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Cremophor RH 40
July 2005
Supersedes issue dated September 2004
MEMP 030713e-05/Page 1 of 8
= Registered trademark of
BASF Aktiengesellschaft
Excipients
Actives
Contract Manufacturing
Value Added
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Cremophor RH 40
Cremophor RH 40
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Generic name
Chemical nature
Properties
Specification
Congealing point
Saponification value
Hydroxyl value
Acid value
lodine value
Water content, K. Fischer
pH value of 10% aqueous solution
Colour strength of 10% aqueous solution (Ph. Eur.)
Viscosity, Hoeppler, at 25 C, 30% aqueous solution
Ash
Heavy metals
1626C
5060
6075
1
1
2%
67
Yellow 6 max.
2040 mPa s
0.25%
10 ppm
Unless stated otherwise, the analytical methods have been taken from
the monographs Macrogolglycerol Hydroxystearate (Ph. Eur.) and Polyoxyl
40 Hydrogenated Castor Oil (USP/NF). The product fulfills the requirements
of these monographs.
Solubility
Stability
Cremophor RH 40
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Application
Solubilization
8.8 g
25.0 g
ad 100.0 ml
Fig. 1
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Cremophor RH 40
Fig. 2
Fig. 3
Cremophor RH 40
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Miconazole
Gramicidin
Eucalyptol
Azulene
Oil of anise
Oil of sage
Cremophor RH 40 is also very suitable as an emulsifying agent. It will emulsify a wide range of hydrophobic substances, e. g. fatty acids, fatty alcohols
and drugs.
Toxicity
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Cremophor RH 40
PBG-Number
10 067 363
Packaging
Drums of 60 kg capacity.
Storage
Shelf life
Note
The data contained in this publication are based on our current knowledge
and experience. In view of the many factors that may affect processing and
application of our product, these data do not relieve processors from carrying
out their own investigations and tests; neither do these data imply any guarantee
of certain properties, nor the suitability of the product for a specific purpose.
Any descriptions, drawings, photographs, data, proportions, weights etc. given
herein may change without prior information and do not constitute the agreed
contractual quality of the product. It is the responsibility of the recipient of our
products to ensure that any proprietary rights and existing laws and legislation
are observed.
July 2005
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BASF Aktiengesellschaft
Fine Chemicals Division - Pharma Solutions - 67117 Limburgerhof - www.pharma-solutions.basf.com
Cremophor RH 40