Oils CIR EXPERT PANEL MEETING DECEMBER 13-14, 2010ADMINISTRATIVECosmetic Ingredient Review Commitment... Credit Since 1976 CUR Memonandua Tos ‘CR Exper Panel Members and Lisisons From: (Chvisna L. Burnet and Monice Fume, Scientie WiteAnalss Dae: November 3, 2010 Subject: ‘rat Report ofthe Plan Derived Edible Oi Group ‘Atthe Augus!2010 meting the CIR Expert Pael reviewed reports on ele vegetable oil nd nat ls nd determined hat there ‘were no major dfeenes in the overall toxiily potential these ol proupe These reports were merged ina one report ob ‘tamed Plan Derive Eble Oils While the Pac! aged thatthe ete ol for which fat acid profiles were avaible (mos ofthe ingredients) could be determined to besten the present practice of use and concentration, Here wa concer ver ingredient for wich fy hd profile dua were not available. Accordingly, the Panel sod an Insfflent Data Announcement. Aditonl dna needs Included hemes eompositn,spectcally fat acd profiles, ofthe il for which those data were not given in he ep are rowed. These oils incloed ‘Aciida Chnensis (Kiwi Seed Oi ‘Aeuies Molceanas Bakaly Seed Oil “Art Lappa Seed Oil [Burdock] ‘Avena Salva (Ot) Kernel Oi, ‘Bassin Buyracea Seve Buter ‘Busia Lata Seed Bute [Mabwa} ‘Brassica Naus Seed Oil Rapeseed) Biassia Oleacea Acephila Sed OW [Kale] Basia Olercea lia (Sroeol) Seed Oi (Camelia Japonica Seed Oi ‘Camelia Kies Seed Oi [Tea] ‘Camelia neni Seed Oil ‘Canario dieu See Oi (Gain) {CaryoearBrsiense Fri il (Pog) CGitrus Paras (Grapetit) Seed Ot Git Limon (Lemon) Seed Oi {Goi Lacryme-obi (Job's Tears Sed Oi (Corus Americana (Haz Seed Oi (Grambe Abyssinia Sood Oil (Abyssinian Mustard] Elacis Oeifere Keone! Oi (Pai), Fragara Chiloeais (Stawber)) Seed Oi Fagara Vesca(Suawberr) Seed Ol Fragaria Virginian (Suawberry) Seed 01 Cevuina Avellan Ot (Chilean Hazel) ipponkse Rhamnoides Oil [Sex-Buckthorn) ippophae Rhamsoides Prat Oi (Sex-Buskhor] Iwingla Gabonensis Kemal Butt [Disa] Lifts Cylindiea Sod Ot Lut) Lips Aus Seed Oi! White Lupine) pum Barbara Seed Ol [Gol Bery) NeindsCitiflia Seed Oil (Noni) (ls Europaea (Olive) Husk Os Psilora Eau Sed Ol (Pasion Frit) Penta Volatile Seed Oi (Seka Inch) hus Mats (Apple) Sed Oi bes Rubrum (Curran) Seed Oi Rows Canin Fruit Oil (Dog Rose] Rabus Chameemons Sed Oi [Cloudbery] Sthinaophiyion Taraneni Keel Oi [Mongongo] Slybum Mariani Seed Oi [This] Solanum Lycoperscun (Formas) Seed Oi Solanum Lyeopersicum (Tomato) Frit Oi ‘Torreya Nucifera Seed Oi [Kaya] Vaccinium Myla Sed Oi [ery Vaccinium Vit {ea Seed Oi Ligonbery] ‘egeuble (Olu) Oil CAS No, 48586-68.3)‘Addon! data on chemical properties and faty acid compositions aswell as HRIPT sues, on numerous ois have been ‘iter discovered inthe pubheditratuec eeived from the Pessoal Care Products Coun and ae incorpraed in ‘his draft repr in Tables 3, 4 and 7, respectively. Approximately half fhe ingredients for which dare were fay acid ‘composition dla neds have been adresed with covery thal some ofthe ingredient are synonyms for oher Ingredients for hich we hve dt Due spain to the voluminoss amount of unpublished dats, data wil be arcessible ‘nine, Paper capes wil be mailed ot ony by requ. Mates were cncovereleceved ater the data cut-off deadline sd wil be provided tthe Panel in Wave 2 supplemental dstbton, (CR stat received afew comments regarding incorporating the suc ofthe impurity, ei, nto the repr. "lowever,no meation was made about incorporating te src of ltxin. Te thee value ang thse scares into ‘he eport Ihre, they willbe added inthe net Sage ofthe report, which would be reviewod bythe Panel in March fhe data provided are now sient forthe Panel oases the safety of thse ingredients, teniativeconcson shout be develope regarding thor safety in cosets, slong with rationale frat concasion The epot wil then be sed a5 Tentative Safety Assessment For your convenience, the material fr this report can also be found at hp: cr-safety ore stmSAFETY ASSESSMENT FLOW CHART. ie ever Jel oe on expr Pne netesens | nepon car 2 eH on erin —1 [omer ronrast fT \-- gd relia + wont ete) ea am | [eso iF | ate | A A fame a soa Smeg) fr Rnart vearreeont Clg] 4 oot nmerteen | oxecom i? oma ak es Sete sapncannanpees [PETA —p] onarrretaroe pokcoer a be sem (oda hccomment oad | Draft R$ ‘DRAFT FINAL REPORT Qrekamentd rat | wha cor run Final Report. + “Te Citta tif fh pubic the don nove open the Yea ond prepares aR sateen frei by the Parl. Ar ane eview, the tater ese the Pookie ‘*i rat amended Report (AR) avails, te Pansy ehots reso fot IR sal rere DAR for Pane! Review A tapert Panel Dacian — cxcamenttorrane Review TS OptiontorRereview(CAR Expert Panel History with Plan-Derived Fable Os ‘Apel 2010 and June 2010 CIR isued Scenic Literature Reviews fo Vegetable ils and Nut Oils, spectively tamed Pln-Derived Edible Oils While te Pane agred that he eile ils for which ty ac profiles were available, mos of he ingredients) could be determined obese nthe present practice of wean concentration, there was concer ver ingredients for whic fay ack [ofl it were not available. Accordingly, the Pael issued an Isufcent Data Announcemest. Ince chemical eompostion, special fy ad profes, of theo for whch those data Were mt given in he repr are teeded. These ol inched ‘Actiiia Chinesis (Kivi) Seed Oil ‘Alearies MolceanusBakoly Seed Oi ‘etm Lappa Seed Ol [Budock] ‘Avena Sav (Ou) Kerel Oi Basia Butyraces Seed Buter ‘Basia Latifoia Seod Baer [Mahwa} Bassca Naps Seed Ol [Rapeseed] ‘BrasicaOlearca Acepbala Seed Oi [Kale] Basses Oleracs lisa (Brose) Seed 01 Camelia Japonica Seed Oi Camelia Kes Seed Oi [Te (Camellia Sinnsis Seed Oi (Carita Indium Sed Oi [Gali] (CaryoearBrasiiese Frit Oi (Pei) ‘Gitus Part (Grapeta) 3ee0 Gs Limon (Lemon) Seed Oi! CCoix Lacynafob (b's Tears) Seed it CCryls Americana (Hazel Seed Ot (Grambe Abyatnca Seed Oi (Abyssinian Mustard) eis Oefera Kerel Oi [Pam Fraparia Chloensis(Srawbeny) Sead Oil Fragaria Vesa (Stabe) Seed Oi Praga Vgginiana (Saber) Seed Oit 2010 -The CIR Expt Panel evewed reports on ele vegetable ei and nut ols nd determined hat there were ‘omar differences inthe over towiity potenti of these two ol groupe. These reports were eged int ae report be ‘Gevuia Avellna Oil [Chilean Haz) Fippophae Rharoides Ol [Sea-Busknor) Hippophse Rharnides Prat Ol [Set-Buckbors) Irvingia Gabonensis Kerel Biter [Da] {ata ylindie Seed Ot (Lt) Lapin Albis Sod Oi [White Lapine] yen Barbara Seed Oi (Goji ery) ‘Morinda Cilia Seed Oi [Noa ‘es Europaea (hive) Husk Oi Pastors dls See Oi [Pasion Frit) Piukenetia Voile Seed Oi [Sacha inhi) yrs Malas (Agee) Sed Oi Ries Rabrom (Cura) Seed Oil Rosa Canina Frit Oi (Dog Rose ‘Rebus Cnamacmons Sed [cloucbery) Schiaziphyton Taranen Kemel Oi [Mongongo) Silybum Marana Seed Oi (Ths) Solum Lycoperscum (Torta) Sed Oi Solanum Lycopescum (Tomo) Fit Oi ‘Torey Nocera Seed Oi (Kays) Vaccinium Myris Seed O [Biber] ‘Vaccinium Viti- sea See Ol [igor] Vegetable (us) Oi (CAS No, 68956-553) ‘Additional dt nodeLiterature Sesh on Pant Derived Edible Oils Tae = [a a Ings rect Latin il NCD nee commen ame CAS nbn, ele The it igre rh Sener hw Noe 20 ach 8200 hgh 2 Spee hhmiaiala HL ELAR a en HES = { 1ae iwi Hepes Gaeta Ser [ Redegestes Capra es of Upon gest Cs OT ates (Cos SOBRE Fsteun cose Passe Rage Ca [Ss copa [ign Coal A Carr bs Tea] TOT io eto as SOs ged eo 7 as Sates [Css TOT acs fo angina OF cope Pgs Seo be Geen a Kea Eat sO [sesessed POT a ces Ps BE Feat a Ri og gage a Heo AE [resi cates ures Ge OF gus Vera Set OF e000 Cosa en) STO ‘acgemnd ComesHEE Peony SE Hereeteaer™ Heart ea eee an eee a Heater Pepe) | Rerretue Tir ss ae See [soe Raha Seso Schon tines ene Ser des Se STE hm sss OTT Faia ie pi TOT x Ti Anton Wien GOT cua Seg (Wan Cen SE seam Wa asf moa [ier Gore ion Caan ie SOT eee Oa Nay CTE er an Ga ‘Alea sang neater ee gions Ve Artis pga (Pana) Ow eel panel api hae ead ‘xine ht ata wo iain teary Fr te nseTRANSCRIPTS/MINUTESREPORTDraft Tentative Report Plant-Derived Edible Oils, and Other Derivatives as Used in Cosmetics November 18, 2010 The 2010 Cost gredient Review Expert Panel memes are: Chairman, Wilma F. Brgfeld, MD. FACE Donald V, Beso, MD; Ronald A Hil, PRD, Cut D. Klassen, Ph.D; Daniel C. Lier, Ph.D. James G Mark, J, M.D; Ronald C. Sank, PD ; Thomas Sloga, PAD. and Paul W. Sayer, D-VIM, Ph.D. The CIR Directors F- Alan Andetse, PD. This This report was prepared by Cristina Buret and (©Cosmetic Ingredient Review 101 17%Stet, NW, Suite 412 0 Washington, DC 20036-4702 © ph 202.331.0651 0 fx 202.331.0088 @INTRODUCTION. Chemisuy.... ee Processing ene = Aalyieal Meio eee Trp Cosmetic co Non Cosmetic oe at CARCINOGENICITY oo a “Anacadium Oceideniaie (Cashew) Seed Oi ANIMAL TOXICOLOGY ‘Derma itton’SenstationPhottnily “Adansonia Digit Seed Ol [Boob ‘Arachis Hypogsea (Peanut Oi Butyrospermur Paki (Shea) Buter (Carhart Tacorv (Saflower) Ol {Cocos Nucifers (Coconut) Oi aan Gayl Avelana Hazeh Seed Oi = c leis Guneensis (Pal) Oi a ‘Goxsypum Herbaceur (Cotton Soe Oi. Hippophse Rhamnoes Oi (Se2-Bukshor) ‘Olen Europea (ive) Frit i. ‘Ory Sativa (Rice) Bran Oil and Geom Oi. 7 Prunus Amygealus Dull Sweet Almond) Oi = : : ‘Sesamum Indium Sesame) Seed Oi es — “eicum Vulgar (Wheat) Germ Oi Zea Mays (Cor) Oi oe ~ — (ocala Intaton| ic = “Adansonia Digi Scod Oi [Babb = ‘Aleurites Molueana Seed Ol Butyrspenmum Pasi (Shes) Bane {es Naien (Corona, Hyped Cont Oi, oc Acid. Ebeis Guinee sis (Pal) Oilman ‘Gossypium Herbceum (Cotton) See Ol Linum Ustatssimum (Linseed) Seed Oi ‘Oa Europea (Oe) Frit Oi. : (Ory Sava (Rice) Bran and Rie Germ Oil nnn a Pris Angéalus Duis (Sweet Almond) Oil. Ribes Nigum Slack Cura) Seeé Oi : cf ‘Sesumum Indcum (Sesame) Seed Oi : “eieum Valgare (Phe) Germ Oi Zea Mays (Co) Oi, : CLINICAL ASSESSMENT OF SAFETY. : leon/Senizaon/Alegenciy/Phtoonisiy. cular Imitation Ligum Ustaissimum (insed) Seed Oi bes Nigrm (Black Caran) Seed Ot : CComecogenicy. : ee ‘Ribes Nigrum (lack Cuan) Seed Oi : oe Phottoicty/Photosesitzaton : ‘Cocos Nucifera(Coconu Oi and Sodium Cocaie. Prunus Amygealus Dulis Sweet Almond) Olle — ‘Clini Titles Stade, Z e “Alesites Moiosana Seed Oi “Anacardium Oseiéentale (Cashew) Seed Oi : ‘Cocos Nucitea (Coconut) Oi : Giycine Soja Soybean) Oi... ete Helianthus Annas Sunfower OlMacadamia Seo Oi (es Europes (Olive) Frit Oi. aan Peres Gratis (Avocado) Oi. : : a one SUMMARY. : FIGURES AND TABLES. wns 7 Figure 1. General struct of fais and oe Figure 2 Basco efierent flower * ‘Table |. Plant-derived edible ols andthe darvaives*-.ssnsnnmsnnmnnnnnnnnnnsnnmsnnnnnnet® ‘able 2 Previonly reviewed ol nd fay sid ngrdients rf ‘Table 3. Chemical properties for plantdeived edible is Seeeiieecacdast ‘Table 3 Chemical popes for plant-derived ele ol (continue). 26 ‘Table 4 Tos fay acid composition of plant-derived eae ols)" : oe “able Sa. Frequency of us according to duration snd expoure. 39 ‘able 5b, Curent and hisocl Fequeney and concetaton of we according oration and typeof expoaure = previously reviewed ingredients so “Table Se. Ingredients with no reported use oncentations or uses. st ‘Table 6 Nor-soeneti ures of oie Ss “able 7 Clini ieation and seniiation tes onl : 6 REFERENCES. oriNTRopuCTION (it derived rom eile veges, ruts, sed, andre and groundnuts have ben safely consumed by humans for millennia, While nut and some fits an vegetables themceves may site allegi reacions in certain individuals the rind cis erivd from these plants geneilly pose no signifies sft coneem folowing oa expose, nd their general biology is ‘well characterized dc to extensive use in ood mati. This safer assessment wl focus Solely onthe basic chemi, manuftctring)pedotion, wes and irtation and sesitaton data available on thee cls they ae uted in cosmic ingredients ‘Various oils ave been used onthe skin sae antiquity. Italy used for anointing in elgious ceremonies, cis and thie ‘components ave also been ong used on the skin for cosmetic purposes, They are used in a wie varity of cosmetic procs for ‘heir skin conditioning, olive, emollient, moisturizing and ote properties, The il it of ingredient in his reper, which includes is, hydrogenated ol, unsaponifbls cl fay acids, and sali ofthe fay ads, sound in Tale 1. White a age umber of oils derive fom pans are inched inthis iterate review, hee a commonality in tht they al are mixtures of ‘wiglyeuiescomtning fay aids and fay acd derivatives the safeyof which in cosmetics ave been established, In preparing this epor, numerous inconsistencies were noted with bth taxonomic and INCI naming conventions. This ‘por includes the macadamia nt nredens, Macadamia Integfolia Seed Oi and Macadamia Temiflia Seed Oi, wich are poe am 9,= om st : ET ‘hsmnt2a,Tes FS ene monyCt) ae saHIPBO ae alae ; en waitporeeg Da gem oeng nny onag open ig omen) 959-1492 Hp em 9 oe pe ammuggy mun omens one FD)? pwsledeoy ween) re int Shean htt” "Chama ime) 8 4 INP ea PE HLF MEL‘sunsodxs pu uojeanp oy Suspsosye ano Gtonbasy “es 200TR He Cooma) sana pe apa apneTTT — aT TT (comms) toes ae5 Wr 7% WW SRT Tomo oR CTT TTR — aT |e TTR) — ae | HTTa POS IPT HT] — PY ST oie — are | THOT OTTpuyol pmcenc | ‘omy snlra) —anercarom — aesum og paw FE tne cement ama jo tn a oe ah ne pm en msn) sua paoa IT a SOT SSS saree ARR SFr ‘yop panne Asnoysoud- aunsodxo Joa pu wqyeanp 0 uypsoae asn fo uonesusouos pur {ouanboyfeU0}H pu NOLIN “95 2198aregeveveeeey‘Table Se. Ingredients with no reported we concentrations or wes. Aan Digan Sus yopmad stil ‘ci ly Se ‘iceaes ptt on ge Sett etapa unger sed ‘Bite Ace ‘yop eb ‘ins Bry Sod Bute ‘rope ar Cm Fait ochre Ol nape Indeed flowy So Eis Oe pts Sra er kt 8 npn “tos tinos Pn) Seas ‘opm! Whe Cem i Unpntate: ‘Si eam) Ses Up sO Unseen er ‘in Ai i) Se OX Una, Msn ea Sed ‘Sin Aum (Ome Ses ingle) Ha Oi ‘Gime uml Dainese oben Ge opt So tn Soi i Ss (ios ctr Caan Sot te Fons tse {Liem dab ean) SO oueam Ente Sanaa oui Syoogeun ace ‘je Cu et 08 a En Cimon a os Fem fice "put ao Smee) Set Fone Sm Epo hsm Groen SOF Fra Amini Suet Aton) Unapentatien Epo Ven aonb Seo Frou reise Of Cmaps pons Vestn ean Sed 2 ec lope mse Sot ot Scares sete ‘eToys daa ign set 8 Sea acd ‘Beton yea ee Of Uno ‘St nea (Sear) Sed eer ‘oer Ae paom Rema ‘Somes eae ‘opens ce Con See Simm Coc ‘Mon Caer Seiad ‘ode pct Scheie onto rapa Sent! Unoniatr Sotumtaperie doen ie Sed Ssiemsore Indep ine St nmin Eom owt ie ‘roared ge et Of Usaaiaie “Teasin Aion ine) Gem 1 ogra nc ‘earn Ve ne) GeO Usapaiee ‘doen antl Ela ea “eimum Ceymonen (ebony Sct doen etc OF ss‘a sean pee ns xm age en NA rete fnge ne nhl anon ty ne nd aa ees 07 OH THURS ION 9 HGEL,7 eesao pes emma amy 0 rrpoddreerioresenia mony i09STATS a DLL,et te rayiog nan (sy NL SS SRT6 i a ai a as woe us an Pano Fes oMD umpteen tt a ea Si OR NT Top aE AA‘Bia Ba Hc a ga pp svar seen (st) 1 KD HT a 7 pepe rn PS ey SEINE aS TEU a a cd aia NTS pena pa TAT “yo wo pay aNOZ REDS pues NORE HOH LAME,= espa eng eo mm (em ep assis bl cor non a) UN i i mes eae an RTO syne py ven ent © pa geno sa “ a ew oer ab pov “yo wo DIF HoTEATREDY poe WORT WH LUE: olsun tama) sing mnpand ab “so wo saps wopezsuRS paw wORENAAy UND LEDrp eae sm rmenodin no mB mS Sa anwoasornin eeranarie Sana8 “soe soppy pane iron sepa dneorpoinienfomenny mange sours yo suey Gomly emmy mee ote puny nny emeomy sen ao true woes) Ey se omgy nas) ety st eryotnmery mows ona ouetcay si CCR Pane Book Paesno psig oe) um 6 PaaS “So wo jp wRTERS uw UOTAN TOI mrao eg) ewe2 1“ wv. 8 [REEERENCES Gotschalck TE and Baily JE. Iemational Cosmetic Ingredient Dictionary and Handbook. 2010, Bus Washingt, DC: Personal Care Products Coun, ‘Cente for New Cops Plant Products Macadamia itegafla Maiden Bethe and Macadamia taps Johnson, 17-1598 hap sees peed sestoy cudnt Aeoeted 520: nv. Storey, WB. The Temi group of Macadam specie. Pacific Science. 1965,19:507-54, Gotsshalck TE ond Bai JE. lnternationa Cosmetic Ingredient Dictionary and Handbook, 2008, 12ti(3} Washington, DC: CTFA. Miliakbari,H and Shai F. Oxidative stabiliyof wee mt ol J Agric Food Chem, 2008;56:4751-4759. Salute, DK, Chavan,-K, Adsl, RN, and Kadam, $8. Word Oisads: Chemistry, Tecnology, and Usiion ‘New York Van Nostrand Reinhold, 1992, Andersen, FA Final Report ofthe Amended Sait Assessment of PEGS, TIT. 3004;234Sapp.2):28-47 0,16, 25,30, and 40 Soy Sea Us Phannacopei 2008-2009 Food Chemicals Codex. thd Baltiore: United Book Press ne, 2008, Bailey’ Indusia it & Ft Products. John Wiley & Son, 1996. John L, Seaton & Co, Lu. Oil sed processing, Unpublished dat 2010. Davros, , Ala F, Pome, G, Kelly, B, tuo, 1B, Thiam, M, Diallo, OB, and Bouvet, JM. Near infaed Specorcopy fr ighthroughput harcsteriation es wee (Vitel paradxa) ft profile J Aerie ood Chom. 2010, Sous, A, Metis, 1A, Fn, ICFR, Beso, A, Estevaho,L, and Psi, JA. Chemical compositin, ‘nd anixidantand antnucrobial actives ofthe hazelnut (Cus avellana L) clvs. Fed Chem Panaol 2008;45:1001 1807 tive, Holeapek, M,Jandera, P 2deradck,P, and Hrba,L.Chaacteriation of tiaeylglycero and diacyglyerl ‘omposto of slant ol using high-performance qui cromatography-stmospheric pressure chemi Ionization mass spectometry.J Chromatogr 4. 200:1010:195218 ‘Sarva SA, Cabral, EC, Bes, MN and Cxtharin, RR. Amazonian vegetables and fs: Fast piston and ‘qty cool via tinylayceol (TAG) prols from dry mar assted laser desorption nization ine- of lght (MALDI-TOF) mass speetromety fingerprinting. J rie Food Chem, 2008,57:40304034 ‘Tevber, $8, Brown, RL, and Haapanen, LAD. Allegenity of gourmet nt ils processed hy different methods, J “Alieyg Clin Iran. 1997998) 302-507. ‘Crevel,R.W., Kes M.A. and Koning, M.M,Allargeniy of fined vegetable ols. Food Gham Tsico! 2000;38(4):382393. ‘Andersen. (Final repr: on the safety assessment of peanut (aachishypogns) il, hydrogenated pero, ‘peanut ac, est lheeries and peant (archi hypogaea) Nour. Jnr Taxol 200;20Supp2)48- Haley, A.B, Marti, ME, Ruf M. E, Jacobs, FO. and Jacobs, RL, Sunflower lis not alegeie unfwer seed senstv patents J Alergy Cin Imunol, 1986.78 410, oa, 2, 2 2 2s, 26, n. 28 ». 20. a 2 2. Zits, N, Eval, Y, Meche, M, Kanny, G., Monere-Vaurin,D. A. Ncoas, JP and Fremont, S. Influence ‘of refining stepson uac allergenic protein coateat in sunilowe iJ aergy Clin Immuno 20105 (5):962367 (Olszewski, A, Pons, L, Mout, F, Ainone Gat, I Kany, G, Moneret-Vauin, DA, and Gueant, JL oation ahd carcierzaton of protic allergens in refined peat i. Clin Ex ergy. 199828 880-859, Ramazzoti, M, Malnaei, N, Passagl, L, Moiond, M, Manso, Vinci .F and Depnnocent, D. ‘Aly investigation on prcin content in refined seed i mpieons in fod allergy. Food Chem Toxo. 2008,46(11) 33833388 Porat, O., Carson, B, Fallsuom, S.P., and Hanson, LA. Detesion of soy pti in Soy lecithin margaroe and, ‘cea, soo Int Arche Alergy App! Inara. 198578303 ‘Avazara, H., Kava, H, Baba, M, Mats, T and Komiyama, A. Antigens ofthe proteins in soy lecithin and 09 ol in soybean sliery. Clr Exp Alergy. 199828 1889-1868 Pascke, A, Zuker K, Wigoaki M, and Steinhart H. Determination of he IgE-bindng activity of sy leita and ‘elite and non-tetied soybean is. J Chromatogr B. 200756285258 Andersen (ed) Fil pot on he safety assesment of sesame ol ell Tsiol 19881248)261.277, Andersen FA (cd) Fal epot on he safety assessment of Eluesguincensis (al) ol, lai uinenss gan) ere ol hydrogenated pal i and hydrogenste pln kare i IJ Taxco. 200;19(Suppl2)7.28, Andersen Ae) Fil epot onthe safety assesment of hydrogenated cotnted ol cotonsced (Gossypium) ‘i eonseed acd cotoseed ljcerie, and hydrogenated couonse!glycerie. nt J Taxa 2001;20¢Suppl 2):21-28, AnversenF-A (oi). Amended final report onthe sfety assessment of Oryza stv (ce) brn oil, Oryza sativa (ecejgerm ol rie bran ai Oryza save (ce)ran wax, hydrogenated ce bran wax, Ora sativa (rie) bran exact, Oryza sativa (Fie) ext, Oryza stv (rie) geom power, Oryza save (fc) starch, Oryza sativa (ie) ban, ydrly2ed ice bran exact, hydrolyzed rice ban psc, hydolyzed ioe extack. and yarljzed ie poten. tJ Tio! 200628iSuppl 291-120. 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Amended Safty Assessineut of Cocos Nuvfera (Coconut) Oi, Ceconut Ae, -Hyarogeated Coconut Ol, Ammonium Cocomonogleeice Slt, utyene Glycol Cocat, CapyirCapricCoco Glyerides, Cocogeerids, Coconut Alcohol, Cocenu il esyl Estes, Dery {Covote, Ether Cocat, Hycrogensoa Cace-Gcsides,Iodecl Cocos, Lauy| Coco, ‘Magnesium Cocoate, Met Cecoats,Oxtyodecs Cocoa, Pentel Cocat,Poiasium Cocos, Potssun Hydrogenated Cocoate, Sodium Cocate, Sodium Covomotoglyeeride Sulfate, Sod Hydrogenated Coat and Tidy Cocoate Avaliable rom CIR. 208 6. 3s 36 , 38 ». 41 2. 4. 4s 8 9. European Medicines Agency (EMEA). Working party on herbal medicinal prods. Final postion paper on the ‘slergeni poteny of herbal matical products coining says or pean protein. EMEAVHMPWP/S704, aa rea pes con 2004 Peas, R. W. Websters Medial Desk Dictionary, 198, Springfiel, MA: Merriam-Webster, Ine ‘Budavar 8, The Meck Index: An Encyclopedia of Chemicals, Dros, nd Biologicals. 1989.10: Rabway, I: Merck and Co, ‘Wood, GE. 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Charateristies of ere oils from Elovs oer, FI hybrids and bick-ross with Elais uieensis. J St Food Agric 198238204208, 180, Enlghened Product Co Anaya Stay Life Dyramis Aci -Pa 1 2010 msec Paget i, Aecesed 1-25-2010 191. stl C, Fay LB, Stance M, Guny D, and Lambelt P. Characterization of Chiles zen (Gerana ‘velana Mod sed ol. J4OCS. 1998;75:(8: 1057-1040, 192. Kaminskas A, Bids V,BudrioneneR, HentasonV, Pers Rand KucinskeneZ. Fay aid composition of ‘sea bucbom (Hippoplae rhanmolde .) pulp ol of Liduasia ogi stored at diferent temperatures Biologia. 206,239, 193. Center for New Crops & Plant Products Juglans regia L. 1-7-1998. Tin. wonw hon purducedulnewsiondike ens Josie cea han, Acceaed $-202010, 194, Centr fr New Crop & Plant Prot Moringa oleifes Lam. I-7-1998 weroddke-enetey Mong oles Mo, Avoesed 1-25-2000 1095. Cente for New Crop & Plt Prous Prams lis (Mil) D.A Webs. 1998 hon hon oe Si, Ascessed 520-2010 196, Osean M, Nutrient composition of rose (Roms canis L) aed andl J Med Fon 2002;50):197-40 197, Marla Neural Products Marla Natural Produ: Technical Info - Oi 2010. nr rl 7a "Actesed1-262010 198, EL-Malsh MH, E-Stami M, and Hassaein MM. Detaled ses on some lps of Siybum marian (L) seed i Grasasy Acces, 2003;54(8) 397402 199, Natural Soureing Cupuseu Bur. 2009. ThyJnauralsouringconipradutasptorodus -vegbauereupneucat"Amvzoniani ‘Accessed 1-27-2010. 200, Center for New Crope& Plat Produets Alerts oluecna (L) Willd. 1997 Thins uno hor ensmplduke sts Alcunies malice nl, Accessed 5-20-2010 201, Cente for New Crops & Plant ProduetsAnacardium occidental L 12-22-1997 bunk, Accessed -20-2000 202, Cente for New Crops & Plant Products Arsh hypogaea L 1997 ‘Assessed 520-2010, 6203. Centr for New Crops & Plant Products Cocos nucifera L. 1996 WD i ed neerptdke ents ocos ie Accented 5-20-2000 204, Cemer for New Crops & Plt Products Julans regia L 1-7-1988 ns Aeveied $-20.2010 208. Comer for New Ciops& Plant Products Prana dis (Mill) DA. Webb. 1998 Pyuisuleshin Accessed $-20-2010, 206. Consumer Product Testing Co. Repente ns patch testo ip product containing 0.01% Adansonia Digata Seed ‘Oil, Expormen reference number: CO8-113.02. Unpublished data, 4-29-2008, 207. BioSeree Testing Serves, Ine. Human subject repeat insult pth est skin itationsenstization evaluation of Pytotena Organic Basbab Oi. SCS Study No: 08-042, 200. BioSeren Testing Services, ne 208. nical Research Laboratories, Ine. Repented insu pach test of produc 8854 SA (sal conditioner containing (0:1595% Olea Europea (Ove) Fruit Oi, 605% Prunus Ammeniaca (Apricot) Keme Oi, 005% Simmondsa Chines ojos) Seed Oi, Prunus Amygats Dlcs (Sweet Almond) Oil, 0.005% ‘leases Molucana Seed Oi 0.15% Cocos Nucfea (Coconut Oi ané 0.005% Ticum Valgare (Wheat Germ Oi). 12-5.2005, 208. Yunginger, JW and Caobris, SD. Investigation ofthe allergenicity of refined peanut i-comtaining topical ‘dematlogic agen in penons who are sensitive opeants. Cu, 200682) 153-155, 210, Insts DExpertise Clinique. Senitsation an etaneus compatibility stady of face scram eontining 25% ‘Sesumim Indcum (Sesime) Seed Oi, 20% Helamthus Aras (Sunflower) Sed Oi, 1.749% Pramas “Armeniaa (Arion) Kernel Oil, 15% Simmondsia Chinesis Jojoba) Seed Oi, 1% Pruns Amygdas Dales (Sweet Almond) Oil, 5% Arana Spinosa Kernel Oi apd 2% Borago Officinas Seed Oi. Repor [N*BOT2O0ERDI = Version i, 2010 211, TKL Research. Repeated asl patch test stay of formu no. 6853925 akin salve containing 10% Frunas “Amypdals Duis (Sweet Almond) Oi, 16% Persea Grassi (Avocado) Oi, 10% Olea Ewopaca (ive Frat Oi 8% Ses Indicun (Sesame) Seed Oi and 10% Arzaia Sposa Kere! Oi). Study ‘No, DT028310. 1-1-2007 212. Harrison Research Laboratories, Ine: Us test under he supervision of a dermatologist of formula no. 6853925 (kin save containing {0% Prunus Amps Dulcs (Sweet Almond) Oi, 10% Perea Graissina (Cvocado) Oi, 10% Olea Europa (Ove) Fruit Oil 8% Sesmum Indcun (Sesame) Seed Oi and 10% “Argnia Spinosa Kernel Oi. Stuy no, DT02417, 816-2007 213. Produet Investigations Ia. Deteminatin ofthe rating and sensitning propensities of ptick (containing 1% “Astocaryr Murua Seed ute) oa haa skin. Uopubaal data 9302008, Pont Investigations, Ine 214. Clinial Research Laboratories, Ine. Repeated insult patch est on lipstick formulation containing 4% Astroaryum Muramars Seed Buter. CRL stdy no. CRLS9608-4, Unpublished dt 1-208 215. Clinical Research Laboratories, Ine Repeat insult patch est on lis formulation conning 4% Astocaryum Murumara Seed Buter. CRL study 0. CRLEOGOES. Unpublished dat. 1-208 216. linia Research Laboratories, Ine Repeat inl pach test on lipsick formation contsinng 4% Astocaryum Mararara Seed Butler. CRL study no. CRL9608-6, Unpublished dat 8-1-2008 217. Clinical Research Laboratories, Ine Repeated isu patch est on lipstick formulation conning 4% Astocaryum ‘Murumnura Seed Bute. CRL study ao: CRL109108-1. Unpublished data 11-11-2008. 218, Clinical Research Laboratories, ne Repeated insult patch ston Iisick formulation containing 4% Astocryum ‘Murumare Seed Bute. CRE study ao: CRL109108-2. Unpublished data 81-2008, ”219, Clinical Research Laboratories, ne Repeated insu pach test ona lipstick formulation conning 4% Astocaryum ‘Murumura Seed Bute CRL study ne: CRLI14608-6. Unpublished dat 11-21-2008. 220. RCTS, ne. Clinical safety evaluation. Human repeated insult patch est witha body and hand formation Conaiing 3% Avena Sativa (Oat) Kerel Oil RCTS study no 1712 &I718, Unpublished dat 98.2008 221, TKL Research. Repeated insult pach test ona body and hand formulation contin 1% Borago Officials Sed (Oil, TKL study 0 DSIOSIO7103807. 622-2007. 222, Consumer Product Testing Co. Repeated inst patch eto baby il containing 5% hydrogenated rapeseed ‘Unpublished dats 1999 223, Product Investigations, ne, Dtemination ofthe imitating and sensitizing propensities ofa air continet (Contising 05% Brasia Oeace alien (Brocco Seed Oi) ox human skin. Unpublished dats 11-1L- 2008, Product Investigation, ne 224, Loden, Mand Anderson, AC. Effect of tically applied lipids on surictan-viated skin, Br J Dermatol 1996:138:215.200 225, Inst Expertise Clinique, Sensation and exaneous sompatibity ty of product 40899102 (lp ‘onitone containing 0.1% Buyrospermum Paci (Shea) Bute, 0.7% Olea Europea (Olive) Frit Oi, (01% RibesNigrum (Black Cuan) Oi and 0.2% Persea Gratisima (Avocado) Oi), Report No, 'B050427RD9. 622-2005. 226, Instn D Expertise Clinique, Senstisation and etaneous compatibility study of product 60946418 (ream for very ‘ry sin containing 2% Butyrospennu Pari (Shes) Biter, 2.5% Promos Anmeniaca (Apricot) Kernel Ot {and 0.25% Ries Nigrum (Black Cuan) Oi). Report No. BO4I7I3RDB6, 412-2008 227, BVIC Romania. Human repeat insult patch st with challenge for Formula No, 695315 1 (Tae cream containing 4% ‘Butyroxpermum Paki (Shes) Buter and 2% Pras Armentien (Apricot) Kerel Oil). DTOS7120. ‘Unpublished dats, 2010 228, EVIC Romania. Human repeat insult patch st with challenge fo Formula No, 69506912 (ye cram containing 2% Pruns Armenia Apes) Kerel Oi sl 4 Buyospermam Pak (She) Bute DTO3S57S ‘Unpublished data 2010 229, Product Investiatios, ne, Human repeat inst pach est formula no, 83803 (ip los cotsnin 2.08089% ‘Buyrospenmim Park (Shea) Bur). Study o,PLISONOO2. Uapublshed dai 2008. 230, TKL Reseach Human epest inst patch est on formula no 38002 (ip gloss containing 23.7057% Butyrospermum Paki (Shea) Bute. TKL sid report no, SO3608-, Unpublished dn. 208, 231, TKL Reseach Human ees ns patch est on frmult no. 754842 (ip wax containing 24 08768% ‘Butyrospermum Paki (Sha) Buen). TKL sty report no, DS108007-9, Unpublished data 2008, 232, BPISKINSNC. Cytotoicty study on ecosreted human epidermis oral T5442 (ip wax containing 24 08768% Butyrospermum Paki (Shes) Bute. Study no. O7-EPITOL-323, Unpublished data 2008 233, Groupe Dennscan. Use test under the supervision of «dermatologist of formula 755195 lip gloss conning 124.75792% Buteospermum Park (She) Bue). Study no, OBES382. Unpublished data. 2008 234, Clini Research Laboratories, ne Rees insult patch est on a ody and nd proc conning 45% Butyrospermam Paki (Shea) Buter. CRL study number CRL106504-1. Unpublished dt. 2004, 235, Climial Research Laboratories, ne Repeat insult patch est on a ody an hand produc contin 45% Butyrospermam Pari (Shea) Buter. CRL study number CRLI06804-2 Unpublished data. 2004,2%, 2, 2. 2. 2, 20, 2a, 2s 2s, 246 27 248, 28. 280. 251 282, Clinica Research Laboratories, ne. Repeated insult patch est on a ody and handprodvet conning 45% Butyrospermum Paki (Shes) Buter. CRL study number CRL 1065043, Unpoblshd it. 208 Clinics Research Laboratories, ne. Repeat igult patch est on a body and ang prodt conning 45% Butyrospermar Paki (Shea) Bute. CRL study number CRLIO6506-4, published dna. 2004, Clini Resarch Laboratories, ne. Two Week "dermatologist std” sft in-use study of body an hard produ contsining 45% Buyrospermum Pari (Shes) Bute. Cline sady number CRL 106606, Unpublished data 2008, Cia Research Labortores, ne, Repestod insult patch est ofa cul softener containing 60% Buyrospermum Par (Shea) Suter Clisial dy number CRL2990%. Unpublished dt 2008 Harrison Reserch Labortries, Ic. Final report repeated insult patch testo bocy powder containing 02499% (Cametna Sativa See Oil Repor 00-125. npublised dats, 2000. Haron Research Laboratories, ne ‘TKL Research, Homan peat ngl patch text with hallenge of formula no, 1082(18 B (ol estment containing "7% Prnus Arypdalus Dues (Sweet Almond) Oil and 7% Camelia Satva Seed Oi) TKL Study Report No. DS108609-2: Unpublsied dia, 2008, ‘Consumer Product Testing Co, Repeated insult patch tes on a ipstick conning 00985% Camelia Sinensis Seed (Oil Ref No. C08.539407. 2008 Consumer Product Testing Co. Repeated insult pach est of liptik contining 00988% Carelli Sines Seed (Oil Re. No, CO8.S398.08. 2008 Product Investigations ne. Determination ofthe ietaing ud sensitizing propensties oF a body ci (containing "4.7% Canola Oil on human skin Unpublished data 2008. Preduc lvesigations, Ie ‘TKL Research, Repested incl patch fest of formula no, 9991052 (lensing ol ris-off eontinng 20% Zea Mays (Corn Geom Ol 5% Carthanus Tinctorius (SafMower) Seed Oil, % Sizmondsa Chinensis (obs) Seed (i, 0.5% Mecadamia Telia Seed Oi, and 0.0% Moving Okifera Seed Oil). TL Stuly Report No ‘DTO36977 Unpublished dat 2010 Insta Expertise Cline. Senstsation an cutaneous compat sty ofa massage ol containing 398% Helianthus Annuus(Sunlows) Seed Oi, 30% Carhanus Tacteris(SeMlows) Seed Ol, 3% Prunss ‘Amypéalus Dukes (Sweet Almond) Oi, 0% Simmondsia Chinen Jojba) Seed Oi, and 5% Corus ‘Avllana (Haze) Seed Oi Repor po. BOBOS42RD6. Unpublished dat. 208. PraductInvesigations, ne. Determination of te iitatng and sensitizing propensities of psc (containing 0.1% CCerocar Brains Fruit Oi) on human skin. Unpublished dat, 2009. Products investigations, nc. 118 Conslteny Liited. Human repent ist atch st fs UV SPF cream contsning 1% Chemopodivm Quinos ‘Seed Oil Report no, 6601 final. Unpublished da. 2003, 1 Consltaney Limite, 18 Consultancy Liited. Human repeat insult patch est of ¢ UV SPF ream contin 1% Chenepodiam Quinos ‘Seed Oi Repor no 06427 final: Unpublished dat, 2002, 1§ Constancy Limited, Clinica Research Laboratories, ne. Repeated insult patch es ofa ici of consning 2% Cus Lantus (Waterelone) Seed Oi. Unpublished data 2009. Clinical Research Labyatories, ne arson Research Laboratories, Ine. Final report repented ns patch tt of rod! 674976 | (lp balm conning 31% Cooos Nucifera (Corona) Ol, 25% Prunus Amada Dues (Sweet Almond) Oil 24% Prunus Persia (Peach Kemel Oil and 3.6% Hydrogenated Cotonsed Oi), HRL Pane! 07-127, Unpublished nn 2007, Personal Care Products Coun. Summaries of HRIPT studies of produ! contirng Crambe Abyinaica See Oi ‘anda prodeet containing Macadamia Teri Seed Oi. Unpublished din. 2010,253. EVIC France, Checking inhuman of th acceptability of cosmetic produc er aplication under mal nitions of use subjective assesment of coxmetcacepablity (soap containing 1.6% Sodom Palate, 15% Sodium Palm Kemelate and 1% Helianthus Anns (Sunflower) Seed Oi), Suds reference: DT034521. 12-17 2008 256. Produit Investigations Ine. Determination ofthe iitating and senzing propensities of an eye treatment (Coniining 05% Euterpe Oleraca Fruit Oil on huan skin. Unpublished dat. 2007. Prodct Investigations, ine 288. Personal Cae Products Council Summaries of HRIPT stu of products conning plat ils, Unpublished data 612010 256. Clinical Reseach Laboratories, Ine Repeated insult patch test on lipstick containing 39% Hysopestel Soybean Oil and 12% Hiyropented Olive Oi. CRL sty no: CRLI28208-3. Unpublished data 12-242008 257. Inst DExpetise Clinique, Senstisation and eatancous compatibility of product 78152819 kin eeam ‘conuining 6% Helnthus Annus (Sunflower) Seod Oil, 0.39% Rosa Canina Fru Oil an 0.2% Ribs Nigrum (Black Currant Oi). Report No. B10017 RDS. 5-4-2010 258, EVIC Portgul. Human repeat insult patch est with challenge of formula $91559 208 (fice cream fi dry skin ‘cotiaiing 3% Butytospemim Park (She) Bute, 1% Prunus Ameniaca(Avieo) Kern! Oi and (0-264 Helianthus Annus (Suflower) Seed Oi). Study eeference DTO20375. 11-21-2006 289. linia! Research Laboratories, Ine Rees inst patch test of ail repr produc containing 7.3% insanthes Alba (Meadowfoa) Seed Oi. Unpublished data. 200. Clinical Research Laboratories, ne 260, Consumer Produ! Testing Co, Repeied ins patch et ona mascara contiing Linum Usitasiumam (Linseed) ‘Seed Oil at 9%. Experiment efrence nmber CO83409.02. Unpubiied dt, 910-208 261, Product Investigations, ne Determination ofthe iran and sensitizing peopensites of Hpstick(entsning 2% ‘Mangers Ince (Mango) Seed Ot) on human skin. Unpublished dst 2003, Product nvetgains, Ine 262. Consumer Product Testing Co, Repete inal patch txt protocol of an eyiner containing 3.87% angi Indien (Mango) Seed Oi. Unpublished dat, 2004. Consumer Prodet Testing Co. 263. Product Investigations, ne. Determination ofthe iiatng and sensitizing propensities of facial lotion (coming TM Mangiera Indica (Mang) Seod Bute) en human kin. Unpublished dt, 2008. Pret Investigations Ine. 216, TKL Research, Repeated incl patch test of body product consining 9% Maier Indian (Mano) Seed Bur. ‘Unpublished da. 201, 265, Produc Investigations, Ine. Determination ofthe ivan and senstiing propensities of an eye weament (Containing 394 Mocings leryeospem Seed Oi) on human skin. Unpublished data 2007. Product, Investigations te 266. Oreateich Research Corporation. recive pach west study of foundation containing 1.99% OenatheaBiemis ‘Cvening Pintose) Ol, Unpublished dt. 2007 267. Inst DExpentse Cinque. Sensation and etaneos compatibility sty of body lotion contin 1.5% Olek Europea (Olive) Frit Oi. Repro, BO¢1222RD2- Unpublished dt, 2008 268. linia! Resear Laboratories, ne. Repeated insult patch sto a body mse contiing 2% Olea Furey. (Olive) Fair Ol, Unpublished dats 2007 269. Consumer Product Testing Co. Repeated insu puch test ona conditioning hair ol containing 58.70% Olea uropac (Olive) Frit. Unpublished dt, 2003, 80270. Product Investigations ne. Human repeat insu pach test summary formula No 852069 (Foundation conaiing (9.644 Olea Europe (live) Fut Oi): Repot no. 25673: Unpublised data, 2009. Product Tavestigations, Ie 271, Product Investigations, Ine, Dteninaion f the tating and sensitizing propensities on human skin fora figraned by mist containing 25% Os Evopaes (live) Oil Unsaponifiabes, Unpublished dt, 2007 272, Clinical Research Laboratories, ne Repestd insult puch ts of body bar Sap consing 17.64% sodium ova ‘Unpublished dats 2008 273, Consumer Product Testing Co. Repete ins puch tet of cream cleanser sntsiing 379% Orhignya Olefre ‘Seed Oi, Unpublished data 2006, Consumer Produc Testing Co. 274. Consumer Product Testing Co. Repete inst patch tof isick continng 0.509847% Poketa Volubilis ‘Sod Oil Experiment reference number: C8-5394,06, Unpublshsd dita 2008, Consumer Product, Testing Co, 275, TKL Reseach. Repeated inrl patch test of preshav lotion containing 39% Vit Vines (Grape) Seed Oil and (0.04% Prunus Domestic Seed Oi, TRL Stady No: DS108206'3. Lapulished dt, 2-15-2007 276, TKL Reseach HRIPT ofan ee mask containing 0.2% Ries Nigram (Black Cura) Seod Oi RIPT 07-7331-036 ‘Unpublsed ata (Samar). 2007 277, QResearch. week use study ofan ey mask containing 0.2% Ribes Nigram Black Cuan) Sed Oi Use "7351-086. Unpublished data (summary). 2007, 278. Consumer Product Testing Co. Repented ins patch esto cream cleanser soning 0.023% Solanum Tycopesicum (Tomaia) Seed Oi, Unpublished dts, 2006 Consuer Product Testing, Co 279,. Product Investigations, ne. Determination ofthe intting ad sensing propensities of ip balm (ontining 501% Theobroma Cacao (Cocos) Seed Buter) on human skin, Unpublished dat. 2006. Product Tnvesigations tbe 280,_ Product Investigations, ne. Determination ofthe itating an sensing propensities of lip balm (conning 5% “Theobroma Grandioram Seed Ber) on buman skin, Unpublished ata, 208, Product Investigations, Ins 281, Clinial Resear Laboratories, ne Repstd insult patch st of founda consining 4% Vegetable Oi ‘Unpublished dats 2005. Cina! Research Laboratories, Ine 282, Consumer Produc Testing Co. Exclusive repented incl patches on lipstick containing 4% vegetable il. Ref. "No. C07-0193.12 Unpublished data 2007 283. Clinical Research Laboratories, ne Repeated insult patch est fan ee shadew containing 11% vegeubl oi, CRL- study pub: CRLI46064. Unpublished dt. 30-2006 284, Clinical Research Laboratories, ne. Repeated insult patch es of product 1061119 (asanecd oi containing 0% Vis Vinfera (Grape) Seed Oi). Study No, CRLS209.11-3-2008 285, Clini Research Laboratories, les. Repstd ist patch st of ip prod: eontsining 0.5% hydogented ‘rapeseed ol. CRL study umber: CRLSSS0S-S. Unpublished dat 98-2008, aDATAPersonal Care Products Council Committed to Safely, ually & lnsovetion ‘Memorandum TO: F. Alan Andersen, PhD. Director - CCSMETIC INGREDIENT REVIEW (CIR) FROM: fomBaley,md LL S.Q___¢[aalt0 Industry Liaivon to the CIR Expert Pane! August 23, 2010 (Comments or the Draft Report on Vegetable Oils Prepared for the August 30-31, 2010 CIR Expert Panel Meeting ‘More information about the composition ofthe plat oils can be found in the published lereture, Please see the attached examples of references that may be useful for additional composition information. p.l -Please state that the simple salts are salts of the fatty acids. 3,43, Table Sd - As some of these ingredients have recently be reviewed (or e-reviewed) and found ‘tw be safe, and because use concentrations were relatively high, new concentration of use information is not gcing to be collected on Carthamus Tinctorius (Safflower) Seed Oil, Oryza Sativa (Rice) Germ Oil, the Sesame ingredients (2009 use information) and the Cam ingredients. pS Although the LLNA isan alternative method, it isnot an in vitro method .S In the Rice Oil summary, what are the units for 5S. .B - As some phototoxicity studies are summarized inthe itation/Sensitization/Allergenicity section, Phototonicity should be added to this heading. .10 - Did the recommendation to avoid soybean oil include dermal exposure? Or was this study (reference 48) focused on dietary exposure? 1p.21, 25, Table - Ben Oil (p.21) and Moringa Oil (p.25) are from the same species, Moringa olefera. AO, Table 5b - Use informtion was collected forthe 2009 re-review of the Sesame ingredients. That _use information shouldbe included in this table. p42, Table Sc - Why is Vitis Vinifera (Grape) Seed Oil included in the Table of Ingredients not reported to be used? On p.37, Table Sa Vitis Vinifera (Grape) Seed Oils listed as having 465 uses according to the VCRP. Use concentrations of 0.001-43% have been reported. All the of ingredients in Table Se were not checked to sec if there are any other ingredients that have uses. p41, Table 5b - Please define NS atthe end ofthis table. AT, Table 7 - Please sce revised memo 8 and add thatthe face and neck product contained 5% Rubus daeus (Raspberry) Seed Oil, 1101 17 Sreet, NW, Suit 300] Woshngtn, 20036-4762 | 202:391.1770| 202.331.1964 (fx | wpersonalarecoundorgExamples of Additional References for Plant Oil Composition Information (identified by searching Google for oil name composition; or as described below; the objective ‘was to find one reference per oil; no searching was done forthe other ingredients included inthis report) But jue in-cos itorLibeary/153/REDPALM 2 ‘blaeis Ulestera Kemel Out ‘Tan BK, Berger KG. 1982. Characteristics of kemel oils from Eleis oleifera, FL hybrids and back-cross with Blacis guitcensis. Journal of the Science of Food and Agriculture 332): 204-208. ‘Olea Europaca (Olive) Husk Oil ‘Bouaziza M, Fkia I, emaia H, Ayadib M, Sayadia S. 2008. Effect of storage on refined and husk olive oils compositior: Stabilization by addition of natural antioxidants from CChemlal olive leaves. Focd Chemistry 108, Issue 1:253-262. ‘Actinisia Chinensis (Kiwi) Seed Cil Although from the abstract it is no: clear if Kiwi Seed Oil is in this article, this article does come up on Google when searching forthe composition of Kiwi Seed Oil 1Lsa M, Holeape M, Bohac M. 2009 Statistical evaluation of triacylglycerol composition in plant oils based on high-performance liquid chromatography-atmospheric pressure chemical ionization mass spectrometry data. Journal of Agricultural and Food Chemistry 57(15): (6888-6898, ‘This book may also be useful for Kiwi Seed Oil as well as other oils Gunstone FD, Harwood IL, Dijksta, AJ. 2007. The Lipid Handbook with CD-ROM, 3 edition. CRC Press (Geareh Google books for The Lipié Handbook) ‘Arctium Lappa Seed Oi ‘Although it may be possible to extract a fixed ol from the seed of Arctium lappa, internet searching suggests the essential oils more common ‘Astrocaryum Murumuru Seed Buter ‘The following article was found by searching the Agricola database at dhup/lagricols.nal,usda gov Saraiva SA, Cabral EC, berlin MN, Rodrigo R. 2009. Amazonian vegetable oils and fats: Fast ‘ypification and quality comrol via triacylglycerol (TAG) profiles from dry matrix assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry fingerprinting. Journal of agricultural and Food Chemistry 57(10): 4030-4034. Abstract: “Amazonian oils and fats display unique triacylglycerol (TAG) profiles and, because of their economic importance as renewable raw materials and use by the Page 1 of 2cosmetic and food industries, are often subject to adulteration and forgery. Representative samples of these oils (andiroba, Brazil nut, burt, and passion fruit) and fats (cupuau, murumuru, and ucuba) were characterized without pre-separation or derivatization via dry (solvent-free) matrix-assisted laser {desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Characteristic profiles of TAG were obtained for each oil and fat, Dry MALDI-TOF MS provides typification and direct and detailed information, via ‘TAG profiles, oftheir variable combinations of fatty acids. A database from spectta cold he developed and may he use for their fast and reliable typifcation, application screening, and quality contol." ‘Avena Sativa (Oat) Kemel Oil ‘See: hutp/ixb.ox ordiournals.ore/cei/content/fullerma 12502 ‘Bassia Butyracea Seed Buter Bassia Latfolia Seec Buter ‘See: httpu/worw,personalearemagazine com/Print aspx Story=4685 (This article includes many ‘additional oils) ‘The following reference was found by searching Sclerocarya Birrea on PubMed. Ogbobe 0. 1992. Physico-chemicsl composition and characterisation of the seed and seed ol of| Sclerocarya trea. Plant Foods Hum Nutr. 42(3):201-6. Abstract: “The shysicochemical composition of Sclerocarya birrea was assesied by standard ‘metheds and was found to contain 11.0% Crude oil, 17.2% Carbohydrate, 36.70% Crude protein 34% fibre and 0.9% crude saponins. The fatty acid dstribution in the seed oll was obtained by fractionating the voatised fatty acid by GC-MS. The oil is made up of nine fatty acids of which palmitic, stearic and arachidonic acids are the most dominant.” Page 2 of 2@ Personal Care (=)Products Council & Committed to Safety, Quality & Innovation Memorandum TO: F Alan Anéersen, PhD. Director - COSMETIC INGREDIENT REVIEW (CIR) FROM: John Bailey, moO e(asiio Industry Liaison tothe CIR Expert Panel DATE: August 23,2010 SUBJECT: Comments onthe Draft Report on Nut Oils Prepared forthe August 30-31, 2010 CIR [Expert Panel Meeting pl - Please state that the simple salts ar salts of the fatty acids. 4 - Please provide the reference for “One source” reporting use of Corylus AWvellana Seed Oil at concentrations up to 100%, -T - Please include the typ> of tesi(s) in which guinea pigs were tested for sensitizatcn to Cocos, ‘Nucifera (Coconut) Oil and Hydrogenated Coconut Oil. 1.16 ~ Please state thatthe 0.51% Plukenetia Volubilis Seed Oil was in a formulation. p.16- It would be helpful o state that the efficacy studies were in humans, p.21-22, Table 3 - What is meant by the row heading Appearance? It seems that Specific Gravity Values are in this row, 1101 17h ret, Mw, Ste 300] Washington, B.¢20036-4702 | 202:31.1770 | 202.331.1969 fx) | wepertonlerecondlorg ‘OR Pane Book Pe 117