of persistent data, usually associated with computerized software designed to update, query, and retrieve components of the data stored within the system. A simple database might be a single file containing many records, each of which includes the same set of information. For researchers to benefit from the data stored in a database, two additional requirements must be met:easy access to the information a method for extracting only that information needed to answer a specific biological question
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THERAPEUTIC TARGET DATABASES
A database to provide information about the known and explored therapeutic protein and nucleic acid targets, the targeted disease, pathway information and the corresponding drugs directed at each of these targets. Also included in this database are links to relevant databases containing information about target function, sequence, 3D structure, ligand binding properties, enzyme nomenclature and drug structure, therapeutic class, clinical development status
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THERAPEUTIC TARGET DATABASES
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Statistics of this database This database currently contains 2,025 targets, including 364 successful, 286 clinical trial, 44 discontinued and 1,331 research targets, 17,816 drugs, including 1,540 approved, 1,423 clinical trial, 14,853 experimental drugs and 3,681 multi-target agents (14,170 small molecules and 652 antisense drugs with available strucuture or oligonucleotide sequence). Targets and drugs in this database cover 61 protein biochemical class and 140 drug therapeutic classes respectively.
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The Therapeutically Relevant Multiple Pathways Database is designed to
provide information about such multiple pathways and related therpaeutic targets described in the literatures, the targeted disease conditions, and the corresponding drugs/ligands directed at each of these targets. This database currently contains 11 entries of multiple pathways, 97 entries of individual pathways, 120 targets covering 72 disease conditions along with 120 sets of drugs directed at each of these targets. Each entry can be retrieved through multiple methods including multiple pathway name, individual pathway name and disease name. Additional information provided include protein name, synonyms, Swissprot AC number, species, gene name and location, protein sequence (AASEQ) and gene sequence (NTSEQ) as well as potential therapeutic implications while applicable. Cross-links to other databases are provided which include Genecard, GDB, Locuslink, NCBI, KEGG, OMIM, SwissProt to facilitate the access of more detailed information about various aspects of the particular target or non-target protein.
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A database for facilitating the search for drug adverse reaction target. It contains information about known drug adverse rection targets, functions and properties. Associated references are also included.
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DRUG POTENCY DATABASES
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Information of Drug Activity
Data DPD is a relational database focusing on providing activity information of drugs, clinical trial compounds and experimental agents directed at their corrosponding therapeutic targets. Also included in this database are links to relevant databases containing information about target function, sequence, 3D structure, ligand biding properties, enzyme nomenclature and drug structure, therapeutic class, clinical development status. Currently this database contains 5000 records of activity for around 3000 compounds direced at about 500 tagets. Near 300 compounds in DPD have already approved or been
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POTENTIAL DRUG TARGET
DATABASE (PDTD)
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PDTD is a dual function database that associates an informatics database to a structural database of known and potential drug targets. PDTD is a comprehensive, web-accessible database of drug targets, and focuses on those drug targets with known 3D-structures. PDTD contains 1207 entries covering 841 known and potential drug targets with structures from the Protein Data Bank (PDB). Drug targets of PDTD were categorized into 15 and 13 types according to two criteria: therapeutic areas and biochemical criteria.
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The database supports extensive searching function using PDB ID, target name and category, related disease. Each record of drug target was prudently annotated by hyperlinks to other databases, such as DrugBank, TTD, ExPASy Proteomics Server and KEGG etc. In conclusion, PDTD serves as the cornerstone for TarFisDock to identify the potential binding targets insilico
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DRUGBANK
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INTRO TO DRUGBANK
The DrugBank database is a unique bioinformatics and cheminformatics
resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information. The database contains 6711 drug entries including 1447 FDA-approved small molecule drugs, 131 FDA-approved biotech (protein/peptide) drugs, 85 nutraceuticals and 5080 experimental drugs. Additionally, 4227 non-redundant protein (i.e. drug target/enzyme/transporter/carrier) sequences are linked to these drug entries. Each DrugCard entry contains more than 150 data fields with half of the information being devoted to drug/chemical data and the other half devoted to drug target or protein data
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BIOINFO DATABASE
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HumanCyc is a bioinformatics database that describes human metabolic pathways and the human genome. By presenting metabolic pathways as an organizing framework for the human genome, HumanCyc provides the user with an extended dimension for functional analysis of Homo sapiens at the genomic level. For example, HumanCyc has tools for analysis of human metabolomics and gene-expression data
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PROTEIN DATABANK
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The Protein Data Bank (PDB) archive is the single worldwide repository of information about the 3D structures of large biological molecules, including proteins and nucleic acids. These are the molecules of life that are found in all organisms including bacteria, yeast, plants, flies, other animals, and humans. Understanding the shape of a molecule helps to understand how it works. This knowledge can be used to help deduce a structure's role in human health and disease, and in drug development. The structures in the archive range from tiny proteins and bits of DNA to complex molecular machines like the ribosome. The PDB archive is available at no cost to users. The PDB archive is updated each week at the target time of Wednesday 00:00 UTC (Coordinated Universal Time). The most recent release is timestamped and linked on every page in the top right header.