Gui Pi Tang

Da Zao - Jujube
Warm
TCVM Thermal Nature:
Cold Cool Neutral Warm Hot

TCVM Indications:
Spleen Qi and Heart Blood Petechiae and/or purpura
Deficiency Tongue: Pale and dry
Prolonged hemorrhage Pulse: Thin and weak
No stamina or anxiety

Chinese Principles of Treatment:

Nourish Blood, tonify Spleen Qi.

Contraindications: None

Dosage:
Horse - 15 g twice daily as top dressing on
feed
Dog/Cat - 0.5 g per 10 to 20 lb body weight
twice daily

Ingredients and Actions:

Latin Name Ingredients Actions
Ginseng Ren Shen Tonifies Qi
Atractylodes Bai Zhu Tonifies Qi and strengthens Spleen
Astragalus Huang Qi Tonifies Qi
Poria Fu Ling Drains Damp, strengthens Spleen
Angelica Dang Gui Nourishes Blood
Longan Long Yan Rou Nourishes Blood
Vladimiria Chuan Mu Xiang Moves Qi
Polygala Yuan Zhi Nourishes Heart
Ziziphus Suan Zao Ren Nourishes Heart
900g powder 600g powder
Jujube Da Zao Harmonizes 200 teapills 200-0.5g capsules
200g powder
Zingiberis Sheng Jiang Harmonizes the Spleen and Stomach
Glycyrrhiza Zhi Gan Cao Harmonizes

Distributed through veterinarians only

www.tcvmherbal.com
9700 West Hwy 318, Reddick, FL 32686, USA
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Main Herbs in Gui Pi Tang
Gui Pi Tang comes from Ji Sheng Fang (Formulas to Aid the Living) written by Yan Yong-He in 1253. Gui Pi Tang is used for treating Heart (Blood)
and Spleen (Qi) deficiencies. The clinical signs of Heart (Blood) deficiency include arrhythmia, tachycardia, anxiety and insomnia. Clinical signs of
Spleen (Qi) deficiency include poor appetite, lethargy and bleeding disorder. This fomula is also indicated for disorders in animals in which the
Spleen fails to hold the blood whthin the vessels due to Spleen Qi deficiency. Ren Shen (Ginseng), Bai Zhu (Atractylodes), Huang Qi (Astragalus)
and Zhi Gan Cao (Glycyrrhiza) warm and tonify Spleen Qi. Dang Gui (Angelica) and Long Yan Rou (Longan) nourish the Liver, tonify Heart Blood,
and regulate blood circulation. Fu Ling (Poria), Yuan Zhi (Polygala) and Suan Zao Ren (Ziziphus) nourish the Heart and calm the Shen (spirit).
Chuan Mu Xiang (Vladimiria) moves Qi and prevents the stagnating nature of the tonic herbs from impairing the Spleen and Stomach. Da Zao
(Jujube) and Sheng Jiang (Zingiberis) harmonize the Middle Burner (Zhong Jiao).

Clinical Research on Gui Pi Tang

Clinical studies showed that oral administration of the herbal formula Jia Wei Gui Pi Tang for 12 weeks increased the platelet counts in 7 of 10
patients. In addition, the mean platelet count increased from 33 x 103/l to 62 x 103/l, and the platelet-associated IgG decreased from 433.9 to
192.8 ng per 107 platelets.1 A systematic review including Chinese and English literature of randomized controlled trials was conducted to examine
the efficacy, safety, and composition of Chinese herbal medicine for insomnia. Results showed that Gui Pi Tang is the most commonly used
standardized formula to treat insomnia, while Suan Zao Ren (Ziziphus) is the most frequently used single herb.2 Ren Shen (Ginseng) has long been
used clinically in China to treat various diseases. Recently, the clinical utilization of Ren Shen (Ginseng) to treat heart diseases has increased
dramatically.3 Forty patients with moderately severe Alzheimer's disease were treated with Ren Shen (Ginseng) and results showed significant
improvement on the Alzheimer's Disease Assessment Scale (ADAS) and Mini-Mental State Examination (MMSE). Patients with higher dose group
(4.5 g/day) showed improvements in ADAS cognitive, ADAS non-cognitive, and MMSE score as early as 12 weeks, which was sustained for
24-week follow-up.4 Dang Gui (Angelica) has evident therapeutic effect in treating acute cerebral infarction (ACI) patients. The neuro-function
deficit scores and Barthel scores significantly improved and infarcted volume decreased after Angelica injection.5 Chuan Xiong (Ligusticum) could
effectively inhibit the platelet activation in vivo and correct the TXA2-PGI2 imbalance in blood of the patients with acute cerebral infarction.6

Pharmaceutical Evidence of the Effects of Herbs in Gui Pi Tang

Gui Pi Tang seems to accelerate the recovery of cellular immunocompetence and the recovery of blood cell counts of leukocytes, erythrocytes and
thrombocytes in mice after gamma-ray irradiation, especially when Gui Pi Tang is administered at a concentration of 20 mg per 20 g body weight.7,8
In an ovariectomized (OVX) rat model, one experiment demonstrated that modified Gui Pi Tang (Jia Wei Gui Pi Tang) improved the menopausal
symptoms and increased the locomotor activity of the OVX group, thereby increasing bone mineral density.9 Ginseng pectin (GP) is a potential
therapeutic agent for neurodegenerative diseases. One experiment demonstrated that neuroprotective activities of GP against hydrogen peroxide
(H2O2)-induced neuronal toxicity in different neuronal cells. GP selectively attenuated H2O2-induced damage up to 26% in primary cortical neuron
cells and human glioblastoma U87 cells. This suggests that the protective effects of GP against H2O2-induced apoptosis may be due to the
activation of the phosphorylation of ERK1/2 and Akt.10 The water extract of Suan Zao Ren (Ziziphus) (400 and 800 mg/kg body wt.) can shorten
sleep latency significantly, increase sleeping time and prolong movement convalescence time induced by sodium pentobarbital (55 mg/kg body
wt.) administration in mice.11

Case Study
Cozee is a 25 year old Arabian mare. In March of 2007, the owner noted that Cozee felt hot, was drinking significantly more water and was off in
the left front. Also, she was spending more time lying down. A complete blood panel was taken and early Cushings Disease was suspected.
Cozees treatment consisted of acupuncture given once weekly for three treatments then a fourth given one month later. Chinese herbal formulas
Ophiopogon Powder and Hot Hoof I started on 3/28/2007, after the second acupuncture treatment. On a recheck in August, her tongue appeared
a paler pink, no longer red. Her pulses were now thin and somewhat hard to find. As Qi and Blood deficiency became apparent. Hot Hoof II was
discontinued and Gui Pi Tang was started, and Cozee continued to take Ophiopogon Powder. In November, the tongue was still pale pink, her
pulses were stronger. Si Wu Tang was substituted for Gui Pi Tang for stronger Blood tonification, and the Ophiopogon Powder dosage was lowered
by half. At present time, Cozee continues to do well with only a slight increase in water consumption noted.12

References
1. Yamaguchi, K. et al. Effects of kami-kihi-to (Jia Wei Gui Pi Tang) on autoantibodies in patients with chronic immune thrombocytopenic purpura. Am J
Chin Med. 1993;21 (3-4):251-5
2. Yeung, W.F. et al. Chinese herbal medicine for insomnia: A systematic review of randomized controlled trials. Sleep Med Rev. 2012 Mar 20 [Epub
ahead of print]
3. Zheng, S.D. et al. Roles and mechanisms of ginseng in protecting heart. Chin J Integr Med. 2012 Jul;18(7):548-55
4. Heo, J.H. et al. Heat-processed ginseng enhances the cognitive function in patients with moderately severe Alzheimer's disease. Nutr
Neurosci. 2012 Jul 9. [Epub ahead of print]
5. Liu, Y.M. et al, Observation on clinical effect of Angelica injection in treating acute cerebral infarction. Zhongguo Zhong Xi Yi Jie He Za
Zhi. 2004,24(3):205-8. [Article in Chinese]
6. Liu, Z. et al, Effects of Ligusticum wallichii on the plasma levels of beta-thromboglobulin, platelet factor 4, thromboxane B2 and 6-keto-PGF1 alpha in
patients with acute cerebral infarction. Zhong Xi Yi Jie He Za Zhi. 1991,11(12):711-3, 707. [Article in Chinese]
7. Hsu, H.Y. et al. Effects of Kuei Pi Tang on cellular immunocompetence of gamma- irradiated mice. Am J Chin Med. 1993;21(2):151-8.
8. Hsu, H.Y. et al. Preliminary study on antiradiation effect of Kuei Pi Tang. Am J Chin Med. 1991;19(3-4):275-84.
9. Kanai, S. et al. Effect of kami-kihi-to (Jia Wei Gui Pi Tang) for experimental osteopenia. Am J Chin Med. 2005;33(1):41-8
10. Fan, Y. et al. Neuroprotective effects of ginseng pectin through the activation of ERK/MAPK and Akt survival signaling pathways. Mol Med
Report. 2012,5(5):1185-90
11. Fang, X.S. et al. Pharmacological studies on the sedative-hypnotic effect of Semen Ziziphi spinosae (Suan Zao Ren) and Radix et Rhizoma Salviae
miltiorrhizae (Dan Shen) extracts and the synergistic effect of their combinations. Phytomedicine. 2010,17(1):75-80
12. Mackinnon L. Cozees early Cushings disease successfully managed with acupuncture and Chinese herbal fomulas. TCVM News Letter. 2008,6:9-
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