Professional Documents
Culture Documents
2.
3.
4.
5.
But for now we'll concentrate on the simple carbohydrates, which can
be separated into monosaccharides and disaccharides
6.
7.
8.
All these mono and disaccharides exist in our diet with the exception of
galactose which is only present in our diet as part of lactose
9.
10.
11.
12.
13.
14.
Through that process we are able to utilise the energy that is available in
the disaccharides by forming the monosaccharides which can be subsequently
absorbed into the bloodstream and used as an energy source
Animation: Chemistry of carbohydrates part 2
1.
2.
3.
4.
When we talk about blood sugar actually refers to glucose in the blood
5.
There are also other sugars: invert sugar or inverted sugar is a mixture
of equal amounts of glucose and fructose
6.
7.
Invert sugar is a little bit sweeter than sucrose and has a number of
industrial uses including in the production of alcoholic beverages
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
1.
2.
Weve discussed the simple carbohydrates and now well focus on the
complex carbohydrates
3.
4.
5.
6.
7.
Now depending on the type of food : rice, bread, corn , the type of
starch is in a different conformation
8.
9.
1.
2.
3.
4.
5.
6.
It?s this portion that we refer to as dietary fiber and in the colon dietary
fiber may be subjected to fermentation by the resident bacteria
7.
There are a number of definitions of dietary fiber, but one of the more
simple ones is : Dietary fibers are : dietary carbohydrates that are not subject
to digestion by endogenous enzymes but may be digested by bacteria in the
colon
8.
9.
10.
The most common classification separates dietary fiber into two main
classes : the soluble or viscous fibres and the in-soluble or non-viscous fibres
11.
12.
The reason for differentiating between fiber already present in the food
which is the first category and fiber added to the food which is the second and
third category, is that the beneficial property of fiber naturally present in the
food have been scientifically well validated
13.
14.
People are told to eat plenty of fiber as fiber supports proper function of
the GI tract and prevents constipation and in addition fiber has several other
health benefits which we?ll discuss later in the course
15.
Our daily fiber intake hovers around 20 gr in most western countries but
some people may not even reach 10 gr per day whereas intake of other people
easily exceeds 40 gr per day
The text and pictures below provide additional information about the
chemistry of dietary fiber for those of you who would like to know more
about this topic. It falls outside the scope of the MOOC
Arabinoxylans are abundant in various cereals (wheat, rye, barley, oat, rice,
corn). They are the major hemicellulose component of flour and bran. The
active ingredient in psyllium is an arabinoxylan. It consists of highly branched
acidic arabinoxylan comprising of xylan backbone chain with xylose and
arabinose forming the side chains. Psyllium is one of the most widely used
fiber supplements in the world and added to food as a laxative.
The mannans can be separated into galactosemannans and glucomannans.
The major galactosemannan is guar gum. It also called guaran and is obtained
from guar beans. In chemical terms, guar gum is a polysaccharide composed
of the sugars galactose and mannose. Xanthan gum is a glucomannan
resembling guar gum. It is a polymer of glucose, mannose, and glucuronic acid.
Both guar gum and xanthan gums are used extensively in the foods
manufacturing as food thickening agent due to its high viscosity. Foods that
contain guar or xanthan gum include yogurt, salad dressing, bakery products,
ice cream, etc.
Fructans are polymers of fructose. Fructans with a short chain length are
known as fructooligosaccharides. The best known representative of the
fructans are the highly fermentable inulins. Some glucose moieties can be
present in inulin. Different inulins are distinguished based on the degree of
polymerization. The plant most commonly used for extraction of inulin is
chicory. Inulin is naturally present in various foods, such as asparagus, leek,
onions, and banana. In addition, inulin is added to foods as a functional prebiotic food ingredient to confer a health benefit. The chemical structure of
inulin is shown below.
INSOLUBLE FIBER
Insoluble or non-viscous fiber is insoluble and less fermentable. Certain
insoluble fibers such as cellulose are not fermented at all.
Cellulose is a linear chain of glucose, similar to amylose, except that the
glucose units are linked in such a way that our digestive enzymes cannot break
them. As a result, cellulose leaves the human body completely undigested.
Ruminants such as cows have special bacteria in their stomach that produce
cellulase, allowing them to break down cellulose and thus utilize cellulose for
fuel.
Unlike other dietary fibers, lignins do not belong to the carbohydrates. They
are complex polymers of aromatic alcohols. It is the second most abundant
natural polymer in the world, next to cellulose.
Hemicellulose describes a diverse set of polysaccharides composed of
different monosaccharides. They have been discussed under soluble fibers.
Resistant starches are starches that are not subject to regular digestion in the
GI tract. Resistant starch has the same glucose linkages as regular starch but is
folded differently. Depending on the type, they may be partially fermented in
the colon by the gut microbiota. Resistant starch can be divided into distinct
groups:
RS1: physically inaccessible starch (coarsely ground or whole kernel grains),
RS2: granular starch (uncooked potato, unripe banana flour), RS3: retrograded
starch (cooked and cooled starchy foods), RS4: chemically modified starches.
Fructose
Glucose
Amylose
A is false, B is false
A is false, B is true
A is
A is false, B is false
A is
A is true, B is false
The following questions are extra questions covered in the extra part on the
chemistry of dietary fiber
The following is a soluble fiber:
Resistant starch
Pectin Pectin - correct
Cellulose
Lignins
A. Lignin is a polysaccharide
B. Cellulose is a polysaccharide
A is true, B is true
A is false, B is false
is true - correct
A is true, B is false
A is false, B is false
A is
A is true, B is false
Assignment
Drag the right answer to the right place and check if the answers are correct.
DROPDOWN
(8/8 points)
At least half of the energy in our food is derived from __________, principally
from __________, but also from simple sugars. Carbohydrates are classified as
__________ carbohydrates (the __________ ) or simple carbohydrates (the
__________ saccharides and disaccharides). Each of the three disaccharides
__________, __________ and maltose contains a molecule of glucose paired with
either __________, galactose or another glucose.
Carbohydrates - correct
Carbohydrates
starch
complex
starches
mono
sucrose
starch - correct
complex - correct
starches - correct
mono - correct
sucrose - correct
lactose
fructose
lactose - correct
fructose - correct
Introduction to carbohydrate
content of foods
WHY
to be able to estimate your personal carbohydrate intake, to have insight into
which foods contribute most to our own carb intake
LEARNING OUTCOME
to know the approximate carb (including fiber) content of major foods, to know
the major carbs sources across the world
KEY TOPICS
Fiber, sugar, starch, carbohydrate rich foods.
Concentrations of macronutrients
in food
breads are made to look like white (to make it more appealing to children) but
have fiber added. Always check the list of ingredients.
Animal products including milk and milk products contain little to no fiber.
Sometimes, fiber is added to yogurt to create a functional foods.
MULTIPLE CHOICE
(4/4 points)
Which carbohydrate can be found in a steak ?
triglyceride
glycogen glycogen - correct
fructose
amylose
corn starch
A is true, B is false
MULTIPLE CHOICE
(2/2 points)
Look up the amount of carbohydrates in the following foods and select the
sequence that shows the proper ranking of foods from high to low
carbohydrate content (per 100 grams) ?
banana, white bread, whole milk, apples
whole wheat bread
look up the amount of carbohydrates in the following foods and select 4 items
which contain approximately the same amount of carbohydrate (per 100
grams):
potato, banana, grape juice, pasta (boiled) potato, banana, grape juice,
pasta (boiled) - correct
brussels
1.
2.
3.
4.
5.
6.
7.
8.
And digestion doesnt restart again until the food reaches the
duodenum; the first part of the small intestine
9.
Where the pancreatic juices added to the food, the pancreatic juice
contains an enzyme called : pancreatic amylase
10.
Thats also a starch degrading enzyme and through its action, starch the
polymer of glucose, is broken down into much smaller units; ultimately
maltose, the disaccharide of two glucose subunits\R
11.
12.
13.
14.
15.
16.
And this happens after uptake by the intestinal cells, the so called :
Enterocytes
17.
The part of the enterocytes that borders the interior of the small
intestine has special transporters
18.
19.
20.
And what is important to realize is that once they enter the bloodstream
the monosaccharides immediately go through the portal vein to the liver
21.
They are not distributed across the body.They first go to the liver so the
liver can decide on what happens to these monosaccharides
22.
Actually that means that for fructose, most of the fructose, is actually
cleared or almost all of it is cleared ,so no fructose reaches the tissues outside
the liver
23.
24.
25.
26.
That happens through the microbiota, the bacteria that reside in the
colon and we call this fermentation
27.
28.
29.
30.
31.
But also may travel further away for instance reaching the liver and have
positive effects elsewhere.On top of that we produce other gasses: Methane
being one of them, hydrogen sulphate being a very foul smelling one and there
is other gasses that we produce\R
32.
33.
34.
There is a lot of research activity going on trying to figure out how the
microbiota is changing in response to certain dietary changes and also what
the impact of the changes in the microbiota may be on human health
35.
And for many diseases were finding links and hopefully in the next few
years well get a lot more insight into the importance of the gut microbiota
36.
So in short what Ive told you How dietary carbohydrates are digested,
that essentially we require a number of enzymes mainly amylase and various
disaccharidases that break down the starch and the disaccharides into
monosaccharides That the non-digestible carbohydrates or dietary fiber ends
up in the colon where it is subjected to digestion or fermentation by the
bacteria that reside there and that can give rise to various products including
short chain fatty acids
MULTIPLE CHOICE
(3/3 points)
all of the
the same transport mechanism fructose and glucose are absorbed via the same
sucrase and
salivary amylase
Introduction to carbohydrate
metabolism
WHY
to be able to judge possible health effects attributed to certain types of carbs
LEARNING OUTCOME
to know what happens to glucose once it enters into our bloodstream
KEY TOPICS
Blood glucose, insulin, glycogen, muscle, liver.
Carbohydrate metabolism
This animation shows how carbohydrates are metabolised in the body.
1.
2.
3.
4.
How they are distributed across the body and how is that regulated
5.
Consider the situation after a meal, after a meal your blood glucose level
will go up and that increase in blood glucose level will trigger the pancreas to
release a hormone called insuline
6.
Insuline has two major actions: It stimulates the uptake of glucose into
tissues and it stimulates the conversion of glucose into the storage form of
glucose which is called glycogen
7.
8.
After a while the decrease in blood glucose level will trigger the
production of another hormone by the pancreas which is called glucagon
9.
10.
11.
As a result blood glucose level is maintained and the cycle restarts again
12.
Lets discuss in a little bit more detail the storage form of glucose called
glycogen and there are two organs in the body where we store glycogen
13.
The first one is the liver, and basically glycogen is a polymer of glucose
that resembles starch
14.
It is formed after a meal when blood glucose levels are high but it is
broken down during fasting when you dont eat, when you need to maintain
your blood sugar levels
15.
16.
17.
What about glycogen in the muscle? Glycogen in the muscle has a very
different function
18.
19.
20.
21.
If you would start running up the stairs the glycogen that is in stored in
your thigh muscles, would be used as an energy source
22.
23.
24.
25.
Then we have the possibility to convert glucose into fat, we can convert
carbohydrate into fat
26.
The body has that ability, which means if you overeat on sugar, you can
become obese very easily
27.
28.
That is a serious limitation that especially has its impact during fasting
because it causes our body to break down very valuable tissues to provide
glucose, when we are for instance in a state of fasting or famine
29.
But overall the point that I want to make today is that glucose
metabolism is carefully regulated
30.
The main aim is to maintain stable blood sugar levels and the reason for
that is that the body can only function, the brain can only function if it gets a
sufficient amount of glucose
31.
32.
We can store glucose in the form of glycogen in liver and muscle and we
can convert carbohydrate into fat if we consume too much of it
Glycemic index
Carbohydrate-containing foods differ in their ability to raise blood glucose
levels, which has been translated into the so called glycemic index (GI). Strictly,
the glycemic index is defined as the incremental area under the blood glucose
response curve of a specific portion of a test food expressed as percentage of
the response to the same amount of carbohydrate from a standard food taken
by the same subject. In more simple terms, the glycemic index describes the
relative increase in blood glucose after consuming a particular food in
comparison with a standard food. Foods that have a high GI cause a more
pronounced increase in blood glucose, whereas foods with a low GI cause a
shallow increase in blood glucose.
The GI of a food is determined by the type of carbohydrate(s) present in the food, the
food matrix, and by the presence of other macronutrients in the food. GI tables imply
that the GI is constant for a particular food, but there is major variation depending on
variety, ripeness, cooking methods, and processing. The GI may also vary between
individuals and within an individual depending on the time of the day, prior food
consumption etc.
Food that have a high GI include white bread, white rice, glucose, and potatoes. Food
with low GI include beans, whole grain cereals (oats, brown rice, wheat, rye), and most
fruits and vegetables. Interestingly, fructose has a low GI.
The major criticism of the GI is that it is defined for isolated foods (which we rarely eat
in isolation) and that it fails to take into account the total amount of carbohydrate
consumed. In response, the glycemic load was introduced which represents the
glucose tolerance
glycemia
glucose ranking
secretin
glycogen
glucagon is
raises blood glucose levels glucagon is released during fasting and raises blood
true - correct
A is false, B is false
A is true, B is false
Section exam
MULTIPLE CHOICE
(7/8 points)
saccharose
galactose
A is false, B is false
A is false, B is true
A is true, B is
A is
A is true, B is false
are highest when waking up levels of insulin in the blood are highest when
waking up - correct
insulin and glucagon are produced by the pancreas
glycogen in muscle is only available as an energy source for local use
to synthesize fat
A is false, B is false
A is
A is true, B is false
Divide what you eat into four categories: breakfast, lunch, diner, and
snacks.
Write down what you eat throughout the day; making a list at the end of
the day may make you forget items.
Go digital! There are plenty of apps available for your smartphone that
can help you keep track of your food and macronutrient intake.
Example of a random Dutch food diary:
Meal
Time
Quantity
Breakfast
7.30 am
200 mL
Coffee
2 slices
Bread
15 g
Butter
15 g
Chocolate Sprinkles
Snack
Lunch
Snack
10 am
12.45 am
3.00 pm
1 slice
150 mL
Full-fat yoghurt
200 mL
Coffee
Muffin
200 mL
Milk
200 mL
Tea
4 slices
Bread
Boiled egg
2 slices
25 g
Sliced sausage
330 mL
Coke
4.30 pm
Apple
Evening meal
6.00 pm
1 dish
Snack
8.30 pm
200 mL
Tea
Biscuits