Professional Documents
Culture Documents
Anticaries Agents
Caries
Tooth decay
Attributed to the action of acids mostly lactic, obtained from oral bacterial
metabolism of dietary carbohydrates
Buildup of plaque on the tooth surface aids in the decay process by forming pockets
or crevices on the teeth surface where food can enter
Brushing
Remove materials from the tooth surface before it hardens into calculus, since a
smooth surface make it difficult for the adherence of food particles and bacteria
Fluoride
Contain in floss and brush that can prevent caries
Topically or internally(orally) administered
Internally: in solution or rapid soluble salts are deposited in the bone or developing
teeth with the remainder excreted by the kidney
Has higher concentration on the surface layer of the enamel in both erupted or
unerupted teeth
Dental fluorosis
Too much fluoride in the tissue fluids
Mottled enamel: chalky and soft indicating a loosely bound structure
Food pigments adsorbed to the enamel making a mottled appearance
Occurs in area where the fluoride concentration of drinking water exceeds 2 pp.
Only occurs during excessive ingestion of fluoride
Lethal adult dose for NaCl: 2 to 5 g
2.2 mg NaF in 1 ppm fluoride
Two hypothesis of for fluoride:
That fluoride decreases the solubility of the enamel in acid
Bacterial inhibition hypothesis which is based on the enzyme inhibitory properties of
fluoride
Orally administered: places fluoride into systemic circulation allowing the fluoride to lay
down unerupted teeth as they are formed
Fluoridation of the public water supply
Most convenient dosage form
Done by adding sodium fluoride or a fluorosilicate, yielding a fluorine concentration of
0.7 to 1 ppm = average daily intake of 2.2 mg NaF based on six glasses of water
Sodium fluoride
NaF
White odorless powder
Soluble in water; insoluble in alcohol
Oxygen USP 31
Dephlogisticated air, Aire Vital, Fire air, Aire Puro
Commercial Production:
o Fractional Distillation of Liquid Aire ( Linde Process) :Air is liquefied by a
combination of low temperature and high pressure; gives 86% pure oxygen; also
produces commercial nitrogen
o Electrolysis of water: electric current is passed through water containing 15%
NaOH or KOH , water breaks down into its component elements, H2(liberated at
the cathode) and O2( liberated at the anode); iron electrode separated by an
asbestos cloth diaphragm
o In laboratory, O2 can be obtained by either thermolysis of ClO3 with MnO2 as
catalyst or by the action of water on Na2O2
Supports combustion more energetically than does air
1 vol : 32 vol H2O; 1 vol: 7 vol of alcohol at 20C ; 1 vol : pressure of 760mm of Hg
Responsible for oxidative changes in paint , fats and oils
Antioxidants are used to lessen the effects of oxidation
Stored in cylinders which is usually green colored or carry a green label
Kept away from fire
Standard purity 99% and limits CO2, halogens, acids or alkalis and oxidizing substances
As inhalant for cyanosis and dyspnea ( difficulty in breathing)
Pure oxygen inhalation uninterrupted for 1 2 days can cause edema of the lungs if not
regulated
Given when poisoned by carbon monoxide, coal gas, nitrous oxide and chloroform
Carbon Dioxide
Carbonic acid gas, Carbonic Anhydride
Aqueous soln is acid to litmus
1 liter at 0C and at pressure of 760mm of Hg weighs 1.977g
1 vol: 1 vol H20
Stored in gray metallic colored cylinders
Administered in concentrations up to 7% in O2 stored in grayish green cylinders
20C it is liquefied at pressure of 59 atm
Dry ice: CO2 cools at 79C to form a solid CO2, used as refrigerant, destroy tissue by
freezing it
Used as respiratory stimulant ( when mixed with O2 and air) for persons suffering from
impairment of the respiratory organs in diseases such as pneumonia and asphyxiation
Dry ice used for treatment of acne, angiomas ( tumor made up of blood and lymph
nodes), corn and calluses, eczema, moles, psoriasis and warts
Used to make carbonated drinks
Nitrous Oxide
Laughing Gas, Nitrogen Monoxide, Dinitrogen Monoxide
N2O
Store in blue containers
Coercible ( condensable) gas
Sweetish taste, agreeable odor
Soluble at low water temp
Revives combustions
Can be distinguished from oxygen by the test of adding NITRIC OXIDE: O2 form reddish
brown vapors of NO2 and N2O3 while nitrous oxide will NOT REACT.
When inhaled in small doses it can cause INEBRIATION
Large doses or mixed with 1 vol of O2 used as an anesthetic
Used in dentistry as anesthesia when extracting the teeth etc.
Nitrogen
N2
Azote
Non flammable, does not support combustion
Sold in Black cylinders
Has little therapeutic use
Used as pharmaceutical air for displacing air to increase shelf life
Used in parenteral and topical preparation must be indicate in the label
RESPIRATORY STIMULANT
Ammonium Carbonate NF 26
Preston salt, Sal Volatile, Bakers Ammonia, Ammonium Sesquicarbonate
Consists of varying proportions of Ammonium bi carbonate ( NH4HCO3) and ammonium
carbamate ( NH2CO2NH4) such that it yields between 34 to 40 % ammonia without
EMPYREUMA ( odor of animal and vegetable matter when charred in a closed vessel)
Alkaline to litmus
Loses ammonia and carbon dioxide when exposed to air becoming opaque the
converted to friable porous lumps or white powder of ammonium bicarbonate
Decomposed by hot water
Hard translucent state to white powder is caused from total loss of NH3 and CO2 from
ammonium carbamate leaving ammonium bicarbonate
The basis of smelling salts
Valuable in hysterical syncope
Used as leavening agent
Source of Ammonia
Expectorants
Used orally to stimulate the flow of the respiratory tract secretions
Allows ciliary motion and coughing to move the loosened material toward the pharynx
more easily
Used in the treatment of respiratory disorders in which secretions are purulent , viscid
or excessive.
Terpinhydrate: agent used, may have a direct effect on the bronchial secretory cells
Ammonium chloride
Sal ammoniac, salmiac, ammonium muriate
Hygroscopic
Ammonium ion marked increases the secretions, especially saliva, mucous and sweat.
As expectorant ; it renders the secretions less viscous and less tenacious
Crude form used in solution as an electrolyte for voltaic batteries
Systemic acidifier and chloride replenisher
Potassium Iodide
KI
Kalium Jodatum
Saturated solution prepared by dissolving 1000g of KI salt in 680 ml of Hot water the
cooled then diluted to exactly 1 liter
Cubicle crystals either transparent and colorless or opaque or as white granular powder
Slightly hygroscopic 1 g : 0.7 ml of H2O
Expectorant
Employed in the treatment of bronchitis, asthma, emphysema and sinusitis
Antifungal agent
Antitussive agent
Treatment of goiter
Iodide salt: when small amount of KI is added to table salt
ANTIDOTES
Emetic(300mg)
Astringent on tonic( 10 to 30 mg)
TABLETING AIDS
Calcium sulfate
CaSO4
Gypsum, alabaster, satin spar, light spar for the dehydrate calcium sulfate
Anhydrous or contains two molecules of H2O of hydration ( CaSO4.2H2O)
Fine to slightly yellow white odorless powder
Anhydrous form marketed as DRIERITE used as rechargeable laboratory and industrial
desiccant( drying agent)
Tablet diluent( both anhydrous and dihydrated forms)
Plasters of Paris
o CaSO4.1/2H2O
o Used as supportive casts by physicians
o Dental impressions by dentists
Colloidal Silicon Dioxide
SiO2
Submicroscopic fused silica prepared by the vapor phase hydrolysis of a silicon
tetrachloride(SiCl4) at 1100C
Tablet diluent
Suspending agent
Thickening agent
LUBRICANTS
SUSPENDING AGENTS
Altering the surface character of the solvent (surfactants) and other thickening agents
Bentonite
Al2O3.4SiO2.H2O
Soap clay, mineral soap, wilkinite
Nucleus
Contains protons and neutrons
Surrounded by electrons
Electrons = protons
Protons = atomic number
Isotopes
Same atomic number(same no. of protons) but different mass numbers(diff. no. of
neutrons)
Same chemical and physical properties
Different kinetics or rate of chemical reaction
When radioactive isotopes DECAY, they emit particles or quantities of energy that are characteristics of
the particular isotope involved.
Major particles of decay:
Alpha particles
Heaviest and slowest
Helium nucleus containing 2 protons and 2 neutrons
Atomic mass of 4 and atomic number of 2
Move at relatively slow speed (0.1 the speed of light)
Penetrating power is very low
Stopped by a sheet of paper or tin sheet of aluminum
Emitted from elements having a atomic number greater than 82
Beta particles
Negatively charged species having a mass of an electron
Radiopharmaceutical preparations:
Preparations
synonym
Sodium chromate Cr
Chromitope sodium
51(atomic mass) injections
rachromate - 51
Gold Au 1998 Injection
Aurcoloid 198, Aureotope,
Auroscan
Sodium Iodide I 123 solution
Iodotope I 125
Iodotope I - 131
Robengatope I - 131
Hippuran - 131
Sodium Pertechnetate
Phosphotope
Uses/organ
Determination red blood cell,
volume
Scintillation scanning of the
liver
Function of the thyroid gland;
scanning of the thyroid gland(
position and possible tumor
location)
Blood and plasma volumes
and determination of cardiac
output
Radioactive tracer in the
determination of liver
function
Determine kidney function
Scintillation of the kidney and
brain
treatment of polycythemia
vera (increase in RBC) and
localization of intraocular
tumors
Brain scanning for
determining the presence and
location of neoplastic lesions
Diagnostic agent for
pernicious anemia