Professional Documents
Culture Documents
This measure relates the dose of the drug required to produce a desired effect to that which produces an
undesired effect. (p. 8)
A. therapeutic index*** B. Idiosyncratic effect C. Tolerance
D. Potency
2.
This is the fraction of unchanged drug reaching the systemic circulation following administration by any
route:(p. 41)
A. Absorption
B. First Pass Effect C. Bioavailability***
D. Bioequivalence
3.
In this clinical phase of drug development, the drug is studied in patients with the target disease to determine
its efficacy. (p. 72)
A. Phase 1
B. phase 2***
C. phase 3
D. phase 4
4.
In this clinical phase of drug development, the drug is studied in patients with the target disease to determine
its efficacy. (p. 72)
A. Phase 1
B. phase 2***
C. phase 3
D. phase 4
5.
This is an irreversible inhibitor of GABA aminotransferase and is useful in the treatment of partial seizures and
WEST syndrome: (p. 404)
A. vigabatrin ****
C. lamotrigine
B. tiagabine
D. gabapentin
6.
7.
8.
9.
Immediate metabolic precursor of dopamine that penetrates the blood-brain barrier: (p.464)
A. carbidopa
B. levodopa
C. selegiline
D. ropinorole
17. Drug interaction of older MAO inhibitor with tyramine ingested in food:(p. 505)
A. depression
B. Hypertensive reactions***
C. hypotension D. mania
18. The following are sites of the major classes of anti-hypertensive drugs, except:(p.158 )
A. Sympathetic nerve terminals
B. -receptors of juxtaglomerular cells that release rennin
C. Hypothalamus
D. Vasomotor center
19. The following statements regarding selection of anti-hypertensive drugs are correct, except: (p. 179)
A. ACE inhibitors are particularly useful in diabetic patients with evidence of renal disease.
B. White race responds better to diuretics and calcium channel blockers than to -blockers and ACE
inhibitors.
C. Beta-blockers or calcium channel blockers are useful in patients who have angina.
D. Diuretics or ACE inhibitors are useful who also have CHF
20. The following are the determinants of vascular tone, except:(p. 182)
a.Increasing cGMP
b.Increasing cAMP in the vascular cells
c.Decreasing intracellular calcium
d.Stabilizing or preventing depolarization of the vascular smooth muscle cell membrane
21. The following are the pharmacodynamics of nitroglycerine, except: (p. 184-185)
A. Smooth muscle relaxation
B. Decreased ventricular preload
C. Responsible for a decrease in platelet aggregation
D. Increased cardiac output
22. The following are the pharmacodynamics of NSAIDs, except: (p. 598-599)
A. Mediated chiefly through inhibition of biosynthesis of prostaglandins
B. All NSAIDs inhibit platelet aggregation
C. All NSAIDs are anagesic, anti-inflammatory and antipyretic
D. They are all gastric irritants as well
23. The following are disease-modifying antirheumatic drugs, except: (p. 608)
a. Methotrexate
b. Cyclosporins
c. Corticosteroids
d. Azathioprine
24. This agent inhibits cell wall synthesis by binding firmly to the D-Ala-D-Ala terminus of nascent
peptidoglycan pentapeptide. It inhibits the transglycosylase, preventing further elongation of
peptidoglycan and cross-linking. ( p. 768 )
A. Cycloserine
B. Vancomycin C. Teicoplanin
D. Bacitracin
25. This agent is a potent inhibitor of microbial protein synthesis. It binds reversibly to the 50 S subunit of the
bacterial ribosome and inhibits peptidyl transferase step of protein synthesis. This agent is active against
rickettsiae but not chlamydiae: ( p. 774)
A. Chloramphenicol
B. Chlortetracycline
C. Amikacin
D. Penicillins
26. These agents readily bound to calcium deposited in newly formed bone or teeth in young children. When
drug is given during pregnancy, it can be deposited in the fetal teeth, leading to fluorescence,
discoloration, and enamel dysplasia: ( p. 778 )
A. Azithromycin
B. Linezolid
C. Tetracyclines
D. Aminoglycosides
27. This drug is split by intestinal microflora to yiels sulfapyridine and 5 aminosalicylate and is widely used in
ulcerative colitis, enteritis and other inflammatory bowel diseases. (p. 794-795)
A. Sulfadoxine B. Sulfamethoxazole
C. Sulfasalazine
D. Sulfadiazine
28. Blocks the conversion of cholesterol to pregnanolone and causes reduction in the synthesis of all
hormonally active steroids; used in pts. with breast Ca (page 674)
A. metyrapone B. trilostane C. aminoglutethimide D. spirinolactone
29. A glucocoorticoid antagonist that is an antifungal imidazole derivative, that is potent and rather
nonselective inhibitor of adrenal and gonadal steroid synthesis: (page 674)
A. aminogluthetimide B. ketoconazole C. trilostane D. mitotane
30. The most widely used mineralocorticoid, with both mineralocorticoid and glucocorticoid activity: (page
672)
A. aldosterone
B. deoxycortisone
C. fludrocortisone
D. cortisone
31. Act as a partial agonist at estrogen receptors in the pituitary, to treat infertility in women by stimulating
ovulation: (page 699)
A. tamoxifen
B. clomiphene C. danazol D. mifepristone
32. An antiandrogen that prevents synthesis of dihydrotestosterone by inhibiting the activity of 5-
reductase: (page 705)
A. spirinolactone B. cyproterone C. finasteride D. flutamide
33. Effects of progesterone: (page 690)
A. increase basal insulin levels
C. promotes breast development
B. promotes blood coaguability
D. affects protein metabolism
34. Mazzoti reaction, as an adverse effect is seen with the use of this agent, characterized as eosinophilia,
rashes due to the release of foreign particles from the dying microfilariae: : (page 908)
A. niclosamide B. diethylcarbamazine C. piperazine D. chloroquine
35. A depolarizing muscular blocking agent used as an alternative to mebendazole in the treatment of
ascariasis and enterobiasis: (page 917)
A. piperazine citrate B. pyrantel pamoate C. praziquantel D. primaquine
36. Kills dormant liver forms in malaria: (page 889)
A. piperazine citrate B. pyrantel pamoate C. praziquantel D. primaquine
37. The drug that could accelerate antithrombin activity resulting to blockade of the coagulation cascade at
the at the thrombin level, thus preventing the formation of a clot is: (p. 567)
A. Warfarin
B. Heparin ans
C. Coumarin
D. Plasmin
38. This is an antiplatelet drug whose mechanism of action involves inhibition of thromboxane synthesis, thus
consequently, prevention of platelet aggregation & thrombus formation: (p. 574)
A. Clopidogel
B. Ticlopidine
C. Aspirin ans
D. Dipyridamole
39. Among the thioamide antithyroid drug, which one is preferred for pregnant women because it crosses the
placental barrier less readily thus will not affect the fetus?( p. 651)
A. Methimazole
B. Carbimazole
C. Propylthiouracil ans
D. Ipodate
40. Which beta blocker is most widely used to control the symptom of hyperthyroidism? (p. 653)
A. Propranolol ans
B. Metoprolol
C. Labetalol
D. Guanithidine
41. Drugs that competitively inhibit CYP enzymes cause
a. Decrease in concentration of the object drug
b. Increase in concentration of object drug
c. Decrease efficacy of object drug
d. Irreversible inactivation of the enzyme
42. The mechanism of action of benzodiazepines is explained by:
a. Substitution for GABA
b. Direct activation of GABA receptors
c. Increase duration of GABA gated chloride channel opening
d. Increase frequency of GABA gated chloride channel opening
43. The use of benzodiazepines in the chronic treatment of seizures is limited because of their
a. high toxicity effects
c. tolerance
b. slow absorption
d. low therapeutic index
44. Which should be observed to minimize adverse effects of sedative hypnotics?
a. Always give a very low dose.
b. Doses should be given at daytime.
c. Combine two drugs with different toxicities
d. Efficacy of therapy is based on patients subjective response
45. A 50 y/o male coca cola executive was using fluoxetine for depression but decided to stop taking the drug
for it affects his sexual performance and even said he is getting older. He is also a tobacco user. What
is the next best drug to use?
a. Bupropion
c. citalopram
b. Sertraline
d venlafaxine
46. A fly catching movement of the tongue commonly observed as a drawback of all typical antipsychotics is
called
a. lead pipe rigidity
c. tardive dyskinesia
b. rabbit syndrome
d. akathisia
47. The most hepatotoxic general inhalational anesthetic
a. Nitrous oxide
c. isoflurane
b. Sevoflurane
d. halothane
48. A 55 year old female has post-menopausal osteoporosis. Which is not a recommended drug?
a. Estrogen
c. Biphosphonate
b. Calcium
d. Calcitonin
49. Corticosteroid with most potent anti-inflammatory activity:
a. Prednisone
c. Betamethasone
b. Dexamethasone
d. Cortisone
50. Drug of choice (DOC) for endometriosis in young women
a. danazol
c. mifepristone
b. leuprolide
d. misoprostol
51. The effect of diethylstilbestrol intake taken during pregnancy on female infants:
a. vaginal adenocarcinoma
c. cervical polyp
b. endometrial carcinoma
d. breast fibroadenoma
52. The most common adverse effect of clomiphene is
a. hot flushes
c. constipation
b. hair loss
d. headache
53. A 65 year old married man was found to have greatly enlarged prostate. Which one of the following
drug is MOST likely to suppress prostatic growth without affecting libido?
a. Spironolactone
c. Ketoconazole
b. Finasteride
d. Flutamide
54. Testosterone therapy may be indicated for the treatment of erectile dysfunction in which of the following
situation?
a. Aged patient
c. Alcoholism
b. Hypogonadism
d. Depression
55. Major mechanism of action of aspirin as NSAID is
a. Reversible COX inhibitor
c. Irreversible PG biosynthesis inhibition
b. Chemotaxis inhibition
d. Down regulation of IL-1
56. Which of the following is the drug of choice for inducing labor
a. Oxytocin
c. Methyl ergonovine
b. Misoprostol
d. Dinoprostone
57. The primary consideration in all clinical trials is to
a. Determine the safety of the drug
b. Determine the efficacy of the drug
c. Ensure that there is no risk to the subject
Ans. B.
Katzung, 9th edition, p. 25-27.
Pharmacodynamics
66. In what condition are the drugs phenoxybenzamine and phentolamine useful?
A. pheochromocytoma
C. essential hypertension
B. migraine attacks
D. benign prostatic hyperplasia
Ans. A.
Katzung, 9th edition, pp. 144-146.
Adrenergic Receptor Blockers
67. Acetylcholine acts by:
A. increasing adenylyl cyclase activity
B. decreasing cGMP concentrations
C. activating the IP3, diacylglycerol pathway
D. all of the above
Ans. C
Katzung, 9th edition, p.97
Cholinergic Agonists
68. Which of the following antihypertensive agents has the best documented evidence for prophylaxis against
migraine attacks?
A. pindolol
C. clonidine
B. propranolol
D. prazosin
Ans. B.
Katzung, 9th edition, pp. 148 and 156
Adrenoceptor Antagonists
69. Which is a direct effect of nitrates when given in the usual doses for the management of angina?
A. increased preload
C. increased cardiac contractility
B. increased afterload
D. smooth muscle relaxation
Ans. D.
Katzung, 9th edition, p. 190.
Vasodilators / CVS Drugs
70. A college friend consults you regarding the suitability of the therapy his doctor has prescribed for severe
hypertension. He complains of postural and exercise hypotension ("dizziness"), some diarrhea, and
problems with ejaculation during sex. Which of the following is most likely to produce the effects that
your friend has described?
A. propranolol
C. hydralazine
B. guanethidine
D. captopril
Ans. B.
Katzung, 9th edition, p. 166.
Antihypertensive / CVS Drugs
71. The most important pharmacologic action of digitalis in the treatment of heart failure is its ability to:
A. reduce venous pressure
C. produce diuresis in edematous patients
B. increase heart rate
D. increase myocardial contractile force
Ans. D.
Katzung, 9th edition, p. 205.
Cardiac Glycosides / CVS Drugs
72. Side effects of oxytocin use in a woman in labor includes the following, EXCEPT:
A. increase in BP
C. fetal death
B. uterine rupture
D. diuresis
Ans. D.
Katzung 9th edition, p. 621
Hormones and Pituitary glands / Drugs used for Endocrine Disorders
73. An antithyroid drug which may be given to reduce the vascularity of the thyroid gland prior to
thyroidectomy:
A. RAI
B. PTU
C. methimazole
D. Lugol's iodine
Ans. D.
Katzung, 9th edition, p. 633
Thyroid & Antithyroid Drugs / Drugs used for Endocrine Disorders
74. Drugs that decrease bone resorption include the following, EXCEPT:
A. calcitonin
C. alendronate
B. estrogen
D. fluoride
Ans. D.
Katzung, 9th edition, p. 719
Agents that affects bone mineral homeostasis
75. Which drug is used as an antiretroviral agent?
A. oseltamivir
C. indinavir
B. famciclovir
D. ribavirin
Ans. C.
Katzung, 9th edition, p. 820
Anti-viral Agents
76. Which of the following enzymes is inhibited by the binding of a beta lactam antimicrobial with penicillinbinding proteins (PBPs)?
A. beta-lactamase
C. peptidyl tranferase
B. transpeptidase
D. acetylase
Ans. B.
Katzung, 9th edition, pp. 734-735 and 764.
Beta-lactams / Antimicrobials
77. A poor farm helper from Palawan was diagnosed to have falciparum malaria by blood smear. The safe,
cost-effective, and readily available agent to prescribe if this farmer has an allergy to sulfonamides is:
A. Fansidar
C. chloroquine
B. quinine
D. mefloquine
Ans. B.
Katzung, 9th edition, p. 869
Anti-malarial Drugs / Antiprotozoals
78. Radical cure for malaria is achieved by giving:
A. chloroquine
C. mefloquine
B. quinine
D. primaquine
Ans. D.
Katzung, 9th edition, p.871
Anti-malarial Drug
79. There is a sudden increase of atypical pneumonia secondary to Mycoplasma, Chlamydia, and Rickettsia in
the Pneumonia Ward of a tertiary hospital. Majority of patients were treated with doxycycline. All of the
following ADRs are to be watched out for in these patients EXCEPT:
A. photosensitivity
C. superinfection
B. fetal bone defects
D. renal failure
Ans. D.
Katzung, 9th edition, pp. 758
Tetracyclines / Antimicrobials
80. Which of the following agents may predispose to the development of
A. erythromycin
C. vancomycin
B. metronidazole
D. clidamycin
pseudomembranous colitis?
Ans. D.
Katzung, 9th edition, p. 761
Antimicrobials
81. A patient with persistent chronic cough and fever had no response to adequate doses of oral penicillin.
The PE showed normal chest findings. Further PE showed bullous myringitis. A chest Xray showed
infiltrates in the right lower lobe. Which of the following antimicrobials would be effective?
A. parenteral penicillin G
B. chlarithromycin
C. vancomycin
D. gentamicin
Ans. B.
Katzung, 9th edition, pp. 760
Macrolides / Antimicrobials
82. A 4 year old boy that has diarrhea and malnutrition was noted to have a mixed parasitic infection of
Ascaris, Capillaria philippinensis, and Trichiuris trichiura. The single agent that could be effective for this
patient is:
A. pyrantel pamoate
C. diethylcarbamazine
B. mebendazole
D. niclosamide
Ans. B.
Katzung, 9th edition, pp. 889-895. Harrison, 15th edtition, p. 1249.
Anti-helmintic Drugs
83. Activated charcoal may be used to treat poisoning due to the following EXCEPT:
A. primaquine
C. propoxyphene
B. aspirin
D. iron overdose
Ans. D.
Katzung, 9th edition, p. 989
Management of Poisoned Patient
84. This herbal plant endorsed by the DOH is useful for the relief of muscle pain:
A. Yerba Buena
C. Tsaang gubat
B. Akapulko
D. Sambong
Ans. A.
DOH Manuals.
Herbal Medicines
85. On regular follow-up for tuberculosis, you noticed that the visual acuity of Vilma worsened from 20/20 to
20/50 in both eyes after only three weeks of HRPE. Your approach in management would be to
discontinue:
A. all of the 4 drugs and reintroduce one drug at a time
B. ethambutol and refer to an ophthalmologist
C. pyrazinamide and refer to an ophthalmologist
D. ethambutol, reintroduce it after 1 week, and refer to an ophthalmologist
Ans. .
Katzung, 9th edition, p. 786.
Anti-tuberculosis Drugs
86. Phenytoin is administered intravenously for acute management of seizure, but when given at a rapid
rated can cause
A. generalized seizure
C. cardiac arrhythmia
B. gingival hyperplasia
D. gastrointestinal disturbances
Answer C.
Goodman and Gilman, 10th edition, p. 530.
Anti-epileptic drugs / CNS Drugs
87. Which anticonvulsant is safe in pregnancy?
A. hydantoin
C. valproic acid
B. trimethadione
D. none of the above
Answer D.
Katzung, 9th edition, pp. 398.
Anti-epileptic drugs / CNS Drugs
88. Which of the following is a common mechanism of action shared by all NSAIDs?
A. inhibition of arachidonate release from the plasma membrane by ihibiting
phospholipase
B. Inhibition of histamine release by inhibiting mast cell degranulation
C. Inhibition of the production of prostaglandin and thromboxane from arachidonic acid through
inhibition of prostaglandin H synthesis
D. Inhibition of the the formation of leukotrienes by inhibiting lipoxygenase
Answer: C.
Katzung, 9th edition, pp. 263, 306, 577, and 581
Agents which controls prostaglandin effect / CNS Drugs
89. The primary reason why aspirin has been displaced by NSAIDs as first choice drug of pediatric
rheumatologists is because:
A. poor inflammatory effect and gastric irritation
B. poor inflammatory effect and Reyes syndrome
C. lack of liquid preparation and high toxicity effect
D. need for frequent administration and association with Reyes syndrome
Answer D.
Katzung, 9th edition, p. 579-581. Goodman and Gilman, 10th edition, p. 698.
Agents which control prostaglandin effect / CNS Drugs
90. The intravenous anesthetic producing the so-called "dissociative anesthesia" is:
A. fentanyl
C. ketamine
B. thiopental
D. propofol
Answer: C.
Katzung, 9th edition, pp. 413-414. Goodman and Gilman, 10th edition,
pp. 346-347.
General Anesthetic / CNS Drugs
91. Your patient requests you to give her a sedative-hypnotic that not will not only calm her down or put her
to sleep but will make her forget the whole operating room experience as well. To facilitate this request
your drug regimen should include:
A. midazolam
C. phenobarbital
B. succinylcholine
D. etomidate
Answer: A.
Katzung, 9th edition, p. 413-415.
General Anesthetic / CNS Drugs
B
92.
The process by which the amount of drug in the body is reduced after
administration but before entering the systemic circulation is called
A. Excretion
B. First-pass Effect
C. Metabolism
D. First-order elimination
MPL: 0.33
Page 43
C
93. Which of the following terms best describes an antagonist that interacts directly
the antagonist and not at all, or only incidentally, with the receptor?
A. Pharmacologic antagonist
B. Partial agonist
C. Chemical antagonist
D. Physiologic antagonist
MPL: 0.33
Page 16
with
B 94.
A child has swallowed the contents of 2 bottles of a nasal decongestant whose
primary ingredient is a potent, selective adrenoceptor agonist drug. The signs
of alpha activation that may occur in this patient include
A. Bronchodilation
B. Cardioacceleration (tachycardia)
C. Vasodilation
D. Pupillary dilation (mydriasis)
MPL: 0.33
Page 127
A 95.
Ms. Green has severe hypertension and is to receive minoxidil. Minoxidil is a
powerful arteriolar vasodilator that does not act on autonomic receptors. When
used in severe hypertension, its effects would probably include
A. Tachycardia and increased cardiac contractility
B. Tachycardia and decreased cardiac output
C. Decreased mean arterial pressure and decreased cardiac contractility
10
MPL: 1.0
Page 141
B 103
Which one of the following is characteristics of enalapril treatment in patients
with essential hypertension?
A. Competitively blocks angiotensin II at its receptor
B. Decreases angiotensin II concentration in the blood
C. Decreases renin concentration in the blood
D. Increases sodium and decreases potassium in the blood
MPL: 0.5
Page 173
A 104
A visitor from another city comes to your office complaining of incessant cough.
He has diabetes and hypertension and has recently started taking a different
antihypertensive medication. The most likely cause of his cough is
A. Captopril
B. Losartan
C. Propranolol
D. Verapamil
MPL: 0.5
Page 172
B 105.
A 106.
The antianginal effect of propranolol may be attributed to which one of the
following?
A. Block of exercise-induced tachycardia
B. Decreased end-diastolic ventricular volume
C. Dilation of constricted coronary vessels
D. Increased cardiac force
MPL: 0.5
Page 195
B
107. A patient is admitted to the emergency department following a drug overdose. He is noted to
have a severe tachycardia. He has been receiving therapy for hypertension and angina. A drug that often
causes tachycardia is
A. Diltiazem
B. Isosorbide dinitrate
C. Propranolol
D. Verapamil
MPL: 0.33
Page 185
B 108.
Drugs that have been found to be useful in one or more types of heart failure
include all of the following, EXCEPT
A. Na+/K+ ATPase inhibitors
B. Alpha-adrenoceptors agonist
C. Beta-adrenoceptors antagonists
D. ACE inhibitors
MPL: 1.0
Page 127
D 109.
B 110.
A patient with long-standing diabetic renal disease and hyperkalemia and
recent-onset heart failure requires a diuretic. Which of the following agents
11
111. Inflammation is a complex tissue reaction that includes the release of cytokines, leukotrienes,
prostaglandins, and peptides. Prostaglandins involved in inflammatory processes are produced from
arachidonic acid by
A. Cyclooxygenase -1
B. Cyclooxygenase-2
C. Lipoxygenase
D. Phospholipase A2
MPL: 0.5
Page 312
B 112.
A 113.
Successful therapy of heart failure with digoxin will result in which one of
the following?
A. Decreased heart rate
B. Increased afterload
C. Increased aldosterone
D. Increased renin secretion
MPL: 1.0
Page 206
D 114.
D 115.
C 116.
One effect that theophylline, nitroglycerin, isoproterenol, and histamine have
in common is
A. Increased gastric acid secretion
B. Direct stimulation of cardiac contractile force
C. Tachycardia
D. Postural hypotension
MPL: 0.25
Page 1023
B 117.
12
C 118
You are on your way to take an examination and you suddenly get an attack of
diarrhea. If you stop at a nearby drugstore for an over-the-counter opioid with
antidiarrheal action, you will be asking for
A. Codeine
B. Dextromethorphan
C. Loperamide
D. Diphenoxylate
MPL: 1.0
Page 527
C
119.
D
120.
accurate?
B 121.
A 52-year-old woman presented with intense pain, warmth, and redness in the
first toe on her left foot. Examination of fluid withdrawn from the
inflamed joint
revealed crystals of uric acid. In the treatment of this womans acute attack of
gout, the advantage of using indomethacin instead of colchicines is that indomethacin is
A. Less likely to cause acute renal failure
B. Less likely to cause severe diarrhea
C. Less likely to precipitate sudden gastrointestinal bleeding
D. More likely to prevent another acute attack
MPL: 0.6
Page 605
A 122.
A 27-year-old woman with amenorrhea, infertility, and galactorrhea was
treated with a drug that successfully restored ovulation and menstruation.
Before being given the drug, the woman was carefully questioned about
previous mental health problems, which she did not have. She was advised
to take the drug orally. The drug used to treat this patient was probably
A. Bromocriptine
B. Desmopressin
C. Leuprolide
D. Human gonadotropin hormone
MPL: 0.5
Page 468
D 123.
C 124.
13
D 125.
D 126.
For patients who have been on long-term therapy with a glucocorticoid and
who now wish to discontinue the drug, gradual tapering of the glucocorticoid
is needed to allow recovery of
A. Depressed release of insulin from pancreatic B cells
B. Hematopoiesis in the bone marrow
C. Normal osteoblast function
D. The hypothalamic-pituitary-adrenal system
MPL: 0.6
Page 671
B 127.
B 128.
C 129.
A 54-year-old obese patient with type 2 diabetes and a history of alcoholism
probably should not receive metformin because it can increase the risk of
A. A disulfiram-like reaction
B. Excessive weight gain
C. Lactic acidosis
D. Hypoglycemia
MPL: 0.5
Page 728
B 130.
Which of the following drugs is MOST likely to cause hypoglycemia when used
as monotherapy in the treatment of type 2 diabetes?
A. Acarbose
B. Glyburide
C. Miglitol
D. Rosiglitazone
MPL: 0.4
Page 726
D 131.
A patient needs antibiotic treatement for native valve, culture-positive infective
entericoccal endocarditis. His medical history includes a severe anaphylactic
reaction to penicillin G during the past year. The best approach would be
treatment with
A. Amoxicillin-clavulanate
B. Aztreonam
C. Meropenem
D. Vancomycin
MPL: 0.4
Page 768
C 132.
14
Page 776
D 133.
In patient with culture-positive enterococcal endocarditis who has failed to
respond to vancomycin because of resistance, the treatment most likely to
be effective is
A. Clarithromycin
B. Erythromycin
C. Minocycline
D. Linezolid
MPL: 1.0
Page 782
D 134.
Which of the following adverse effects is most likely to occur with sulfonamides?
A. Neurologic effects, including headache, dizziness, and lethargy
B. Hematuria
C. Fanconis aminoaciduria syndrome
D. Skin reactions
MPL: 0.2
Page 793
135.
On her release from hospital, the patient is advised not to rely solely on oral
contraceptives to avoid pregnancy because they may be less effective while
she is being maintained on antimycobacterial drugs. The agent most likely to
interfere with the action of oral contraceptives is
A. Ethambutol
B. Isoniazid
C. Rifampin
D. Pyrazinamide
MPL: 1.0
Page 806
C 136.
Chemical interactions between this drug and cell membrane components
can result in the formation of pores lined by hydrophilic groups present in the
drug molecule
A. Caspofungin
B. Griseofulvin
C. Nystatin
D. Fluconazole
MPL: 0.25
Page 1049
D 137.
D 138.
Which of the following drugs binds to a viral envelope protein preventing
conformational changes required for the fusion of viral and cellular membranes?
A. Abacavir
B. Adenavir
C. Oseltamivir
D. Enfuvirtide
MPL: 0.33
Page 820
No
Question
Ans
139.
Which of the following is NOT an expected effect of muscarinic
C
agonists instilled into the conjunctival sac?
a. Contraction of the smooth muscle of the iris sphincter
b. Contraction of the ciliary muscle
c. Mydriasis
d. Improves aqueous humor outflow in the canal of Schlemm.
140.
Nausea, vomiting, diarrhea, urinary urgency, salivation, sweating,
D
cutaneous vasodilation and bronchial constriction are caused by an
overdose of:
a. Ipratropium
b. Pirenzepine
the
Ref page4
97
105
15
141.
142.
143.
144.
145.
146.
147.
147.
148.
c. Benztropine
d. Pilocarpine
In normal individuals and more so in patients with airway disease, the
administration of this agent causes cause some bronchodilation and
reduction in secretion.
a. Atropine
b. Metacholine
c. Carbachol
d. Bethanechol
113
114
137
156
341
352
350
358
268
16
149.
150.
151.
152.
153.
154.
155.
156.
157.
158.
577
583
583 584
169
173
177
178
206
849
851
17
159.
160.
161.
162.
163.
164.
165.
166.
167.
b. hemoglobinuria
c. flushing
d. visual disturbances
TT, 7yo male public elementary school student develops mixed soiltransmitted helminthic infections. Which of the following drugs is
appropriate?
a. Pyrantel pamoate
b. Praziquantel
c. Mebendazole
d. Metronidazole
This group of antimicrobials kills bacterial cells interfering with the
transpeptidation reaction of bacterial cell wall synthesis
a. Tetracyclines
b. -lactam antibiotics
c. Macrolides
d. All of the above
868
726
732
733 734
737
749
532
537
628
18
168.
169.
170.
630
710
Generics Act
of 1988
Basic and Clinical Pharmacology by: Bertram G. Katzung, 10th edition, 2007
_____
171. All of the following factors can affect the rate and extent of drug absorption EXCEPT
A. lipophilicity
C. protein binding
B. intestinal motility
D. presence of P glycoprotein transporter
ANS C p.41
_____
_____
173. The amount of a drug dose that reaches the systemic circulation in the unchanged form is:
A. Bioavailability
C. Cmax
B. Clearance
D. half-life
ANS A p. 40
_____
174. A laboratory experiment is being conducted in which an animal is injected with a non-competitive
antagonist to the histamine receptor. Which of the following best describes this drug?
A. The drug binds to the histamine receptor and partially activates it.
B. The drug binds to the histamine receptor but does not activate it.
C. The drug binds to the receptor, but not where histamine binds and prevents the receptor from being
activated.
D. The drug irreversibly binds to the histamine receptor and renders it ineffective.
ANS C p. 16
_____
_____
176. At low doses, dobutamine receptor selectivity and activity will primarily result to:
A. bronchodilation
C. uterine contraction
B. dilatation of renal bladder vessels
D. increase in cardiac
contractility
ANS D p.133
_____
19
A. lidocaine
B. amiodarone
C. quinidine
D. verapamil
ANS B pp 228
_____
_____
179. Drug interaction seen with concomitant spironolactone and ACE inhibitor use
A. ACE inhibitors may decrease renal perfusion decreasing the action of spironolactone in the collecting
tubules
B. Additive afterloader effect
C. Enhanced hyperkalemia*
D. Enhanced vasodilating effect of ACE inhibitors because of inhibition of metabolism by spironolactone
ANS C p. 177
_____
180. The following anti-hypertensive drug should be used with caution in patients on potassium-sparing
diuretics
A. losartan*
C. hydrochlorthiazide
B. verapamil
D. methyldopa
ANS A p. 177
_____
181. Accumulation of bradykinin due to ACE inhibition is responsible for these adverse effects EXCEPT
one:
A. cough
C. angioedema
B. hypotension
D. hyperkalemia
ANS D p. 177
_____
182. The absence of reflex tachycardia with the use of ACE inhibitors is due to
A. downward resetting of the baroreceptor
B. mild decrease in peripheral vascular resistance
C. enhanced sympathetic activity
D. inhibition of RAA system
ANS A p. 176
_____
183. This adverse effect of nitrates can be prevented by providing nitrate-free interval between
administration
A. dependence
C. tolerance
B. hypotension
D. tachycardia
ANS D p. 186
_____
184. Which of the following drug combinations will give the best hemodynamic effects of decreasing
filling pressure and increasing cardiac output in CHF patients?
A. furosemide and dopamine
C. captopril and digoxin
B. digoxin and verapamil
D. furosemide and digoxin
ANS A p. 208
_____
185. The drug of choice for converting paroxysmal atrial tachycardia to normal sinus rhythm
A. propranolol
C. quinidine
B. adenosine
D. flecainide
ANS B p. 231
_____
186. This class I antiarrhythmic drug has marked negative inotropic action and therefore should not be
used in patient with heart failure
A. quinidine
C. disopyramide
B. procainamide
D. lidocaine
ANS D p.225
_____
187. The risk of Torsades des pointes is highest with the use of
20
A. sotalol
B. flecainide
C. bretylium
D. amiodarone
ANS D p. 223
_____
_____
C. disopyramide
D. amiloride
189. A 60 year old male has dilated cardiomyopathy and is on digoxin. He complains of nausea and
vomiting and you think he has digitalis toxicity. Which of the following drugs he is taking most likely
enhanced this?
A. Furosemide*
C. spironolactone
B. Carvedilol
D. captopril
ANS A p. 204
_____
_____
191. A patient in CHF has developed oliguria because of low cardiac output. To improve renal perfusion,
dopamine must be given at this dose in ug/kg/min
A. 2*
C. 15
B. 10
D. 20
ANS A p. 133
_____
192. A.M. a 55 year old known hypertensive was found to have heart block on ECG. Which of the drugs
below should not be given?
A. Spironolactone
C. captopril
B. Verapamil*
D. prazosin
ANS A p. 175; 230
_____
193. Rapid intravenous administration of this drug may cause respiratory depression:
A. phenytoin
C. phenobarbital
B. lamotrigine
D. carbamazepine
ANS C p.359
_____
194. This drug increases free phenytoin levels due to protein binding displacement.
A. Cimetidine
C. chloramphenicol
B. salicylates
D. isoniazid
ANS B p.377
_____
195. Which of the following antidepressants will produce a life-threatening syndrome of hyperthermia,
muscle rigidity and myoclonus when administered with MAO?
A. Fluoxetine
C. imipramine
B. trazodone
D. clomipramine
ANS A p. 486
_____
196. Ideally, baseline liver function tests are done prior to giving this anticonvulsant
A. topiramate
C. valproic acid
B. levetiracetam
D. gabapentin
ANS C p. 387
_____
21
ANS A p.380
_____
198. Orthostatic hypotension is most common with which of the following antipsychotic agents:
A. Perphenazine
C. chlorpromazine
B. Haloperidol
D. olanzapine
ANS C p.461
_____
_____
200. Based on the mechanism of action, the following antimicrobial is NOT selectively toxic:
A. piperacillin
C. amphotericin B
B. cotrimoxazole
D. gentamicin
ANS B p. 763
_____
201. Which of the following antibiotics is effective against both aerobes and anaerobes?
A. metronidazole
C. aztreonam
B. gentamicin
D. chloramphenicol
ANS D p. 752
_____
202. This antibiotic is frequently associated with 8 th nerve damage in the offspring if given to pregnant
women, thus classified under pregnancy risk category D
A. Clarithromycin
C. ciprofloxacin
B. Tetracycline
D. streptomycin
ANS D p. 759
_____
203. Maculopapular rash with this antibiotic is non-immunologic in nature and does not preclude the use
of chemically related antibiotics in the future
A. Erythromycin
C. amoxicillin
B. Cefalexin
D. cotrimoxazole
ANS C p. 733
_____
204. A 15 year old college student came in because of headache, fever, chills and photophobia. Thick and
thin smears showed P. vivax. The oral drug of choice to rid the blood of plasmodia is
A. Quinine
C. mefloquine
B. Primaquine
D. chloroquine
ANS D p.846
_____
_____
206. The following antiviral agents DOES NOT require activation by phosphorylation and it directly inhibits
DNA and RNA polymerases as well as HIV reverse transcriptase
A. penciclovir
C. cidofovir
B. acyclovir
D. foscarnet
ANS D p. 797
_____
_____
208. A 50 year old male receiving anti-TB treatment develops mono-articular arthritis. Which of the
following could have caused it?
A. pyrazinamide and ethambutol
C. ethambutol + streptomycin
B. rifampicin + pyrazinamide
D. ethambutol + INH
22
209. Of the following, the mechanism of actions of this antifungal does not involve inhibition of cell
membrane synthesis
A. Terbinafine
C. flucytosine
B. Fluconazole
D. griseofulvin
ANS C p. 784
_____
_____
211. Which of the following statements is TRUE regarding the direct genomic pharmacodynamic action of
glucocorticoids (GC)?
A. GCs diffuse into cell cytoplasm and into nucleus where it binds to glucocorticoid response element
(GRE) and act as transcription factor, upregulating gene transcription
B. GCs diffuse into cell cytoplasm and bind to steroid receptors leading to release of heat shock proteins
and dimerization of steroid receptor complexes which translocate into nucleus and bind to GRE,
inducing or inhibiting gene transcription
C. GCs diffuse into cell cytoplasm, binding to steroid receptors, the steroid-receptor complexes then
bind to transcription factor inhibiting synthesis of pro-inflammatory cytokines
D. GCs activate cell membrane enzymes leading to formation 2nd messenger
ANS B p. 639
_____
212. The main mechanism of action is to lower post meal glycemic excursion:
A. metformin
C. acarbose
B. glipizide
D. nateglinide
ANS C p. 700
_____
213. This drug is an estrogen agonist in the bone but an estrogen antagonist in breast tissue:
A. raloxifene
C. tamoxifen
B. alendronate
D. calcitonin
ANS A p. 672
_____
_____
215. The main mechanism for its effectiveness in diabetics is the release of endogenous insulin
A. sulfonylurea
C. biguanide
B. thiazolidinedione
D. alpha glucosidase inhibitor
ANS A p. 694
_____
216. The main action as anti-diabetic agent is to stimulate the nuclear receptors that regulate the
transcription of genes encoding proteins involved in protein and carbohydrate metabolism
A. insulin
C. sulfonylurea
B. thiazolidinedione
D. biguanide
ANS A p. 686
_____
217. Which of the following glucocorticoids has the least mineralocorticoid effect and is best for
decreasing cerebral edema associated with increased intracranial pressure?
A. Prednisone
C. dexamethasone
B. Hydrocortisone
D. prednisolone
ANS C p. 641-644
_____
23
219. A class of proteins that functions as drug receptors that mediate the actions of endogenous chemical
signals such as neurotransmitters and hormones:
A. enzymes
B. regulatory proteins
C. structural proteins
D. transport proteins
Application
Answer: B
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 11
220. Receptor/s coupled to G protein that modulate the production of intracellular second messengers
include/s
A. muscarinic receptor
B. alpha adrenergic receptor
C. leukotriene receptor
D. all of the above
Application
Answer: C
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 22
221. The neuromuscular blocker succinylcholine acts by:
A. Depolarizing muscle endplate receptors
B. Repolarizing muscle endplate receptors
C. Inhibiting the release of acetylcholine from the nerve ending
D. Blocking the access of acetylcholine at the myoneural junction
Recall
Answer: A
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 437
222. Therapeutic benefit/s of 2 receptor agonists include:
A. antihypertensive
B. antiglaucoma
C. antidiarrheal
D. all of the above
Application
Answer: D
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, pp. 130 - 131
24
C. Amphetamine
D. Methylenedioxy-Methamphetamine (MDMA, Ecstasy)
Recall
Answer: A
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 520
226. Characteristic physiologic sign of Cannabis intoxication includes:
A. increased pulse rate
B. pale conjunctivae
C. miotic pupil
D. high blood pressure
Application
Answer: A
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 526
227. Which among these intravenous general anesthetics produces a dissociative type of anesthesia?
A. Propofol
B. Ketamine
C. Thiopental
D. Midazolam
Application
Answer: B
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 415
228. Painless digital vasospasm is a dose-related complication of long term
treatment with:
A. Levodopa
B. Bromocriptine
C. Selegiline
D. Tolcapone
Recall
Answer: B
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 453
229. The peripheral metabolism to Levodopa can be prevented if it is given
concomitantly with:
A. Carbidopa
B. Amantadine
C. Biperiden
D. Bromocriptine
Application
Answer: A
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition,
p. 449, p. 454
230. An overdose of this opioid causes mydriasis instead of the characteristic miosis of opioid toxicity:
A. Hydromorphone
B. Meperidine
C. Methadone
D. Morphine
Application
Answer: B
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 511
231. Which of these group of tissues would be the first to take up appreciable amounts of inhalational
anesthetics?
A. Fat
B. Muscle
C. Vessel-rich
D. Vessel-poor
Recall
25
Answer: C
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 405
232. A narcotic-addicted patient is given this drug as a substitute to be able to control the withdrawal
symptoms:
A. Hydromorphone
B. Meperidine
C. Methadone
D. Disulfiram
Recall
Answer: C
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p.510, p. 520
233. The duration of action of the intravenous barbiturate anesthetic thiopental is largely determined by:
A. Spontaneous degradation
B. Hepatic extraction
C. Renal clearance
D. Redistribution
Application
Answer: D
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 412
234. This drug inhibits binding of leukotriene D4 to its receptor on target tissues
A. Montelukast
B. Zilenton
C. Ipratropium bromide
D. Omalizumab
Recall
Answer: A
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 330
235. The mechanism of action of corticosteroids in the treatment of bronchial asthma includes
A. directly relax airway smooth muscle
B. enhance bronchial reactivity
C. inhibit airway mucosal inflammation
D. prevent release of chemotactic agents
Application
Answer: C
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 328
236. A non-steroidal anti-inflammatory drug that irreversibly acetylates and blocks platelet
cycloocygenase is
A. Naproxen
B. Mefenamic acid
C. Aspirin
D. Ibuprofen
Recall
Answer: C
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 577
237. Corticosteroids must be used with great caution in patients with
A. osteoporosis
B. varicella
C. peptic ulcer
D. all of the above
Application
Answer: D
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 652
238. The most common adverse effect of Aspirin is
A. gastric upset and ulcers
B. renal toxicity
C. asthma
26
D. hepatotoxicity
Recall
Answer: A
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 581
239. A uricosuric drug that decreases body pool of urate in patients with
tophaceous gout is
A. Allopurinol
B. Colchicine
C. Probenecid
D. Meloxicam
Recall
Answer: C
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 598
240. Sinoatrial and atrioventricular nodal tissue are affected markedly by
A. Diltiazem
B. Verapamil
C. Nifedipine
D. Amlodipine
Recall
Answer: B
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 196
241. The beneficial effect of Captopril in patients with heart failure is attributed to:
A. reduction in afterload
B. increased preload
C. increased myocardial contractility
D. all of the above
Application
Answer: A
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 209
242. Beta blockers with membrane-stabilizing action, useful as anti-arrhythmics include:
A. Metoprolol
B. Propranolol
C. Acebutolol
D. All of the above
Recall
Answer: D
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 151
243. Which of the following antiarrhythmic drugs act by blocking sodium channel?
A. Lidocaine
B. Verapamil
C. Sotalol
D. Adenosine
Application
Answer: A
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 226
244. Antibiotic/s shown to be effective when applied topically in the treatment of acne vulgaris include/s:
A. Clindamycin
B. Erythromycin
C. Metronidazole
D. All of the above
Application
Answer: D
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 1017
245. This organophosphate compound is thought to have a cholinesterase inhibitory action which
temporarily paralyzes the adult Schistosoma haematobium worms.
A. Metrifonate
27
B.
C.
D.
Niclosamide
Mebendazole
Pyrantel pamoate
Recall
Answer: A
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 891
246. Which of these drugs selectively inhibits microtubule synthesis and glucose uptake in nematodes?
A. Piperazine
B. Mebendazole
C. Pyrantel pamoate
D. Diethylcarbamazine citrate
Application
Answer: B
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 891
247. For onchocerciasis and strongyloidiasis, this drug is the first choice because it causes fewer systemic
and ocular reactions:
A. Diethylcarbamazine citrate
B. Metrifonate
C. Ivermectin
D. Bithionol
Application
Answer: C
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 890
248. Most of the serious adverse effects of Penicllins are due to:
A. Blood dyscrasias
B. Hypersensitivity reactions
C. CNS reactions
D. Hepatic impariment
Application
Answer: B
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 741
249. The following anti-TB drugs are potentially hepatotoxic, EXCEPT:
A. RIfampin
B. Isoniazid
C. Pyrazinamide
D. Streptomycin
Recall
Answer: D
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 784-786
250. This Anti-TB is relatively contraindicated in young children whose visual acuity and red-green color
assessment can not be adequately assessed:
A. Isoniazid
B. Rifampin
C. Ethmabutol
D. Pyrazinamide
Recall
Answer: C
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 785
251. This antibacterial is available as a nasal ointment useful in the elimination of nasal carriage of
Staphylococcus aureus:
A. Neomycin
B. Muprocin
C. Polymycin B sulfate
D. Bacitracin
Application
Answer: B
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 1016
28
252. A drug that is used almost solely as an alternative treatment for gonorrhea in patients whose
gonococci are resistant to other drugs is:
A. Ofloxacin
B. Tetracycline
C. Doxycycline
D. Spectinomycin
Recall
Answer: D
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 771
253. Excessive anticoagulant effect results in bleeding from Warfarin can be reversed by:
A. discontinuance of the drug
B. administration of Vitamin K
C. administration of fresh frozen plasma
D. all of the above
Application
Answer: D
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 552
254. The amount of elemental iron per 325 mg tablet of hydrated ferrous sulfate is ___ mg:
A. 36
B. 65
C. 80
D. 106
Application
Answer: B
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 531
255. The preparation of choice for thyroid replacement and suppression therapy is:
A. Liothyronine
B. Levothyroxine
C. Dessicated thyroid
D. Thyrogloculin
Recall
Answer: B
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 630
256. The combination of estrogens and progestins exert their contraceptive effect largely through
A. inhibition of pituitary function
B. production of a mucoid cervical secretion
C. alteration in the motility of the uterine tubes
D. enhancement of the rupture of the ovarian follicle
Application
Answer: A
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 673
257. The most dangerous complication of Thioamides is:
A. lupus-like reaction
B. hepatitis
C. agranulocytosis
D. exfoliative dermatitis
Recall
Answer: C
Reference: KATZUNG, Basic and Clinical Pharmacology, ninth edition, p. 633
258. The major use of this drug is in the treatment of endometriosis
A. Nifepristone
B. Danazol
C. Tamoxifen
D. Clomiphine
Recall
Answer: B
29
Ans. D p.41
Ans. D p. 55-56
268. Selective COX-2 inhibitors differ from nonselective COX inhibitors in that selective COX-2 inhibitors
have no:
A. analgesic-antipyretic and anti-inflammatory effects
B. gastrointestinal side effects
C. effects on platelet aggregation
30
D. renal toxicities
269. Pharmacologic effects of alcohol include stimulation of the:
A. central nervous system
B. heart
C. smooth muscles of the blood vessels
D. secretion of gastric acid
Ans. B p. 582
Ans. D p. 368
270. One of the following general anesthetics with their respective blood:gas partition coefficients is most
soluble in blood:
A.Nitrous oxide 0.47
B. Enflurane 1.40
C. Halothane 2.30
D. Methoxyflurane 12.0
Ans. D p. 403
271. Reserpine blocks this step in adrenergic transmission:
A. synthesis of the transmitter
B. incorporation of norepinephrine into the vesicle
C. release of the neurotransmitter
D. reuptake into presynaptic neuron
Ans. B p. 169
272. A 24 year old male was brought to the emergency room after having allegedly drank poison. He had
constricted pupils, was noted to have salivation and sweating, wheezing, vomiting and diarrhea: The
poison must have been:
A. atropine
B. organophosphate
C. opiate
D. ephedrine
Ans. B p. 101
273. Therapeutic applications of atropine include/s:
A. peptic ulcer
B. bradycardia caused by myocardial infarction
C. urinary retention
D. constipation
Ans. B p. 115
Ans. D p. 117
Ans. D p. 133
276. Drugs like quinidine, procainamide and disopyramide are useful in the treatment of:
A. congestive heart failure
C. status asthmaticus
B. thyrotoxicosis
D. arrhythmia
Ans. D. pp. 227-229
277. A 65-year old male was admitted at the intensive care unit disoriented with a blood pressure of
220/120. Which of the following drugs will be most appropriate:
A. Sodium nitroprusside
C. Methyldopa
B. Clonidine
D. Aldactone
Ans. A p. 175
278. Propranolol and other beta-adrenergic receptor antagonist have the following effect/s on the heart
that makes them useful as antiarryhthmic agents:
A. Depress automaticity
C. Reduce heart rate
B. Prolong A-V conduction
D. All of the above
Ans. D. p. 232
279. All of the following are true of sodium nitroprusside EXCEPT:
A. The gold standard for use in hypertensive crisis
B. Mechanism of vasodilating effects similar to nitrates
C. Sensitive to light
D. Metabolite is pharmacologically inert
Ans. D. p.175
280. In patients with congestive heart failure, the use of angiotensin converting enzyme inhibitors will
increase
31
A. peripheral resistance
B. preload
281. One of the following antianginal agents is contraindicated in patients with vasospastic angina:
A. Propranolol
C. Diltiazem
B. Verapamil
D. Isosorbide dinitrate
Ans. A. p. 198
282. Methyldopa as antihyperatensive agent exerts its effect by conversion to alphamethylnorepinephrine which stimulates centrally this receptor:
A. alpha-1
C. alpha-2
B. Beta-1
D. Beta-2
Ans. C. p. 166
283. Aminopenicillins, Carboxypenicillins and Ureidopenicillins compared to Penicillin G:
A. Are not effective for oral adminsitration
B. Have lesser tendency to cause hypersensitivity reaction
C. Have greater activity against gram-negative bacteria
D. Are resistant to B-lactamse
Ans. C. p. 741
284. Clavulanic acid is added to Ampicillin in order to:
A. Prevent occurrence of diarrhea
B. Protect the beta-lactam ring from destruction
C. Increase the bioavailability by increasing absorption
D. Increase the pH of gastrointestinal tract
Ans. B. p. 741
285. The most common side effect of erythromycin is:
A. Gastroinetstinal upset
B. red neck syndrome
C. Pseudomembranous colitis
D. Nephrotoxicity
Ans. A p. 759
286. Bacterial synergism is produced by the following drug combination:
A. Tetracycline and penicillin G
B. Cephalexin and gentamycin
C. Tetracycline and chloramphenicol
D. Tetracycline and streptomycin Ans. B p. 846
287. This antimicrobial drug may provoke acute gouty arthritis:
A. Pyrazinamide
B. Ethambutol
C. INH
D. PAS
Ans. A p. 786
Ans. D p. 824
289. This agent apparently acts as a GABA agonist at the neuromuscular junction and causes flaccid
paralysis of the nematode:
A. Mebendazole
B. Piperazine
C. Bephenrium
D. Pyrantel
Ans. B p. 861
290. This antimicrobial agent is also effective for amebic abscesses that fail initial therapy with
metronoidazole:
A. Chloroquine
B. Amodiaquine
C. Mefloquine
D. Primaquine
Ans. A p. 867
291. Adverse effects of aminoglycosides include all, EXCEPT:
A. Nephrotoxicity
B. Cardiotoxicity
C. Neuromuscular blockade
D. Ototoxicity
Ans. B p. 767
32
Ans. D
293. This is a partial agonist inhibitor of estradiol at the estrogen receptor and used in the palliative
treatment of advanced breast cancer:
A. Donazol
B. Diathylstilbesterol
C. Tamoxifen
D. Mefepristone
Ans. C p. 679
294. Clomiphone enhanced pregnancy by:
A. Preparing the uterus for implantation
B. Inhibiting estradiols negative feedback
C. Increasing sperm motility
D. Inhibiting ovulation
295. The most common side effect of insulin is:
A. Lipid deposition
B. Renal dystrophy
C. Insulin allergy
D. Hypoglycemia
Ans. B p. 681
Ans. D p. 703
33