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1. Introduction
A pupillometer is a device used for accurate measurement of a patient's pupils
which can be used in many different applications (Mantry, Banerjee et al. 2005).
Pupillometry has long been used in a research setting to study the autonomic
nervous system, drug metabolism, pain responses, psychology, fatigue, and sleep
disorders.
Pupillometer examinations are frequently conducted on those undergoing
physical exams to become firemen, emergency workers, or policemen. The
reactions of the pupil can, of course, suggest the use of narcotics, especially
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when the pupil remains less reactive and small. The pupillometer may also
suggest early symptoms of progressive joint or tissue disorders, which would
disqualify one to serve as an emergency or law enforcement worker. Another
application is that the pupil diameter is recognized as one of the limiting factors
for visual outcome in cataract and refractive surgery (Verdon, Bullimore et al.
1996).
Pupil size and movement can be measured by either infrared videography
or computerized pupillometry. The advantage of infrared videography is its
possibility to measure the pupil size without any background light while its
disadvantage is its low resolution picture quality. The advantage of videography
and computerized pupillometery is the quality of pictures with much higher
resolution, while the system functions with a background light and therefore a
fully scotopic conditions may be difficult to achieve(Schnitzler, Baumeister et
al. 2000). Such a system has been attempted to be modified with low price
camera systems(Patil, Gale et al. 2007), however it still suffers from the high
background light and non-scotopic conditions. Most of the available instruments
on the market are either as table instruments or handheld instrument with the
disadvantage of monocular testing of only one eye while the other eye has to be
occluded.
Considering the fact that, only health care services with solid economy can
supply these tools to their patients groups. In practice, it would mean that
this form of technology would only be available to a certain group of patients
which again might be in contradiction of the universal design definition and
spirit. By designing an instrument that is easy to be manufactured in addition to
be less expensive, it would make the instrument also available for medical
systems with lower budgets.
In short, there is a need for a pupillometer, which can measure pupil
diameter while having fairly good accuracy, being handheld with a lower price
than the existing instruments.
In this paper, we have suggested an infrared based pupillometer instrument
by using a modified low-cost webcam and few light emitting diodes (LEDs)
which are controlled by the Labview computer program.
2. Pupillometery instrument
2.1 Resolution of the web camera and its modifications
In order to find out the best camera resolution needed in this application, small
dots with different diameters was printed on A4 sheets by an inject printer
(Canon Pixma iP2600). The diameter of these dots was then measured by a
microscope (Olympus, GX71), which had a digital camera (Olympus, DP71),
and a picture analyzing software. The camera could be adjusted to resolutions as
high as 4080x3072 pixels (12.5Mpixel) and as low as 640x480 pixels.
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Based on the requirements for the measurements error and analysis of the
microscope camera in figure 2, a webcam with a resolution of 1280x960 pixels
would satisfy the criteria.
A USB based webcam (iMicro IM210) with resolution of 1280x960
(1.3Megapixels) was carefully opened and the lens connected to the camera chip
was separated. The IR filter which usually is attached at the top of the camera
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chip was carefully removed by using a scalpel. A piece of developed 35mm film
with an ISO100 was cut into the same dimension as the filter and placed on the
chip while the lens was re-assembled into its place again. By holding a TV
remote control in a distance of about 4 cm, it was possible to adjust the lens in
order to achieve an optimal focus.
Three light diodes (Everlight, HIR204/H0) with a light wave of 850nm and a
viewing angle of 60 were chosen. The LEDs were placed around the
camera lens with a distance of 1.5cm. This means that the distance of the LED
had to be at least 2.6 cm if the light beam should not directly reflect back to the
camera. A distance of 3.6 cm was chosen in order to make sure that the
reflection of IR light would not interfere with the picture analysis in Labview
Vision systems.
Three light diodes (Everlight, HIR204/H0) with a light wave of 850nm and
a viewing angle of 60 were chosen. The LEDs were placed around the
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camera lens with a distance of 1.5cm. This means that the distance of the LED
had to be at least 2.6 cm if the light beam should not directly reflect back to the
camera. A distance of 3.6 cm was chosen in order to make sure that the
reflection of IR light would not interfere with the picture analysis in Labview
Vision systems.
Three RGB light emitting diodes (Kingbright, KDA0 198) were also placed in
the same distance as the IR LEDs. These diodes contain blue, red and green light
chips in one package. The wavelength peak of red, green, and blue are 627nm,
565nm, and 430nm, respectively. There is a slight displacement from the center
axis of the chip which may result into a slight different beam angles. However,
this is very small changes within the chosen distance and therefore its influence
was ignored in this study. When all chips were switched simultaneously, the
LED would produce white color for stimulating eye within a broad visual
spectrum range.
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To place the light diodes and the electronic in a compact assembly, an old
welding goggle (Norweld,USA) was chosen for this solution. Due to
improvement of ambient light influence, all glasses and air filters at the front
and the sides of the goggle were carefully removed (see figure 5a) and the built
electronic circuit board with the webcam was mounted in place with a black
plastic cover on top (see figure 5b). The only disadvantage of this solution was
that the goggle had to be placed on the face of the subject as tight as possible in
order to minimize any influence of the ambient light. To make the project as
simple as possible, we only made the system with one stimulation and
measuring unit on right eye. However, it is fully possible to add another unit on
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The pubil size at both conditions had an average value of 4.40.3mm. When
stimuli of 5.6mcd was applied for a duration of 10 seconds, the pupil size
changed to 3.80.2mm. The stimuli of 20mcd resulted to a diameter of
2.20.1mm.
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Acknowledgement
This project was partly carried out by our electrical and electronic engineering
students at bachelor level. The author would like to use the opportunity to thank
Jon Fredrik Vle, Alexander Stams og Reza Sharkanloo to contribute to this
project.
References
Bar, K. J., M. K. Boettger, et al. (2005). "Lateralization of pupillary light
reflex parameters." Clin Neurophysiol, vol. 116, nr.4, pp. 790-8.
Colvard, M. (1998) "Preoperative measurement of scotopic pupil dilation
using an office pupillometer." J Cataract Refract Surg, vol.24,
nr.12,pp. 1594-7.
Helgesen, A., J. Hjortdal, et al. (2004) "Pupil size and night vision
disturbances after LASIK for myopia." Acta Ophthalmol Scand, vol.
82, nr.4, pp. 454-60.
Mantry, S., S. Banerjee, et al. (2005) "Scotopic measurement of normal
pupil size with the Colvard pupillometer and the Nidek
auto-refractor." Cont Lens Anterior Eye, vol.28, nr.2,pp. 53-6.
Patil, S. G., T. J. Gale, et al. (2007) "Design of Novel Assessment
techniques for opiod dependent patients." Poceedings of the 29th
annual international conference of the IEEE EMBS: 3737-3740.
Rosen, E. S., C. L. Gore, et al. (2002) "Use of a digital infrared
pupillometer to assess patient suitability for refractive surgery." J
Cataract Refract Surg, vol. 28, vol.8, pp. 1433-8.
Schnitzler, E. M., M. Baumeister, et al. (2000) "Scotopic measurement of
normal pupils: Colvard versus Video Vision Analyzer infrared
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