Professional Documents
Culture Documents
Biotechnology Engineering
3rd Semester
Theory
4th Semester
Theory
Contact Hours
Contact Hours
L-T-P Credit
Code
3- 1- 0
3- 1- 0
BSCP1206 Physics II
3- 0- 0
OR
BSCP1207 Physics of Semiconductor Devices
BSCC1208 Chemistry II
OR
BSMS1209 Material Sciences
3- 0- 0
3- 0- 0
3- 1- 0
3- 1- 0
Code
Subject
3- 0- 0
OR
HSSM3205 Organisational Behavior
BEME2209 Fluid Mechanics & Machines
3- 0- 0
PCBT4201 Biochemistry
3- 0- 0
Theory Credits
L-T-P Credit
Theory Credits
20
19
Practical/ Sessional
Practical/ Sessional
HSSM7203 COMMUNICATION AND INTERPERSONAL 0- 0- 3
PCBT7201Biochemistry Lab
0- 0- 3
0- 0- 3
Subject
27
0- 0- 3
0- 0- 3
0- 0- 3
26
BSCM1205 Mathematics
Module-I
- III
(18 hours)
Partial differential equation of first order, Linear partial differential equation, Non-linear partial
differential equation, Homogenous and non-homogeneous partial differential equation with
constant co-efficient, Cauchy type, Monges method, Second order partial differential equation
The vibrating string, the wave equation and its solution, the heat equation and its solution, Two
dimensional wave equation and its solution, Laplace equation in polar, cylindrical and spherical
coordinates, potential.
Module-II
(12 hours)
Complex Analysis:
Analytic function, Cauchy-Riemann equations, Laplace equation, Conformal mapping,
Complex integration: Line integral in the complex plane, Cauchys integral theorem, Cauchys
integral formula, Derivatives of analytic functions
Module III
(10 hours)
Power Series, Taylors series, Laurents series, Singularities and zeros, Residue integration
method, evaluation of real integrals.
Text books:
1. E. Kreyszig, Advanced Engineering Mathematics:, Eighth Edition, Wiley India
Reading Chapters: 11,12(except 12.10),13,14,15
2. B.V. Ramana, Higher Engineering Mathematics, McGraw Hill Education, 2008
Reading chapter: 18
Reference books:
1. E.B. Saff, A.D.Snider, Fundamental of Complex Analysis, Third Edition, Pearson
Education, New Delhi
2. P. V. ONeil, Advanced Engineering Mathematics, CENGAGE Learning, New Delhi
BSCP1206
PHYSICS-II
This one semester physics course is divided into three (Modules). Module-I deals with some aspects of
nuclear accelerators, Module-II introduces certain features of condensed matter physics and Module-III
deals with certain aspects of fibre optics and different types of lasers and crystal defects.
Module-I
This unit covers the basic principles and applications of different types of accelerators and their important
applications.
Need for nuclear accelerators.
D.C. Accelerators: Cockcroft-Walton, Van de Graff, Tandem accelerators.
R.F. Accelerators: Linear accelerators, cyclotrons, electron accelerator, betatron.
Application of nuclear accelerators - Production of radio isotopes, Radiation processing of materials,
medical applications.
This unit covers the basic principle, properties of nanoparticles.
Nanoparticles.
Properties, Classification & characterization of nanoparticles, fabrication of nanoparticles, Structure of
carbon nanotubes, types of carbon nanotubes, Properties of (Electrical, thermal) carbon nanotubes,
Quantum Dots.
Module-II
Study of crystal structure by diffractions methods, Braggs condition for crystal diffraction, Laues
Condition, Miller indices, Reciprocal laltice, Geometrical Structure factor, Atomic form factor.
Energy bands in solids: Kronig-Penney model, allowed bands and forbidden gaps, elemental and
compound semiconductors.
Superconductivity: Superconductors and their properties, Meisners effect, Type-I and Type-II
superconductors, thermodynamic properties of superconductors, London equation, Application of
superconductors
Module-III
Defects in crystal:-Schottky and Frenkel defects, color centres, dislocation.
Laser: - Principle of lasing, Properties of laser, Ruby laser, He-Ne laser, semiconductor laser(construction
and working). Application of laser.
LED: Principle, construction of operation and application, Introduction to fiber optics, basic characteristics
of optical fibers, optical fibre communication system.
Books Recommended
Text books
(1) Concepts in Engineering Physics,Md.N.Khan
(2) Physics-II, B.B.Swain, P.K.Jena.
Reference Books
(3).Principles of Nanotechnology, Phani Kumar
(4) Physics-II, Randhir Singh, Shakti Mohanty,
(5) Physics-II, A.Serway,W.Jewett
(6) Solid state Physics, W.Ashcroft, N.David Mermin,
(7) Introduction to Solid State Physics, C.Kittel,
(8) Solid State Physics, Dan Wei
BSCP 1207
1.Introduction to the quantum theory of solids: Formation of energy bands, The k-space diagram (two
and three dimensional representation), conductors, semiconductors and insulators.
2.Electrons and Holes in semiconductors: Silicon crystal structure, Donors and acceptors in the band
model, electron effective mass, Density of states, Thermal equilibrium, Fermi-Dirac distribution function
for electrons and holes, Fermi energy. Equilibrium distribution of electrons & holes: derivation of n and p
from D(E) and f(E), Fermi level and carrier concentrations, The np product and the intrinsic carrier
concentration. General theory of n and p, Carrier concentrations at extremely high and low temperatures:
complete ionization, partial ionization and freeze-out. Energy-band diagram and Fermi-level, Variation of
EF with doping concentration and temperature.
3.Motion and Recombination of Electrons and Holes: Carrier drift: Electron and hole mobilities,
Mechanism of carrier scattering, Drift current and conductivity.
Module II (11 Hours)
4.Motion and Recombination of Electrons and Holes (continued): Carrier diffusion: diffusion current,
Total current density, relation between the energy diagram and potential, electric field. Einstein
relationship between diffusion coefficient and mobility. Electron-hole recombination, Thermal generation.
5.PN Junction: Building blocks of the pn junction theory: Energy band diagram and depletion layer of a pn
junction, Built-in potential; Depletion layer model: Field and potential in the depletion layer, depletion-layer
width; Reverse-biased PN junction; Capacitance-voltage characteristics; Junction breakdown: peak
electric field. Tunneling breakdown and avalanche breakdown; Carrier injection under forward biasQuasi-equilibrium boundary condition; current continuity equation; Excess carriers in forward-biased pn
junction; PN diode I-V characteristic, Charge storage.
6.The Bipolar Transistor: Introduction, Modes of operation, Minority Carrier distribution, Collector
current, Base current, current gain, Base width Modulation by collector current, Breakdown mechanism,
Equivalent Circuit Models - Ebers -Moll Model.
Module III (12 Hours)
characteristics, Comparison of the Schottky barrier diode and the pn-junction diode. Ohmic contacts:
tunneling barrier, specific contact resistance.
8.MOS Capacitor: The MOS structure, Energy band diagrams, Flat-band condition and flat-band voltage,
Surface accumulation, surface depletion, Threshold condition and threshold voltage, MOS C-V
characteristics, Qinv in MOSFET.
9.MOS Transistor: Introduction to the MOSFET, Complementary MOS (CMOS) technology, V-I
Characteristics, Surface mobilities and high-mobility FETs, JFET, MOSFET Vt, Body effect and steep
retrograde doping, pinch-off voltage,
Text Books:
1. Modern Semiconductor Devices for Integrated Circuits, Chenming Calvin Hu, Pearson Education/Prentice
Hall, 2009.
2. Semiconductor Physics and Devices, 3rd Edition, Donald A. Neamen, Tata McGraw Hill Publishing Company
Limited, New Delhi.
Reference Books:
1. Fundamentals of Semiconductor Devices, M.K. Achuthan and K.N. Bhatt, Tata McGraw Hill Publishing
Company Limited, New Delhi.
2. Solid State Electronics Devices, 6th Edition, Ben. G. Stretman and Sanjay Banarjee, Pearson Educ, New Delhi.
3. Physics of Semiconductor Devices, 3rd Edition, S.M. Sze and Kwok K. Ng, Wiley India Pvt. Limited, New Delhi.
4. Physics of Semiconductor Devices, 2nd Edition, Dillip K. Roy, University Press (India) Pvt. Ltd., Hyderabad.
5. Solid State Electronics Devices, D.K. Bhattacharya and Rajnish Sharma, Oxford University Press, New Delhi.
BECS2212 C++
Module I
(08 hrs)
Introduction to object oriented programming, user defined types, structures, unions,
polymorphism, encapsulation. Getting started with C++ syntax, data-type, variables, strings,
functions, default values in functions, recursion, namespaces, operators, flow control, arrays and
pointers.
Module II
(16 hrs)
(08 hrs)
Dynamic memory management, new and delete operators, object copying, copy constructor,
assignment operator, virtual destructor.
Template: template classes, template functions.
Namespaces: user defined namespaces, namespaces provided by library.
Text Books:
1. Object Oriented Programming with C++ - E. Balagurusamy, McGraw-Hill Education (India)
2. ANSI and Turbo C++ - Ashoke N. Kamthane, Pearson Education
Reference Books:
1.
2.
3.
4.
5.
6.
HSSM3204 Engineering
Module-I:
(12 hours)
Engineering Economics Nature and scope, General concepts on micro & macro economics.
The Theory of demand, Demand function, Law of demand and its exceptions, Elasticity of
demand, Law of supply and elasticity of supply. Determination of equilibrium price under perfect
competition (Simple numerical problems to be solved). Theory of production, Law of variable
proportion, Law of returns to scale.
Module-II:
(12 hours)
Time value of money Simple and compound interest, Cash flow diagram, Principle of economic
equivalence. Evaluation of engineering projects Present worth method, Future worth method,
Annual worth method, internal rate of return method, Cost-benefit analysis in public projects.
Depreciation policy, Depreciation of capital assets, Causes of depreciation, Straight line method
and declining balance method.
Module-III:
(12 hours)
Cost concepts, Elements of costs, Preparation of cost sheet, Segregation of costs into fixed and
variable costs. Break-even analysis-Linear approach. (Simple numerical problems to be solved)
Banking: Meaning and functions of commercial banks; functions of Reserve Bank of India.
Overview of Indian Financial system.
Text Books:
1. Riggs, Bedworth and Randhwa, Engineering Economics, McGraw Hill Education India.
2. D.M. Mithani, Principles of Economics.
Reference Books :
1. Sasmita Mishra, Engineering Economics & Costing , PHI
2. Sullivan and Wicks, Engineering Economy, Pearson
3. R.Paneer Seelvan, Engineering Economics, PHI
4. Gupta, Managerial Economics, TMH
5. Lal and Srivastav, Cost Accounting, TMH
Behaviour
Module I :
The study of Organizational Behaviour : Defination and Meaning, Why Study OB
Learning Nature of Learning, How Learning occurs, Learning and OB.
Foundations of Individual Behaviour : Personality Meaning and Defination, Determinants of Personality,
Personality Traits, Personality and OB.
Perception Meaning and Definition, Perceptual Process, Importance of Perception in OB. Motivation
Nature and Importance, Herzbergs Two Factor Theory, Maslows Need Hierarchy Theory, Alderfers
ERG Theory, Evaluations.
Module II :
Organizational Behaviour Process : Communication Importance, Types, Gateways and Barriers to
Communication, Communication as a tool for improving Interpersonal Effectiveness, Groups in
Organizations Nature, Types, Why do people join groups, Group Cohesiveness and Group Decisionmaking Managerial Implications, Effective Team Building. Leadership-Leadership & Management,
Theories of Leadership-Trait theory, Leader Behaviour theory, Contingency Theory, Leadership and
Followership, How to be an effective Leader, Confict-Nature of Conflict and Conflict Resolution. An
Introduction to Transactional Analysis (TA).
Module-III :
Organization : Organizational Culture Meaning and Definition, Culture and Organizational
Effectiveness. Introduction to Human Resource Management-Selection, Orientation, Training and
Development, Performance Appraisal, Incentives Organizational Change Importance of Change,
Planned Change and OB techniques. International Organisational Behaviour Trends in International
Business, Cultural Differences and Similarities, Individual and Interpersonal Behaviour in Global
Perspective.
Text Books :
1. Keith Davis, Organisational Behaviour, McGraw-Hill.
2. K.Aswathappa, Organisational Behaviour, Himalaya Publishing House.
Reference Books :
1. Stephen P. Robbins, Organisational Behaviour, Prentice Hall of India
2. Pradip N. Khandelwal, Organizational Behaviour, McGraw-Hill, New Delhi.
3. Uma Sekaran, Organizational Behaviour, TATA McGraw-Hill, New Delhi.
4. Steven L McShane, Mary Ann Von Glinow, Radha R Sharma Organizational
Behaviour , TATA McGraw- Hill.
5. D.K. Bhattachayya, Organizational Behaviour, Oxford University Press
6. K.B.L.Srivastava & A.K.Samantaray, Organizational Behaviour India Tech
7. Kavita Singh, Organizational Behaviour, Pearson
BEME2209 Fluid
Module I
(12 Lectures)
Introduction : Scope of fluid mechanics and its development as a science
Physical property of Fluid: Density, specific gravity, specific weight, specific volume, surface
tension and capillarity, viscosity, compressibility and bulk modulus, Fluid classification.
Fluid static Pressure, Pascals Law, Pressure variation for incompressible fluid, atmospheric
pressure, absolute pressure, gauge pressure and vacuum pressure, manometer.
Hydrostatic process on submerged surface, force on a horizontal submerged plane surface,
force on a vertical submerged plane surface.
Buoyancy and flotation, Archimedes principle, stability of immersed and floating bodies,
determination of metacentric height.
Fluid kinematics : Introduction, description of fluid flow, classification of fluid flow. Acceleration of
fluid particles, flow rate and continuity equation, differential equation of continuity,
Module II
(10 Lectures)
Fluid dynamics : Introduction, Eulers equation along a streamline, energy equation, Bernoullis
equation,
Hydraulic Measurements: Water level measurements, velocity measurements, discharge
measurements, venturimeter, orifice meter, current meter, pitot tube, orifice, notch and weir.
Module III
(14 Lectures)
Hydraulic turbines and pumps: Impulse and reaction turbines, construction and working
principle of tangential, radial and axial type turbines. Power of turbines, efficiency of turbines.
Construction and working principles of centrifugal type pumps. Power and efficiency of the
pump. Positive displacement pump.
Hydraulic systems: hydraulic accumulator, hydraulic intensifier, hydraulic ram, hydraulic lift,
hydraulic crane, hydraulic press, hydraulic torque converter.
Text Books
1. Fluid Mechanics and hydraulic machines, Modi & Seth
2. Hydraulics fluid machines and fluid machines by S. Ramamrutham
Reference Books:
1.
2.
3.
4.
5.
6.
PCBT4201 Biochemistry
Module-I
(16 Hr.)
Introduction to Biomolecules:
Structure and Function of Carbohydrates: Monosaccharide, Oligosaccharides, Polysaccharides (Starch,
Glycogen, Cellulose), Optical Isomerism;
Structure and Function of Lipids: Saturated and Unsaturated Fatty Acids, Triacylglycerols,
Phosphoglycerides, Sphingolipids, Waxes and Sterol;
Structure and Function of Proteins: 20 Amino acids, Peptide bond, Hierarchy of protein architecture,
Ramachandran Plot, 3-D structure;
Structure and Function of Nucleic Acids: DNA, RNA, Double Helix Model of DNA, Denaturation and
Renaturation DNA;
Structure and function of Hormones, Minerals and Vitamins; Bio-complexes: Nucleoproteins, Glycoproteins, Lipoproteins and Vitamin complexes.
Module-II
(12Hr.)
Principle of Bioenergetics: Bioenergetics and Thermodynamics; Phosphoryl group transfer and energy
currency-ATP; Biological Oxidation and reduction reactions
Metabolism-I: Introduction to metabolic processes;
Metabolism of Carbohydrates: Glycolysis, TCA Cycle, ETS and Oxidative Phosphorylation, HMP
pathway, Gluconeogenesis , Glycogen metabolism;
Metabolism of Lipids: Anabolism (Saturated and Unsaturated), Catabolism (- Oxidation, -Oxidation)
and Energetics of lipid metabolism;
Metabolism Of Nucleic Acids: Catabolism and anabolism of purine and pyrimidine nucleotides.
Module-III
(12Hr.)
Metabolism-II: Metabolism of proteins: Properties of Amino acids, Biosynthesis of amino acids ( Valine,
Serine, Histidine and Glutamic Acid); Protein Catabolism ( Genetic code and Protein synthesis); Protein
Turnover, Protein Targetting.
Enzymes: Properties of Enzyme, Classification of Enzymes, Mechanism of enzyme action, Kinetics of of
enzyme action, Activation energy, Enzyme Inhibition, Coenzyme, Apozyme and Holozyme
Text Book
1. Principle of Bio-Chemistry Lehinger, Nelson and Cox
2. Biochemistry of Biochemistry by L. Stryer
3. Fundamentals of Biochemistry Voet & Voet
4. Biochemistry by Zubay.
5. Biochemistry, C.B.Powar & G.R.Chatwal, Himalaya Publishing House.
6. Biochemistry, Rastogi, Tata McGraw Hill.
HSSM7203
Lab
30 hours
This course will focus on communication in professional (work-related) situations of the kind that
BPUT graduates may expect to encounter on entering the professional domain.
Some typical forms of work-related communication, oral or written, are listed below. Practice
activities for all four skills can be designed around these or similar situations.
1.
2
a.
b.
BECS7212
PCBT7201
Biochemistry Lab
PCME7202
Group A
1. Determination of equilibrium of coplanar forces.
2. Determination of Moment of Inertia of Flywheel
3. Determination of tensile strength of materials by Universal Testing Machine.
Group B
4. Determination of Metacentric Height and application to stability of floating bodies.
5. Verification of Bernoullis Theorem and its application to Venturimeter.
6. Determination of Cv and Cd of Orifices.
Group C
7. Calibration of Bourdon Tube Pressure gauge and measurement of pressure using
manometers.
8. Study of Cut-Sections of 2 stroke and 4 stroke Diesel Engine.
9. Study of Cut-Sections of 2 stroke and 4 stroke Petrol Engine.
th
4 Semester
PCBT4202
Module-I
Organization of Cell (Prokaryotic and Eukaryotic), Cell Wall & Cell Membrane, Cell Organelles (Plastid,
Golgibodies, Mitochondria, Ribosome), Nucleus, Cytoskeleton, Cell Cycle, Cell Divisions- Mitosis and
Meiosis, Molecular Organization of Chromosome (Nucleosome concept), Cell-cell signaling( G-protein
and Receptor mediated).
Module-II
(16Hr.)
Module-III
(12Hr.)
Quantitative Inheritance: Polygenes and Multiple alleles, Introduction to QTLs and its inheritance,
Detection of QTLs
Population Genetics: Hardy-Weinbergs law, Genetic Equilibrium, Changes in gene frequency, Genetic
Drift, Effect of evolutionary forces on genetic equilibrium of apopulation.
Developmental genetic with reference to Arabidopsis and Drosophilla.
Text Books
1. Theory & Problems in Molecular & Cell Biology, Stansfield, Tata McGraw Hill
2. The Cell Molecular approach, Geoffrey M. Cooper, ASM press Washington D.C. Sinauer Associates, Inc.
3. Principles of Genetics, Robert Tamarin, Tata McGraw Hill
4. Molecular Biology of Cell Alberts, Garland Science, Taylor & Francis Group.
6. Concept of Genetics by Klug.
7. Genetics, David R Hyde, Tata McGraw Hill.
Chemistry - II
BSCC1208
Module I
1.Water Technology: Hardness of Water : Types of hardness, Units of hardness and their interrelation,
Determination of hardness(EDTA method
technology
(internal
and
external
ion
exchange
methods
MODULE-II
1. Fuels: Classification of fuels, calorific value, (Determination by Dulongs formula),G.C.V&N.C.V
Liquid fuel: Classification of petroleum, Refining of petroleum , Cracking, Knocking and anti
knocking,cetane and octane numbers . Unleaded petrol, synthetic petrol, power alcohol
Gaseous Fuel : Producer gas, Water gas, LPG , CNG, Kerosene gas
Combustion Calculation.
2.Battery technology
Introduction, Batteries and cells, Basic components of battery, its Classification characteristics,Chemical
batteries(dry, Lead acid & gel batteries) Alkaline batteries(zinc-air,aluminium-air,Nickel metal hydride
battery) Reserve batteries(magnesium-copper,Gordan-magnesium battery) Nickel cadmium battery
Module III
1.POLYMER . Polymer: Types, polymerization process and mechanisms
Conducting polymers(poly aniline, poly acetylene),polymer composite(carbon fiber)
Preparation. Properties and uses of following polymer(polyethylene,PMMA,PTFE
Bakelite,polyurethanes,polycarbonate)
2 Nano materials
Nano material; Carbon nano tube,(synthesis, properties and application.) Application of nano material in
medicine, fuel cell, catalysis (only general idea)
Text Books:
1.Engineering chemistry by Putti R.vIjayasararhy ,PHI Ltd
2. Engineering chemistry by P.C jain and M. jain
Reference Books:
1. Engineering chemistry by N Krishnamurthy ,p vallinaygam, Dmadhavan, PHI Ltd
2. Engineering chemistry by mary,jane.shultz ,Cengage learning publication
3. Engineering chemistry by R.Gopalan,D.venkaapaya,and SNagarajan, Vikas publishing house.
Science
MODULE I
Text book:
1. Vijaya M. S., Rangarajan G, Materials Science, TMH
2.Introduction
to
Materials
science
for
engineers
James.F.shackelford,Madanapalli.k.Muralidhara ,Pearson(sixth edition)
Reference Book:
1. Rajendra V., Marikani A., Materials Science, TMH
2. Van Vlack L. H., Elements of Material Science and Engineering, Addison Wesley
3. Raghavan , Material Science
4. Callister W.D., Materials Science and Engineering, John Wiley & Sons.
5. Smith, Materials Science & Engineering.Mc. Graw Hill.
6. Processes and Material of manufacture : Lindberg, PHI.
by
BECS2208 Database
Management System
Module I :
(10 hours)
Database System Architecture - Data Abstraction, Data Independence, Data Definitions and
Data Manipulation Languages. Data models - Entity Relationship(ER), Mapping ER Model to
Relational Model, Network .Relational and Object Oriented Data Models, Integrity Constraints
and Data Manipulation Operations.
Module II :
(12 hours)
Relation Query Languages, Relational Algebra and Relational Calculus, SQL.
Relational Database Design: Domain and Data dependency, Armstrong's Axioms, Normal
Forms, Dependency Preservation, Lossless design.
Query Processing Strategy.
Module III:
(10 hours)
Transaction processing: Recovery and Concurrency Control. Locking and Timestamp based
Schedulers.
Database Recovery System: Types of Data Base failure & Types of Database Recovery,
Recovery techniques
Text Books:
1. Database System Concepts by Sudarshan, Korth (McGraw-Hill Education )
2. Fundamentals of Database System By Elmasari & Navathe- Pearson Education
References Books:
(1)
(2)
(3)
(4)
(5)
PCBT4203
Micro Biology
Module-II (16Hr.)
Microbial growth and metabolism: Pattern of bacterial growth, Growth kinetics, Monods Equation,
Synchronous Growth and its Kinetics, Continuous culture and its growth kinetics, Growth inhibitory
substances. Metabolism of carbohydrate in bacteria, Enerdoudorf,s pathway and glyoxalate pathway,
Energy transduction mechanism in bacteria, Cyanobacteria and nitrogen fixation, Anaerobic respiration.
Microbial genetics: Organization of bacterial and viral genome, Plasmids and Episomes, Genetic
recombination in bacteria (Transformation, Conjugation and Transduction), Genetic analysis in bacteria,
DNA repair mechanisms in bacteria, Transposons, Mutation in Microorganisms.
Module-III (14Hr.)
Food Microbiology: Microbiology of foods, Types of microbes associated with food spoilage, Food
preservation methods, Food poisioning, Microbiology of Milk and dairy products.
Medical Microbiology: disease causing bacteria, virus and fungi; Antimicrobial agents, Antibiotics,
Disinfectants and Vaccines
Environmental Microbiology: Microbiology of water, Microbiology of Air, Baceriological analysis of
water & water treatment, Microbiology of extreme environments (Halobacteria, Methanogens,
Thermofiles), Microbiology of sewage.
Text Books :
1. Text book of Microbiology by Stanier.
2. Microbiology, R.S. Mehrotra, Tata McGraw Hill
3. Microbiology by Pelczar
4. Brock Biology of micro-organisms
5. Microbiology by Presscort.
6. Microbial Genetics- Freifelder
7. Mol. Genetic of bacteria by R. Snyder
8. Microbiology by Atlas
9. Microbiology by Devis
PCBT4204
Molecular Biology
Module-II (10Hr.)
Transcription: Components of transcription machinery in prokaryotes and eukaryotes, Transcription
factors, Transcription process (Initiation, Elongation, Termination), Transcription factors, m-RNA
processing, Pre and Post transcriptional processing, Capping and poly (A) tailing, m-RNA stability, mRNA editing, Gene Silencing
Module-III (14Hr.)
Translation: Genetic code- the principle of translation, Translation machinery (t-RNA, Aminoacyl
synthetase, Ribosome), Translation process, Post translational modification of protein.
Regulation of Gene Expression: Constitutive and Induced gene expression, Regulation of gene expression
in prokaryotes and eukaryotes, Operon model (Lac-operon and Trp- operon), DNA methylation.
Molecular evolution (DNA based phylogenetic trees and its applications), Introduction to recombinant
DNA technology.
Books :
1. Text Book of Molecular Biology By Padmanabhan and Shastri.
2. MOLBIO Avinash & K. Upadhyaya, Himalaya Publishing House.
2. Mol. Biology. by Turner.
3. Mol. Biology of Gene Watson
4. Principles of Mol. Biology - OS Prim Rose
5. Recombinant DNA Technology Watson
6. Mol. Cell Biology. - Baltimore
BECS7208
1. Use of SQL syntax: insertion, deletion, join, updation using SQL. (1 class)
2. Programs on join statements and SQL queries including where clause. (1 class)
3. Programs on procedures and functions. (1 class)
4. Programs on database triggers. (1 class)
5. Programs on packages. (1 class)
6. Programs on data recovery using check point technique. (1 class)
7. Concurrency control problem using lock operations. (1 class)
8. Programs on ODBC using either VB or VC++. (1 class)
9. Programs on JDBC. (1 class)
10. Programs on embedded SQL using C / C++ as host language. (1 class)
PCBT7204
1. Chromosome preparation from onion root tip (Mitosis) & grasshopper testis (Meiosis).
2. Isolation, purification of DNA from plant sample and its yield estimation.
3. Isolation, purification of DNA from blood sample and its quantification using UV
spectrophotometer.
4. Isolation, purification of DNA from bacterial sample and its quality assessment using UV
spectrophotometry.
5. Isolation of plasmid DNA and estimation its size using agarose gel electrophoresis.
6. Effect of gel concentration on solidification and migration of DNA sample
7. Restriction digestion of supplied DNA sample and estimate the molecular weight of the
fragments resulted.
8. Elution of the DNA from the supplied gel and assess the integrity of the fragments.
9. Isolation and purification of RNA from plant/bacterial sample and its quantification using
UV spectrophotometer..
10. Isolation and purification of protein from the supplied sample and its quantification using
UV spectrophotometer.
PCBT7203
1. Micrometry: calibration of stage and ocular micrometer and measurement of microbial sample.
2. Staining of microbial sample ( Grams Staining, Capsule staining, Fungal staining)
3. Media preparation and sterilization (Slant, Stab and Broth culture)
4. Isolation of micro organisms from natural habitats (Air, Water, Soil & Milk)
5. Establishment of pure culture by streak plate and serial dilution method.
6. Study the bacterial growth curve using spectrophotometer and viability assessment.
7. Antibiotic assay and estimation of Zone of inhibition.
8. Chemical assay and MIC determination of antibiotics.
9. Biochemical assay of microorganisms (Starch Hydrolysis, Casein Hydrolysis and IMVIC test).
10. Microscopy: Study of Compound, Phase contrast and Fluorescence Microscopes.
*****************************************
th
6th Semester
Semester
Credit
Hrs
Credit
HSSM3304 Biostatistics
3-0-0
3-0-0
3-0-0
3-0-0
4-0-0
3-0-0
PECH5304
PCBM4302
PECS5304
PEIT5302
Subject
Total
Theory
Subject
Credit
Hrs
Credit
3-0-0
PCBT4304 Bioinformatics
3-0-0
4-0-0
3-0-0
3-0-0
3-0-0
Practical / Sessionals
19
Total
19
3
3
Practical / Sessionals
PCBT7303
PCBT7302
PCBT7301
Immunotechnology lab
Total
0-0-3
0-0-3
0-0-3
2
6
PCBT7306
PCBT7305
PCBT7304
Downstream process
Engineering & Enzyme tech.
lab
Plant Biotechnology &
Industrial Microbiology lab
Bioinformatics lab
Total
25
**Industrial / Institutional visit should be made ( at least one visit per semester)
0-0-3
0-0-3
0-0-3
2
6
25
Subjects
Basic Science
including
Math.
Humanities,
Social &
Mangt. Study
Engg. Sc., TA
& Comp.
Engg.
Professional
Core
Professional
Electives
Free Electives
Project
Seminar,
Vivavoce. &
Training
Total
1st
2nd
3rd
4th
5th
6th
7th
8th
Total
24
Recommended
as per
Dayaratnam
Committee.
25-30
27
25-30
17
17
47
30-35
15
16
13
59
45-55
10
23
25-30
3
3
3
2
2
3
8
3
9
10
5
20-25
10-15
5-10
28
28
27
26
23
204
25
25
22
PCBT4301IMMUNOLOGY
& IMMUNOTECHNOLOGY(3-0-0)
Module-I:
The origin of Immunology, types of immunity, humoral and cell mediated immunity, Primary
and secondary lymphoid organ, antigen, cells of immune system, immunoglobulin and
antibodies, Major Histocompatibility Complex (MHC)
Module-II:
Antigen processing and presentation, synthesis of antibody and secretion, Molecular basis
of Immunology, Molecular basis of antibody diversity, polyclonal and monoclonal antibody,
complement system, antigen-antibody reaction.
Module-III
Immune response and tolerance: Regulation of immune response, immune tolerance, hyper
sensitivity, autoimmunity; graft versus host reaction, Immuno- deficiency and immunoproliferate diseases. Dysfunctions of immune system and their modulation, Approaches for
correcting immune dysfunction, Vaccinology, Monoclonal antibody technology.
Text Books:
1. Immunology: Lydyard, P.M., Whelan, A., Fanger, M.W., 1st Ed., Viva Books.
2. Essential Immunology: Roitt, I.M., 9th Ed.(1997) Blackwell Scientific, Oxford, UK.
3. Immunology: Kuby, J. 3rd Ed. (1997) Freeman W. H., oxford.
4. Immunotechnology by A Khan, Pearson Publication
Reference:
1. Microbiology and Immunology by B K Patnaik, T.C. Kar, H.N. Thatoi, India-Tech publication. New
Delhi
PCBT4302 GENETIC
Module-I:
Basic principle of DNA isolation and purification; Restriction endonuclease, Ligase and other modifying
enzymes; DNA& RNA Markers, Linker, Adapter and MCS; Gene cloning vectors- Plasmid,
bacteriophage, cosmid, BAC, YAC; Expression vectors: basic concept, bacteria and yeast based
expression vector; Gene library- genomic and c-DNA, contig library; Polymerase Chain reaction, Blotting
techniques: Southern, Northern, Western, Dot and Slot; Nucleic acid hybridization;
Module-II:
Basic concept of gene cloning; Cloning of interacting gene: two hybrid and three hybrid assay; Cloning of
differentially expressed gene; DNA micro arrays and Chips- principle and manufacturing process; DNA
finger printing and DNA foot printing; DNA Sequencing; Site directed mutagenesis; Expression of
heterologous gene; In vitro transcription and translation; Gene knock out strategies; RNA interference:
Antisense RNA, si RNA and mi RNA; Ribozyme Technology.
Module-III:
Molecular markers- Types (RFLP, RAPD, AFLP, SCAR, SSR, SNP, EST), Principle and methodology;
Application of molecular markers: in diagnostics, gene tagging, gene mapping, Physical mapping, Map
based cloning of gene and cloning of QTLs.
Genome projects: Human, Rice; Gene therapy and its applications; DNA vaccines and rDNA products;
Genetic engineering regulations and safety guidelines.
Text Books:
1. H S Chawla, Plant Biotechnology, Oxford University Press
2. T A Brown, Gene cloning and DNA Analysis, Black well publishing
3. Primerose et al., Principle of gene manipulation and genomics, Black well publishing.
Reference
1. Sambrooks et al., Molecular cloning (Vol.I,II,II), CSH Press.
2. Spurr N & Young TD, ICRF Hand book of genome analysis, Blackwell
PCBT4303UPSTREAM
ENGINEERING
PECH5304 PROCESS
INSTRUMENTATION
(3-0-0)
Module - I
Basic concepts and qualities of measurement, Level measurement: Methods of
liquid level measurement, Direct methods, Hook-type level indicator, sight glass,
Float-type level indicator, Displacer level detectors, Indirect methods, Hydrostatic
pressure type, Pressure gauge method, Air bellows, Air purge system, Liquid purge
system, Electrical methods.
Module II
Flow Measurement: Methods of flow measurement, Inferential flow measurement,
Quantity flowmeters, Mass flowmeters, Calibration of flowmeters, Selection of
flowmeters.
Pressure measurement: Pressure, Methods of pressure measurement, Manometers,
Elastic pressure transducers, Measurement of vacuum, Force-balance pressure
gauges, Electrical pressure transducers, Pressure switches, Calibration of pressure
measuring instruments, Maintenance and repair of pressure measuring instruments,
Troubleshooting.
Module III
Temperature measurement: Temperature, Temperature scales, Methods of
temperature measurement, Expansion temperature, Filled-system thermometers,
Electrical temperature instruments. Pyrometers: Radiation and optical,
Methods of composition analysis: Spectroscopic analysis, Absorption spectroscopy,
Emission spectroscopy, Mass spectroscopy
Text books and References :
1. D. P. Eckman, Industrial Instrumentation, Wiley Eastern Ltd.
2. C. S. Rangan, G. R. Sarma and V. S. V. Mani, Instrumentation, Devices and
Systems, TMH.
3. J. P. Bentley, Principles of Measurement Systems, Longman
4. S.K.Singh, Industrial instrumentation and control, Tata Mc Graw-Hill.
PCBM4302 SIGNALS
Module I
(10 hours)
Discrete-Time Signals and Systems:
Discrete-Time Signals: Some Elementary Discrete-Time signals, Classification of
Discrete-Time Signals, Simple Manipulation; Discrete-Time Systems : Input-Output
Description, Block Diagram Representation, Classification, Interconnection; Analysis
of Discrete-Time LTI Systems: Techniques, Response of LTI Systems, Properties of
Convolution, Causal LTI Systems, Stability of LTI Systems; Discrete-Time Systems
Described by Difference Equations; Implementation of Discrete-Time Systems;
Correlation of Discrete-Time Signals: Crosscorrelation and Autocorrelation
Sequences, Properties.
Selected portions from Chapter 2 (2.1, 2.2, 2.3.1, 2.3.3, 2.3.4, 2.3.5, 2.3.6, 2.4, 2.5,
2.6.1, 2.6.2) of Textbook I
Properties of Continuous-Time Systems:
Block Diagram and System Terminology, System Properties: Homogeneity, Time
Invariance, Additivity, Linearity and Superposition, Stability, Causality.
Selected portions from Chapter 4 (4.2, 4.4) of Textbook II
Module II
(12 hours)
The Continuous-Time Fourier Series:
Basic Concepts and Development of the Fourier Series, Calculation of the Fourier
Series, Properties of the Fourier Series.
Selected portions from Chapter 8 (8.3, 8.4, 8.7) of Textbook II
The Continuous-Time Fourier Transform:
Basic Concepts and Development of the Fourier Transform, Properties of the
Continuous-Time Fourier Transform.
Selected portions from Chapter 10 (10.3, 10.6) of Textbook II
Module- III
(13 hours)
The Z-Transform and Its Application to the Analysis of LTI Systems:
The Z-Transform: The Direct Z-Transform, The Inverse Z-Transform; Properties of
the Z-Transform; Rational Z-Transforms: Poles and Zeros, Pole Location and TimeDomain Behavior for Causal Signals, The System Function of a Linear TimeInvariant System; Inversion of the Z-Transforms: The Inversion of the Z-Transform
by Power Series Expansion, The Inversion of the Z-Transform by Partial-Fraction
Expansion; The One-sided Z-Transform: Definition and Properties, Solution of
Difference Equations.
Selected portions from Chapter 3 (3.1, 3.2, 3.3, 3.4.2, 3.4.3, 3.6.1, 3.6.2) of
Textbook I : The Discrete Fourier Transform: Its Properties and Applications:
Frequency Domain Sampling: The Discrete Fourier Transform; Properties of the
DFT: Periodicity, Linearity, and Symmetry Properties, Multiplication of Two DFTs
and Circular Convolution, Additional DFT Properties.
Selected portion from Chapter 7 (7.1.2, 7.2.1, 7.2.2, 7.2.3) of Textbook 1.
Text Books:
1.
Digital Signal Processing Principles, Algorithms and Applications by J. G. Proakis and D. G.
Manolakis, 4th Edition, Pearson.
2.
Fundamentals of Signals and Systems - M. J. Roberts, TMH
Reference Book:
1.
Signals and Systems - P. R. Rao, TMH.
2.
Signals and Systems A Nagoor Kani, TMH
3.
Signals and Systems by Chi-Tsong Chen, Oxford
4.
Principles of Signal Processing and Linear Systems, by B.P. Lathi, Oxford.
5.
Principles of Linear Systems and Signals, by B.p. Lathi, Oxford
PECS5304 THEORY
OF COMPUTATION
(3-0-0)
Module I
10 Hrs
Alphabet, languages and grammars. Production rules and derivation of languages.
Chomsky hierarchy of languages. Regular grammars, regular expressions and finite
automata (deterministic and nondeterministic). Closure and decision properties of
regular sets. Pumping lemma of regular sets. Minimization of finite automata. Left
and right linear grammars.
Module II
12 Hrs
Context free grammars and pushdown automata. Chomsky and Griebach normal
forms. Parse trees, Cook, Younger, Kasami, and Early's parsing algorithms.
Ambiguity and properties of context free languages. Pumping lemma, Ogden's
lemma, Parikh's theorem. Deterministic pushdown automata, closure properties of
deterministic context free languages.
Module III
14 Hrs
Turing machines and variation of Turing machine model, Turing computability , Type
0 languages. Linear bounded automata and context sensitive languages. Primitive
recursive functions. Cantor and Godel numbering. Ackermann's function, murecursive functions, recursiveness of Ackermann and Turing computable functions.
Church Turing hypothesis. Recursive and recursively enumerable sets.. Universal
Turing machine and undecidable problems. Undecidability of Post correspondence
problem. Valid and invalid computations of Turing machines and some undecidable
properties of context free language problems. Time complexity class P, class NP,
NP completeness.
Text Books:
1. Introduction to the theory of computation: Michael Sipser, Cengage Learning
2. Introduction to Automata Theory, Languages and Computation: J.E. Hopcroft and J.D
Ullman, Pearson
Education, 3rd Edition.
3. Introduction to Computer Theory: Daniel I.A. Cohen, Willey India, 2nd Edition.
Reference Books:
1. Introduction to Languages and the Theory of Computation: Martin, TMH, 3rd Ed.
2. Introduction to Formal Languages, Automata Theory and Computation: K. Kirthivasan,
Rama R, Pearson Education.
3. Theory of computer Science (Automata Language & computations) K.L. Mishra N.
Chandrashekhar, PHI.
4. Elements of Theory of Computation: Lewis, PHI
PEIT5302 DATA
Module - I
12 Hours
Overview: Data warehousing, The compelling need for data warehousing, the
Building blocks of data warehouse, data warehouses and data marts, overview of
the components, metadata in the data warehouse, trends In data warehousing,
emergence of standards, OLAP, web enabled data warehouse, Introduction to the
data warehouse project, understanding data warehousing Architecture, Data
warehousing implementation, from data warehousing to data mining.
Module - II
14 Hours
10 Hours
PCBT7303 UPSTREAM
construction of
friction factor against NRe.
2. Experiments on flow measuring devices - in closed conduit using (a) Venturimeter,
(b) Orifice meter (c) Rotameter.
3. Study and verification of conservation of energy of a flowing liquid in a Bernoullis
apparatus.
4. Determination of Pressure drop for flow through packed bed & verification of Ergun
Equation, Kozeny-Karman equation, Blake-Plummer Equation.
5. To Determine the Overall heat transfer coefficient of a concentric pipe heat
exchanger based on the inside diameter of the tube.
6. To calculate the heat loss in a lagged pipe made of various insulating materials.
7. Determination of volumetric mass transfer coefficient (Kla) of gas-liquid system.
8. Determination of mixing time in stirred tank reactor.
9. To determine the coefficient of absorption/adsorption in packed bed columns.
10. To separate the solute from one phase to another (aqueous to solvent) phase by
liquid-liquid extraction.
PCBT7302 r-DNA
PCBT7301 Immunotechnology
lab(0-0-2)
6th Semester
HSSM3303
Module I:
Ecological Concepts: Biotic components, Ecosystem Process: Energy, Food Chain, Water cycle, Oxygen
cycle, Nitrogen cycle etc., Environmental gradients, Tolerance levels of environment factor, EU, US and
Indian Environmental Law. Chemistry in Environmental Engineering: Atmospheric chemistry, Soil
chemistry. Noise pollution- Noise standards, measurement and control. Water Treatment: water quality
standards and parameters, Ground water. Water treatment processes, Pre-treatment of water,
Conventional process, Advanced water treatment process.
Module II:
Waste Water Treatment: DO and BOD of Waste water treatment process, pretreatment, primary and
secondary treatment of waste water, Activated sludge treatment: Anaerobic digestion, Reactor
configurations and methane production.
Air Pollution : Air pollution and pollutants, criteria pollutants, Acid deposition, Global climate change
greenhouse gases, non-criteria pollutants, air pollution meteorology, Atmospheric dispersion. Industrial
Air Emission Control. Flue gas desulphurization, NOx removal, Fugitive emissions.
Solid waste, Hazardous waste management, Solid Waste Management, Source classification and
composition of MSW: Separation, storage and transportation, Reuse and recycling, Waste Minimization
Techniques. Hazardous Waste Management, Hazardous waste and their generation, Transportation and
treatment: Incinerators, Inorganic waste treatment. E.I.A., Environmental auditing,
Module III:
Occupational Safety and Health Acts, Safety procedures, Type of Accidents, Chemical and Heat Burns,
Prevention of Accidents involving Hazardous substances, Human error and Hazard Analysis. Hazard
Control Measures in integratednsteel industry, Petroleum Refinery, L.P.G. Bottling, Pharmaceutical
industry. Fire Prevention Detection, Extinguishing Fire, Electrical Safety, Product Safety. Safety
Management- Safety Handling and Storage of Hazardous Materials, Corrosive Substances, Gas
Cylinders, Hydro Carbons and Wastes. Personal Protective Equipments.
Text Book
1. Environmental Engineering, Irwin/ McGraw Hill International Edition, 1997, G. Kiely,
2. Environmental Engineering by Prof B.K. Mohapatra, Seven Seas Publication, Cuttack
3. Industrial Safety Management, L. M. Deshmukh, Tata McGraw Hill Publication.
Reference
1. Environmental Engineering by Arcadio P. Sincero & Gergoria A. Sincero PHI Publication
2. Principles of Environmental Engineering and Science, M. L. Davis and S. J. Masen, McGraw 3. Hill
International Edition, 2004
4. Environmental Science, Curringham & Saigo, TMH,
5. Man and Environment by Dash & Mishra
6. An Introduction to Environmental Engineering and Science by Gilbert M. Masters & Wendell P. Ela PHI Publication.
7. Industrial Safety Management and Technology, Colling. D A Prentice Hall, New Delhi.
PCBT4304
BIOINFORMATICS (3-0-0)
Module-I:
Searching Biological Data From databases: Finding the information stored and its retrieval methods at
NCBI, EMBL and DDBJ, Protein Data Bank(PDB), NDB, CCSD, PIR, Swiss Prot, EMBL, Pfam, EST,
SNP, Metabolic pathways databases, EMP, KEGG, MetaCyc, structural databases: SCOP, CATH
,Retrieving microbial and viral genome information.
Module-II:
Sequence alignment and analysis: Fast Alignment methods: Genome Comparison and Database
Searching, Local and global alignment and application in determining gene and protein families,
statistics of local alignment, Multiple sequence alignment and dynamic programming, Sequence profile
and HMM, Basic algorithms for prediction of ORF, promoters, splice sites, UTRs Sequence variation and
molecular evolution :significance of Ka/Ks.
Module-III:
Molecular modelling and drug design: Computational tools and Techniques: Homology modelling,
Molecular mechanics and force fields, molecular dynamics simulation, Docking methods, Drug design
Process, drug like Property of a molecule, target identification, Drug design process for a known and
unknown target. Basic idea about Molecular descriptors and QSAR analysis.
Text Books:
1. Mount DW, Bioinformatics: Sequence and Genome Analysis, Spring Harbor Press
2. Arthur Lesk, Introduction to Bioinformatics, Oxford University Press.
3. Baxevanis AS and Ouellette BF, Bioinformatics: A Practical Guide to the Analysis of Genes and
Proteins, Wiley International Science.
4. Bryan Bergeron, Bioinformatics computing, Prentice Hall Inc
5. Bernhard houbold ,Thomas Wiehe,Introduction to computational biology : an evolutionary approach
Blkhauser verlag press
Reference:
1. Tao Jiang, Ying Xu, Michael Q. Zhang, Current Topics in Computational Molecular Biology, MIT press.
2. Thomas lengauer,Bioinformatics from genome to drug .WILLEY-VCH press.
PCBT4307
Module-I:
Microbial Processes and fermentation technology: Introduction to fermentation technology, Microbial
growth and product formation kinetics in batch, continuous and feed batch fermentation, Large scale
production: submerged, solid and semi-solid fermentation, Microbiological processes for production of
organic acids; solvents; antibiotics, enzymes, polysaccharides; lipids; pigments and aroma.
Module-II:
Commercial media and strain development: Media selection and development for industrial production,
Isolation, selection, characterization of microorganisms, stock culture, development inocula, strain
improvement: induced mutation, over producing decontrolled mutants, genetically engineered strain and
fermentation.
Module-III:
Stability of enzyme: Enzyme stabilization by selection and genetic engineering, protein engineering.
Application of enzymes in industry, analytical purpose and medical therapy. Application of Biocatalyst,
Group transfer redox, Elimination, isomarization and rearrengement, C-C bond cleavage, Reaction
environment rebuilding, chemical modification, intramolecular cross linking and immobilization.
Text Books
1. Principle of Fermentation Technology , P.F. Stanbury, A. Whitaker and S.J. Hall, Elsevier
2. Industrial Microbilogy, Prescot and Dunn,
3. Biochemical Engineering and Biotechnology Handbook, Atkinson, B and Marituna, F., The Nature
Press, Macmillan Publ. Ltd.
4. Biochemical Engineering Fundamentals, Bailey & Olis. MGH.
PCBT4305 PLANT
BIOTECHNOLOGY (3-0-0)
PCBT4306 DOWNSTREAM
Module -I:
Introduction; An overview of bioseparation. Separation of cells and other insolubles from
fermented broth. Filtration and microfiltration, centrifugation (batch, continuous, basket). Cell
disruption: Physical methods (osmotic shock, grinding with abrasives, solid shear, liquid shear),
Chemical methods (alkali, detergents), Enzymatic methods
Module -II:
Ultra-filtration: Semipermeable membranes, membrane geometry and ultrafiltration module
configuration. Chromatography: Adsorption chromatography, Ion- exchange, gel-filtration, affinity,
high pressure / performance liquid chromatography (HPLC), hydrophobic chromatography.
Reverse phase (RP) and thin layer chromatography (TLC).
Module-III:
Separation of soluble bio-products: Liquid-liquid extraction, aqueous two-phase extraction,
precipitation, adsorption. Other bioseparation techniques like Dialysis, electro-dialysis, Liquid
Electrophoresis.roducts polishing : Crystallization and drying.
Text Books:
1.
M.R. Ladisch, Bioseparations Engineering, Wiley Interscience 2001
2.
Kennedy and Cabral, Recovery processes for biological materials.
3.
Heinemann, Product Recovery in Bioprocess Technology, Butterworth Publication.
4.
Roger G. Harrison, Paul W. Todd, Scott R. Rudge, and Demetri Petrides, Bioseparations
Science and Engineering, Oxford University Press, USA (October 31, 2002)
PEBT5303
BIOMATERIALS (3-0-0)
Module-I:
Introduction to biomaterials, Structure and properties (mechanical, thermal, optical,
electrical and surface) of biomaterials, Synthetic polymer, Biopolymer
Module-II
Novel Biomaterials and uses in engineering and tissue engineering: Hydrogels, selfassembling peptides. Implants materials: metallic implant materials, stainless steels, Cobased alloys, Ti-based alloys; ceramic implant materials, aluminum oxides,
hydroxyapatite glass ceramics carbons. Polymeric implant, Polymers for drug delivery:
types of polymer, pharmaceutical polymers, physicochemical properties of polymers and
relationship with structure, properties, kinetics, mechanisms and applications.
Module- III:
Biocompatibility and blood compatibility, Biomaterials: its foreign body response in a
body. Biological interface, interaction with biomaterials and adhesion, Biological response
to implants, 2D and 3D matrices (scaffolds) of biomaterials for tissue engineering, Soft
tissue and hard tissue replacement, cardiovascular implants, Biomaterials for
ophthalmology, orthopaedic and dental implants, Biologically functional biomaterials,
Testing and clearance of biomaterials, Evaluation of biomaterials.
Text Books
1. Buddy D. Ratner Allan S. Hoffman Frederick J. Schoen Jack E. Lemons. Biomaterials
Science, Second Edition: Wiley Science 2004.
2. Bhatt SV, Biomaterial, Narosa publishing house
3. Park J and R. S. Lakes R S, Biomaterials: An Introduction, Springer 2009
PEBT5302
Module-I:
Introduction to Molecular Modelling and its applications Biomolecular modeling problems:
protein folding, protein misfolding, nucleic acid/ protein interactions, and RNA folding.
Basic concepts of quantum mechanics, ab initio, semi-empirical and density functional
theory calculations, Molecular size versus accuracy. Approximate molecular orbital
theories. Molecular mechanisms, energy calculations, Bond stretch, Angle bending,
torsional terms, Electrostatic interaction- Van der waals interactions. Miscellaneous
interactions.
Module-II:
Introductionto molecular dynamics and simulations; Molecular Dynamics using simple
models; Dynamics with continuous potentials, Constant temperature and constant
dynamics; Conformation searching and systematic search; Monte-carlo simulation of
biomolecules and bio-polymers.
Comparative modeling of protein: by homology- the alignment, construction of frame work,
selecting variable regions, side chain placement and refinement, validation of protein
models Ramchandran plot, threading and ab initio modeling.
Module-III:
Analog based drug designing : Introduction to QSAR. lead module, linear and nonlinear
modeled equations, biological activities, physicochemical parameter and molecular
descriptors, molecular modelling in drug discovery.
Structure based drug designing: 3D pharmacophores, molecular docking, De novo Ligand
design, Free energies and solvation, electrostatic and non-electrostatic contribution to free
energies. 3D data base searching and virtual screening, Sources of data, molecular
similarity and disimilarity searching, combinatorial libraries generation and utility.
Text Book:
1. A R Leach, Principles and applications of modeling, Prentice Hall.
2. Hans Pieter, Heltje & Gerd Folkens, Molecular Modelling, VCH.
References:
1. Jonathan Good man, Chemical Applications of Molecular Modelling, Cambridge Press
PEBT5301
NANOBIOTECHNOLOGY (3-0-0)
Module-I
Introduction to Nanosciences and Nanotechnologies. Exploration of biology and biological systems,
biology at the nano-interface. Cell nano structure interaction.
Module-II
Structural and functional principles of nanobiotechnology. Protein and DNA based nanostructures.
Microbial synthesis of nanoparticles, magnetosomes, bacteriorhodopsin. Micro- and nano -fabrication;
Micromachining: MEMS
NEMS; BioMEMS; Scanning probe techniques (SPM). Molecular
nanotechnology. Carbon nanotubes, nanoparticles and nanowires. Polymeric nanocontainers for drug
delivery.
Module-III
Microfabricated devices to study directed cell migration, drug and gene delivery, Nano-particles and
imaging applications, Nanoanalysis and nanobiosensors; Lab-on-a-chip devices and their potential in
nanobiotechnology.
Text Book:
1. Niemeyer C M and Mirkin C A, Nanobiotechnology: Concepts, Applications and Perspectives, Wiley
VCH, 2004
2. Chattopadhyaya KK and Banerjee AN, Nanoscience and Nanotechnology, PHI learning Pvt. Ltd.
PCBT7306
Downstream Processing:
1. Harvesting cells using filtration or centrifugation techniques, identification of extracellular
products (enzyme / poly saccharide / some other traceable element) from fermentation broth or
shake-flask culture broth.
2. Cell disruption by homogenizers, osmotic shock, sonication and French press.
3. Protein fractionation using precipitation/solvent extraction techniques.
4. Protein fractionation using chromatography (gel filtration and ion-exchange)
5. Separation of proteins and DNA using affinity chromatography
Enzyme technology laboratory:
1. Enzyme assay techniques (e.g Alkalne phosphatase / Amylase / Invertase /
dehydrogenases) using whole cells and/ or purified enzyme; Kinetic studies and determination of
Km and Vmax
2. Effect of inhibitors on enzyme kinetics
3. Immobilization of cells and enzymes using different matrices (PVA, alginate, etc.)
4. Application of immobilized cells and enzymes in batch and continuous stirred tank reactors.
5. Biotransformation reaction using whole cell and/or enzyme(s).
PCBT7305 PLANT
Plant Biotechnology
1. Media preparation, sterilization, explant preparation and establishment of meristem culture
2. Study of organogenesis and multiple shoot generation
3. Somatic embryogenesis in carrot and encapsulation somatic embryo or PLBs
4. Anther culture of Datura
5. Establishment of suspension culture
6. Agrobacterium mediated transformation (Co-cultivation & GUS expression)Industrial Microbiology
1. Preparation of starter culture of yeast in grape juice
2. Submerged fermentation in single-culture, co-culture condition
3. Production and optimization microbial metabolites (Ethanol or Citric acid) and study of fermentation
kinetics
4. Analysis of alcohol or citric acid by spectrophotometric method and gravimetric method.
5. Fermenter operation and study of product formation by batch culture.
PCBT7304 BIOINFORMATICS
LAB (0-0-3)
1. Retrieving Human genome data, OMIM, SNP databases to understand genetic and metabolic
disorders. (At least 2 each)
2. Mining genomic data to identify genomic features: codon usage, repeats, Homologous sequences etc.
3. Making Phylogenetic tree of given sequences by using ClustalW and PHYLIP.
4. Gene and promoter prediction for Prokaryotes and eukaryotes (comparative analysis by using different
tools: at least 3)
5. Learning about molecule visualisation software like Rasmol, Pymol etc.
6. Primary Structural databases: pdb, ndb, ccsd and Derived databases of structures: DSSP, FSSP,
CATH & SCOP.
7. Prediction of secondary structures of proteins: at least 3 methods
8. Prediction of Tertiary structure of proteins and Validation of model protein structure: Energy
minimization, Procheck, verify 3D, Prosa II, ERRAT etc.
9. Molecule drawing. Conversion of 2D structure to 3D structure.
10. Molecular docking and analysis of receptor with ligand
**************
Credit
Hrs
Credit
3-0-0
3-0-0
Professional Elective
PEBT5401 Protein Engineering.
3-0-0
3-0-0
3-0-0
3-0-0
PECS5401
PEEC5416
Subject
8th Semester
Subject
Credit Credit
Hrs
3-0-0
3-0-0
3-0-0
3-0-0
Free Electives-III
PECS5410 Algorithms in Bioinformatics
PECE5404 Process Simulation & Modeling
12
Total
Total
Practical
Theory
18
PCBT7401
Minor Project
0-0-2
PCBT7403
Major Project
0-0-6
PCBT7402
0-0-2
PCBT7404
PCBT7405
Entrepreneurship project
Comprehensive Viva
0-0-2
0-0-3
2
3
Total
Total
4
11
22
23
ELISA and hybridoma technology, Use of enzymes in clinical diagnosis, Use of biosensors
for rapid clinical analysis, Diagnostic kit development for microanalysis, Genetic diseases
and DNA based diagnoses, DNA vaccine, Gene Therapy, Toxicogenomics
Module III
Text Books
1. Balasubramanian, Bryce, Dharmalingam, Green and Jayaraman(ed), Concepts in
Biotechnology, University Press, 1996
2. Epenetos A.A.(ed), Monoclonal antibodies: applications in clinical oncology, Chapman and
Hall Medical, London
3. Text book of industrial pharmacy by S R Hiremath, Orient Black Swan publication
ARTIFICIAL INTELLIGENCE
Module 1
What is Artificial Intelligence? AI Technique, Level of the Model,Problem Spaces, and
Search: Defining the Problem as a State Space Search, Production Systems, Problem
Characteristics, Production System Characteristics, Issues in the Design of Search
Programs.Heuristic Search Techniques: Generate-and-Test, Hill Climbing, Best-first Search,
Problem
Reduction,
Constraint
Satisfaction,
Means-ends
Analysis,Knowledge
Representation: Representations and Mappings, Approaches to Knowledge
Representation, Using Predicate Logic: Representing Simple Facts in Logic, Representing
Instance and ISA Relationships, Computable Functions and Predicates, Resolution, Natural
Deduction.Using Rules: Procedural Versus Declarative Knowledge, Logic Programming,
Forward Versus Backward Reasoning, Matching, Control Knowledge.Symbolic Reasoning
Under Uncertainty: Introduction to Nonmonotonic Reasoning, Logics for Nonmonotonic
Reasoning, Implementation Issues, Augmenting a Problem-solver, Depth-first Search,
Breadth-first Search.Weak and Strong Slot-and-Filler Structures: Semantic Nets, Frames,
Conceptual DependencyScripts, CYC.
Module 2
Game Playing: The Minimax Search Procedure, Adding Alpha-beta Cutoffs, Iterative
Deepening. Planning: The Blocks World, Components of a Planning System, Goal Stack
Planning, Nonlinear Planning Using Constraint Posting, Hierarchical PlanningOther Planning
Techniques.Understanding: What is Understanding, What Makes Understanding Hard?,
Understanding as Constraint Satisfaction.Natural Language Processing: Introduction,
Syntactic Processing, Semantic Analysis, Discourse and Pragmatic Processing, Statistical
Natural Language Processing, Spell Checking.
Module 3
Learning: Rote Learning, Learning by Taking Advice, Learning in Problem-solving, Learning
from Examples: Induction, Explanation-based Learning, Discovery, Analogy, Formal Learning
Theory, Neural Net Learning and Genetic Learning. Expert Systems: Representing and
Using Domain Knowledge, Expert System Shells, Explanation, Knowledge Acquisition.
Text Book:
1. Elaine Rich, Kevin Knight, & Shivashankar B Nair, Artificial Intelligence, McGraw Hill, 3rd
ed.,2009
References:
1. Introduction to Artificial Intelligence & Expert Systems, Dan W Patterson, PHI.,2010
2. S Kaushik, Artificial Intelligence, Cengage Learning, 1st ed.2011
BIOMEDICAL INSTRUMENTATION
Module I
(10 Hours)
(13 Hours)
(14 Hours)
1.
2.
Reference Books:
1.
8th Semester
MARKETING MANAGEMENT (3-0-0)
Objective of the Course: The course aims at introducing the basic concepts of marketing to
the undergraduate students in engineering. The learning shall help the students in better
designing, manufacturing and selling product/ service packages keeping competitive market,
customers and cost in view.
Module -I
(10 hours)
Marketing Management: Concept, Process, Functions and relevance in the current context.
Marketing Environment: Elements of micro and macro environment
Competition Analysis: Factors contributing to competition, porters five forces model,
Identifying and analyzing competitors.
Marketing Planning : Exploring Opportunity, Product market selection, Marketing Planning
Process.
Market Research and Information Systems: Research Process, The Internet and World Wide
Web based Information collection and processing, Database, Data Warehouses and Data
Mining, Global Market Research.
Consumer Behavior: Factors influencing consumer behavior, consumer decision process.
Organizational buying behavior.
Module- II
(10 hours)
Market Segmentation, Targeting and Positioning: Definition, Bases of segmenting consumer
and Industrial markets. Target Market strategies: Market Positioning.
Market Demand Forecasting: Key Terms, Forecasting Tools: Short term tools: Moving
average and Exponential smoothing methods, Long-term forecasting Tools: Time series
analysis, Econometrics methods, Qualitative tools : Buying Intention Survey, Sales Force
Opinion and Delphi Techniques.
Product Planning : Product Life Cycle, New Product Development Process, Branding
Strategy, Positioning a Brand, Brand Equity, Packaging and Labeling, Product-mix and
Product Line, Planned Obsolescence.
Module - III
(10 hours)
Pricing Decision: Objectives and Factors influencing pricing, Pricing method and strategies.
Integrated Marketing Communication(IMC)- Concept of IMC, the marketing communication
process, Promotion Mix, elements of promotion mix, Direct marketing.
Channels of Distributions: Types of intermediaries, functions of distribution channels, channel
levels, Designing Distribution Channels, Physical Distribution, Supply Chain Management
(Basic only).
Trends in Marketing: Green Marketing, Customer Relationship Management, E-marketing,
Rural Marketing and Service Marketing (concepts only)
Books:
Text Book:
1. Etzel , Walker ,Stanton and Pandit, Marketing, 14/e, Tata McGraw Hill.
2. Saxena, Marketing Management Tata McGraw Hill, 4/e.
Reference
1. Grewal, Levy, Marketing Tata McGraw Hill, special Indian edition.
2. Karunakaran Marketing Management, Himalaya Publishing House, 2010/e.
3. Kotler, Keller,Koshy and Jha, Marketing Management, 13/e, Pearson Education.
ALGORITHMS IN BIOINFORMATICS
Module 1
(3-0-0)
Module I
Modeling: Fundamentals of mathematical models and formulation Continuity equation,
Equation of motion, Transport equations, Energy equation, Equations of state, Equilibrium,
Chemical kinetics and their applications; Lumped and distributed parameter models Fluid
systems, C.S.T.R. (single, series, isothermal, constant hold up, variable hold up, gas phase
pressurized and non-isothermal), Single component vaporizer, Multi-component flash drum,
Batch reactor, Reactor with mass transfer, Ideal binary distillation column, Batch distillation,
Heat exchanger, etc;
Module II
Optimization: Single variable optimization (analytical, dichotomous search, fibonacci, golden
section, regula falsi), Multivariable optimization (analytical, geometric programming, linear
programming), Convergence methods (Newtons methods, direct substitution, Wegsteins
method).
Module III
Simulation:; Techniques of digital simulation Information flow, from process to information
flow diagram, From information flow diagram to numerical form, Recycles, Calculation of a
recycle set, etc.
Essential Reading:
1. W. L. Luyben, Process Modelling, Simulation and Control for Chemical Engineers,
McGraw Hill, 1990.
Suggested Readings:
1.
B. V. Babu, Process Plant Simulation, Oxford University Press, 2004.
2.
S. S. Rao, Engineering Optimization: Theory and practice, New Age Publishers,
1999.
3.
A. Hussain and K. Gangaiah, Optimisation Techniques for Chemical Engineers,
Macmillan, 2001.
4.
B. W. Bequette, Process Control: Modeling, Design and Simulation. Prentice-Hall
India, 2006.
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