Pharmacology Review

June 2, 2014
Q1: 57 Year old man presents steady colicky pain in right
hypochondrium nausea vomiting and temperature of 102. Lab WBC
13,400. USG obstructed cystic duct which of the following agents
would be drug of choice for treatment of patients pain?
Meperidine: Pain Killed Biliary Colic
Meperidine: least side effect
Q2: 28 YOF Rehab Center Memphetamine Abuse. Drug
counselor starting taking it to get high. Which MOA
responsible for reinforcing methamphetamine?
Memphetmaine : Induces Dopamine release*
Cocaine**
Q3: Benzos used as preanasthetic medication in cirrhosis of liver
without fear CNS depression because the drug is.
Benzo is Conjugated Extrahepatically
Other: LOTS Loxazepam Ozaxepam T..pam S Pam all
extrahepatic conjugation
Q4: OD on Benzodiazapene what is the treatment?
Flumenazil overdoses
Q5: Valproac Acid in children particular side effect seen?
Valproic Acid used in Migraine Headache, Bipolar Disorders
Children side effect: Hepatitis
Q6: Anasthesiologist include sevoflurane in protocols. Recovery from
anasthesisa with sevofluorane is associated with?
Low blood gas coefficient: short time to induce anesthesia short time
to finish in blood
SevoFluorane: Low Blood-Gas Partition Coefficient means
Rapid Recovery

Q7: 7 YOF reported 2nd grade teacher staring spell 5-10 sec.
Which treatment?
Absence Seizure: Ethosuximide- blocks high amplitude low threshold
ca2+ channel
Q8: FSH LH used for infertility due to pituitary insufficiency. SE of GN
administration include?
FSH LH stimulation side effect: Ovarian Enlargement + Rupture
Q9: Thryoid prep for maintenance replacement therapy is
which of following drugs?
LEVOTHYROXINE: synthroid for maintenance therapy
Q10: Excess hair growth and swelling of legs. What is drug X?
Metapyrone: extra hair growth: ACTH Antagonist
Q11: 72 YOM treated leuprolide. MOA of drug?
Synthetic analog GnRH
GnRH decrease FSH and LHdecrease estrogen progesterone
Q 13: 68 YOM pill rolling remor. Which drug inhibits metabolism that is
deficient in patient?
Inhibit the dopamine metabolismSelegiline: MAO inhibitor
Tocapone+Ecapone: COMT Inhibitor
Q 14: DMII treated glyburide + metformin comes to your office
frequent hypoglycemia. Replace Glyburide with GLP2 analogue less
likely to produce hypoglycermia. More likely to produce weight loss.
Which drug most likely prescribed?
Exenatide: GLP 1
Q 15: 8 YO Child eosinophilia. Roundworms Ascarias Lumbricoids. Most
effective treatment?
Asc. Lumbricoids: Albendazole

Q 16: Progestin receptor antagonist.

Mifespristone: Progestin Antagonist
Misoprostone: Prostaglandin Analog also used abortificient*
dont confuse
Q 17: 63 DMII Malaise Myalgia Respiratory Distress
Metformin: Lactic Acidosis
Metformin HCO3 goes down pH= 7.27
Lactic acidosis
Q 18: 64 YOM BPH prescribed 5a reductase prostrate. Which
has been prescribed to him?
Finasteride
Q 19: Diabetic patient developed severe hypoglycemia lapse
unconscious state. Other IV 50% Dextrose a recommended
treatment would be?
DM II Patient Shock: Glucagon Administer + Dextrose
Q 20: 61 YOM frequent urination thirst fatigue DM II. Treatment
contraindicated impaired renal function and drug failure.
Glitazone: Heart + Kidney Side Effects
Sensitize Tissue Peripheral more receptive to Insulin
moa: SAR site induce hyperpolarization
Q 21:
Urine: Calcium PotassiumVolumeIncrease
BloodpH:Increase
LoopDiuretic:Furosemide
Q22:NEincreaseBPnowBPnolongerincreasingthinka1blocker
Labetolol:Alpha1Blocker
Q23:55YOWgraphingcoronaryvessels,overnightdevelopsHTN.Administer
doseMilirinine.ResultisincreaseofCO.WhichbestdescribesMOAaction
MILRINONE:InhibitsPDE3

Sildenafil:InhibitsPDE5
Theophylline:InhibitsPhosphodiesterase

Q24:VariousANSBPfrombaselineresponseidentifydrugX.
Phentolamine
Q25:Ondansetronadministedanhourbeforeendofsurgery.Likelyreasonfor
givingondansterontopatient?
PreventPostOpNausea+Vomitting
Q26:42YOMchangingfacialfeatures,mandibleandwidespacedteethGHHigh
Acromegalyr/xOctreotride
Q27:30YOMpresentdrugXdilateseye.
Anticholinergic:Tropicamide
Alpha1dilateseye
Q28:Manpresentstachycardia.
AFIBTreatment:Amiodarone+Warfarin
AFibRecognize*
UnstablePatient:Pulse,ColdClammy,Hypotension:SynchronizedCardioversion
Adenosine:SVT
Q29:61YOMdrugshiftscharttorightK+Channelonlyaffected:
ClassIV:Bretylium
IA:movesredlinetored
procainamidequinidine
Decreasevmax
IncreaseAPD
Bothsodiumpotassiumchannel

IB:movesredlineleft:
APDdecrease:

lidocaine*onlyconditionlineisbefore

IC:VmaxMostEffect
fleci+mori
ARPunchanged
mosteffectNa+channel
Kchannel:increase
amiodaronebretyliumsotalol
Sotalol:impotence,headache,depression,carefulasthmatic
Amiodarone:SmurfSkin
Q30:Womenthickenedgumssincenewmedication.Whichanticonvulsant
medicationislikelyresponsible?
Phenytoin:preventsactivechannelfrominactivechannel
Q31:AntiarrythmicblocksK+channelandBBlocker
Sotalol
Q32:67YOMUnstableConfusion,Dizziness,AlteredMentalStatus,BP83/56
Pulse:140AVNodalReentrantTachycardia.Beststepmanagement?
SynchronizedCardioversion
Q33:57YOMAntiArrythmicDrugLidocaine.Whichbestdescribesthis
medication.
Lidocaineworksonischemicareasintheheart.
Q34:55YOMAFib.HemodynamicallyUnstableWhichisbestmanagement?
SynchronizedCardioversionAmiodarone+Warfarin
Q35:Sidenafilalsousedtotreatwhichcondition?
Sidenafil:PulmonaryArterialHypotension
Q36:DrugutilizesNOPathwaytocauserelaxationofsmoothmuscle?
Na+Nitroprusside
Q37:72YOMCardiogenicShockdiagnosedHF.Whichdrugstimulates
myocardialcontractility?
Dobutamine:stimulatecardiaccontractility

Q38:58MBPH121/71whichdrugwouldhebenefitfrom?
Doxasocinwrong!HispressureisGood
Tamsulosin:bloodpressuregoodandhehasBPH
Q39:manreleasedandgivenprophylaxesforSVT.Whichdrugprescribed
prophylaxis?
Diltiazem
SVTTreatment:Adenosine
SVTProphylaxis:Diltiazem,Verapamil
Q40:29YOPatientSWSD.Followingdrugtreatmentofcondition.
Modafinil:SleepWorkshiftdisorder
Q41:BZ1receptorsleepingpill.Mostlikelyprescribeddrug?
ZolpidemZolpilol:BZ1only
Noeffectanxiety