Therapeutic drug levels

Therapeutic drug level are laboratory tests to look for the presence and the amount of
specific drugs in the blood.

How the Test is Performed

Blood is drawn from a vein, usually from the inside of the elbow or the back of the
hand. The site is cleaned with germ-killing medicine (antiseptic). The health care
provider wraps an elastic band around the upper arm to apply pressure to the area and
make the vein swell with blood.
Next, the health care provider gently inserts a needle into the vein. The blood collects
into an airtight vial or tube attached to the needle. The elastic band is removed from
your arm.
Once the blood has been collected, the needle is removed, and the puncture site is
covered to stop any bleeding.
In infants or young children, a sharp tool called a lancet may be used to puncture the
skin and make it bleed. The blood collects into a small glass tube called a pipette, or
onto a slide or test strip. A bandage may be placed over the area if there is any
bleeding.
See also: Venipuncture
The sample is then taken to the laboratory, where it is checked for the particular drug
specified by your health care provider.

How to Prepare for the Test

Some drug level tests require preparation. Your health care provider will tell you how
to prepare.

How the Test Will Feel

When the needle is inserted to draw blood, some people feel moderate pain, while
others feel only a prick or stinging sensation. Afterward, there may be some
throbbing.

Why the Test is Performed

With most medications, you need a certain level of drug in your bloodstream to obtain
the desired effect. Some medications are harmful if the level rises too high and do not
work if the levels are too low.

Monitoring the amount of the drug found in your blood allows your health care
provider to make sure the drug levels are within an effective range.
Drug level testing is especially important in people taking drugs such as:

Procainamide or digoxin used to treat abnormal beating of the heart

Dilantin or valproic acid used to treat seizures
Gentamicin or amikacin, antibiotics used to treat infections

Testing may also be done to determine how well your body breaks down the drug (
metabolism), or how it interacts with other necessary drugs.

Normal Results
Following are some of the drugs that are commonly checked, followed by the normal
target levels:

Acetaminophen: varies with use

Amikacin: 15 to 25 mcg/mL
Aminophylline: 10 to 20 mcg/mL
Amitriptyline: 120 to 150 ng/mL
Carbamazepine: 5 to 12 mcg/mL
Chloramphenicol: 10 to 20 mcg/mL
Desipramine: 150 to 300 ng/mL
Digoxin: 0.8 to 2.0 ng/mL
Disopyramide: 2 to 5 mcg/mL
Ethosuximide: 40 to 100 mcg/mL
Flecainide: 0.2 to 1.0 mcg/mL
Gentamicin: 5 to 10 mcg/mL
Imipramine: 150 to 300 ng/mL
Kanamycin: 20 to 25 mcg/mL
Lidocaine: 1.5 to 5.0 mcg/mL
Lithium: 0.8 to 1.2 mEq/L
Methotrexate: greater than 0.01 mcmol
Nortriptyline: 50 to 150 ng/mL
Phenobarbital: 10 to 30 mcg/mL
Phenytoin: 10 to 20 mcg/mL
Primidone: 5 to 12 mcg/mL
Procainamide: 4 to 10 mcg/mL
Propranolol: 50 to 100 ng/mL
Quinidine: 2 to 5 mcg/mL
Salicylate: 100 to 250 mcg/mL
Theophylline: 10 to 20 mcg/mL
Tobramycin: 5 to 10 mcg/mL
Valproic acid: 50 to 100 mcg/mL

Note:

mcg/mL = microgram per milliliter

ng/mL = nanogram per milliliter

mEq/L = milliequivalents per liter
mcmol = micromole

Normal value ranges may vary slightly among different laboratories. Talk to your
doctor about the meaning of your specific test results.

What Abnormal Results Mean

Values outside the target range may be due to minor fluctuations or may be a sign that
you need to adjust the dose of the medicine. A dose may need to be skipped if the
value measured exceeds the following levels.
Following are toxic levels for some of the drugs that are commonly checked:

Acetaminophen: greater than 250 mcg/mL

Amikacin: greater than 25 mcg/mL
Aminophylline: greater than 20 mcg/mL
Amitriptyline: greater than 500 ng/mL
Carbamazepine: greater than 12 mcg/mL
Chloramphenicol: greater than 25 mcg/mL
Desipramine: greater than 500 ng/mL
Digoxin: greater than 2.4 ng/mL
Disopyramide: greater than 5 mcg/mL
Ethosuximide: greater than 100 mcg/mL
Flecainide: greater than 1.0 mcg/mL
Gentamicin: greater than 12 mcg/mL
Imipramine: greater than 500 ng/mL
Kanamycin: greater than 35 mcg/mL
Lidocaine: greater than 5 mcg/mL
Lithium: greater than 2.0 mEq/L
Methotrexate: greater than 10 mcmol over 24-hours
Nortriptyline: greater than 500 ng/mL
Phenobarbital: greater than 40 mcg/mL
Phenytoin: greater than 30 mcg/mL
Primidone: greater than 15 mcg/mL
Procainamide: greater than 16 mcg/mL
Propranolol: greater than 150 ng/mL
Quinidine: greater than 10 mcg/mL
Salicylate: greater than 300 mcg/mL
Theophylline: greater than 20 mcg/mL
Yobramycin: greater than 12 mcg/mL
Valproic acid: greater than 100 mcg/mL

Risks

Veins and arteries vary in size from one patient to another and from one side of the
body to the other. Obtaining a blood sample from some people may be more difficult
than from others.
Other risks associated with having blood drawn are slight but may include:

Excessive bleeding
Fainting or feeling light-headed
Hematoma (blood accumulating under the skin)
Infection (a slight risk any time the skin is broken)