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The criteria used to diagnose depression is the same in postpartum states. In addition to these
criteria, other symptoms may include fear or feelings of guilt about being a "bad" mother, or
possibly extreme fear that some harm will come to the baby. These thoughts help distinguish
postpartum from other kinds of depression (Table 1).
Women with postpartum major depressive episodes may also have severe anxiety, panic
attacks, spontaneous crying long after the usual duration of "baby blues" (ie, 3-7 days
postpartum), disinterest in the new infant, and insomnia (manifested as difficulty falling
asleep).
When assessing whether a symptom is a sign of depression or a normal postpartum reaction,
the individual's circumstances need to be considered. A woman's level of exhaustion or
irritability may be quite normal when her infant is 2 weeks old and nursing frequently, but
may not be normal when her baby is 4 months old and sleeping soundly through the night.
Sleep deprivation can cause fatigue and poor concentration, but the degree of these symptoms
needs to be carefully assessed.
Although there are a number of rating scales for depression, one that has been validated in the
postpartum population is the Edinburgh Postnatal Depression Scale (EPDS) (Table 2).[17] A
new instrument called the Postpartum Depression Screening Scale (PDSS)[18,19] also shows
promise as a screening tool.
Less severe presentations of depressive illness are often missed and frequently dismissed by
patients and healthcare professionals as normal after childbirth. It is generally advised that
screening for postpartum affective disorders should become routine. The suggested ideal time
to screen is at the standard postpartum medical visit at 6 weeks and at subsequent pediatric
visits.[2]
Treatment of PPD generally depends on the type and severity of the symptoms. With
postpartum blues, additional emotional support or extra help caring for the newborn may be
the only intervention necessary. Patient education is important and women should be directed
to contact their physicians if symptoms persist beyond the second postpartum week. If
symptoms persist or become more severe then professional treatment may be warranted. In
mild cases in which the depression does not interfere with the mother's functioning,
psychotherapy may be of benefit. If the symptoms are of a more severe major depression then
carefully selected antidepressant medication may be needed and this should be combined
with counseling and support as well.
As in non-postnatal depression, there is great variability in the type of symptoms as well as in
the intensity of depressed mood. Treatment should be guided by these parameters as well as
the degree of functional impairment.
In general, there are too few studies on the most effective treatment of PPD, and "postpartum
major depression demands the same course of treatment as nonpuerperal major depression."[2]
There is a tendency to treat women with PPD less intensely than those with non-pregnancyrelated affective episodes. The dose of medication may be suboptimal or the duration of
treatment too short. Women who are breastfeeding must be informed that all psychotropic
medications, including antidepressants, are secreted in the breast milk at varying
concentrations.[20] "Data do not suggest that one antidepressant is safer than another for
women who breastfeed. Choices of medications should be based as usual on prior response to
antidepressants and side effect profile."[2]
Some studies have suggested that progesterone and estrogen may be effective agents for
treatment of PPD.[21,22] These studies are preliminary, however, and additional research is
required to clarify these issues. Also, for severe depression in which medication is either not
an option or problematic, electroconvulsive treatment may be a viable alternative.
It is estimated that approximately 40% of births occurring annually in the United States are
complicated by some form of postpartum mood disorder.[10] Since "baby blues" are estimated
to occur after 40% to 80% of deliveries, both practitioners and patients tend to view this as a
"normal" phenomenon.[23] Postpartum disorders occur on a spectrum from mild to severe.
Between these 2 extremes is PPD, a major depression that is unique and can become a serious
complication following childbirth. Unfortunately, many of these patients suffer from PPD for
more than 6 months and, if untreated, approximately 25% are still depressed after 1 year.[21]
Awareness of the impact of these disorders is only the beginning, and attention needs to be
directed toward prevention. The traditional "wait and see" attitude may be appropriate for
women with postpartum blues or those who have low risk, but women with high-risk factors
need to be educated and closely monitored by their physician and healthcare professionals.
Prophylactic treatments such as psychotherapy, counseling, and support groups could make a
significant difference in the well-being of the mother, the child, and the family.
The editors of Medscape Psychiatry have put together a collection of resources (see sidebar
for Related Resources) with clinicians and consumers in mind. Included are links to
organizations such as the National Women's Health Information Center, Postpartum Support
International, as well as related Medscape articles.