P-24 Prof. Dr.

Gabriella Hegyi, et al - Oncothermia combination with Traditional Chinese

Medicine: Proposal on Chinese Herbal Medicine approach

Oncothermia combination with Traditional Chinese Medicine:

Proposal on Chinese herbal medicine approach
St Istvan University

Hegyi1 G. Han Bingsheng2 Li Jian3 H-B. Andocs4 G. Szasz5 O. Szasz6 A.

(1) Department of Complementary Medicine, Medical School, University of Pecs, Pecs, Hungary; (2) North China Coal Medical University, Tangshan City, China; (3) Shenzhen

TCM Hospital, Shenzhen, China; (4) Department of Pharmacology and Toxicology, Faculty of Veterinary Science, St Istvan University, Budapest, Hungary; (5) OncoTherm Kft
Paty, Hungary; (6) Department of Biotechnics, Faculty of Engineering, St Istvan University, Budapest, Hungary Szasz Andras@gek szie hu

Objective
Hyperthermia is an ancient oncology method It is the very first treatment modality for this type of disease, having 5000 year history [1], based on the Sun as the overall curative force in ancient Egypt Later Hippocratic paradigm
described it using physiological process (acidosis) to eliminate the malignant tissue This natural approach is in well correlation with the far away developed medical concept in the same ancient time the Traditional Chinese Medicine
(TCM) [2] This medical philosophy was also based on natural harmony inside and outside the human organism In progress of historical time TCM had been more sophisticated and developed, but the hyperthermia could not keep
abreast with the development of the medicine, and was hindered by other western medical methods (WMM) However in late 80th of last century a new paradigm of hyperthermia was developed, the oncothermia method (OTM) [3]
OTM applies the ancient hyperthermia on different way, replacing the static thermal driving force to dynamical equilibrium concept, promoting the natural processes in curative direction [4] It is a matter of course to make synergy
between the two approaches, uniting the best line of TCM and OTM Our present article underlines the main connections with the herbal medicine of TCM (Chinese Herbal Medicine CHM) and oncothermia

TCM history sketches

TCM Oncology
tracess itts roots
n & tortoise
s
O c
t as far back
b c as the 16thh 11th centuries BCE, as recorded on bones
shells Oncology
between
were first
o g was first
f t recorded in text form in Zhou Li compiled
o
e e n 221 & 207 BCE
BC Tumors
u
discussed
ne Huang
s d in
n the
t earliestt recorded
o d book on
n Chinese
e Medicin
M
n Di Neii Jing The Jin,
n Sui & Tang
n Dynasties,
220
907
E The ettiology , pathology
& treatmentt off tumors
The
2
9 7 CE
p
o s was expllored & studied
t
e use off Herbs,
Acupun
cture & Moxi
her recor
e Medical
ical texts
texts Diet
upunc
oxibustion
bustion for the treatment
treatment of tumors
tumors was
was furt
furth
recorded in Chines
Chinese
Diet
of tumors
Therapy began to be
E The Song & Qing Dynasties, 960 1911
e discussed around 581 CE
9 1 CE Theories
e
t
r
developed
very
rapid
period especially
between
CE
prescriptions were
e
v
a dly during this
t
p c
b t e 960 & 1368
1
C Herbal
r
e e more
widely used in the treatment of Cancer Pattern
a well as prognosis
r
s became more
o e well
r identification
n & treatment as
developed
Integrative
e
g a e Medicine,
e 1949
9 9 Present The
h development
n off Western
s r Cancerr treatments Large scale
clinicall & laboratory
h into
& Western medicine
&
o y research
n integrated
n
e Chinese
e
n on
n the
e prevention, diagnosis
d g o
treatment of Ca
ancer
medicine
treatments of Cancer
a
c Integrative
t
e c
n
are
e the
h wave of the
e future

TCM Tre
eatment
t n of Tumors
T
Phlegm
Damp Transform
Ph
r n o m Phlegm & Dispel
e Damp
a
Liver
Qi Stagnation
Qi
L
n Sooth
o Liver & Regulate
R
Blood
Blood & Transform
Blood Stasis
Blo Stasiss Invigorate
v
f
St s
Heat
Toxicityy Clear Heat & Resolve Toxicity
H
o t
Spleen/Kidney
Sp
n y Deficiency Tonify Spleen
Sp e & Kidney
n y
Qi & Yin Deficiency (Qi
Tonify
( i & Blood
o Deficiency)
f
n
Qi &
Yin/Blood
Yn
Effect of Ginseng on
tumor suppression [8]

Method

Effec
TC
eatment
ment
Effect
f cts of TCM
CM Treat
n
Perspe
Persp
r ective

Western
Western
se

Enhance
nhance
immun
e immune
ne functi
n on
o
Rest
es
bala
the endocr
endoc
e tore
o e the balance
a nce off the
e d rine system
Promote
Promote
t blood prod
duction
c n
Protect
tion of
Protec
marrow & the
the function
func
Heart, Liver
Liver &
e t the marro
f
o the
t Heart,
Kidneys
Kidneys

Impr
n in the diges
Imp
absorption
di
trac
m rove absorptio
d gestive
e tive
v tract
t t
Boost
c function
Boostt the metabolic
metaboli
fun
m
c n
u ction
Stimulate
the
Stimulate
the bod
regulating
ability
m
o y'ss self regulating
n ability
Reduce the side
surger
radiotherapy &
side effects
effects of surgery
surgery, radiotherapy
chemother
y wh
ness
hemoth
while imp
ro
their effective
effectiveness
h m erap
e apy
proving
oving their
n s

Nu Zhen Zi
Ji Xue Teng
Ze He Che
Gui Ban Jiao
Xuan Shen
Sha Shen
E Jiao
Dan Shen
Da Zao
Zhi He Shou Wu
Long Yan Rou
Gan Cao

Blood Stasis Heat Toxicity

Dang Gui
Chuan X ong
Dan Shen
Chi Shao
Yi Mu Cao
Yue Ji Hua
Ling X ao Hua
Tao Ren
Hong Hua
Ji Xue Teng
San Qi
Ru Xiang
Mo Yao
San Leng
E Zhu
Pu Huang
Ma B an Cao
Hu Zhang
Zhong J e Feng
Xi Shu
Shui Hong Hua Zi
Liu Ji Nu
Niu Xi
Zao Jiao Ci
Gui J an Yu
Chuan Shan J a
Tu Bie Chong
Shui Zhi
Meng Chong
Xue Jie
Shi Lian Chuan
Wu L ng Zhi

Spleen
/Kidney

Bai Hua She She Ren Shen

Jin Y n Hua
Dang Shen
Ye Ju Hua
Bai Zhu
L an Q ao
Fu Ling
Ban Bian L an
Huang Qi
Ban Zhi Lian
Shan Yao
Chong Lou
Gan Cao
Pu Gong Y ng
Rou Gui
Zi Hua Di D ng
Rou Cong Rong
Yu X ng Cao
Y n Yang Hua
Ban Lan Gen
Tu Si Zi
Bai J ang Cao
Bu Gu Zhi
Huang Q n
Ba Ji Tian
Huang Lian
Gou Qi Zi
Haung Bai
Nu Zhen Zi
Ku Shen
He Shou Wu
Shan Dou Gen Shu Di Huang
Long Dan Cao
Huang J ng
Shi Shang Bai
Zi He Che
Tu Fu Ling
Shan Zhu Yu
Bi X e
Sheng Di Huang
Zhi Mu
Da Qing Ye
Ma Chi X an
Bai Tou Weng
Ren Gong N u Huang
Ya Dan Zi
T an Hua Fen

Phlegm
/Damp
Gua Lou
Zao Jiao Ci
Fa Ban X a
Bai J e Zi
Dan Nan X ng
Shan Ci Gu
Zhe Bei Mu
Ting Li Zi
Q an Hu
X ng Ren
Cang Zhu
Fu Ling
Huo Xiang
Pei Lan
Yi Yi Ren
Che Qian Zi
Jin Qian Cao
Bi X e
Tong Cao
Zhu L ng
Mu Gua
Du Huo

Liver Qi
Stagnation
Chen Pi
Ju Ye
Zhi Ke
Fo Shou
Chuan L an Zi
X ang Fu
X ang Yuan
Q ng Pi
Zhi Shi
Mu X ang
Yan Hu Suo
Da Fu Pi
Yu Jin
Da Dou Zi
Ba Yue Zha
Da Hui Xiang
Chen X ang
Hou Po
D ng X ang
Bai Dou Kou
Mei Gua Hua
Gou Qi Zi
Jiu X ang Chong

Extracts from the Roots of Lindera strychifolia Induces

Apoptosis in Lung Cancer Cells [9]

Stagnation of Qi & Blood

TCM diagnostic phenomena and actions for tumor

Qi & Yin/Blood Deficiency
Qi & Yin
B ood
Ren Shen
Xi Yang Shen
Dang Shen
Huang Qi
Bai Zhu
Fu L ng
Huang Jing
Shan Yao
Dang Gui
Bai Shao
Gou Qi Zi
Shu Di Huang

Vital
Su
r
a Qi & Cultivating
TCM Diagnosis
(Basic
o
a i Principles)
Pr n
s Supporting
Expelling Pathogenic Factors in TCM
TCM
the
Root
TCM
t Root
o in TCM
approach
Holism,
l s , complex
p
h of the
h
Soothe Liver & re
regulate Qi
living
and its environment
g system
y
e v
n
Nourish
Qi & Yin/Blo
u
Blood
d

Invigorate
gorate
Blood
d
&
Transform
Blood
ood
Invi
Bloo
Bl
I g r t Blo
o m Blo
o d
of patterns
Identification
e t
t r s & conditions
o d
Ton
fy Spleen
Kidney
o fy
e & Kidney
n y
Stasis
Stasis
(seeking
root causes
e k
a s of disease)
e s
fy Liver & Kidney
Ton
Kidney
o fy
Transf
form Phlegm & dissipate
Trans
ssipate
clu
T
e clumps
lumps
Clear
Clear Heat
Heat & resolve
resolve Toxici
Toxicity
xicity
TCM Etiology
TCM
T M Treatment
T a me (Basic Principle)
Pr n
)
TCM Pathology
Pa h
External
pathogenic
t
h g n factors
f t
Same disease,
, many patterns
s
t
Yin
Yin Yan
Yang imbalance
imbalance
Internal
damage
n
a e of 7 emotions
m
Many patterns,
, same disease
t
a

Disharmony
o of Qi & Blood
Improper
diet
m
According
g to
o person,
n time
t e & place
Dysfunction
sfunction of Zang
Zang Fu organs
organs
Defic
eficiency & depletion
epletion of the
Resultant
s a local manifestation
a f t o of Toxic
o
organs
pathogenic
factors
o
os
Stagnation of Phlegm Fluid
lu

TCM
TCM Diagnosis
Diagnosis of TumorsPhlegm Dam
Damp
Liverr Qi Stagnat on
o
Blood
Blood Stasis
Heat
e t Toxicity
c

Spleen/Kid
ney De
ncy

Spleen/Kidn
Deficie
ficien
Qi & Yin Deficiency (Qi & Blood Deficiency)
D c

TCM
TCM Asserts
Vitall Qi can
the
can stre
trrengthen
the patient
patie
resistance
n t
entts resistan
s ce
to infecti
ce cell
infection
enhan
cell mediated
mmuni
e on
o & enhance
n
e immunity
m ty
Surgery damages
Blood and affects
affec

mages Qi & Blood

affects the
functioni
functionin
tioning of the Zang
Zang Fu organ This
This

is
man
ifest
pletio
damage
a ifests
f ts as depletion
on & damage
g of Qi &

Blood,
y of Ying
Blood, disharmony
disharmon
Wei Qi &
h r
n Qi & Wei
disharmony
of
disharmony
of Spleen & Stomach
Stomach
h r
a
nt
bility
Treatment
Treatme
aim
reducing
possib
r a
n iss aimed
med at reducing
g the
h possi
of recurr
is & cr
recurrrence
en
metastasis
creating
ating
e ce
c & metastas
g an
appro
priate
radiothe
approp
iate condition
ondition for
ra
o future
t
r diother
d t rapy or

chemotherapy
emother
h rapy
p

Asian governments hope that high volume screening

and r gorous cl nical trials will unlock the secrets of
anc ent herbal remedies and that the results will
pass mus er with Western scientists [10]

Cancer and TCM0

Combining
TCM & Western Medicine in
mb
i Surger
r ry, Chemotherrapy
y & Radio
d otherapy
e
The Role
Canc
off TCM in Cancer
ategie
R l o
a er Treatment
t n Strrategi
ies
Supporting
ultivating
iva
e Root
o t
g Vital Qi & Cult
v ting
n the
Dispel Pathogenic
Fac
Pathogenic
Fa
t
actor
TCM in redu
ects & increasing the
reducing
cing
side
effe
reduc
ing the si
side eff
effectivene
y::
effectiveness
ss
Radiotherapy
fe t
s off Radiotherap
a
a y & Chemotherap
mo e
overall
results
treatme
prevent
local
Enhance the ov
verall resu
r s ltss off the treatment
t entt & prevent
n local
o
constric
co
onstriction
s ction
n & recurre
encce
toxic reactions
reactit ons & adv
adverse
side
effect
s
Reduce
e u toxic
a verse si
e effec
f tts
Improve hemat
hematopoiesis,
poiesis, protect
protect renal & hepatic
Improve
functioni
func
u ctionin
n ng
Reduce
gastr
tro intesti
ntestinal
side
e u gas
a si
d effects
s nal
Alleviate
viate
pneumon
tis,, proctiti
titiss & cy
cysti
Alle
t radiation
n pneumoni
nitis
ystittis
vomiti
miting
ng
Reduce
e u vo
Increase immune
immune function
function & ra
survivval
al rates
Incr
raise long term surviv
rates
TCM
TCM wi
will:
ill:
Supplement Qi & nourish
nourish Blood
Blood
Suppleme
Spleen & harmonize
harmon
th
Fortify
r y the Spl
o ize
iz the
t e Stomach
supplement
upplement the
the Liver & Kidneys
Kidneys
Enrich & supple
Re
toxici
xicity
ty & transform P
Ph
hlegm
Relieve
elieve
v to
Clear
Cllear
resolve
toxi
e r heat & resolv
lve toxicity
t city
c

Immunohis ochemical s aining of PCNA and TUNEL n LL 2 ce l s c transplanted n m ce At 1 week before

transplantat on of LL 2 cancer ce ls mice rece ved L strychi ol a extracted solution daily unt l the end of the
experiment At 35 days af er L strych fo ia treatment tumors were resected and examined his ologica ly (n =
11/group) Photographs show the typical immunoh stochem cal appearance in umor issues from mice of
control (a and c) and L strychi ol a extract (5 0 mg/m ) treated mice (b and d) Cell prol feration and apoptosis
were detected us ng anti PCNA antibody (a and b) and a mod fied TUNEL me hod (c and d) respectively
Graphs show change in PCNA pos tive and TUNEL posit ve ce l number in the tumor t ssue Values represent
the means SD

Befor
Surgery
Before
e Surgery
Go
Goal
G al
Improv
bodys ability
Improve
e the body
ability to
thstan
m
t withstand
s nd surgery
r
Reduce
po
perative complic
complications
ost operative
p ations
e u pos
Control
of the
development
o t the development
m
a
e disease
Benefit
erative re
Benefit postoperativ
postop
habilit
p
ehabilita
a l tation
o

TCM
wi
will:
T
Supplemen
Blood
Supplement
nt Qi & nourish Blood
Forti
& augment
r fyy the Spleen
Sp
e t Qii
Enrich
Supplement
h & Supplement
e t the Liv
L er & Kidneyss
After Su
Surgery
Goal:
Reduce the possibi
lity of
possibility
of recurrence &
metastasis
e
Create
e t an
a appropriate
a condition
n for
o future
radiotherapy
& chemotherapy
e
c
o
TCM will:
Tonify
o f Qi & Blood
Harmonize
Ying & Wei
r
Q
W Qi
Harmonize
Spleen & Stomach
r
St
c

Proposal

There are various CHM substances ac ng palliative or curative on tumorous diseases For example of pain
reduction the Senecio palmatus For curative treatments special moxibustion techniques with various complex
mixture of herbs could be applied [5] Synergetic effects of the OTM and CHM is expected due to the well targeted
tumor tissue by OTM in combination with the effective CHM like Tongyou sum plant Also the effect of ginseng and
its Nrf2 cancerpreventive action with oncothermia is investigated, and genarlly the apoptotic possibilities for various
TCM herbs The effect of synergy will be investigated by in silico, in vitro and in vivo experiments, using special
OTM device for laboratory use (EHY110, Oncotherm) The latest histomorphological and mmunohistochemical
methods will be used for evaluation,; mainly concentrating on p53 tumor suppressor protein and the apoptotic
pathways, including beta catenin Protocols of clinical studies will be worked out on the basis of the experimental
results

Potential of the synergy of high-tech OTM and TCM is extremely huge. We are
ready to work out the European alternative of the East meets West in cancer
care collaboration [6] on the basis of the widely applied TCM evidences [7].

References

[1] Seegenschmiedt MH Vernon CC (1995) A Historical Perspective on Hyperthermia in Oncology In: Seegenschm edt MH Fessenden P Vernon CC (eds) (1995) Thermorad otherapy and thermochemotherapy Vol 1 Springer Ver ag Berlin Heidelberg
[2] Unschuld Paul Ulrich (1985) Med cine in China: A History of Ideas University of Californ a Press
[3] Andocs G Szasz O Szasz A (2009); Onco hermia treatment of cancer: from the labora ory to c inic E ectromagn B ol Med 28(2):148 65
[4] Szasz A Szasz N Szasz O (2010) Oncothermia Principles and Pract ces Springer Ver ag (http://www spr nger com/biomed/cancer book/978 90 481 9497 1?changeHeader) Heidelberg Dordrecht
[5] Longo F (2007) Traditional Chinese Medicine in Oncology n Proceedings of the 56th S C I V A C Nat onal Congress ; June 1/3 2007 (pp 230 232) Rim ni
[6] McMaster un versi y Explores Evidence based Ch nese medicine http://www integrativeonc org/mcmaster un vers ty exp ores evidence based chinese med cine
[7] J n Ling Tang Bao Yan Liu Kan Wen Ma (2008) Traditional Chinese Medicine The Lancet 373:1938 1940
[8] Saw CL L Qing Wu Ah Ng Tony Kong Anti cancer and potent al chemopreven ive actions of ginseng by activating Nrf2 anti oxidat ve stress/anti nflammatory pathways Ch nese Medic ne 2010 5:37
[9] Yun Mo Li et al Extracts from the Roots of L ndera strychifo ia Induces Apoptosis in Lung Cancer Ce ls and Pro ongs Surv val of Tumor bearing Mice The Amer can Journal of Chinese Medicine Vol 31 No 6 857 869 2003
[10] Normile D The New Face of Trad tional Chinese Medicine 10 JANUARY 2003 VOL 299 SCIENCE www sciencemag org

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