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HNBB

Buscopan
Drug Classes

Antispasmodic
Anticholinergic
Therapeutic Actions

Hyoscine-N-butylbromide (HNBB) acts by interfering with the transmission of nerve


impulses by acetylcholine in the parasympathetic nervous system.

Buscopan exerts a spasmolytic action on the smooth muscle of the gastrointestinal,


biliary and urinary tracts. As a quaternary ammonium derivative, hyoscine-Nbutylbromide does not enter the central nervous system. Therefore, anticholinergic
side effects at the central nervous system do not occur. Peripheral anticholinergic
effects result from a ganglion-blocking action within the visceral wall as well as from
anti- muscarinic activity.

Indications

Buscopan Tablets are indicated for the relief of spasm of the genito-urinary tract or
gastro- intestinal tract and for the symptomatic relief of Irritable Bowel Syndrome

Presentation & Administration

Intravenous (IV)

20mg in 1ml (solution)

Dilute required dose to 10ml with normal saline. Inject slowly over 3-5 minutes.
Compatible with the following IV fluids:
Normal saline, 5% glucose glucose and sodium chloride
May be given into the side arm when the above IV fluids are being infused. Store at
room temperature. Protect from light.
IM or SC:

Inject undiluted into a large muscle mass or subcutaneously


Per-orem

Buscopan 10mg (white)


Gastro-Soothe 10mg (white)
Contraindications

Buscopan Tablets should not be administered to patients with myasthenia gravis,


megacolon and narrow angle glaucoma. In addition, they should not be given to
patients with a known hypersensitivity to hyoscine-N-butylbromide or any other
component of the product.

Adverse Effects

CNS: dizziness, anaphylactic reactions, anaphylactic shock, increased ICP,


disorientation, restlessness, irritability, dizziness, drowsiness, headache, confusion,
hallucination, delirium, impaired memory
CV: hypotension, tachycardia, palpitations, flushing
GI: Dry mouth, constipation, nausea, epigastric distress
DERM: flushing, dyshidrosis
GU: Urinary retention, urinary hesitancy
Resp: dyspnea, bronchial plugging, depressed respiration

EENT: mydriasis, dilated pupils, blurred vision, photopobia, increased intraocular


pressure, difficulty of swallowing.
Nursing Considerations

Drug compatibility should be monitored closely in patients requiring adjunctive


therapy
Avoid driving & operating machinery after parenteral administration.
Avoid strict heat
Raise side rails as a precaution because some patients become temporarily excited
or disoriented and some develop amnesia or become drowsy.
Reorient patient, as needed, Tolerance may develop when therapy is prolonged
Atropine-like toxicity may cause dose related adverse reactions. Individual tolerance
varies greatly
Oerdose may cause curare-like effects, such as respiratory paralysis. Keep
emergency equipment available.

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