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Introduction
In my introductory report - Multiple Chemical Sensitivity: An Introduction I proposed that the
symptomatology of MCS has its root cause in the nervous system, specifically the limbic system
(amygdala, hypothalamus). This was followed by my report - The Hypothalamus & Human Nervous
System with a focus on the hypothalamus, a nuclei within the limbic system. My next report Neural
Sensitization and MCS was a review of the MCS medical literature which strongly implicated the
nervous system, specifically the limbic system, as the primarily organ system responsible for many of the
symptoms of MCS. Finally, in my report The Olfactory-Limbic System - I looked deeper into the limbic
system and its connection to olfaction and MCS.
Which leaves the obvious question what is causing the limbic system to dysfunction?
This report will focus on one possible cause of a dysfunctional limbic system improper metabolism and
detoxification of sulfur in the human body. Sulfur and sulfur compounds are ubiquitous and essential to
all life. Sulfur and sulfur compounds are found occurring in rocks, soil, ground water, ocean waters and
in the atmosphere. They are found occurring in fruits, vegetables and animal meats. Sulfur and sulfur
compounds not only occur naturally in both humans and nature, but as well as being a waste by-product
(pollution) of industry and other human activities (i.e. vehicle exhaust).
Regardless of the source, once in the human body sulfur and sulfur compounds must be metabolized
and detoxified properly. Poor metabolism and detoxification can occur due to a variety of reasons such
as: nutritional deficiencies, lack of appropriate enzymatic activity, heavy metal toxicity, viral or bacterial
infections and genetic defects. The inability of the body to properly metabolize and detoxify sulfur and
sulfur compounds results in the buildup of excitotoxic and neurotoxic compounds. The buildup of these
toxic compounds greatly affects the limbic system, thereby causing a variety of symptoms in not only
the nervous system, but the endocrine and immune systems as well.
Along with discussing the many aspects of sulfur and sulfur compounds, this report and the next report
will also be discussing chemical processes that take place in both the environment and the human body.
Therefore, my previous report Chemistry: A Primer should be used as a reference if need be.
Sulfur (S)
Characteristics of Sulfur
Non-metal
Atomic number 16
Atomic mass - 32.065
Number of isotopes 25 isotopes:
4 of which are stable isotopes (95% - 32 with 16 neutrons, the remaining
5% - 33 with 17 neutrons, 34 with 18 neutrons, 36 with 20 neutrons)
21 of which are unstable radioactive isotopes but are short lived (seconds
to days).
Sulfur is the tenth most abundant element in the universe. It is a pale yellow,
tasteless, odorless and brittle material that is non-toxic. Sulfur is solid at room
temperature, but melts easily at a temperature of only 239o - slightly above the
boiling point of water (212o). Sulfur does not dissolve in water (insoluble) and
forms stable compounds with all elements except the noble gases.
As compared with oxygen, which can form covalent bonds to one, two or exceptionally three other
atoms, the most striking feature of sulfur is its added ability to bond to four, five or six atoms.
Sulfur burns if heated and is referred to as brimstone in ancient literature fire and brimstone.
In nature sulfur can primarily be found occurring in three forms 1) elemental sulfur, 2) sulfides, and 3)
sulfates. Together these three forms of sulfur constitutes about 0.05 percent of the Earths crust. After
oxygen and silicon, sulfur is the most abundant constituent of minerals.
ground using a process called the Frasch process. Because the boiling point of sulfur is low, the Frasch
process involves pumping down superheated steam down into the deposits, causing the sulfur to liquefy.
The liquefied or molten sulfur is then removed by pumping air down into the deposits, causing it to rise
to the surface. Once on the surface the molten sulfur once again solidifies. The Frasch process produces
sulfur of very high purity of 99%.
This process is used when naturally occurring large deposits of elemental sulfur are found. However,
most of the Earths sulfur is found in underground deposits tied up as rocks, common minerals and
salts or buried deep in the ocean in oceanic sediments.
Some materials containing sulfur with
their percentage content are:
Material
Wt. %
Earths crust
Soil
Coal
Oil
Natural Gas
Gypsum
0.052
0.01 - 0.05
1-14
0.1 14
0.1 40
18.6
Because sulfur is found naturally in the Earths soil it therefore is also found naturally in plants and
animals. Sulfur in the soil, usually in the form of sulfate, is taken up and assimilated by plants. The
sulfate (SO42-) is first taken up by the plants roots, then through a series of enzymatic processes the
plant reduces it to sulfite (SO32-), then to sulfide (S2-) and finally the sulfur is incorporated into an organic
sulfur compound. These organic sulfur compounds are usually proteins consisting of the sulfur amino
acids cysteine, and methionine. Animals or livestock obtain sulfur by simply ingesting plants.
Some foods containing sulfur with their percentage content are:
Food
Wt. %
Cabbage
Alfalfa
0.98
0.5
Oats
Barley
Apple
Beef
Egg Whites
0.41
0.30
0.45
0.1
1.6
In the atmosphere, sulfur can be found as part of a variety of sulfur compounds (i.e. sulfur dioxide,
hydrogen sulfide) that originate from natural processes. Hot springs and steam vents, such as those in
Yellowstone National Park are examples where emissions of sulfur compounds are found. Other
examples are volcanic vapors and sea spray which play an important role. Even microscopic bacteria and
phytoplankton (ocean waters) get into the act by releasing sulfur compounds such as dimethyl sulfide
(C2H6S) into the atmosphere.
Sulfur is also found tied up in coal, petroleum and natural gas. These raw materials are valuable fuels for
powering and supplying energy to a countrys infrastructure. The burning of these substances takes
place on both an individual level (cars, lawnmowers, oil furnaces, etc.) and an industrial level (power
plants, refineries, smelters, etc.) which both result in the poisonous gas sulfur dioxide (SO2) being
released into the atmosphere. To reduce sulfur dioxide emissions a chemical process has been
developed to remove sulfur from petroleum and natural gas. This process called the Claus process uses a
technique called hydrodesulfuization (HDS).
HDS involves catalytic treatment (increases chemical rate) with hydrogen to convert the various sulfur
compounds present to hydrogen sulfide. The hydrogen sulfide is then separated and converted to
elemental sulfur. So much elemental sulfur is removed during this process that about 4,000,000 tons of
sulfur are recovered in the U.S. each year from natural gas, petroleum refinery gases and smelter gases.
Uses of Sulfur
Eighty-five percent of the elemental sulfur that is removed by HDS is used in the manufacture of sulfur
dioxide (SO2). The primary use of sulfur dioxide is in the production of the end product of sulfuric acid
(H2SO4), which is one of the chemical industries most important raw materials.
Another major use of elemental sulfur is in pesticides:
Currently, sulfur is registered by EPA for use as an insecticide, fungicide and rodenticide on
several hundred foods and feed crop, ornamental, turf and residential sites. Sulfur is applied in
dust, granular or liquid form, and is an active ingredient in nearly 300 registered pesticide
products.
Sulfur has been know and used as a pesticide since very early times and has been registered for
pesticide use in the U.S. since the 1920s. (EPA 1991)
Dusting sulfur, elemental sulfur in powdered form, is a
common fungicide for grapes, strawberry, many
vegetables and several other crops. It has a good
efficacy against a wide range of powdery mildew
diseases. In organic production, elemental sulfur is the
most important fungicide. It is the only fungicide used
in organically farmed apple production against the main
disease apple scab. It is also used against peach scab
and rot, peanut leaf spots, grape mildew, pecan leaf
curl, etc.
Smaller amounts of sulfur are used to vulcanize natural
rubbers (to treat rubber with heat and sulfur to harden
it and make it more durable). Sulfur is also used in the
manufacture of gunpowder, fireworks, matches,
detergents, corrosion-resistant concrete, and
photographic chemicals. In the world of personal care
products and medicines, sulfur is used in permanent
wave lotions, shampoos, skin care products, fungal
creams and in pharmaceuticals (i.e. sulfa drugs).
Sulfide (S2-)
Sulfide (S2-) is composed of a single sulfur atom (S) with two extra electrons in its valence shell. Making
sulfide an anion of sulfur with a negative two (2- ) charge. Sulfide is exceptionally basic and exists in
strongly alkaline aqueous solutions.
Use
Mercury sulfide /
Cinnabar
Sulfate (SO42-)
Sulfate (SO42-) is composed of a central sulfur atom (S) surrounded by four
equivalent oxygen atoms (O) with two additional electrons in its valence
shell. This makes sulfate a fully oxidized polyatomic anion of sulfur with a
negative two (2- ) charge.
Strontium sulfate /
Celestine
Uses
Barium sulfate /
Barite
Copper sulfate /
Chalcanthite
Algaecide
Magnesium sulfate /
Epsomite
Sulfates are also use in a variety of personal care products such as - toothpaste, hair curling products
and shampoo.
Because both soil and groundwater contain sulfates it is only natural that sulfate will be found in
vegetation. This will be covered in more detail in the next section.
In the atmosphere sulfate, an anion with a (2- ) charge will attract other cations (+) elements to become
electrochemically stable. Sulfate may bind with ammonium (NH4+), calcium (Ca 2+) or hydrogen (H+).
Sulfate, in the atmosphere occurs as microscopic particles and can serve as condensation nuclei for the
formation of ice crystals, which may settle from the atmosphere as rain or snow. If the sulfate is bonded
to hydrogen the precipitation will be acidic and therefore contributing to the phenomena of acid rain.
Sulfur Compounds
Along with sulfate there are numerous chemical compounds containing sulfur. Listed and described
below are several that are relevant to this report.
Forest fires
Scientist estimate that natural sources release 80 to 290 million tons of sulfur dioxide into Earths
atmosphere annually. Volcanoes being the major natural source, for example: in 1991 Mt. Pinatubo in
the Philippines released between 15 and 30 million tons of sulfur dioxide into the atmosphere.
Power plants burning of coal accounts for over 60% of human sulfur dioxide emissions
Commercial-Institutional heating plants
Industrial boilers
Petroleum refining
Metal smelters - smelting of sulfide ores
Pulp mills - production of paper products
The chief use of manufactured sulfur dioxide (SO2) is as feedstock for the preparation and production of
further sulfur compounds - sulfur trioxide (SO3), sulfites (S32-) and especially the end product of sulfuric
acid (H2SO4). However, sulfur dioxide is also used as an industrial reducing agent, a solvent disinfectant,
a refrigerant, a bleaching agent, and a fumigant.
After listing the above usages it might surprise one to learn that sulfur dioxide is also used as a food
preservative. Foods are either exposed to the gaseous form or are dipped in a liquid form of sulfur
dioxide. Foods such as dried fruit, vegetables, meats, wine and beer may undergo this form of food
preservation. Interestingly, sulfur dioxide is also used in the manufacturing of sulfites which too are food
preservatives. Together sulfur dioxide and sulfites are heavily used throughout the food and restaurant
industry as a preservative agent in foods.
Sulfite (SO32-)
Sulfite (SO32-) is composed of one sulfur atom (S) bonded to
three oxygen atoms (O) with a negative two (2- ) charge.
This makes it another polyatomic anion of sulfur. Sulfites are the
salts of sulfurous acid (H2SO3), formed by replacing
one or both of the hydrogen atoms with a metal or a radical
(i.e. sodium sulfite - Na2SO3). In general, sulfites are moderately
strong reducing agents.
Sulfites are naturally occurring compounds that nature uses to prevent microbial growth. They are
found naturally on grapes, onions, garlic and many other plants.
Though sulfites can be found in nature, they too are manufactured on a large scale by the chemical
industry. Sulfur dioxide gas (SO2) dissolves fairly readily in water (H2O) to create a solution of sulfurous
acid (H2SO3). Sulfurous acid gives rise to two series of salts a normal sulfite ion (SO32-) and a hydrogen
sulfite ion (HSO3-).
Sulfites are heavily used by the food industry as a preservative. Sulfites are commonly found in wines (to
prevent spoilage and oxidation) dried fruits, dried potato products, jams, canned vegetables, soup mixes,
condiments, etc. etc. etc.. Sulfites are used in pharmaceuticals to maintain the stability and potency of
certain medications. And sulfites are used as a reducing agent for bleaching and to prevent rust.
There are several types of sulfites the most important of which is
sodium sulfite (Na2SO3). Sodium sulfite produced as a white crystalline
or powder is readily soluble in water. It is a strong reducing agent and
reacts with oxidants. It is primarily used in pulp
and paper industry. Though it also has uses in
water treatment as an oxygen scavenger agent,
in the photographic industry to protect
developer solutions from oxidation and in textile
industry as a bleaching agent. Sodium sulfite is
also extensively used for preserving foods as well.
Crude petroleum
Natural gas - which can contain up to 28% hydrogen sulfide (this is why natural gas wells are
referred to as sour gas wells - offensive stench).
Volcanic and hot spring vapors.
Oceanic surface waters, where most of the marine metabolic turnover takes place.
Swamps, shallow lakes, ground water, deep wells, plumbing systems, water softeners and water
heaters. Hydrogen sulfide is produced in these areas by sulfur-reducing bacteria (uses sulfur as
an energy source) which break-down sulfur containing organic materials. The other common
factor with these areas is they are deficient in oxygen.
Mammals flatulence and waste.
Paper/pulp mills.
Other sources of industrial hydrogen sulfide are Coke ovens (heating of coal) and Tanneries (leather).
Whether the source of hydrogen sulfide originates from man or nature, once in the atmosphere, it will
through a series of conversions slowly be oxidized to sulfate.
Large amounts of hydrogen sulfide are recovered, as a raw material, in the removal or separation of
sulfur from petroleum and natural gas during production. A substantial amount of this hydrogen sulfide
is converted to solid elemental sulfur. The remaining hydrogen sulfide is used extensively in chemical
laboratories as an analytical reagent (a pure chemical) usually as a liquid compressed gas.
References
Baird C., Environmental Chemistry 3rd Edition, W.H. Freeman Company, 2004
Meyer B., Sulfur, Energy and Environment, Elsevier Scientific Publishing Company, 1977
Nickless G., Inorganic Sulphur Chemistry, Elsevier Publishing Company, 1968
Nriagu O. J., Sulfur in the Environment, John Wiley and Sons, 1978
OSHA Fact Sheet Hydrogen Sulfide, U.S. Department of Labor, 2005
Pesticides and Toxic Substances, Registration Eligibility Document FACTS Sulfur, United States Environmental
Protection Agency, May 1991
Silberberg M.S., Chemistry: The Molecular Nature of Matter and Change, 2 nd Edition, The McGraw-Hill Companies
Inc. 2000
Silverthorn D.U., Human Physiology: An Integrated Approach, Pearson Education Inc., 2004
Tortora G., Introduction to the Human Body: The essentials of Anatomy and Physiology, Biological Sciences
Textbooks, 2010
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