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Desipramine
Protriptylline
SSRIs
Sertraline
Citalopram
Breathing Related Sleep Disorders
1. Obstructive sleep apnea hypopnea, central sleep apnea and
sleep related hypoventilation
Characterized by sleep disruption caused by sleep related
breathing disturbance , leading to excessive sleepiness,
insomnia, or hypersomnia.
Breathing disturbance include; apnea, hypoapneas, oxygen
desaturation
A. apnea three types, obstructive, central, mixed
Obstructive Sleep Apnea Hypopnea
Either 1 or 2
Evidence by polysomnography of at least five obstructive apneas
or hypopneas per hour of sleep and either of the following sleep
symptoms :
A. nocturnal breathing disturbances : snoring , snorting/gasping,
or breathing pauses during sleep
B. Daytime sleepiness, fatigue, or unrefreshing sleep despite
sufficient opportunities to sleep not explained by medical
condition or another mental disorder
Obstructive Sleep Apnea Hypopnea
Evidence by polysomnography of 15 or more obstructive apneas
and /or hypopneas per hour of sleep regardless of accompanying
symptoms
A. Apnea
1. Obstructive sleep apnea caused by cessation of air flow
through the nose or mouth in the presence of thoracic breathing
movements >> decrease in arterial oxygen saturation and
transient arousal respiration assumes normally
Occurs middle aged overweight men
( pickwickian syndrome )
Seen patients with smaller jaws , acromegaly, hypothyroidism
Loud snoring and intervals of apnea
Obstructive Sleep Apnea
Other symptoms :
Excessive daytime sleepiness , daytime sleep attacks , morning
headaches, morning confusion, depression, anxiety, may have
cardiac arrhythmia, systemic and pulmonary hypertension,
decreased sexual drive,
Shift work
Unspecified advance sleep phase, non 24 hour , irregular or
disorganized sleep wake pattern
Quality of sleep normal
Treatment bright light therapy ; uncertain but melatonin is
suggested
Parasomnias
Non rapid eye movement sleep arousal disorders
- Recurrent episodes of incomplete awakening from sleep ,
usually occurring during the first third of major the major sleep
episode , accompanied by either one of the following :
1. sleepwalking
2. sleep terrors
Continuation
No or little dream imagery is recalled
Amnesia for the episodes is present
Episodes cause clinically significant distress or impairment
B. Parasomnias
unusual or undesirable phenomena during sleep or on the threshold of
wakefulness
1. nightmare disorder vivid dreams in which one awakens
frightened
Occurs during REM sleep
TX: benzodiazepines, tricyclics, SSRIs
Parasomnias
Sleep terrors
Occurs during deep, NREM sleep , stage III or IV sleep
Occurs during adolescence or later may be the first symptom of
temporal lobe epilepsy
Treatment rarely needed; diazepam as needed
Parasomnias
Sleep walking type somnambulism
Brief episodes of leaving bed and walking about without full
consciousness
Begins between 4-8 years with peak at age 12 ; disappears
spontaneously
Treatment : reassurance and education
Precaution include window guards and other measures to prevent
injury
Benzodiazepines can be used to suppress stage IV sleep
Rapid Eye Movement Sleep Behavior Disorder
Repeated episodes of arousal during sleep asociated with
vocalization and /or complex motor beahviors