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Zoonoses
Definitions
A zoonosis is a type of communicable disease
that is transmissible from a vertebrate animal to
man. Normally it is a disease of animals
Rabies
Plague
West Nile Virus
Eastern Equine
Encephalitis
Brucellosis
Anthrax
Trichinosis
Rocky Mountain
Spotted Fever
Lyme Disease
Typhus
Leptospirosis
Q Fever
Tularemia
Hantavirus
9Epidemiologic Triad
9 Epidemiologic Triad
AGENT
Chain of Infection
Modes of Transmission
Spectrum of Disease
Herd Immunity
Terminology: Incubation, Latency, and Infectious Periods
Levels of Disease
HOST
ENVIRONMENT
Definition: Agent
A microorganism,
chemical, nutritive
element or physical
factor whose
presence or absence
is essential for a
particular disease or
condition to occur
Host Factors
Age, sex, ethnic group, nutritional status,
socioeconomic status
Types of Agents
Bacteria
Virus
Protozoa
Parasite
Fungi
Diet deficiency
Diet excess
Radiation
Chemicals
endogenous
exogenous
Heat, cold
Genetic traits
Stress
Host Factors
Personal behaviors: smoking, diet, drinking,
sexual practices, exercise
Host Factors
Host Factors
Environmental Factors
Environmental Factors
Environmental Factors
Epidemiologic Triad
Agent, host, environment
9 Chain of Infection
Modes of Transmission
Spectrum of Disease
Herd Immunity
Terminology: Incubation, Latency, and Infectious Periods
Levels of Disease
Endemic, Epidemic, Cluster, Pandemic
9Chain of Infection
Chain of Infection
Agent leaves the reservoir/host
Portal of exit
Mode of transmission
Portal of entry
Infects the new susceptible host
Chain of Infection
Chain of Infection
Reservoir - the natural habitat in which an
agent lives, grows and multiplies
Human - persons with symptomatic illness,
or may be inapparent or chronic carriers
Animal - cows, pigs, sheep, raccoons, bats,
dogs, cats, birds, rodents, etc.
Environmental - plants, water, soil
Tuberculosis
Diphtheria
Pneumonia
Influenza
Measles
Chicken Pox
Smallpox
Mumps
Syphilis
Gonorrhea
Herpes
Smallpox
HIV
Chlamydia
Respiratory tract
Urine
Feces
Conjunctiva
Skin lesions
Percutaneous
Placental
Typhoid fever
Hepatitis
Shigellosis
Salmonellosis
Cholera
Amebic Dysentery
Giardiasis
Chain of Infection
9 Modes of Transmission
Spectrum of Disease
Herd Immunity
Terminology: Incubation, Latency, and Infectious Periods
Levels of Disease
Endemic, Epidemic, Cluster Pandemic
Chain of Infection
Examples of Direct Transmission
Direct contact
Droplet spread
Indirect
Air borne
Vehicle borne
Vector borne
Fomites
Inanimate objects capable of transferring
infectious material
Examples: bedding, toys, doorknobs,
combs, clothing, drinking glasses,
cooking utensils, pencils, straws, or
surgical instruments
Malaria
Yellow Fever
WNV
Plague
Typhus
Tularemia
Lyme
Rabies
Salmonellosis
EEE
Filariasis
RMSF
Erlichiosis
Dengue Fever
Hantavirus
Sleeping Sickness
Lassa Fever
Hanta Virus
Chain of Infection
Portal of Entry - the route the agent uses to
get into the new host
Respiratory tract
Ingestion
Dermal
Blood borne
Mucous membranes
9Herd Immunity
9Spectrum of Disease
9Herd Immunity
The decreased
possibility of a group
or community
developing an
epidemic because
there is a specific
level of immunity or
resistance to that
disease in the
population
Herd Immunity
Immunized persons act as a barrier to
spread
The entire population does not have to be
immunized to prevent the occurrence of an
epidemic
9Spectrum of Disease
The progress of a disease with no intervention:
Exposure
Pathological changes
Clinical illness
Symptoms
9Terminology
Incubation period
Time between infection and the onset of
clinical illness
Latency period
Time between infection and when the
individual becomes infectious to others
Infectious period
Time during which the infectious agent may be
shed (host need not be symptomatic)
Portal of entry
Dosage of the agent
Immune response of the host
Rate of growth of the agent in the host
Example: Measles
Incubation period
Latency period
Infectious period
13-18 days
6-7 days*
6-9 days*
Example - Salmonella
6 to 72 hours, usually 12 to 36 hours
Causes gastroenteritis with cramping,
diarrhea, abdominal tenderness,
vomiting, and fever
The diarrhea is usually watery, but may
contain blood or mucus
INFECTION
Remember This?
Ring around the rosies,
A pocket full of posies,
Ashes, ashes!
A Tchoo, A Tchoo!
We all fall down.
Tuberculosis Today
Approximately 1.86
billion people worldwide are infected with
TB, including
Nelson Mandela
Desmond Tutu
Tina Turner
Tom Jones
Mother Bronte
Reverend Bronte
Maria
Elizabeth
Branwell
Emily
Ann
Charlotte
1821
Carrier chronic infection
1825
1825
1948
1848 (Wuthering Heights)
1849 (Agnes Grey)
1855 (Jane Eyre)
Chain of Infection
Modes of Transmission
Characteristics of Infectious Agents
Infectivity, pathogenicity, virulence
Spectrum of Disease
Herd Immunity
Terminology: Incubation, Latency, and Infectious Periods
9 Levels of Disease
Endemic, Epidemic, Cluster, Pandemic
10
9Levels of Disease
Levels of Disease
Endemic
A disease or condition persists within a
certain geographical area
The baseline or expected level of disease
in a community
Does not reflect the preferred level of
disease, which is zero
Epidemic or Outbreak
When the level of disease rises
significantly above the normal endemic
level
Types of Epidemics
Epidemic
30
CASES
25
20
15
10
5
Endemic
0
TIME
Levels of Disease
Cluster
An aggregation of cases that are more than
expected
Clusters may be based on space (geographical
area) or time
A cluster may or may not be an outbreak
Levels of Disease
Pandemic
A widespread epidemic, usually affecting several
countries or continents affecting large numbers
of people and sometimes the entire globe
11
Influenza is Serious
Hippocrates
documented the first
influenza pandemic in
412 BCE
Since 1580, there have
been 31 influenza
pandemics recorded
12
Disease
(2000)
U.S.
Mortality
U.S.
Prevalence
U.S.
Incidence
A Perspective on Communicable
Disease U.S. and Global Statistics
9Prevalence is
9Incidence is the
Disease
(2000)
Lower respiratory
infections
Lung Cancer
160,288
179,400
COPD
119,000
24 million
COPD
Asthma
4,487
31 million
Tuberculosis
Tuberculosis
2,460
12,942
Influenza
1,765
>10,000 cultured
specimens
Pertussis
6,755
Measles
81
SARS (2003)
192
SARS
(1 Nov 2002 to 30 July 03)
Global
Mortality
Global
Prevalence
Global
Incidence
4.1 million
248.3 million
3 million
600 million
2.7 million
1.86 BILLION
10.2 million
Asthma
180,000
150 million
Influenza
500,000
>100 million
(5 M severe)
Pertussis
400,000
43.1 million
Measles
777,000
40 million
774
8,098
13
Questions?
Lunch
14