name

Structure

IUPAC Name

Trade Names

Manufacturer

Selling Price

Dosage Form
and Strength

Chemical
Indication

Pregnancy
Category
Mepivacaine

(RS)-N-(2,6-
dimethylphenyl)
- 1-methyl-
piperidine-2-
carboxamide
Carbocaine 2%
(Mepivacaine
hydrochloride)

Polocaine 3%
(Mepivacaine
hydrochloride)

Polocaine
MPF
(Mepivacaine
hydrochloride)
Hospira, US

Dentsply
Pharmaceutical
, US

APP
Pharmaceutical
, US
$17.75

$12.25

$16.75
Injectable
solution (1%,
1.5%, 2%, 3%)

Injectable
solution (1%,
1.5%, 2%, 3%)

Injectable
solution (1%,
1.5%, 2%, 3%)
This medication
is a local
anesthetic,
prescribed for
inducing local or
regional
analgesia and
anesthesia
during surgical
procedures,
labor, or delivery.
It works by
preventing
nerves from
transmitting
painful impulses
to the brain.
C (Either
studies in
animals have
revealed
adverse
effects on the
fetus and
there are no
controlled
studies in
women or
studies in
women and
animals are
not available.)
Isoflurane

Aerrane

Florane

Baxter
Healthcare

Singapore
Pharmawealth
Lifesciences

P1,500

Inhalation
solution
100mL x1s

Inhalation
solution 100%
x 100mL x 1s

General
inhalation
anesthetic
B (Either
animal-
reproduction
studies have
not
demonstrated
a foetal risk
but there are

Forane

Isocane

Phil
Pharmawealth/
Minrad
Isoflurane
Abbott

Lunan

Minrad
P 4,327.58

Inhalation
solution
100mL x1s

Inhalation
solution
100mL x1s

Inhalation
solution
100mL x1s

no controlled
studies in
pregnant
women or
animal
reproduction
studies have
shown any
adverse
effects.)
Benzocaine

Ethyl 4-
aminobenzoate
Auralgan

United Home
Burn Ointment

Orajel (UK)

Dermoplast
(US)

Anbesol (US)
Wyeth

United Home

Church &
Dwight UK Ltd
Pretige Brands,
Inc.

Pfizer

Pfizer
559.03 php

70.0php
(15g)

92.0php
(30g)

5.25 pounds

10.79 dollars

6.27 dollars

Otic Solution
(14mg/mL)

Ointment
(10mg/g)

Mouth Gel (
10% w/w)

Spray (20%)

Oral gel (20%)

Benzocaine is
used to reduce
pain or
discomfort
caused by minor
skin irritations,
sore throat,
sunburn,
teething pain,
vaginal or rectal
irritation and
many other
minor pain on a
surface of the
body
C(Either
studies in
animals have
revealed
adverse
effects on the
fetus and
there are no
controlled
studies in
women or
studies in
women and
animals are
not available.)
Prilocaine
and
Lidocaine

Lidocaine: 2-
(diethylamino)-
N-(2,6-
dimethylphenyl)
acetamide

Prilocaine: (RS)-
N-(2-
methylphenyl)-
N2-
propylalaninami
de
Asthesia

Prilox

Emla

Emla D.A.C

Oraqix

Unichem, India

Neon Labs Ltd.,
Maharashtra,
India

AstraZeneca,
Canada

DAC, Iceland

Dentsply
Pharmaceutical
, United States

360.00 Indian
Rupees

56.20 Indian
Rupees

$39.00 (USD)

109.95 ISK

$99.95 (USD)
Cream
(lidocaine
2.5%,
prilocaine 2.5
%)

Ointment
(lidcaine 25mg,
prilocaine 25
mg)

Patch (1 g of
Emla Emulsion)

Patch (1g of
Emla Emulsion)

Periodontal Gel
2.5 %/2.5 %

Local anesthetic

B(Either
animal-
reproduction
studies have
not
demonstrated
a foetal risk
but there are
no controlled
studies in
pregnant
women or
animal
reproduction
studies have
shown any
adverse
effects.)
Bupivacaine

(RS)-1-butyl-N-
(2,6-
dimethylphenyl)
piperidine-2-
carboxamide
Ultracaine

Pivacaine

Bupicaine
Heavy

Pivacaine- D
Jayson
Pharmaceutical
s Ltd.

ACI Ltd.

Chemist
Laboratories
Ltd.

ACI Ltd.
0.25% x 20ml
vial: 35.40 IP;
0.5% x 30ml
vial: 60.00 IP

0.25% x 20ml
vial: 45.00 IP

4ml amp x
10s pack:
280.00 MRP

4ml amp x
0.25% or 0.5%
Solution for
injection

0.25%
Solution for
injection

80mg/ml
Solution for
injection

80mg/ml
Bupivacaine is
indicated for
single dose-
infiltration into
surgical site to
produce
postsurgical
anesthesia. It is
also indicated for
Peripheral nerve
block,
sympathetic
nerve block, and
caudal blocks.
C (it has an
action that
crosses the
placenta it has
been
approved as
an obstetrical
anesthesia.
However
Bupivacaine is
excreted into
human milk.
The risk of
continuing

ANTHELMINTICS
GENERIC NAME IUPAC NAME STRUCTURE BRAND NAME INDICATION PREGNANCY
CATEGORY
1.Albendazole methyl N-[6-
(propylsulfanyl)-1H-
1,3-benzodiazol-2-
yl]carbamate

1.HYEMEX chewable
tab 400 mg (P25/tab)
manufactured by:
Blue sky
Treatment of single &
mixed intestinal
nematode infections
including ascariasis,
Category C
Either studies in
animals have
revealed adverse

BUPI Plain

Popular
Pharmaceutical
s Ltd.
10s pack:
300.00 IP

0.5% x 30ml
vial: 60.00
MRP
Solution for
injection

0.5%
Solution for
injection

However it is
most commonly
used as local
anesthetic in
epidural
anesthesia
during labor.
and
discontinuing
the drug is
being
discussed with
the patient.)
LIDOCAINE
HCl
2-
(diethylamino)-
N-(2,6-
dimethylphenyl)
acetamide
Euro-Med
Lidocaine HCl

Elin Lidocaine
HCl

Phil
Pharmawealth/
Atlantic
LidocaINE

Xepacaine

Xylocaine
Euro-Med

Elin

Atlantic Lab

Gland Pharma

Astra
Zeneca

(2mL) P
8.96/amp
(5mL) P
12.32/amp
(20mL) P
36.96/vial
(50mL) P
66.08/vial
P27.50
P65

P 1,757

P2,125
20 mg /mL 2%
Solution for
injection

2% x 10mL
50mL

20mg/mL

20mg/mL

10mg/dose(10
%)
(2%)
Local and
regional anesth:
local infiltration
and peripheral
and central nerve
block.

B ( Animal
reproduction
studies have
failed to
demonstrate a
risk to the
fetus and
there are no
adequate and
well-
controlled
studies in
pregnant
women )

2.ALMEX chewable
tab 400 mg (25s
pack/94 MRP)
manufactured by:
Square Pharmacy
[INDIA]

3. ZENTEL
200mg/5mL
suspension
(P437/bottle)
manufactured by:
GSK

4.ANTHEL 400mg/tab
(500s pack/200 MRP)
manufactured by:
Seema
Pharmaceutical Ltd.

5.AZOLE 400 mg/tab
(20s pack/80 MRP)
manufactured by:
Bio-pharma
Laboratories Ltd.
enterobiasis &
trichuriasis.
effects on the foetus
(teratogenic or
embryocidal or
other) and there are
no controlled studies
in women or studies
in women and
animals are not
available. Drugs
should be given only
if the potential
benefit justifies the
potential risk to the
foetus.
2.Mebendazole methyl (5-benzoyl-1H-
benzimidazol-2-
yl)carbamate

1.BENDEX 100mg &
500 mg/tab (100mg x
30s pack/22.20 MRP;
500mg x 30s
pack/65.99 MRP)

BENDEX 100mg/5ml
suspension (30ml
bot/14.83 MRP)
manufactured by:
Gaco
Pharmaceuticals

2.ERMOX 100
Broad-spectrum
anthelmintic indicated
for the treatment
of nematode infestations,
including roundworm,
hookworm, whipworm,
threadworm, pinworm,
and the intestinal form
of trichinosis prior to its
spread into the tissues
beyond the digestive
tract

Mebendazole is
Pregnancy Category
C, which means that
it has been shown to
cause ill effects in
pregnancy in animal
models and there are
no adequate studies
of its effects in
human pregnancy. It
is unknown whether
it can be passed by
breast feeding.

mg/tablet (100mg x
150s: 111.00 MRP)

ERMOX 100mg/5ml
syrup (30ml
bot/14.83 MRP)
Manufactured by:
Square
Pharmaceuticals Ltd.
3.MEBENDAZOLE
100mg/tab (100 mg x
60 strips/42.60 MRP)
manufactured by:
Gonoshasthaya

4.HELBEN 100
mg/5ml suspension
(30m bot/10.60
MRP) manufactured
by: Ad-din
pharmaceuticals ltd.

5.MEBANTRIN
100mg/tab (30s
pack/22.50 MRP)
Manufactured by:
Pharmadesh
Laboratories Ltd.

*all from Bangladesh
3.Ivermectin 22,23-
dihydroavermectin
B1A + 22,23-
dihydroavermectin
B1B

1.AGIMECT 12 mg
tab (1x4tabs=175
indian rupees)
Manufactured by:
Aegis
Pharmaceuticals
[INDIA]

2.ASCAPIL 6mg tablet
(1 tab= 16.27 rupees)
Manufactured by:
Nicholas Piramai
India Ltd. [INDIA]

3. AVERM PLUS 12
mg tab (1x5tabs= 105
rupees)
Manufactured by:
Biotavia Labs Pvt Ltd.
India

4. BIOVER 6mg tab
(1x10tabs= 2.55 US
dollars)
Manufactured by:
Biogenetic
Pharmaceuticals
[USA]

5. EVRINA 3mg tab
(1x50tabs= 8.50 US
dollars)
Manufactured by:
Pride Healthcare
[USA]
Used in humans in the
treatment of
onchocerciasis and
effective against other
worm infestations such
as strongyloidiasis,
ascariasis, trichuriasis,
filariasis, and
enterobiasis.
B3 (Australia), C (US)
4. Pyrantel Pamoate 4-[(3-Carboxy-2-
hydroxynaphthalen-1-
yl)methyl]-3-
hydroxynaphthalene-
2-carboxylic acid; 1-
methyl-2-[(E)-2-
thiophen-2-ylethenyl]-
5,6-dihydro-4H-
pyrimidine

1.DELENTIN 50mg/ml
syrup (10ml
bot/11.42 MRP)
Manufactured by:
Renata Ltd.
[BANGLADESH]

2.MELPHIN
125mg/tab (100s
pack/166.00 MRP)
Manufactured by:
Beximco
[BANGLADESH]

3. WORMEX
50mg/ml Suspension
(10ml bo/11.00 MRP)
Manufactured by:
Hallmark

4.COMBANTRIN
125mg/5ml
suspension
(P153.50/bot)
Manufactured by:
Zuellig Pharma

5. NEMOCID 250mg
tab (2.31 Rs/3
tablets)
Manufactured by:
Intima (IPCA
Laboratories Ltd.)
[INDIA]
Single or mixed
infestations by
threadworm, pinworm,
roundworm, hookworm,
Trichostrongylus colubriformis
& orientalis.
Category C
5. Praziquantel 2-
(cyclohexanecarbonyl)-
3,6,7,11b-tetrahydro-
1H-pyrazino[2,1-
a]isoquinolin-4-one

1.BILTRICIDE 600 mg
tab Manufactured
by: Bayer phils Inc.

2. FLUXIDE
600mg/5ml
suspension
Manufactured by:
Blue Sky Trading Co.,
Inc.

3. Endure Medical
Praziquantel 600 mg
tab Manufactured
by: Endure Medical
Inc.

4. Swiss Pharma
Praziquantel 600mg
film coated tablet
Manufactured by:
Swiss Pharma
Research Labs Inc

5. Wormguard
(combination of
Febantel/Pyrantel
Pamoate/
Praziquantel)
150mg/144mg/50mg
Manufactured by:
Fanfreluche
Enterprises Inc.

*No available current
price available
Trematodicide provided
for the oral treatment of
schistosome infections
and infections due to
liver fluke.

Category B, no
proven risk for
humans, but it is
advised that
Praziquantel must
not be taken by
mother if breast
feeding..

GROUP 6 ANTIDIABETIC

Name Structure IUPAC Name 5 Trade Names (with
manufacturer and selling price)
Dosage forms and
strengths
Clinical Indication Pregnancy
category

Glibenclamide

5-chloro-N-[2-[4-
[[[(cyclohexylamin
o)carbonyl]amino]s
ulfonyl]phenyl]eth
yl]-2-methoxy-
benzamide

Euglucon (Roche)
10.81 pesos/tab
Euglotab (Acme)
4.75pesos/tab
Daonil (Sanofi Aventis)
5.47pesos/tab
Allase (Interphil) 6.09
pesos/tab
Orabetic (Biolab) 6.16
pesos/tab

Euglucon tablet 5
mg
Euglotab tablet 5
mg
Daonil tablet 5 mg
Allase tablet 5 mg
Orabetic tablet 5
mg

Diabetes Meliitus
type 2

Category
C

Gliclazide

1-(3,3a,4,5,6,6a-
hexahydro-1H-
cyclopenta[c]pyrrol
-2-yl)-3-(4-
methylphenyl)sulfo
nylurea

Diamicron (Servier)
P910.00/pack
Dianorm (Merck)
P761.58/pack
Gluconil (Biolab)
P644.00/pack
Glubitor (LR Imperial)
P708.27/pack
Clibite (Korea United
Pharma) P600.32/pack

Diamicron tablet
80 mg
Dianorm tablet 80
mg
Gluconil tablet 80
mg
Glubitor tablet 80
mg
Clibite tablet 80
mg

For control of
hyperglycemia in
gliclazide-
responsive diabetes
mellitus of stable,
mild, non-
ketosis prone, type
2 diabetes. It is
used when diabetes
cannot be
controlled by
proper dietary
management and
exercise or when
insulin therapy is
not appropriate.

Category
C

Dosage forms
and strengths
category

Metformin HCl

1-
carbamimidamido-
N, N-
dimethylmethanimi
damide

Gludin (Med Choice
Pharma) P3.20/tab
Neoform (GX International
Inc.)
P3.35/tab
Diafat
(Sandoz Philippines
Corporation)
P5.70/tab
Nidcor
(Pharma Nutria)
P4.32/tab
Glumet (L.R. Imperial, Inc.)
P7.22/tab

For people with Type
2 diabetes.
Metformin is
sometimes used in
combination with
insulin or other
medications, but it
is not for treating
Type 1 diabetes.

Category
B

Pioglitazone HCl

5-{4-[2-(5-Ethyl-2-
pyridinyl)ethoxy]be
nzyl}-1,3-
thiazolidine-2,4-
dione
hydrochloride (1:1)

Actos
(Takeda Pharmaceutical
Company )
15 mg x 30s (Php2,027.30)
30 mg x 30s (Php 3,254.55)
Glucozone (Vitalink)
500 mg x 100s (Php 320/box ;
Php 3.20/tab)
Piozone (LR Imperial, Inc)
15 mg x 10s, 30s (Php
509.45/box)
30 mg x 10s, 30s (Php
679.25/box)
Prialta
(OEP Philippines)
15 mg x 50s (Php 794.18)
Actos tablet
15 mg, 30
mg
Glucozone
tablet 500
mg
Piozone
tablet
15 mg, 30
mg
Prialta tablet
15 mg, 30
mg, 45 mg
Zolid tablet
15 mg, 30
mg, 45 mg
Used to lower high
blood sugar
associated with type
2 diabetes. It helps
insulin to work more
effectively. By
keeping blood sugar
at a desired level, It
can help prevent or
delay the long-term
problems associated
with uncontrolled
high blood sugar (e.g.,
kidney disease, eye
problems, nerve
problems, heart
disease). It increases

Category
C

30 mg x 50s (Php 1,069.09)
45 mg x 50s (Php 1,069.09)
Zolid (Getz Pharma)
15 mg x 14s (Php 249.50)
30 mg x 14s (Php 261.75)
45 mg x 14s (Php 336.50)

insulin sensitivity in
muscle and adipose
tissue, and inhibits
hepatic
gluconeogenesis
Dosage forms
and strengths
category

Vildagliptin

(2S)-1-{2-[(3-
hydroxyadamanta
n-1-
yl)amino]acetyl}pyr
rolidine-2-
carbonitrile
Galvus (Novartis Healthcare)
28's(P760.20/box)
Xiliarx (Novartis AG)

Jalra-M (US Vitamins Limited)
10s (198 Indian Rupee or
P142.34)
Zomelis (Piramal Healthcare)
14s( 270 Indian Rupee or
P194.13)

Galvus
tablet 50mg

Jalra-M
tablet
50mg,
500mg
Zomelis
50mg

ANTILIPIDEMIC DRUGS

Name: Simvastatin
Structure:
IUPAC Name: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-
hexahydronaphthalen-1-yl 2,2-dimethylbutanoate

Trade Names:
Manufacturer: Price:
1. Vidastat 20mg Unilab Php 43.39 /tab
2. Cholestad 20mg Littman Drug Corp Php 2,1.37/100 tab
3. Zocor 20mg Merck & Co. Php 41.22/tab
4. Alvastin 10mg
Allied Chemicals & Pharmaceuticals
Pvt.Ltd.
Php 5.04/tab
5. Zosta 40 mg US Vitamins Limited Php 15.00/tab
Dosage Forms and Strength: Tablet 5 mg, 10 mg, 20 mg, 40 mg,
Clinical Indication: For the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease
mortality and cardiovascular events. It can also be used in adolescent patients for the treatment of
heterozygous familial hypercholesterolemia.
Pregnancy Category: X

Name: Fenofibrate
Structure:

IUPAC Name: propan-2-yl 2-{4-[(4-chlorophenyl)carbonyl]phenoxy}-2-methylpropanoate

Trade Names:
1. Fenoflex LR Imperial, Inc. 30's (P1030.49/box)
2. Fenogal SMB Technology 30's (P885.00/pack)
3. Lofibra OEP Phils. Inc 50's (P1090.00/pack)
4. Lipway SR Cathay Drug Co. Inc. 30's (P1041.60/pack)
5. Trolip Gracio Med Phils., Inc. 30's (P823.73/pack)
Dosage Forms and Strength: 160 mg capsule, 200 mg capsule, 250 mg capsule, 300 mg capsule
Clinical Indication: It is mainly used to reduce cholesterol levels in patients at risk of cardiovascular disease. It reduces both
low-density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels, as well as increasing high-
density lipoprotein (HDL) levels and reducing triglycerides level.
Pregnancy Category: C

Name: Rosuvastatin
Structure:
IUPAC Name: (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-
dihydroxyhept-6-enoic acid

Trade Names:
1. Bestor Biocon Limited P32.40/10 tabs
2. Fortius Nicholas Piramal India Ltd. P35.28/10 tabs
3. Crestor AstraZeneca P1,730/30 tabs
4. Rosucol Ajanta Pharma Phil P493.69/30 tabs
5. Rustor InnoGen Pharma P1,065/30 tabs
Dosage Forms and Strength: 5mg, 10mg, 20mg, and 40mg film-coated tablets
Clinical Indication: Rosuvastatin is used for the reduction of blood total cholesterol, HDL cholesterol and triglyceride levels,
and to increase HDL cholesterol levels. Rosuvastatin also is used for reducing the risk of heart attacks,
stroke, and arterial revascularization procedures in patients without clinically evident coronary heart
disease but with multiple risk factors for heart disease.

Name: Atorvastatin
Name: Fluvastatin
Structure:

IUPAC Name: (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid

Trade Names:
1. Canef (EU) 20 &
40 mg
AstraZeneca 84s (P2,680.70)
84s (P2,777.32)
2. Cranoc (US) 20 &
40 mg
Astellas 50s (P2567.29)
50s (P3153.52)
3. Lescol 40 mg Novartis Pharmaceutical 28s (P1,650)
4. Lescol XL 80 mg Novartis Pharmaceutical 28s (P1,912.65)
5. Liposit (US) 20 &
40 mg
Ferrer International 28s (P1890.29)
28s (P2541.67)
Dosage Forms and Strength: 20 mg Capsule, 40mg Capsule, 40 mg Tablet, 80mg Tablet
Clinical Indication: To be used as an adjunct to dietary therapy to prevent cardiovascular events. May be used as secondary prevention in
patients with coronary heart disease (CHD) to reduce the risk of requiring coronary revascularization procedures, for
reducing progression of coronary atherosclerosis in hypercholesterolemic patients with CHD, and for the treatment of
primary hypercholesterolemia and mixed dyslidipidemia
To be used as an adjunct to dietary therapy to prevent cardiovascular events. May be used as secondary prevention in
primary hypercholesterolemia and mixed dyslidipidemia.
To be used as an adjunct to dietary therapy to prevent cardiovascular events. May be used as secondary prevention in
primary hypercholesterolemia and mixed dyslidipidemia.
Structure:

IUPAC Name: 7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-
dihydroxyheptanoate

Trade Names:
1.Lipitor 10mg Pfizer 100's (P3272.75/pack)
2. Ator-10 InnoGen Pharma 30's (P676.50/pack)
3. Avamax 20mg Therapharma 100's (P28.57/pack)
4. Atorwin 10mg Sanofi-Aventis 30's (P552.27/pack)
5. Xantor 80mg Sandoz 30's (P34.00/film-coated tab)
Dosage Forms and Strength: 10 mg capsule, 20 mg capsule, 40 mg capsule, 80 mg capsule
Clinical Indication: Atorvastatin is used for the treatment of elevated total cholesterol, LDL, and triglycerides and to elevate
HDL cholesterol. The effectiveness of atorvastatin in lowering cholesterol is dose-related, meaning that
higher doses reduce cholesterol more. It prevents angina, stroke, heart attack, hospitalization
for congestive heart failure, and revascularization procedures in individuals with coronary artery disease. It
also reduces the risk of myocardial infarction (heart attack), stroke, angina and revascularization
procedures in adults with multiple risk factors for coronary artery disease. Atorvastatin also prevents heart
attacks and strokes in patients with type 2 diabetes with multiple risk factors for coronary artery disease.

ANALGESIC / ANTI-INFLAMMATORY DRUGS

Generic
Name
Structure IUPAC name
Trade
Name
Manufacturer Selling Price
Dosage
Form/s
Strengths
Clinical
Indication
Pregnancy
Category
Celecoxib

4-[5-(4-
methylphenyl)-3-
(trifluoromethyl)-
1H-pyrazol-1-yl]
benzene-1-
sulfonamide
Aubrex Corbridge P26.00/cap Capsule 200 mg
Treatment of
rheumatic
arthritis,
juvenile
idiopathic
arthritis,
osteoarthritis,
signs and
symptoms of
ankylosing
spondylitis,
and of
adenomatous
colorectal
polyps, and
management
of acute pain
Category C
OR
Category D
(in third
trimester
or near
delivery)
Brexen Xeno P19.80/cap Capsule 200 mg
Celcoxx Getz Pharma
P18.83/cap
Capsule
100 mg
P27.24/cap 200 mg
P42.27/cap 400 mg
Celebrex Pfizer
P41.66/cap
Capsule
100 mg
P58.91/cap 200 mg
P79.50/cap 400 mg
Celeflam Flamingo P17.66/cap Capsule 200 mg
Diclofenac

2-[2-(2,6-
dichlorophenyl-
amino)phenyl]acetic
acid
Difenax GXI P5.57/tab Tablet 50 mg
Treatment of
rheumatic
arthritis,
osteoarthritis,
juvenile
rheumatic
arthritis,
ankylosing
spondylitis,
and painful
inflammation
and swelling
Category C
OR
Category D
(in third
trimester
or near
delivery)
Cataflam
Novartis
Healthcare
P13.14/tab Sugar-
coated
Tablet
25 mg
P22.25/tab 50 mg
Clofil Filadams P6.00/tab EC Tablet 50 mg
Votan
Taiwan
Biotech
P18.00/tab Tablet 100 mg
Arthrotec Pfizer (USA) P39.20/tab MR Tablet 75 mg
Generic
Name
Trade
Name
Dosage
Form/s
Strengths
Clinical
Indication
Pregnancy
Category
Ibuprofen

(RS)-2-[4-(2-methyl
propyl)phenyl]pro-
panoic acid
Advil
Pfizer
Consumer
P6.83/caplet Caplet 200 mg Management
of mild to
moderate
Category C
OR
Category D
P74.25/bottle
(60 mL)
Oral
Suspension
100 mg/
5 mL
P7.39/cap
Softgel
Capsule
200 mg
paint and
inflammation
(menstrual
pain, dental
pain,
headaches,
migraines,
sprains,
strains), and
treatment of
rheumatic
arthritis
(juvenile
arthritis,
ankylosing
spondylitis,
osteoarthritis,
and acute
gouty
arthritis)
(in third
trimester
or near
delivery)
Brufen Abbott
P73.50/bottle
(60 mL)
Oral
Suspension
100 mg/
5 mL
P13.13/tab Tablet 600 mg
Dolan FP Pediatrica
P70.75/bottle
(15 mL)
Oral Drops
100 mg/
2.5 mL
P115.51/bottle
(60 mL) Oral
Suspension
200 mg/
5 mL
P69.31/bottle
(60 mL)
100 mg/
5 mL
Faspic Zambon P22.40/tab Tablet 400 mg
Midol Invida
P6.14/tab
Tablet
200 mg
Category B
OR
Category D
(in third
trimester)
P14.55/tab 400 mg
Mefenamic
Acid

2-[(2,3-
dimethylphenyl)
amino]benzoic acid
Hispen Genesis P5.50/tab Tablet 500 mg
For the relief
of pain
including
muscular,
rheumatic,
traumatic,
dental, post-
op and post
partum pain,
headache,
and juvenile
rheumatic
arthritis
Category C
OR
Category D
(in third
trimester
or near
delivery)
Afligec Filadams P6.20/caplet Caplet 500 mg
Dolfenal Westmont
P10.83/tab
Tablet
250 mg
P20.85/tab 500 mg
Dolsten Medic+Aid
P2.95/cap
Capsule
250 mg
P4.95/cap 500 mg
Gisfen S V More P5.54/tab Tablet 500 mg
Generic
Name
Trade
Name
Dosage
Form/s
Strengths
Clinical
Indication
Pregnancy
Category
Tramadol

() cis-2-
[(dimethylamino)
methyl]-1-(3-
Clomadol
Mount
Mettur
P104.00/amp
(1 mL)
Ampule
50 mg/
mL
Relief of p
mild to
moderate to
Category C
Dolotral Stada P17.58/cap Capsule 50 mg
methoxyphenyl)
cyclohexanol
hydrochloride

P106.80/amp
(2 mL)
Ampule
100 mg/
2 mL
severe pain
(chronic back
pain,
neuropathic
pain, surgical
pain, and pain
associated
with cancer or
arthritis
Tramid Euro-Med
P84.00/amp
(1 mL)
Ampule
50 mg/
mL
Pengesic Hovid P12.50/cap Capsule 50 mg
Peptrad Shin Poong
P52.00/amp
(1 mL)
Ampule
50 mg/
mL

ANTIDEPRESSANTS

Name Citalopram HBr
Structure

IUPAC Name 5-Isobenzofurancarbonitrile
5 Trade Names 1. Feliz 20
Manufactured by Torrent
Selling price: 3 10's (P1760.00/box)
2. Lupram
Manufactured by Lundbeck
Selling price: 14's (P1670.00/pack)
3. Celexa
Manufactured by Forest Laboratories (US)
Selling price: N/A
4. Cipramill
Manufactured by Lundbeck (US)
Selling price: N/A
Dosage Forms & Strengths Tablets: 10, 20, and 40 mg
Solution: 10 mg/5 ml
Clinical Indication Depression in patients whose diagnosis corresponds most closely to the DSM-III and DSM-III-R category of major depressive disorder
Pregnancy Category Pregnancy category: C
Use late in the third trimester associated with complications in newborns and may require prolonged hospitalization, respiratory support, and
tube feeding.

Name Escitalopram
Structure

IUPAC Name (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile
5 Trade Names 1. Nexito
Manufactured by Jewim Pharma
Selling price: 10mg 100s (P474.50/box)
2. Feliz S 10/ Feliz S 20
Manufactured by Torrent Pharma
Selling price: Feliz s 10 100's (P3300.00/box)
Feliz s 20 100s (P6000.00/box)
3. Jovia
Manufactured by Medichem
Selling price: 10mg 28's (P1188.21/pack)
4. Lexapro
Manufactured by Lundbeck
Selling price: 5mg 28's (P1650.00/pack)
10mg 14's (P1500.00/pack)
20mg 28's (P6000.00/pack)
5. Morcet
Manufactured by Searle
Selling price: 20mg 250s (P7553.00/pack)
Dosage Forms & Strengths 5mg, 10mg, 20mg film coated tablets
5mg/5ml oral solution

Clinical Indication For major depressive disorder, generalized anxiety disorder, social anxiety disorder, obsessive-compulsive disorder, and panic
disorder(significant behavioral change).
Pregnancy Category Category C
Use late in the third trimester associated with complications in newborns and may require prolonged hospitalization, respiratory support, and
tube feeding.

Name Sertraline HCl
Structure

IUPAC Name (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
5 Trade Names 1. Exulten
Manufactured by: Medichem
2. Serenata
Manufactured by: Torrent
3. Zolodin
Manufactured by: Medchoice Pharma
Selling price: 30's (P38.00/tab, P1140.00/box)
4. Zoloft
Manufactured by: Pfizer
Dosage Forms & Strengths Tablet: 25mg, 50mg, 100mg
Solution: 20mg/ml
Clinical Indication Treatment of symptoms of depression, including depression accompanied by symptoms of anxiety, in patients w/ or w/o history of mania.
Treatment of obsessive-compulsive disorder (OCD), ped OCD, panic disorder w/ or w/o agoraphobia, post traumatic stress disorder (PTSD),
social phobia & premenstrual dysphoric disorder (PMDD).
Pregnancy Category Category C or Category D (if taken in the 2nd half of pregnancy)

Name Fluoxetine HCl
Structure

IUPAC Name N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
5 Trade Names 1. Motivest
Manufactured by: Medichem Pharmaceuticals, Inc.
Selling price: 30s (P974.33/pack)
2. Neuxetin
.Manufactured by: Korea United Pharma (Korea)
Selling price: 30s (P1230.00/pack)
3. Prodin
Manufactured by: MedChoice Pharma, Inc.
Selling price: P38.00/cap, 30s (P1140.00/box)
4. Prozac 20
Manufactured by: Eli Lilly (USA)
Selling price: P125.00/cap
5. Prozyn
Manufactured by: Platinum Pharmaceuticals Ltd. (Pakistan)
Selling price: 30s (P900.00/box)
Dosage Forms & Strengths Capsule: 20mg
Syrup: 20mg/5mL
Clinical Indication Management of generalized anxiety disorder, obsessive compulsive disorder, panic disorders w/ or w/o agoraphobia, social phobia &
posttraumatic stress disorder; bulimia nervosa. Treatment of premenstrual dysphoric disorder.
Pregnancy Category Category C

ANTIDEPRESSANTS

Name Paroxetine Hydrochloride
Structure

IUPAC Name (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;hydrochloride
5 Trade Names 1. Paxil
Manufactured by: GlaxoSmithKline (GSK)
Selling price: Php 70.30/tab

2. Seroxat
Manufactured by: GlaxoSmithKline (GSK)
Selling price: 30s Php 1,792.80/
3. Pexeva
Manufactured by: Noven Pharmaceuticals, Inc.
Selling price: N/A
4. Brisdelle
Manufactured by: Noven Pharmaceuticals, Inc.
Selling price: N/A
5. Panex
Manufactured by: Brown & Burk Phils.
Selling price: Php 79.02/tab
Dosage Forms & Strengths Tablet: 10 mg, 20 mg, 30 mg & 40 mg
Oral Suspension: 10mg/5mL
Clinical Indication This medication is an SSRI antidepressant, prescribed for major depression, obsessive-compulsive disorder, panic disorder, social anxiety and
generalized anxiety disorder. It increases the amount of serotonin, a natural substance in the brain that helps maintain mental balance.
Pregnancy Category Pregnancy category: D
Infants exposed to paroxetine in the first trimester of pregnancy have an increased risk of congenital malformations, particularly
cardiovascular malformations.

ANTIHISTAMINES
A. Name: Cetirizine diHCl
Structure:

IUPAC name: ()-[2-[4-[(4-chlorophenyl)phenylmethyl]-1- piperazinyl]ethoxy]acetic acid
Trade Name Manufacturer Selling Price
Zyrtec Duncan Oral drops 10 mg/mL:
10 mL x 1's (P377.00/bottle)
Oral solution 1 mg/mL:
30 mL x 1's (P205.00/bottle)
60 mL x 1's (P392.00/bottle)
Tablet 10 mg:
100's (P3667.00/box)
RiteMED Cetirizine RiteMED Tablet 10 mg:
100's (P2075.00/box, P20.75/tab)
Virlix GlaxoSmithKline Film-coated tablet 10 mg:
50's (P2300.00/pack)
Oral drops 10 mg/mL:
10 mL x 1's (P391.00/bottle)
Oral solution 1 mg/mL:
30 mL x 1's (P221.80/bottle)
Prixlae Shou Chan Film-coated tablet 10 mg:
100's (P2150.00/pack)
Allerkid Pediatrica Oral drops 2.5 mg/mL:
10 mL x 1's (P142.00/bottle)
Syrup 5 mg/5 mL:
30 mL x 1s (P130.00/bottle)
60 mL x 1s (P212.26/bottle)

Dosage Form and Strength:
tablet 10 mg
oral drops 10 mg/mL and 2.5 mg/mL
oral solution 1 mg/mL
syrup 5 mg/ 5 mL

Clinical Indication:
Cetirizine diHCl is indicated for the relief of symptoms associated with perennial allergic rhinitis due to allergens such as dust mites, animal
dander and molds in adults and children 6 months of age and older. Symptoms treated effectively include sneezing, rhinorrhea, postnasal discharge,
nasal pruritus, ocular pruritus, and tearing.
Cetirizine diHCl is also indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children
6 months of age and older. It significantly reduces the occurrence, severity, and duration of hives and significantly reduces pruritus.
Pregnancy Category:
Category B: Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or
animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in
the 1
st
trimester (and there is no evidence of a risk in later trimester).
B. Name: Loratadine
Structure:

IUPAC name: ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11 ylidene)-1-piperidinecarboxylate

Claritin Schering-Plough Syrup 5 mg/5mL:
30 mL x 1's (P278.91/bottle)
Tablet 10 mg:
100's (P4971.82/box)
Onemin Ampotex Tablet 10 mg:
12's (P334.88/pack)
Allerta Amherst Tab 10 mg:
50's (P1000.00/box)
Syrup 5 mg/5mL:
60 mL x 1's (P200.00/bottle)
Lorano Sandoz Tab 10 mg:
50's (P850.00/pack)
Lorange Willore Pharma Tab 10 mg:
100's (P15.00/tab)

tab 10 mg
syrup 5 mg/5mL

Loratadine is indicated for the relief of symptoms and signs of chronic urticaria sand other allergic dermatologic disorders. It is also used in the
relief of symptoms associated with allergic rhinitis such as sneezing, nasal discharge and itching, and ocular itching and burning.

Pregnancy Category:
the 1
st
C. Name: Fexofenadine HCl
Structure:

IUPAC: 4-[1-Hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl] butyl]-, dimethylbenzeneacetic acid hydrochloride
Fenafex Eadriex Film-coated tablet 120 mg:
30's (P660.00/ box)
Fexet Getz Pharma Film-coated tablet 120 mg:
10's (P242.00/ box)
Neofex GXI Film-coated tablet 120 mg:
50's (P23.00/tab)
Telfast Sanofi-aventis Film-coated tablet 120 mg:
50's (P2311.14/ box)
Film-coated tablet 180 mg:
50's (P2590.68/box)
Rhinogan Beximco/Euro Generics Film-coated tablet 120 mg:
30's (P630.00/ box)

film-coated tablet 120 mg and 180mg
Fexofenadine HCl is indicated for the symptomatic relief of allergic conditions including seasonal allergic rhinitis and chronic urticaria.

Pregnancy Category:
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) an there are no
controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential
risk to the foetus.

D. Name: Diphenhydramine HCl
Structure:

IUPAC name: 2-benzhydryloxy-N,N-dimethylethanamine;hydrochloride

Trade name Manufacturer Selling price
Benadryl AH Johnson & Johnson

Benadryl AH cap 25
mg
100's (P1663.00/pack)
Source: MIMS Philippines
Benadryl AH cap 50
mg
100's (P2810.50/pack)
Benadryl AH syrup
12.5 mg/5 mL
60 mL x 1's (P109.25/bottle)
120 mL x 1s
(P174.50/bottle)
Soniphen United Lab

Soniphen soft-gelatin
cap 25 mg
100's
(P1037.74/pack)
Soniphen syrup
12.5 mg/5 mL
60 mL x 1's (P59.44/bottle)

Amherst Lab Soniphen cap 50 mg
30's
(P339.62/box)
Soniphen inj
50 mg/mL
1 mL x 10's
(P1038.20/ampoule)

Dramelin
Wescrib
Dramelin cap 50 mg 100s
(P263.00/pack)
Dramelin syrup
12.5mg/5mL
60 mL x 1's (P70.00/bottle)
RiteMed
Diphenhydramine
HCl

RiteMed
RiteMed
Diphenhydramine
HCl cap 50 mg
100s
(P700.00/pack)
Source: Mercury Drug Store
Bexil Zhejiang Ruixin
Bexil inj
50 mg/mL
1 mL x 10 x 1's
(P130.00/ampoule)

Capsule 25 mg
Capsule 50 mg
Syrup 12.5 mg/5 mL
o 60 mL
o 120 mL
Injection 50 mg/mL

Antihistaminic: For perennial and seasonal (hay fever) allergic rhinitis; vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and
foods; amelioration of allergic reactions to blood or plasma, dermatographism; as therapy for anaphylactic reactions adjunctive to epinephrine and other
standard measures after the acute manifestations have been controlled.
Motion Sickness: For active and prophylactic treatment of motion sickness.
Antiparkinsonism: For parkinsonism (including drug-induced extrapyramidal reactions) in the elderly unable to tolerate more potent agents; mild
cases of parkinsonism (including drug-induced) in other age groups; in other cases of parkinsonism (including drug-induced) in combination with
centrally-acting anticholinergic agents.

Pregnancy Category:
the 1
st
E. Name: Levocetirizine
Structure:

IUPAC name: 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid
Levocet Natrapharm Tablet 5 mg:
(P16.50/tab)
Zykast Ajanta Tablet 5 mg:
(P27.16/tab)
Xyzal UCB Pharma, Inc. Tablet 5mg:
(P22.40/tab)
Oral solution 2.5/5mL:
(P181.00/bottle)
L-ZET Twilight Litaka Tablet 5 mg:
(P16.00/tab)
Sensitrin XL Lab/ Ambica

Tablet 5 mg:
(P18.00/tab)

oral solution 2.5 mg/5mL
tablet 5 mg

Levocetirizine is indicated for the symptomatic treatment of seasonal and perennial allergic rhinitis including persistent allergic rhinitis and
chronic idiopathic urticarial.

Pregnancy Category:
the 1
st
Generic Name: Mannitol

Structure:

Pregnancy Category: Category C

Dosage Forms and Dosage:
IV infusion Adult 50-100 g. Childn 0.25-2 g/kg body wt. Reduction of intracranial or intraocular pressure 0.25-2 g/kg body wt over 3-60 min.
Renal failure 200 mg/kg body wt over 3-5 min.

IUPAC:
(2R,3R,4R,5R)-Hexan-1,2,3,4,5,6-hexol

Brand Names:
Resectisol
Rennitol
Euromed Mannitol
Global Pharmatrade Mannitol
Sahar Mannitol

#6 CABALLE, HEDRIX AR-AR C. 4B-PH PH-INFO Homework

Name: Losartan K

Structure:

IUPAC Name: (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol

5 Trade names with manufacturer and selling price:
Trade Name Manufacturer Selling Price Dosage Form Strength
Combizar Therapharma P20.48 per tablet Tablet 50 mg
2Zaris Zydus Cadila P19.25 per tablet Tablet 50 mg
Kenzar Plus Euro Generics P18 per tablet Tablet 50 mg
Losacar-H Zydus Cadila P16 per tablet Tablet 50 mg
Neosartan Plus GXI P15 per tablet Tablet 50 mg

Clinical indication:
Losartan Potassium / Hydrochlorothiazide is indicated for the treatment of essential hypertension in patients whose
blood pressure is not adequately controlled on losartan or hydrochlorothiazide alone.
*Note: Losartan potassium is usually mixed with Hydrochlorothiazide and are used as a diuretic. They all have the same indications according to the www.
medicines.org.uk.

Pregnancy category:
a.) Combizar - C; D in 2
nd
and 3
rd
trimesters
b.) 2Zaris C; D in 2
nd
and 3
rd
trimesters
c.) Kenzar Plus - C; D in 2
nd
and 3
rd
trimesters
d.) Losacar-H - C; D in 2
nd
and 3
rd
trimesters
e.) Neosartan Plus - C; D in 2
nd
and 3
rd
trimesters

Jicah Mae Lumbao 4B-PH
Hydrochlorothiazide

6-chloro-1,1-dioxo-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide

1. Hytaz Therapharma 12.5 mg: P5.10/tab
2. Microzide (US) Watson Laboratories 12.5 mg: $41.11 (30 capsules)
3. Esidrix Novartis Pharmaceuticals Corp 12.5 mg: $33.60 (30 capsules)
4. Diuzid Hizon 1. 12.5 mg: P325.00/pack (100s)
5. Pharex
Hydrochlorothiazide
Pascual 12.5 mg: P2.60/tab

Dosage Forms:
Oral: 12.5mg capsules, 12.5mg tablets, 25mg tablets, 50mg tablets
Parenteral: 50mg/5ml solution

Hydrochlorothiazide capsules are indicated in the management of hypertension either as the sole therapeutic agent, or in combination with other
antihypertensives.
Unlike potassium sparing combination diuretic products, Hydrochlorothiazide capsules may be used in those patients in whom the development of hyperkalemia
cannot be risked, including patients taking ACE inhibitors.

Pregnancy Category:
FDA pregnancy category B. Hydrochlorothiazide is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become
pregnant during treatment. Hydrochlorothiazide can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor
if you are breast-feeding a baby.
BUTENAMIDE

Generic Name: BUMETANIDE
IUPAC Name: 3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acid

BRAND NAME MANUFACTURER SELLING PRICE
Bumetanide* Hospira, Inc. Vial 0.25mg/mL ($14.19)
Bumex* F. Hoffman-La Roche Ltd. Vial 0.25mg/mL ($8.19)
Burinex LEO Pharma Tab x 100s (P2,219) ; Amp x 5s
(P2,046)
Fordiuran* Farmacusi Spain Tab 1mg x 20 ($21.08)
Lunetoron* Daiichi Sankyo $0.51/ 1mg tablet
*not available in the Philippines

Dosage Strength:
1 mg (Tablet) ; 0.5mg/mL, 0.25mg/mL (Ampoule)

Bumetanide is indicated for the treatment of edema associated with congestive heart failure, hepatic and renal disease, including the nephrotic
syndrome. Almost equal diuretic response occurs after oral and parenteral administration of bumetanide. Therefore, if impaired gastrointestinal
absorption is suspected or oral administration is not practical, bumetanide should be given by the intramuscular or intravenous route.

Pregnancy Category:
C

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Group 7

Caringal, Rizzalaine Parallag Diane

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