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HARD CAPSULES
Capsules, over time have globally become the choice of pharmacists aspiring towards superior patient
compliance levels, improved release profiles and unique identities. However, given the advantage of liquids
especially in the above mentioned facets, the utility of capsules has slowly but surely diminished.
The advent of Softgel encapsulation has led to the simplification of liquid drug delivery and has had an
impact on sub-optimal manufacturing yield and even quality. Higher costs have driven down demand for
this dosage form.
ACG, a pioneer in capsule technology, working constantly in tandem with the changing trends of the
pharmaceutical industry, has developed the unique Fluidocap technology that allows liquids of a wide
variety to be filled into hard capsules.
Given the promise of assured quality, timely
improvements in yield and significantly lower
costs, liquid filling in hard capsules has proven
to be a highly effective substitute to liquid
dosages as well as Softgels.
The flexibility to fill hard capsules with liquids
in combination with tablets, pellets, and have
capsules within capsules allows R&D centres
across the industry to innovate with ease and
consistently positive results.
The Fluidocap series is offered in various
capacities ranging from a lab model of 1,000
capsules per hour to a high-speed model
offering 60,000 capsules per hour. The
Fluidocap technology is the combination of
various mechanisms and systems that have
been developed at ACG to maximize the yield
and optimize the efficiency of filling liquids
into hard capsules. These systems include:
No Capsule No Fill (NCNF)
Seal free dosing block
Formulation temperature control
Purging of filled capsules
Combination filling provisions
Industrial PC interface
Technologically Driven
ACG-Pam has been pioneering newer and better technologies for over four decades, and helping the
pharmaceutical industry address its challenges. With a dedicated workforce for spearheading the design
and development of class-leading technologies, ACG-Pam is constantly engaged in building a range of
new products. From the Accura range of 100% checkweighers to the highly sophisticated ZRO range of
capsule filling machines to the robust and ecient range of tablet presses, ACG-Pam is driven by a
passion for innovation and developing market-leading technologies. At the heart of these technologies
is our collaboration with leading component manufacturers across the world along with our capability
and state-of-the-art infrastructure to fabricate precision parts in-house.
CODE
Customized Oral Dosage Encapsulation (CODE) helps pharmaceutical companies achieve unique dosage
forms for various combinations of formulations. ACG-Pam oers these retrofittable and completely
customized attachments for dosing a combination of pellets, powder, mini and micro tablets, capsules,
and softgel - all in one capsule. This degree of customization is what dierentiates ACG-Pam from the
rest. Its not just technology, but solutions that are built to suit specific requirements.
Customer Support
Understanding customer needs and responding with prompt information form the core of ACG-Pam's
services. ACG-Pam has a dedicated team of sales and service personnel catering exclusively to customers
all over the world. With oces across India, Brazil, Bangladesh, China, Indonesia, Thailand, the UK and the
US, ACG-Pam ensures it is within the reach of its customers always. Customers also have the convenience
of logging-in their requests for service, spares and equipment directly through ACG-Pams website
www.acg-pam.com
Synergistic Solutions
ACG Associated Capsules and ACG Lukaps - both members of ACG Worldwide - are together the worlds
second largest manufacturers of empty hard capsules. Catering to the global pharmaceutical and dietary
supplement industries in over 100 countries, the companies produce over 80 billion capsules annually
through its three plants in and around Mumbai, India, another plant in Ludbreg, Croatia, and a new
state-of-the-art facility in Indore, India.
FlofitTM
Liquid in Capsule. Solid in Performance.
ACG Associated Capsules, the worlds
second-largest
empty
hard
capsule
manufacturer and a member of ACG Worldwide,
offers Flofit - a two-piece empty hard capsule
that is ideal for filling and band-sealing liquids,
pastes and wax. FlofitTM makes a significant
contribution to the development of efficacious
pharmaceutical products, by providing the
flexibility to rapidly develop and test
formulations in-house. The process can be
scaled-up, yet kept in-house, much similar to
the operations seen in tableting or
powder/pellet filling in hard capsules. In
addition, FlofitTM offers better bioavailability and
enhanced appearance, thereby, improving
patient compliance.
Over the years, various research and development
efforts have documented that liquid in hard
capsules can offer solutions for some
challenging compounds. A large number of
pharmaceutical companies have directed their
research efforts towards investigating and
understanding benefits of encapsulating liquid
in two-piece hard capsules.
Today, pharmaceutical companies across the
world want to extend a number of their
products in liquid-in-hard-capsule. By far, this
remains a relatively unexplored alternative that
could lead to quicker relief for patients, an
extension of the drugs patent life, and most
importantly, manufacturing cost effectiveness.
Fluidocap 1000
R&D Scale Filling and Sealing
The Fluidocap 1000 is a semi-automatic machine that
integrates the filling, closing and band sealing processes
in one compact and robust machine. It comes with the
versatility to process a large variety of capsules from sizes
00 to 4 of both HGC and HPMC (Veg) variety of FlofitTM
capsules designed by ACG for the specific application.
Salient Features
Output: Up to 1,000 capsules per hour
Compact filling and sealing equipment
Mechanisms to handle 40 cps to 3,000 cps formulations
including pastes, hot melt and thixotropics
Band sealing in order to aid integrity of dosage form,
provide brand distinction and enhance shelf life
Flexibility to fill and seal gelatin as well as HPMC
capsules
Up to 1,000 capsules/hour
Temperature of Fill
Temperature Controller
Electric Supply
Compressed Air
60 lpm @ 6 bar
Connected Load
Dimensions (L x W x H)
Gross Weight
425 Kg
Shipping Dimensions
(L x W x H)
Shipping Weight
570 Kg
Layout
1505
1975
1060
830
Fluidocap Filling
Fluidocap filling machines are easy-to-operate fully
automatic machines for liquid filling of two-piece hard
capsules with formulations ranging in viscosity from 10 cps
to 80,000 cps in medium to large batches. The salient
features allow the machine to fill liquids of varied
characteristics such as free flow liquid, pastes,
suspensions, thixotropic, and hot melts.
Salient Features
Hot water circulation to maintain formulation
temperature up to 75 C
Stirrers in hopper to facilitate flow
Inert-gas purging for oxygen sensitive products
IPC features option to feed recipe programs to
ensure easy changeover and flexibility with 21 CFR
Part 11 compliance
Interlocks for safety cover, pressure maintenance
and No Capsule No Fill (NCNF) alerts
ACG FlofitTM capsules for ideal liquid filled capsules
Pellet, tablet, capsule in capsule filling systems
Productivity optimization through ancillary line
systems
Temperature of Fill
Temperature Controller
Electric Supply
220 V, 50 Hz
Vacuum Required
1100 LPM @ 26 of Hg
Compressed Air
60 LPM @ 6 bar
Connected Load
8 kW
2.25 kW (Main machine)
4.95 kW (Main machine + Hot water circulation motors +
Vacuum pump)
7.15 kW (Main machine + Hot water circulation motors +
Vacuum pump + Air compressor)
Dimensions (L x W x H)
Gross Weight
2350 Kg
Shipping Dimensions
(L x W x H)
Shipping Weight
2550 Kg
Fluidocap Sealing
Augmenting the unique identity and providing tamper
evident technology to the liquid filled capsules ACG-pam
oers Fluidocap S40 and S70, band sealing systems. To
ensure high quality and optimized efficiency this
advanced band sealing technology includes key features
and mechanisms.
Salient Features
Dual heating pad system for gelatin temperature
maintained within 2 C
Peristaltic pumps to assist controlled flow of
banding gelatin
Adjustable sealing rollers with delivery optimized
design
Centrifugal blowers for dehumidified air in drying
chamber
Carrier links designed for careful handling of
capsules
Capsule Size
00 to 4
Electrical Requirements
Connected Load
5 kW
Compressed Air
60 LPM @ 6 bar
Peristaltic Pump
Machine Dimensions
(Lx W x H)
Net Weight
S40: 1300 kg
S70: 1500 kg
Shipping Dimensions (L x W x H)
Main Machine
Dryer Unit
Control Panel
S40: 1525mmX1300mmX1930mm
S70: 1525mmX1300mmX1930mm
Gross Weight
S40: 1800 kg
S70: 2000 kg
F20+S40
Layout
500
TRANSFORMER
350
800
VACUUM
PUMP
610
340
600
ELECTRICAL
PANEL
2700
800
500
HOT WATER
CIRCULATION
SYSTEM
1100
COMPRESS AIR
3533
FLUIDOCAP S40
450
800
800
800
CONTROL PANEL
800
FLUIDOCAP F20
1300
800
2900
500
VACUUM PUMP
805
610
TRANSFORMER
3532
3500
60
FLUIDOCAP S40
CONTROL PANEL
780
940
1850
1850
1810
600
2000
2541
2540
FLUIDOCAP F20
145
HOT WATER
CIRCULATION
SYSTEM
OPERATING PANEL
ELECTRICAL PANEL
F40+S70
Layout
500
1050
TRANSFORMER
350
800
VACUUM
PUMP
610
600
2700
1100
ELECTRICAL
PANEL
800
500
HOT WATER
CIRCULATION
SYSTEM
2900
COMPRESS AIR
FLUIDOCAP S70
450
800
800
HMI
FLUIDOCAP F40
1300
800
2900
CONTROL
PANEL
800
800
500
610
TRANSFORMER
60
VACUUM PUMP
CONTROL PANEL
FLUIDOCAP S70
SIDE VIEW
780
940
920
HOT WATER
CIRCULATION
SYSTEM
1850
1810
600
2000
2420
1960
1850
FLUIDOCAP F40
145
OPERATING PANEL
ELECTRICAL PANEL