COURSE CURRICULUM

L T P/S S/W/F/W TOTAL

COURSE TITLE: FUNDAMENTALS OF BIOCHEMICAL ENGINEERING
CREDIT
UNITS
3 - - - 3

COURSE CODE: BCE302

CREDIT UNITS: 3
LEVEL : UG (B.Tech, B.Tech + M.Tech)
Course Objective:

To understand the kinetics of microbial growth, substrate utilization, product formation, methods of sterilization, scale up and modes
of operation of bioreactor for commercial scale production.
Pre-requisites: Basic knowledge of chemical Engineering
Student Learning Outcomes:
Apply unit operations of Biochemical Engineering for commercial purposes.
Recognize the mass- transfer and scale up problems in Bioreactor.
Selection of Bioreactor and its mode of operation for specific applications.
Course Contents:
Weightage (%)
Module I
Growth Kinetics & Mass-Energy Balance
25
Kinetics of microbial growth, substrate utilization and product formation, mass and energy balance in microbial
processes

Module II
Sterilization
Basics of Medium Sterilization, Thermal Death Kinetics, Continuous Sterilization of Media, Air Sterilization
25
Mechanism and Filter Collection Efficiency .
Module III
Mass Transfer & Scale-Up
Mass transfer in Biological reactions, Methods for determination of Mass Transfer Co-efficient , Scale-up principles;
Principles of scale up, Criteria of scale up, Problems related to Scale-up.
25

Module IV
Batch, Fed Batch & Continuous Fermentation
Comparison of batch and continuous fermentation, Analysis of single stage continuous culture, Cell recycle, Two stage
25
continuous Culture, Fed batch fermentation.

Pedagogy for Course Delivery:

Lectures: 39
Seminar/ Presentations: 4
Class Tests: 2
Total: 45

Assessment/ Examination Scheme:

Theory L/T (%) Lab/Practical/Studio (%) End Term Examination

100 N.A. 100

Theory Assessment (L&T):

Continuous Assessment/Internal Assessment End Term
 Examination

Components (Drop Class Test 1 Class Test 2 Home Assignment Attendance

down)

Weightage (%) 10 10 5 5 70

Text & References:

Text Book:
Principles of Fermentation Technology, Stanbury, P.F., Whitaker, A., and Hall, S. J., 2nd Ed. (1997), ISBN-13: 978-0750645010
Bioprocess Engineering Principles, Doran, P. M., (2009), Academic Press, California. ISBN-10: 0122208560

References:
Chemical Engineering, Richardson, J.F. and Peacock, D.J., 3rd Ed. (2006), Butterworth-Heinemann. ISBN: 0 7506 6538 6
Biochemical Engineering Fundamentals, Baily, J.E. and Oillis, D. F., 2nd Ed. (2012), McGraw Hill Education Pvt. Ltd.,
ISBN: 0-13-081908-5