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MORTALITY
SUBMITTED ON:-16-03-2010
MORBIDITY AND MORTALITY
INTRODUCTION:-
Health is essential to socioeconomic development of has gained increasing recognition. Indicators are
required to measure the health status of the community, to compare the health status of a country ,for assessment
of health needs, for allocation of source resources; and for monitoring and evaluating the health resources,
activities and programmes . Variables will help to measure the changes in health status.
INDICATORS OF HEALTH:-
i. Mortality indicators
ii. Morbidity indicators
iii. Disability rates
iv. Nutritional status indicators
v. Health care delivery indicators
vi. Utilization rates
vii. Indicators of social and mental health
viii. Environmental indicators
ix. Socioeconomic indicators
x. Health policy indicators
xi. Indicators of quality of life
xii. Other indicators
MORTALITY :-
Mortality is the condition of being mortal, or susceptible to death; the opposite of immortality.
Epidemiologist often starts the investigation of health experience of a population with information that is
routinely available many countries the fact and cause of death are recorded on a standard death certificate, which
also carries information on age ,sex , date of birth and place of residence.
MEASUREMENT OF MORTALITY:-
Traditionally and universally , most epidemiologic studies begin with mortality data. Mortality data
provide the standing point for many epidemiologic studies.
The WHO Mortality Data base comprises deaths registered in national vital registration systems, with
underlying cause of death as coded by the relevant national authority. Underlying cause of death is defined as “the
disease or injury which initiated the train of morbid events leading directly to death, or the circumstances of the
accident or violence which produced the fatal injury” in accordance with the rules of the International
Classification of Diseases.
The database contains number of deaths by country, year, sex, age group and cause of death as far back
from 1950. Data are included only for countries reporting data properly coded according to the International
Classification of Diseases (ICD).
The basis for mortality data is Death certificate. For ensuring national and international
comparability , it is very necessary to have a uniform and standardized system of recording and classifying death.
bronchopneumonia
Strangulated hernia
diabetes
The international death certificate is in two parts. Part I deals with the immediate cause and the
underlying cause which started the whole trend of events leading to death. The underlying cause of death is
recorded in line C. in the example cited , the underlying cause of death is strangulated hernia. After operation
the patient developed bronchopneumonia as a complication and ended in death. In the part two is recorded any
significant associated disease that contribute to the death but did not directly lead to death.
In order to improve the quality of maternal mortality and infant mortality data and to provide
alternative method to collect data on death during pregnancy and infancy , a set of questions are added to the
basic structure of international; death certificate for use in India.
Crude death rate:- This is considered as a fair indicator of the comparative health of the
people. It is defined as the number of death per 1000 population per year in a given community. It indicates
the rate at which people are dying.
Expectation of life:-
Life expectancy at birth is “the average number of years that will be lived by those born alive into a
population if the current age specific mortality rates persist” life expectancy at birth is highly influenced by the
infant mortality rate where that is high. Life expectancy at the age of 1 excludes the influence of infant
mortality, and life expectancy at the age of 5 excludes the influence of child mortality. It is estimated for both
sex separately.Life expectancy is a good indicator of socioeconomic development in general. As an indicator of
long term survival , it can be considered as a positive indicator.
What is happening to overall standard of living of people in India. One of the broadest standard of
living measure is the life expectancy - the average expected lifespan of an Indian. Here is the data:
Two of the specific death rates are used immensely as valuable indicators of the state advancement of
any country. They are the infant mortality rate and maternal mortality rate. The reason for such reputation are
due to the high relationship noted between the high rate of death among the infants ( and mothers) are poor
standards of living. Raising the standard of living in terms of literacy and improvement in sanitation has had
tremendous impact on reducing these death rates.
The denominator consist of live ( or viable) birth only. This rate may be further considered in terms of
infant dying under 28 days of age (neonates)and those dying between the ages of 28days to 1 below year(post
neonates ).
Since there are distinct differences between the causes of death among neonates and post neonates ,
the above decision provides a more sensitive way of studying the infant mortality. When infant mortality decrease
and living standards improves , the impact is shown much more on the post neonatal death than on neonatal death.
Jouranal study -1
New Delhi, Dec 10 (ANI): Neonatal mortality or death within 28 days of birth is high in India, according
to the latest UNICEF report.
According to the UNICEF’s statistical review “Progress for Children-A World Fit for
Children,” out of the estimated 2.1 million child-mortality (death of children in their first five years of
life) in India, one million are during the neonatal period (within 28 days of birth).
India with 2.1 million under-five child deaths, contributes to about 21 percent of the global
burden of child deaths. India has the largest pool of 9.4 million children, who have never been
immunised in the world.
A UNICEF representative said, “Immunisation in the 80s and 90s was shining in India. After that
it has seen a progressive decline. While in the weaker states such as Bihar, Madhya Pradesh and Rajasthan
the immunisation programme improved, in the well-performing states, such as Gujarat and Maharashtra
they showed a decline. So, the overall decline,”
The representative suggested the need for strengthening the immunisation system, which includes
preservation of vaccine at right temperature, distribution of vaccines from the Centre to States, and
education of health workers. While safe drinking water is essential for child survival, the world is on the
track to meet the Millennium Development Goal (MDG) on safe drinking water. With 84.5 percent rural
and 95 percent urban population having sustainable access to safe drinking water, India is also on the track
to meet this goal.
The report acknowledges that progress of India, which is one of the largest countries of the world,
is key to achieving the MDGs. “With 20 per cent of the world’s children under age of five years,
India needs at least 20 percent of the world’s attention. And, it is getting it,” said UNICEF India
representative Gianni Murzi. (ANI)
Jouranal study- 2
Title: Infant and childhood mortality in India. Mahadevan, K., Murthy, M. S. R., Reddy, P. R., Reddy,
P. J., Sivaraju, S., Gowri, V.
The differential trends in infant and child mortality, and their major determinants were studied in a
sample of 3000 households representing 3 religious and caste groups in Chittoor district, Andhra Pradesh,
India. The highest rate of infant and child mortality was found among the Muslims and Harijans, while the
caste Hindus showed the lowest rate. Infant and child mortality was determined by socio-economic
factors, particularly education and income, housing pattern, age at marriage, number of living children,
prelacteal feeds and breast feeding, and maternal anaemia. Tetanus neonatorum, asphyxia, delivery
problems, diarrhoea and dysentery were influencing mortality. Infant and child malnutrition and
prematurity were other causes of mortality. A reciprocal relationship between infant mortality and fertility
was observed. The determinants varied for instant and child mortality. The conclusion reached is that
while biological and family factors affected infant mortality, family and environmental factors affect early
childhood mortality.
Chart 4: India's Infant
Mortality Rate, Year 2000 – 2005
Maternal death is defined as the death of a woman while pregnant or with in 48 days of termination of
pregnancy irrespective of the duration ,and the site of pregnancy from any cause related to or aggravated to by the
pregnancy or its management but not from accidental or incidental causes.
Journal study
Changing trends in maternal mortality over a decade By Y. Juneja, a, U. Goela and M.New Delhi, India
To study the change in trend in maternal mortality over the last decade and to find out
specific causes of death. Method: A retrospective study was carried out. The admission ledgers of patients
admitted over two 3-year periods (1979–1981 and 1989–1991) were studied to ascertain the total number of
maternal deaths and the specific causes of death.Results: One hundred fifty-eight deaths occurred during 1979–
1981 and 149 deaths during 1989–1991. During the same period therè were 23 098 and 37 763 total births,
respectively, the overall maternal mortality rate thus significantly declining from 684/100 000 total births in
1979–1981 to 394/100 000 total births in 1989–1991. Sepsis followed by hemorrhage and hepatitis were the
leading causes of maternal deaths over the decade. Conclusion: Health education and availability of health
services, largely at a community level, would contribute to reducing the incidence of preventable causes of
maternal deaths such as sepsis and hemorrhage.
The stillbirth or fetal deaths do not enter into the calculation of the usual mortality rates. The WHO
subdivided the fetal death based on gestation as follows :
An early fetal death rate may also be computed ,but full information on early death are usually not
easily available. Some times a ratio is also calculated which is defined as:
Late foetal death=no of foetal death,28 week of gestation Or more occurred during a year х1000
rate No of live births during that year
Another indicator related to the over all health status is the early childhood (1 -4yrs) mortality rate. It
is defined as the number as the number of death at age 1-4 yrs in a given year ,per 1000 children in that age
group at the midpoint of the year concerned . it thus excludes infant mortality.
Value
Year
A child survival rate per 1000 birth can be simply calculated by subtracting the under 5 mortality rate
from 1000 diving this figure by ten shows the percentage of those who survive to the age of 5yrs
It is the proportion of total death occurring in the under 5 age group . This rate can be used to reflect both
infant and child mortality rate . In communities where sanitation is poor the proportion may exceed to 60%
Mortality rates can be computed for specific diseases. As countries begin to extricate themselves from
burden of communicable disease, a number of other indicators such as death from cancer , cardiovascular
disease, accidents, diabetes etc have emerged as measures of specific disease problem.
This rate can be made specific with regard to any subgroup of the population such as age specific death rate
for group A or sex specific death rate for sex M or cause specific death rate for cause C. A refers to a specific
age; C refers to specific cause of death; M and F refers to their gender .
One can also make the rates specific for combination of different subgroups .
Instead of expressing these specific rates per 1000 population a figure of 10,000 or 1,00,000 may
be used to avoid fractions in the quotient.
This study attempts to provide a wider understanding of the differentials in reported health status
in Kerala, while comparing morbidity in the state with other regions in the Indian subcontinent. Reported
morbidity and the duration of life lived with a disease is higher in Kerala. Economic inequalities were found
only in late-working ages and the elderly, primarily due to higher prevalence of life style-associated chronic
conditions in these two age groups. Significant caste-wise differences among adolescents and prime working
ages indicated potential for health problems induced by income deprivation in socially disadvantaged
subgroups. Self-reported morbidity was 65% higher than proxy-reported morbidity. Regional differences were
significant across all age groups, with high morbidity in the most developed region in the state. Results also
suggested the need to factor for self- and proxy-reported status in any analysis of morbidity using similar
survey data.
The Agency for Healthcare Research and Quality (AHRQ) and the Institute for Healthcare Improvement
(IHI) have partnered to explore the scientific controversies around using a mortality measurement
methodology to improve health care quality. The mortality measures would also be used to help track and
reduce mortality nationally and in individual institutions.
In November 2008, AHRQ and IHI convened a meeting in Cambridge, Massachusetts, to discuss these
important issues. Presentations and discussion took place on five existing risk-adjusted mortality measures. In
addition, experts reviewed issues related to:
• The lessons learned from past government efforts to publicly report mortality rates.
• The National Quality Forum's (NQF) intent to vet a national mortality measure or measures.
• The pros and cons of including deaths occurring within 30 days of hospital discharge.
• The progress in measuring diagnosis-specific mortality rates.
In addition, ongoing research to include automated clinical data in risk-adjustment methods was
presented, and research needs were outlined .
A standardized death rate is a crude death rate that has been adjusted for differences in age
composition between the region under study and a standard population. Standardization allows for
comparisons when the population structures differ and is key in assessing the potential influence of
environmental or cultural factors on death rates in a region.There are two ways of computing standardized
death rates – direct and indirect standardization. The results will be a little bit different. The one you would
use varies based on the data available to you.
Direct Standardization (SDR1) calculates a weighted average of the region’s age-specific mortality
rates where the weights represent the age-specific sizes of the standardpopulation.
Indirect Standardization (SDR2) uses age-specific mortality rates from the standard population to
derive expected deaths in the region’s population.
Direct Standardization:
Indirect Standardization:
Choosing which formula to use will depend on what data you have access to. More typically, the data you have
will be the components for indirect standardization. You are more likely to be able to find age-specific
mortality rates for a standard population than for a specific region such as a state. In this case, since I have
given you state population data in thousands, you will need to divide your final result by 1,000.
MORBIDITY
Morbidity has been defined as “any departure, subjective or objective , from a state of
physiological well being” . the problem is equivalent to such terms as sickness , illness, disability etc. The
WHO Expert committee on Health Statistics noted in its 6th report that morbidity could be measured in terms
of 3 units- a. person who ill ; b.the illness that these persons experienced and c. the duration of these illness.
Three aspect of morbidity are commonly measured by morbidity rates and morbidity ratios,
namely frequency duration and severity. Disease frequency is measured by incidence and prevalence rate . the
average duration per per case or the disability rate , which is the average number of the days of disability per
person, may serve as a measure of the duration of illness. The fatality rate may be used as an index of severity.
This section focus on incidence and prevalance rate , which are widely used to describe disease occurrence in a
community.
The value of morbidity data may be summarized as follows ;
They describe the nature and extend of the disease load in the community and thus assist in the
establishment of priorities
They usually provide more comprehensive and more accurate and clinically relevant information on
patient characteristic than can be obtained from morbidity data and are therefore essential for basic
research.
They act as starting points for aetiological studies, and thus play a crucial role in disease prevention
They are needed for monitoring and evaluation of disease control activities
Morbidity indicators:-
To describe health in terms of mortality is rates only is misleading. This is because the mortality
indicators donot reveal the burden of illhealth in a community , as for example mental illness and rheumatoid
arthritis . Therefore morbidity indicators are used to supplement mortality data to describe the health status of a
population. Morbidity statistics have also their own drawback; they tend to overlook a large number of condition
which are subclinical or inapparent , that is , the hidden part of the iceburg of disease.
The following morbidity rates are used for assessing the illhealth in the community.
1. Incidence and prevalence
2. Notification rates
3. Attendance rate at outpatient department, health centres ,etc
4. Admission readmission and discharge rates
5. Duration in hospital and Spells of sickness or absence from work or school
Incidence :-
This is based on the number of cases of disease appearing in a stated period of time divided by the
estimated population at midpoint of this time period . Usually this is defined as : “the number
of NEW cases occurring in a defined population during a specified period of time”. It is given by the formula
=no of new caseof specific disease during given time period х1000
For example , if there had been 500 new cases of an illness in a population of 30,000 in a year , the incidence
rate would be
=500/30,000х1000
Note: incidence rate must include the unit of time used in the final expression . If you wrote 16.7
per 1000,this would be inadequate. The correct expression is 16.7 per1000per year.
It will be seen from the above definition that the incidence rate refers
e) year . If he had suffered twice , he would contribute two spell of sickness in the year. The formula in
this case would be
Incidence measures the rate at which new cases are occurring in a population . It is not influenced by the
duration of the disease . the use of incidence is generally restricted to acute conditions.
• Attack rate
An attack rate is an incidence rate (usually expressed as a percent) , used only when the population
is exposed to a risk for a limited period of time such as during an epidemic. It relates the number of cases in
the population at risk and reflect the extend of the epidemic.
Attack rate
Incidence or attack rates can be made specific in terms of some particular attributes such as age ,
sex, occupation, cause etc
It is defined as the number of exposed persons developing the disease with in the range of incubation
period following exposure to a primary case.
The incidence rate as an indicator of health status , is useful for taking action
i. To control disease
ii. For research into etiology and pathogenesis , distribution of disease , and efficacy of
preventive and therapeutic measures.
For instance , if the incidence rate is increasing ,it might indicate failure or ineffectiveness of the current
control programmes. Rising incidence rate may suggest the need for a new disease control or preventive
programme, or that reporting practice had improved. A change or fluctuation in the incidence of disease may also
mean a change in the etiology of disease,eg; change in the agent , host and environment characteristics. Analysis
in the difference in incidence rates reported from various socioeconomic groups and geographical areas may
provide useful insights into the effectiveness of the health services provided.
Prevalence:-
The term disease prevalence refers specifically to all current cases( old and new) existing at a
given point of time , or over a period of time in a given population. A broader definition of prevalence is as
follows:
“the total number of all individuals who have an attribute or disease at a particular time ( or during
a particular period) divided by the population at risk of having the attribute or disease at this point in time or
midway through the period” .
Although referred to as a rate , prevalence rate is really a ratio. Prevalence is of two type;
• Point prevalence
• Period prevalence
Point prevalence:-
Point prevalence of a disease is defined as the number of all current cases ( old and new) existing at a
given point of time in relation to a defined population. The “point” in point prevalence, may for all practical
purpose consist of a day ,several days or even few weeks depending upon the time it takes to examine the
population sample. It is given by the formula
No of all current cases (old & new)of a specified disease at a given point in time х100
When the term “prevalence rate” is used , without any further qualification , it is taken to mean “ point
prevalence” which can be made specific for age sex and other relevant factors or attributes.
Period prevalence:-
A less commonly used measure of prevalence is period prevalence. It measures the frequency of all current
cases (old and new) existing during a defined period of time ( eg:- annual prevalence) expressed in relation to a
defined population . It includes cases arising before but extending into or through to the year as well as those
cases arising during the year . period prevalence is given by the formula :
=no of existing cases(new& old) of a specific disease during a given period of time interval х100
Case1
Case2 case3
Case4
Case5
Case7 case6
Case8
Jan1 dec 31
Prevalence depends upon 2 factors , the incidence and duration of illness . given the
assumption that the population is stable , and incidence and duration are unchanging , the relationship between
incidence and prevalence can be expressed as:
duration = P/I
The above equation (P= IхD)shows that the longer the duration of disease , the greater its
prevalence. For example , tuberculosis has a high prevalence rate relative to incidence. This is because new
cases of tuberculosis keep cropping up through out the year, while the old ones may persist for months or
years . On the other hand , if the disease is acute and of short duration either because of rapid recovery or
death,the prevalence rate will be relatively low when compared to the incidence rate. In some diseases (eg:
food poisoning ), the disease is so short lived , there is no old cases. The same is true of the condition which
are rapidly fatal , such as homicides . strictly speaking , these events have no prevalence. In other words ,
decrease in prevalence may take place not only from a decrease in incidence, but also from a decrease of the
duration of illness through either more rapid recovery or more rapid recovery or more rapid death.
When we see a change in prevalence from one time period to another , this can result from
change in incidence, change in duration of disease or both. For example ,improvements in treatment may
decrease the duration of illness and thereby decrease the prevalence of a disease. But if the treatment is such that
they preventing death, and at the same time not producing recovery, may give rise to theapparently paradoxical
effects of an increase in prevalence. Further , if duration is decreased sufficiently , a decrease in prevalence
could take place despite an increase in incidence.
Prevalence has been compared with a photograph , an instantaneous record ; and incidence
with a film , a continuous record. Both the terms may perhaps be better understood by taking into consideration
a coffee house. After the coffee house opens in the morning , people keep entering and leaving , each one
remaining inside the coffee house for a short while . At any point of time , say 10 AM , we could go into the
coffee house and count people over there. This corresponds to estimating the prevalence. The rate at which
people enter the coffee house , say 10 people per hour , is equivalent to the incidence . The relationship between
incidence and prevalence is shown below
incidence
prevalence
Recovery death
It is important to note the limitations of prevalence rate . It is not the ideal measure for studying disease etiology or
causation . We hav seen that two factors determining prevalence , namely incidence and duration . Incidence is
related to the occurrence of disease and duration to factors which the ourse of the disease.In other words , the
element of duration reflects the prognostic factors ., and incidence reflects the causal factors . Therefore incidence
rate should be optimally used in the formation and testing of etiological hypothesis . when incidence rates are not
available , prevalence rates (which are readily obtainable) may have to be used, but the contribution of duration
element always has to be assessed.
Uses of prevalence:_-
Helps to estimate the magnitude of health/ disease problems in the community and identify
potential high risk population
Prevalence rates are especially useful for administrative and planning purpose , eg: hospital beds
, manpower needs , rehabilitation facilities ,etc .
In 1980, Dr. James Fries, Professor of Medicine, Stanford University introduced the compression
of morbidity theory. This theory states that "most illness was chronic and occurred in later life and postulated
that the lifetime burden of illness could be reduced if the onset of chronic illness could be postponed and if this
postponement could be greater than increases in life expectancy." (Fries, 1980).
Estimated present lifetime morbidity is portrayed with three possible future scenarios: life extension, shift-
to-the-right, and compression of morbidity. The lines represent the length of life, and the shaded triangles
depict lifetime morbidity. Two arrows are shown for each scenario: The left arrow represents the median age at
onset of chronic morbidity and the right arrow represents the median age at death. Alternative health futures
are determined by the relative movement of these arrows over time. If the arrows separate, lifetime morbidity
increases, and if they come closer, morbidity is compressed. In each scenario, some extension of life
expectancy is envisioned. The illustrative use of age 55 years as the present age of onset of chronic morbidity
is drawn from the data of Bruce B et al showing this to be the median age of detectable chronic disability
(Bruce).
While it is true that good preventive medicine and a healthy lifestyle can postpone disability due to
chronic illness, there comes a stage in every person’s life where significant illness related debility is
experienced. As the illness progresses, it becomes the source of bio-psycho-socio-spiritual suffering.
CONCLUSION:-
The morbidity and mortality rates represent the health status of a specific population. To describe health in
terms of morbidity is only misleading, which will not reveal the burden of illhealth in a community.
BIBLIOGRAPHY:-
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Development Review 18(3): 481-503.
v. Gumber, A. and P. Berman. 1997. "Measurement and Pattern of Morbidity and Utilisation
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