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Indications
Ulcerative colitis, acute exacerbations of MS, and palliation in some leukemias and
lymphomas
Interventions
Systemic administration
WARNING: Give daily before 9 AM to mimic normal peak diurnal corticosteroid levels
and minimize HPA suppression.
Use caution with occlusive dressings; tight or plastic diapers over affected area can
increase systemic absorption.
Avoid prolonged use, especially near eyes, in genital and rectal areas, on face, and in skin
creases.
Teaching points
Systemic administration
Take this drug exactly as prescribed. Do not stop taking this drug without notifying your
health care provider; slowly taper dosage to avoid problems.
Dosage reductions may create adrenal insufficiency. Report any fatigue, muscle and joint
pains, anorexia, nausea, vomiting, diarrhea, weight loss, weakness, dizziness, or low
blood sugar (if you monitor blood sugar).
Take single daily or alternate-day doses before 9 AM; mark calendar or use other
measures as reminder of treatment days.
Frequent follow-up visits to your health care provider are needed to monitor drug
response and adjust dosage.
Wear a medical alert ID (if you ae using long-term therapy) so that any emergency
medical personnel will know that you are taking this drug.
You may experience these side effects: Increase in appetite, weight gain (some of gain
may be fluid retention; monitor intake); heartburn, indigestion (eat frequent small meals;
use of antacids may help); increased susceptibility to infection (avoid crowds during peak
cold or flu seasons, and avoid anyone with a known infection); poor wound healing (if
injured or wounded, consult health care provider); muscle weakness, fatigue (frequent
rest periods may help).
Report unusual weight gain, swelling of lower extremities, muscle weakness, black or
tarry stools, vomiting of blood, epigastric burning, puffing of face, menstrual
irregularities, fever, prolonged sore throat, cold or other infection, worsening of
symptoms.
Do not overuse the injected joint even if the pain is gone. Adhere to rules of proper rest
and exercise.
Anorectal preparations
Maintain normal bowel function with proper diet, adequate fluid intake, and regular
exercise.
Notify your health care provider if symptoms do not improve in 7 days or if bleeding,
protrusion, or seepage occurs.