GESTIS-Stoffdatenbank

2-Hydroxy-2-methylpropionitrile

IDENTIFICATION
2-Hydroxy-2-methylpropionitrile
2-Cyanopropan-2-ol
Acetone cyanohydrin
Hydroxyisobutyronitrile
ZVG No:
CAS No:
EC No:
INDEX No:

27250
75-86-5
200-909-4
608-004-00-X

CHARACTERISATION

SUBSTANCE GROUP CODE

146100 Nitriles
142201 Hydroxy compounds, alcohols, substituted

STATE OF AGGREGATION
The substance is liquid.

PROPERTIES
colourless to yellowish
faint bitter almond-like odour

CHEMICAL CHARACTERISATION
Combustible substance, poorly flammable (flash point > 60 up to 93 C).
Vapours may form explosive mixtures with air when the substance is heated above its
flash point.

Mixable with water.

Slightly volatile.
Acute or chronic health hazards result from the substance.
The substance is hazardous to the aquatic environment.
(see: chapter REGULATIONS).

FORMULA
C4H7NO

Molar mass:
85,11 g/mol
Conversion factor (gaseous phase) at 1013 mbar and 20 C:
1 ml/m = 3,54 mg/m

TOXICOLOGY / ECOTOXICOLOGY

TOXICOLOGICAL DATA
LD50 oral rat
Value:
18,7 mg/kg
Toksikologicheskii Vestnik. Vol. (1), Pg. 29, 1994.
LD50 dermal
Species:
Rabbit
Value:
15,8 mg/kg
American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.
Reference: 02071

ECOTOXICOLOGICAL DATA
LC50 Fish (96 hours)
Minimum:
0,5 mg/l
Maximum:
0,57 mg/l
Median:
0,535 mg/l
Study number:
2
Reference for median:
Dawson, G.W., A.L. Jennings, D. Drozdowski, and E. Rider 1977. The Acute Toxicity of
47 Industrial Chemicals to Fresh and Saltwater Fishes. J.Hazard.Mater. 1(4):303-318
(OECDG Data File)
Reference:

02072

PHYSICAL AND CHEMICAL PROPERTIES

MELTING POINT
Melting point:

-20 C

BOILING POINT
Boiling Point:

82 C

Pressure:

30,7 hPa

DENSITY
DENSITY
Value:

0,93 g/cm

Temperature:

20 C

RELATIVE VAPOUR DENSITY

Ratio of the density to dry air at the same temperature and pressure
Value:
2,93
RELATIVE DENSITY OF THE VAPOUR-AIR-MIXTURE
Ratio of the density to dry air at 20 C and standard pressure
Value:
1,00

VAPOUR PRESSURE
Vapour pressure: 1,1 hPa
Temperature:
20 C

FLASH POINT
Flash point:
Closed cup

75 C

IGNITION TEMPERATURE
Ignition temperature: 540 C
Temperature class: T1
Explosion group: IIA

EXPLOSION LIMITS
Lower explosion limit:
2,3 vol. %
Upper explosion limit:

11 vol. %

SOLUBILITY IN WATER
entirely mixable

HAZARDOUS REACTIONS
Decomposition temperature: > 120 C
Decompositon products:
hydrogen cyanide; acetone
Hazardous chemical reactions:
Risk of explosion in contact with:
sulfuric acid
The substance can react dangerously with:
oxidizing agents
water
alkalies; heat;

OCCUPATIONAL HEALTH AND FIRST AID

ROUTES OF EXPOSURE
Main Routes of exposure:
The main route of exposure for 2-Hydroxy-2-methylpropanenitrile (acetone cyanohydrin,
ACH) in occupational conditions is via the respiratory tract and the skin.[99997]
Respiratory tract:
Exposure to the ACH vapours and the degradation products (particularly hydrogen
cyanide, HCN) that can develop in usual storage conditions might occur, but also
during the heating process and in alkaline reaction conditions.[07729]
Generally, a rapid and practically quantitative resorption via the respiratory tract is
assumed.[99983]
Skin:
Results of toxicokinetic studies are not available, although very many dermal toxicity
tests have been performed.
Resorption rates cannot be assessed due to sometimes extremely differing LD50
values (depending on the species and the test conditions).
The differences were explained by the following: The extent of the realisation of
optimum occlusion conditions, microlesions on the tested skin areas, and simultaneous
inhalation exposure of the test animals.
It was also derived from observations pertaining to humans that the fat content of the
skin exerts a considerable influence on the resorption rate of ACH, since the application
of a lipid cream proved to provide very good skin protection.[07934]
To be on the safe side, very rapid resorption of ACH via the human skin must generally
be assumed.[99983]

Gastrointestinal tract:
Very low oral LD50 values observed in numerous animal experiments demonstrate
rapid and probably complete resorption of the substance or its metabolites (particularly
cyanide) via the gastrointestinal tract.[99999]
Kinetic studies are not available.[99983]

TOXIC EFFECTS
Main toxic effects:
Acute effects: Irritative effects to the eyes and the skin, CNS dysfunctions, massive
metabolic changes; active potential similar to that of hydrocyanic acid;[99983]
Chronic effects: Headache, weakness, possibly dysfunctions of the thyroid
gland.[07934]
Acute toxicity:
Direct eye contact with liquid ACH triggered irritations in humans (details were not
provided).
Skin contact triggers severe irritations up to conditions similar to 1 to 2 grade burns,
depending on the duration of the exposure.
Strong resorptive effects after skin contact were confirmed by numerous animal
experiments.
Apart from local reactions (reddening, swelling, superficial necrosis) the reported
symptoms include lethargy (in rabbits those effects occurred at values of 6.4 mg of
ACH per kg of body weight), shortness of breath and spasms.
The data on the dermal LD50 values are inconsistent (see also skin resorption).
Even in tests according to OECD-402 the values found for the same animal species
(rabbits) amounted to 16, on the one hand, and to almost 800 mg per kg of body weight,
on the other.
However, most of the studies yielded dermal LD50 values between 100 and 200 mg
per kg of body weight.[07934]
Careless handling of ACH led to dermal exposure, probably accompanied by the
inhalation of the substance in one worker.
Nausea, vomiting and subsequent loss of consciousness occurred as early as within
the following 15 minutes.
Despite initially implemented therapy measures (see also First medical assistance),
respiration became irregular and was temporarily suspended.
This condition was followed by spasms in the arms and the legs and deep coma.
Two other toxicity cases (dermal or oral) involved lethal outcomes.
Several slight toxicities entailed cardiac sensations, nausea, vomiting, headache and
ephemeral fainting.[99997]
In an animal experiment an atmosphere saturated (?) with ACH triggered the first
fatalities among rats as early as within 5 minutes.
The 4-hour LC100 value was determined at 125 ppm, and the 4-hour LCLo value
amounted to 62.5 ppm.[07934]
The data on a dose that does not entail a health impairment in humans are inconsistent.
A value of 1 ppm (15-minute maximum concentration) appears to be most
plausible.[00088]

A reliable odour threshold value for ACH in the air is not available, and information on
the warning effect of a bitter almonds odour is thus lacking.[99983]
Oral toxicities with ACH involving the immediate or delayed occurrence of the above
described resorptive effects must be taken very seriously, since the oral LD50 values
found in several animal species amounting to 10-20 mg per kg of body weight point to
an extremely high toxicity on this route of exposure.[99999]
In one reported case the ingestion of alcohol that contained an unknown amount of
ACH resulted in death within 12 hours.[07934]
Chronic toxicity:
Substance-specific information pertaining to repeated exposures of humans is not
available.[99983]
In a subacute inhalation study, rats were exposed to up to 59.6 ppm of ACH for 28 days
(6 hours per day, 5 days per week).
Irritation of eye and nasal mucosae as well as respiratory disorders were found after
exposure to values above 29 ppm.
Hypoactivity and signs of tremor, spasms, hypersalivation, exhaustion were clearly
perceived only in the highest exposure group.
Biochemical and haematological parameters were normal, and pathological-anatomical
and histological studies did not yield abnormal findings.
The cyanate values in the serum and the urine were increased in all exposure groups.
The NOAEL was declared to amount to 9.2 ppm.[99997]
An older chronic inhalation study on rats (3.4 ppm, 2 times per week over 3, 5 or 8
months) revealed morphological changes in the lung tissue (epithelium desquamation,
ulcerations with inflammatory infiltrations) and necrotic changes in the liver and the
kidneys.
HCN-typical damage was not reported, nor was any damage observed in a more recent
subchronic study on rats, even after an external load of up to 57.7 ppm.
It was still assumed that humans might be affected by a chronic toxicity with ACH that
involves the same symptoms as a cyanide toxicity: Headache, weakness, changes in
the olfactory and gustatory senses as well as disorders of the thyroid functions; all
effects were finally triggered by the metabolite thiocyanate.[07934]
However, the blood changes also counted among the symptoms seem less probable
here, since they were definitely ruled out for ACH in the reported animal
experiments.[99997]
Reproductive toxicity, Mutagenicity, Carcinogenicity:
Reproductive toxicity:
Exposure of male or female rats to the inhalation of up to 60 ppm ACH did not trigger
any fertility disorders.[07934]
Further reproductive-toxic endpoints were not sufficiently examined.[99983]
Mutagenicity:
The studies performed to date (in vitro and in vivo) have not yielded any indications of a
genotoxic potential.[07934]
Appropriate information pertaining to humans is not available.
Carcinogenic potential:
Information is not available.[99983]

Biotransformation and Excretion:

ACH is subject to cleavage to cyanide and acetone after (possibly also before)
resorption.
Einrichment in the organism apparently does not take place, since rhodanese-catalysed
reactions with thiosulphate provide a rapid detoxification.
The resulting thiocyanate is eliminated in the urine with a certain delay.[99983]
Annotation:
This occupational health information was compiled on 20.12.1997.
It will be updated if necessary.
This information was translated from German into English by bersetzungsbro Branco.

FIRST AID
Eyes:
Rinse the affected eye with widely spread lids for 10 minutes under running water whilst
protecting the unimpaired eye.
Then, immediately transport the casualty to an eye doctor / to hospital.
[5001]
Skin:
Whilst protecting yourself, relocate the casualty away from the source of danger.
Remove contaminated clothing while protecting yourself.
Cleanse the affected skin areas thoroughly with soap under running water.
Better is rinsing immediately with polyethylene glycol 400 alternating with water for
several minutes. Finish by rinsing with plenty of water.
For approved medical devices, see "Recommendations".
Under no circumstances should alcohol, gasoline or other solvents be used.
In any case as soon as possible [00022]:
Arrange for medical treatment.
Respiratory tract:
Whilst protecting yourself remove the casualty from the hazardous area and take him to
the fresh air.
Lay the casualty down in a quiet place and protect him against hypothermia.
In the case of breathing difficulties have the casualty inhale oxygen.
Have the casualty inhale amyl nitrite from snap-off ampoules.[05001]
In the meantime, summon an emergency physician.[99999]
If the casualty is unconscious but breathing lay him in a stable manner on his side.
Respiratory arrest requires immediate artificial respiration with a respirator.
Mouth-to-mouth resuscitation should only be performed in extreme emergency
situations; utmost attention must be paid to self-protection![00330]
Swallowing:
Rinse the mouth and spit the fluids out.
If the casualty is conscious have him drink copious amounts of liquids (water).
Apply charcoal (3 tablespoons as a suspension in a glass of water).
Make the casualty vomit.
In the meantime, summon a doctor to the scene of the accident as soon as

possible![99999]
Information for physicians:
With regard to its toxic effects ACH can be compared with hydrogen cyanide
(hydrocyanic acid), even if the corresponding symptoms occur with some delay.[99983]
Several (chiefly inhalation and dermal) toxicities have occurred, some of them with
lethal outcomes.[99997]
Symptoms of acute toxicity:
Eyes: Moderate to strong irritative effects;[07934] possibly strongly pronounced vision
disorders triggered by HCN;[99997]
Skin: Depending on the exposure time hyperaemia, swelling, superficial necroses up to
skin reactions similar to burns; rapid or delayed resorptive effects;[07934]
Inhalation: Possibly slight irritative effects on the mucosae; systemic effects might occur
after a probably short latency period;
Ingestion: The irritative potential was not described; immediate or delayed occurrence
of systemic effects (depending on the dose);[99999]
Resorption: Nausea, vomiting, headache, coma with areflexia, possibly cyanosis,
dyspnoea, circulatory collapse, trismus, fibrillations, tonic-clonic spasms.[99997]
First medical assistance:
Direct eye contact with the liquid requires rinsing with saline solution or Isogutt and
possibly pain treatment (as systemic as possible) followed by immediate treatment of
the casualty by an ophthalmologist.[05001]
Resorptive effects must be considered.[99997]
Skin decontamination is performed with soap and water.
In the meantime, rinse the skin with PEG 400, which should be removed with soap and
water after a short period.
Apply flumetasone spray to obvious irritated areas.[07638]
However, the most important target of the therapeutical measures to be performed are
the cyanide-specific resorptive effects.
The casualty must by all means be admitted to hospital.[99999]
In cases of dermal toxicities or toxicities after inhalations, the emergency physician
must immediately decide on the basis of the clinical picture and available information
on the pathogenesis whether ventilation with oxygen and possibly massive application
of thiosulphate (10%, 250 mg per kg of body weight, i.v.) will at first suffice or whether a
Met-Hb former is required, followed by a thiosulphate injection 5 minutes later.
The therapy can only be regarded as optimally coordinated when an analysis of the
blood gases and the cyanide concentration in the blood is available.[00022]
In a case of dermal/inhalation toxicity the following therapy was performed with an
unconscious patient (after vomiting) with (delayed) success:
Inhalation of amyl nitrite, artificial respiration, injection of 10 ml of 3% sodium nitrite
solution immediately followed by the injection of a 10% sodium thiosulphate solution
(100 ml).[99997]
More recent therapy schemes for toxicities with cyanide involve an extreme focus on
the compensation of the lactic acidosis that results from the cytotoxic hypoxia.
The compensation of the lactic acidosis can be achieved with the help of a 5% sodium
carbonate solution during continuous monitoring of the blood gases and the pH
value.[07637]

In recent times the administration of 4-dimethyl aminophenol hydrochloride (DMAP, 3-4

mg per kg of body weight, i.v.) is recommended instead of the nitrite, since the former
triggers fewer side effects.
The casualty must then immediately be given an injection of sodium sulphate (see
above).[99997]
Vomiting should be induced after oral toxicity immediately after the administration of
plenty of water and activated charcoal.[99999]
Gastric irrigation including the administration of activated charcoal should be performed
as soon as possible.
In the event of hypotonia prior (preferably simultaneous) infusion of a plasma-substitute
preparation.[07638]
Treatment of occurring systemic effects according to the above indicated
description.[99999]
Recommendations:
Provide the physician information about the substance/product and treatment already
administered.
According to current findings, the employment of cobalt derivatives as cyanide
antidotes does not provide any particular benefits, particularly as sufficient amounts of
the most effective compound of this series (hydroxycobalamine) are generally not
available.[07900]
In addition to the monitoring of the cyanide and thiocyanate concentrations in the blood
and the blood gases, the blood count as well as the functional kidney and liver
parameters of fundamental importance for the detoxicification process should be
examined in close temporal succession.[99999]
Annotation:
This first aid information was compiled on 20.12.1997.
It will be updated if necessary.
This information was translated from German into English by bersetzungsbro Branco.

SAFE HANDLING

TECHNICAL MEASURES - HANDLING

Workplace:
Provision of very good ventilation in the working area.
The floor must be solvent resistant.
The floor should not have a floor drain.
Washing facility at the workplace required.
Eye bath required. These locations must be signposted
clearly.
When handling excessive amounts of the substance an emergency shower is required.
Equipment:
Use only closed apparatus.
If release of the substance cannot be prevented, then it should be suctioned off at the
point of exit.

Exhaust especially required at higher temperatures.

Consider emission limit values, a purification of waste gases if necessary.
Label containers and pipelines clearly.
Advice on safer handling:
Take care to maintain clean working place.
The substance must not be present at workplaces in quantities above that required for
work to be progressed.
Do not leave container open.
Use leak-proof equipment with exhaust for refilling or transfer.
Avoid splashing.
Fill only into labelled container.
Use solvent resistant utensils.
Avoid any contact when handling the substance.
Prevent seepage into flooring (use of a steel tub).
Use an appropriate exterior vessel when transporting in fragile containers.
Cleaning and maintenance:
Use protective equipment while cleaning if necessary.
Only conduct maintenance and other work on or in the vessel or closed spaces after
obtaining written permission.
Only work with vessels and lines after they have been thoroughly rinsed.

TECHNICAL MEASURES - STORAGE

Storage:
Keep in locked storage or only make accessible to specialists or their authorised
assistants.
Do not use any food containers - risk of mistake.
Containers have to be labelled clearly and permanently.
Store in the original container as much as possible.
Place fragile vessels in break-proof outer vessels.
Use breakable containers only up to 5 litres content.
Keep container tightly closed in a dry and well-ventilated place.
Recommended storage at room temperature.
Keep the substance slightly acidified.
Do not store it for a long period of time.
Conditions of collocated storage:
Storage class 6.1 A (Combustible acutely toxic substances Cat. 1 and 2)
Only substances of the same storage class should be stored together.
Collocated storage with the following substances is prohibited:
- Pharmaceuticals, foods, and animal feeds including additives.
- Infectious, radioactive und explosive substances.
- Gases.
- Other explosive substances of storage class 4.1A.
- Pyrophore substances.
- Substances liberating flammable gases in contact with water.
- Strongly oxidizing substances of storage class 5.1A.

- Ammonium nitrate and preparations containing ammonium nitrate.

- Organic peroxides and self reactive substances.
Under certain conditions the collocated storage with the following sub-stances is
permitted (For more details see TRGS 510):
- Flammable solid substances or desensitized substances of storage class 4.1B.
- Oxidizing substances of storage class 5.1B.
- Combustible solids of storage class 11.
The substance should not be stored with substances with which ha-zardous chemical
reactions are possible.

TECHNICAL MEASURES - FIRE AND EXPLOSION PROTECTION

Technical, constructive measures:
Substance is combustible.
Fire fighting equipment must be available.
Precaution on handling:
Areas in which the substance is heated to above its flash point and processed are
areas of fire hazard.
Keep away from open flames.
Welding only under supervision.

ORGANISATIONAL MEASURES
Instruction on the hazards and the protective measures using instruction manual (
TRGS 555) are required with signature if just more than one minor hazard was
detected.
Instruction must be provided before employment and then at a minimum of once per
annum thereafter.
An escape and rescue plan must be prepared when the location, scale, and use of the
work-site so demand.
The number of employees who work with the hazardous substance must be kept to a
minimum.
Observe the restrictions on juvenile employment as defined in the
"Jugendarbeitsschutzgesetz".
Observe the restrictions on the employment of expectant and nursing mothers as
defined in the "Mutterschutzverordnung".
Only employees are permitted to enter the work areas. Signposting to this effect must
be displayed.

PERSONAL PROTECTION
Body protection:
Depending on the risk, wear a tight protective clothing or a suitable chemical protection
suit.
Respiratory protection:
In an emergency (e.g.: unintentional release of the substance) respiratory protection
must be worn. Consider the maximum period for wear.

Respiratory protection: Gas filter A, Colour code brown.

Perhaps also necessary for improved protection:
Respiratory protection: Combination filter A - P2 or A - P3, recommended A - P3, colour
code: brown-white.
Use insulating device for concentrations above the usage limits for filter devices, for
oxygen concentrations below 17% volume, or in circumstances which are unclear.
Eye protection:
Sufficient eye protection should be worn.
Wear glasses with side protection.
Hand protection:
Use protective gloves. The glove material must be sufficiently impermeable and
resistant to the substance. Check the tightness before wear. Gloves should be well
cleaned before being removed, then stored in a well ventilated location. Pay attention to
skin care.
Skin protection cremes do not protect sufficiently against the substance.
Textile or leather gloves are completely unsuitable.
The following materials are suitable for protective gloves (Permeation time >= 8 hours):
Polychloroprene - CR (0,5 mm)
Butyl rubber - Butyl (0,5 mm)
Fluoro carbon rubber - FKM (0,4 mm)
Following materials are unsuitable for protective gloves because of degradation, severe
swelling or low permeation time:
Natural rubber/Natural latex - NR
Nitrile rubber/Nitrile latex - NBR
Polyvinyl chloride - PVC
The times listed are suggested by measurements taken at 22 C and constant contact.
Temperatures raised by warmed substances, body heat, etc. and a weakening of the
effective layer thickness caused by expansion can lead to a significantly shorter
breakthrough time. In case of doubt contact the gloves' manufacturer. A 1.5-times
increase / decrease in the layer thickness doubles / halves the breakthrough time. This
data only applies to the pure substance. Transferred to mixtures of substances, these
figures should only be taken as an aid to orientation.
Occupational hygiene:
Foods, beverages and other articles of consumption must not be consumed at the work
areas. Suitable areas are to be designated for these purposes.
Avoid contact with skin. In case of contact wash skin.
Avoid inhalation of vapour or mist.
Avoid contact with clothing. Contaminated clothes must be exchanged and cleaned
carefully.
Before cleaning clothes rinse thoroughly first in water.
Increased risk of combustion from wicking.
Before a break it might be necessary to change clothes.
Provide washrooms with showers and if possible rooms with separate storage for street
clothing and work clothing.
The skin must be washed with soap and water before breaks and at the end of work.

Apply fatty skin-care products after washing.

DISPOSAL CONSIDERATIONS
Hazardous waste according to Waste Catalogue Ordinance (AVV).
If there is no way of recycling it must be disposed of in compliance with the respective
national and local regulations.
Collection of small amounts of substance:
Collect in container for toxic, flammable compounds.
Make sure the substance is sufficiently stabilised with diluted acid.
Do not put/place waste into sink or dust bin.
Collection vessels must be clearly labelled with a systematic description of their
contents. Store the vessels in a well-ventilated location. Entrust them to the appropriate
authorities for disposal.

ACCIDENTAL RELEASE MEASURES

Evacuate area. Warn affected surroundings.
The hazardous area may only be entered once suitable protective measures are
implemented. Only then can the hazardous situation be removed.
Wear respiratory protection, eye protection, hand protection and body protection (see
chapter Personal Protection).
Absorb any spilt liquid with an absorbent (e.g. diatomite, vermiculite, sand) and dispose
of according to regulations.
Pump off larger quantities.
Afterwards ventilate area and wash spill site.
Endangerment of watert:
Severe hazard to waters. Avoid penetration into water, drainage, sewer, or the ground.
Inform the responsible authorities about penetration of even small quantities.

FIRE FIGHTING MEASURES

Classes of fires:
B
liquid or melting substances
Suitable extinguishing media:
Water (spray - not splash)
Dry extinguishing powder
Carbon dioxide
Fight large fire with alcohol resistant foam or water spray.
Instructions:
Cool surrounding containers with water spray.
If possible, take container out of dangerous zone.
Heating causes a rise in pressure, risk of bursting and
explosion.
Shut off sources of ignition.

Do not allow runoff to get into the sewage system.

Special protective equipment:
Attention! Hazardous decomposition products may occur.
Nitrous gases (nitric oxides)
Hydrogen cyanide vapours
Wear self-contained breathing apparatus and special tightly sealed suit.

REGULATIONS
Classification:
Acute toxicity, Category 2, oral; H300
Acute toxicity, Category 1, dermal; H310
Acute toxicity, Category 1, inhalation; H330
Specific Target Organ Toxicity (single exposure), Category 1; H370
Hazardous to the aquatic environment, Acute Category 1; H400
Hazardous to the aquatic environment, Chronic Category 1; H410

Signal Word:

"Danger"

Hazard Statement - H-phrases:

H300: Fatal if swallowed.
H310: Fatal in contact with skin.
H330: Fatal if inhaled.
H370: Causes damage to organs.
-------- Affected organs: central nervous system
-------- Route of exposure: Oral
-------- Route of exposure: Dermal
-------- Route of exposure: Inhalative
H410: Very toxic to aquatic life with long lasting effects.
Precautionary Statement - P-phrases:
P233: Keep container tightly closed.
P272: Contaminated work clothing should not be allowed out of the workplace.
P273: Avoid release to the environment.
P310: Immediately call a POISON CENTER or doctor/physician.
P403: Store in a well-ventilated place.
P501: Dispose of contents/container to ...
Registration entry of the manufacturer / importer on the ECHA website
Reference: 07520

The substance is listed in appendix VI, table 3.1 of CLP regulation.

The given classification can deviate from the listed classification, since this
classification is to be complemented concerning missing or divergent danger classes
and categories for the respective substance.
Reference: 99999

GHS-CLASSIFICATION OF MIXTURES
The classification of mixtures containing this substance results from Annex 1 of
Regulation (EC) 1272/2008.
Reference: 07500

WORKPLACE LABELLING ACCORDING TO GERMAN ASR A1.3

Prohibition label:

No Smoking

No admittance for unauthorized persons

No eating and drinking

Warning label:

Caution - toxic material

Precept label:

Use safety goggles

Wear safety gloves

GERMAN WATER HAZARD CLASS

Substance No:
7
WGK 3 - severe hazard to waters
Classification according to the Administrative Regulation of Substances Hazardous to
Water (VwVwS)

TECHNICAL INSTRUCTIONS ON AIR QUALITY CONTROL (TA LUFT)

Chapter 5.2.5 Organic Substances, class I
The following values are in all not allowed to be exceeded in the exhaust gas:
Mass flow: 0,10 kg/hr
or
Mass conc.: 20 mg/m

TRANSPORT REGULATIONS
UN Number: 1541
Shipping name: Acetone cyanohydrin, stabilized
Hazard Identification Number: 669
Class: 6.1 (Toxic Substances)
Packing Group: I (high danger)
Danger Label: 6.1

Special labelling: Symbol (fish and tree)

Tunnel restrictions:
Transports in tanks: passage forbidden through tunnels of category C, D und E.
Other transports: passage forbidden through tunnels of category D and E.

SEVESO III - Directive

Annex I Part 1 Section: E1
Hazardous to the aquatic environment, Category Acute 1 or Chronic 1
Qualifying Quantity
100 t
Column 2:
Qualifying Quantity
200 t
Column 3:
Annex I Part 1 Section: H1
Acute toxic, Category 1
Qualifying Quantity
5t
Column 2:
Qualifying Quantity
20 t
Column 3:

RESTRICTIONS OF USE / BANS OF USE

REACH Regulation (EC) No 1907/2006 Annex XVII
Annex XVII, Point 3
1. The putting into circulation and the utilisation of the substance is not allowed in
decorative objects, games and joke articles.
2. Substances labelled with R 65 which can be utilised as fuels in decorative lamps and
are put in circulation in amounts of 15 l or less must not contain a dye and/or a perfume.
Further information on prohibitions can be taken from the regulation.
Consumer Goods Ordinance
Attachment 1 to 3, Point 5
The substance must not be utilised for the production or treatment of joke articles.

FURTHER REGULATIONS
TRGS 200
Einstufung und Kennzeichnung von Stoffen, Zubereitungen und Erzeugnissen;
Ausgabe Oktober 2011
TRGS 201
Einstufung und Kennzeichnung bei Ttigkeiten mit Gefahrstoffen; Ausgabe Oktober
2011
TRGS 400
Gefhrdungsbeurteilung fr Ttigkeiten mit Gefahrstoffen; Ausgabe Dezember 2010;
gendert und ergnzt September 2012
TRGS 555
Betriebsanweisung und Information der Beschftigten; Ausgabe Januar 2013
TRGS 600

Substitution; Ausgabe August 2008

TRGS 401
Gefhrdung durch Hautkontakt, Ermittlung - Beurteilung - Manahmen; Ausgabe Juni
2008; zuletzt berichtigt Mrz 2011
TRGS 500
Schutzmanahmen; Ausgabe Januar 2008, ergnzt Mai 2008
TRGS 509
Lagern von flssigen und festen Gefahrstoffen in ortsfesten Behltern sowie Fll- und
Entleerstellen fr ortsbewegliche Behlter; Ausgabe November 2014
TRGS 510
Lagerung von Gefahrstoffen in ortsbeweglichen Behltern; Ausgabe Januar 2013,
gendert und ergnzt November 2014
TRGS 800
Brandschutzmanahmen; Ausgabe Dezember 2010

LINKS
International Limit Values
OECD Screening Information DataSet (SIDS)

REFERENCES
Reference: 00001
IFA: Erfassungs- und Pflegehandbuch der GESTIS-Stoffdatenbank (nicht ffentlich)
Data acquisition and maintenance manual of the GESTIS substance database (not
publicly)
Reference: 00022
G. Hommel "Handbuch der gefhrlichen Gter" Loseblattsammlung mit
Ergnzungslieferungen ("Handbook of dangerous goods " loose-leaf collection with
supplement deliveries), Springer-Verlag, Heidelberg
Reference: 00088
RTECS-Datenbankrecherche bis 1998
Reference: 00240
E. Brandes, W. Mller "Sicherheitstechnische Kenngren" Band 1 "Brennbare
Flssigkeiten und Gase" ("Safety-related characteristics" Vol. 1 "Combustible liquids
and gases"), Wirtschaftsverlag NW, Verlag fr neue Wissenschaft GmbH,
Bremerhaven, 2003
Reference: 00330
U. Welzbacher "Neue Datenbltter fr gefhrliche Arbeitsstoffe nach

Gefahrstoffverordnung" Loseblattsammlung mit Ergnzungslieferungen, WEKA-Verlag,

Augsburg
Reference: 00448
Datenbank CHEMSAFE, Version 2.7 (2011), DECHEMA-PTB-BAM
Reference: 01211
GHS-Sicherheitsdatenblatt (GHS Material Safety Data Sheet), Merck
Reference: 02071
Toxicological Data, compiled by the National Institute of Health (NIH), USA, selected
and distributed by Technical Database Services (TDS), New York, 2009
Reference: 02072
Ecotoxicological Data, compiled by the US Environmental Protection Agency (EPA),
selected and distributed by Technical Database Services (TDS), New York, 2009
Reference: 05000
Khn-Birett-Gruppenmerkbltter
Reference: 05001
Khn-Birett-Merkbltter bis 88. Ergnzungslieferung
Reference: 05146
Khn-Birett-Merkbltter: 146. Ergnzungslieferung; 2/2002
Reference: 05300
TRGS 510 "Lagerung von Gefahrstoffen in ortsbeweglichen Behltern" Ausgabe
Januar 2013, gendert und ergnzt November 2014
Reference: 06002
L. Roth, U. Weller "Gefhrliche Chemische Reaktionen" Loseblattsammlung mit
Ergnzungslieferungen ("Dangerous chemical reactions" loose-leaf collection with
supplement deliveries), ecomed-Verlag
Reference: 07500
Verordnung (EG) Nr. 1272/2008 des Europischen Parlaments und des Rates vom 16.
Dezember 2008 ber die Einstufung, Kennzeichnung und Verpackung von Stoffen und
Gemischen, zur nderung und Aufhebung der Richtlinien 67/548/EWG und
1999/45/EG und zur nderung der Verordnung (EG) Nr.1907/2006
(EG-GHS-Verordnung)
Reference: 07520
Europische Chemikalienagentur ECHA: Informationen ber registrierte Substanzen
(European Chemicals Agency ECHA: Information on registered substances)
Reference: 07584
Allgemeine Verwaltungsvorschrift zur nderung der Verwaltungsvorschrift
wassergefhrdende Stoffe - VwVwS vom 27. Juli 2005; Bundesanzeiger Jahrgang 57,
Nr. 142a, vom 30. Juli 2005

Reference: 07635
AUERDATA 98 und BGR/GUV-R 190 "Einsatz von Atemschutzgerten" Ausgabe
11/2009
Reference: 07637
S. Moeschlin "Klinik und Therapie der Vergiftungen" 7. Auflage, Thieme-Verlag,
Stuttgart 1986
Reference: 07638
M. Daunderer "Toxikologische Enzyklopdie - Klinische Toxikologie - Giftinformation,
Giftnachweis, Vergiftungstherapie" Loseblatt-Ausgabe, ecomed-Verlagsgesellschaft
mbH, Landsberg
Reference: 07729
Chemisch-toxikologische Schadstoffkartei, Akademie der Wissenschaften, Leipzig
Reference: 07795
H. Geerien "GloSaDa 2000 Plus - Glove Safety Data"
Reference: 07796
L. Roth "Wassergefhrdende Stoffe" Loseblattsammlung mit Ergnzungslieferungen,
ecomed-Verlag
Reference: 07900
H. Marquardt, S.G. Schfer (Hrsg.): Lehrbuch der Toxikologie; BI-Wissenschaftsverlag,
Mannheim 1994
Reference: 07902
ADR 2015 - Europisches bereinkommen ber die internationale Befrderung
gefhrlicher Gter auf der Strae (ADR)
Reference: 07934
IUCLID-Datenstze 1996, European Commission JRC
Reference: 99983
Literaturlisten - Standardwerke, erweitert (Bibliographical reference - standard works,
extended)
Reference: 99997
Projektgebundene Literaturliste Nr. 1
(Project related bibliographical reference No 1)
Reference: 99999
Angabe des Bearbeiters (Indication of the editor)
This substance datasheet was created with greatest care. Nevertheless no liability irrespective of legal basis can
be accepted.