Zinc Monomethionine -Write Up

In zinc monomethionine, zinc is organically bound to a sulfur containing

essential amino acid- Methionine. This provides a soluble, readily absorbable
and easily
retained source of Zinc.
Methionine
has free radical scavenging activity by virtue of its sulfur atom, as
well as its
chelating ability. This anti-oxidant activity appears to account for its
anti hepatotoxic
activity.
Zinc monomethionine supplementation significantly
increases plasma zinc
levels without affecting plasma copper levels. This is important
since high
levels of zinc often reduce copper absorption.
It helps to strengthen immunity, enhances growth
and has a major role in
several basic cellular functions that are vital to the activities
of immunological
mediators.

Structure

Requirements
The Food and Nutrition Board of the Nutrition
Board of the National Academy of
Sciences has recommended the following Recommended
Dietary Allowances
(RDA) for zinc.
Age (years)

RDA (milligrams/day)

01

05

1 10

10

Males 11 51+1

15

Females 11
51+1

12

Pregnant

15

Lactating
First 6 months

19

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Zinc Monomethionine -Write Up

Second 6 months

16

Significance of
Methionine in human nutrition
L-Methionine is protein amino acid. It is
classified as an essential amino acid for
human and therefore must be supplied in the
diet.
In addition to its role as a
precursor in protein synthesis, L-methionine
participates in a wide range of biochemical
reactions, including the production
of S-Adenosylmethionine (SAM or SAMe), L-cysteine,
glutathione, taurine and
sulfate. SAM itself, as a methyl donor, is involved in the
synthesis of creatine,
epinephrine, melatonin and the polyamines, spermine and spermidine,
among
several other substances.
Antioxidant activity of L-methionine and metabolites of L-methionine appear to
account for its possible anti-hepatotoxic activity. Recent research suggests
that methionine itself has free radical scavenging activity by virtue of its sulfur,
as well as its chelating ability.

Role of Zinc in
human nutrition
Zinc plays roles vital roles in several functions of the human system.
Normal growth and development

Zinc plays important roles

in bone growth and
mineralization and the
development
of
reproductive organs.

Maintaining healthy skin and bones

Zinc deficiency is linked

to various skin disorders,
including eczema, acne,
and excessive flaking
similar to what occurs in
psoriasis. Hair becomes
dull and lifeless looking.

Metabolic processes

Zinc is a component of
various enzyme systems,
and it is essential for the
synthesis
and
metabolism of proteins
and genetic material. The
red blood cells also need
zinc for the proper
transfer
of
carbon
dioxide.

Healing and immune function

Zinc promotes the healing

of
burns
common
infections.

Taste and smell

Zincs role in these

senses enables a person
to distinguish the taste of

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Zinc Monomethionine -Write Up

different foods.

Physiologically, zinc is vital for growth and developments, sexual maturation

and
reproduction, dark vision adaptation, olfactory and gustatory activity,
insulin storage
and release and for a variety of host immune defenses, among
other things.
Zinc deficiency can result in
growth retardation, immune dysfunction, increased
incidence of infections, hyypogonadism,
oligospermia, anorexia, diarrhea,
weight loss, delayed wound healing, neural tube defects
of the fetus, increased
risk for abortion, alopecia, mental lethargy and skin changes.
Zinc may have
immunomodulatory activity. Zinc has putative antiviral, fertilityenhancing and
retinoprotective activities.
Zinc is also very important
to the newborn when breast milk may be its only
source of Zinc.
Zinc also functions as an
antioxidant as well as a membrane stabilizer. The
several roles of zinc in basic cellular
functions such as DNA replication, RNA
transcription, cell division and activation are key
to the activities of vital
immunological mediators.
Zinc is needed for the
development of neutrophils and natural killer cells in the
non-specific immune defense as
well as acquired immunity that is attained
through the activities of T-lymphocytes and
B-lymphocytes.
The usefulness of Zinc to
promote wound healing has been firmly established.
Use of zinc promoted the repair process of the damaged vascular tissue
through stimulus of the lipoxygenase pathway that mediates response to
endogenous growth factors in the healing process. Zinc compounds also has
the healing of gastric ulcers.

Zinc
monomethionine has a nutritional supplement
Both the components of Zinc Monomethionine,
Zinc and Methionine have
potent antioxidant properties.
Certain in vitro studies
indicate that zinc monomethionine can accentuate the
biochemical consequences of oxygen
free radical and it is comparable to other
well-known antioxidants and free radical
scavengers.
Zinc mono methionine has a triple antioxidant action - preventing and
eliminating free radical formation, with methionine offering protection to the
tissues against attack by free radicals.

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