Lovely Professional University,Punjab

Format For Instruction Plan [for Courses with Lectures and Tutorials ]

Course No. BTY522 Course Title: ADVANCES IN BIOPROCESS ENGINEERING L: 3 T: 1 P: 0 Cr: 4

Course Planner :- 13579 :: C.P.Pandia Dhaua Selvan

TextBook

1. Biochemical Engineering Fundamentals 2nd edition Bailey and Ollis(2002)

Other Specific Books

2. Biotechnology (2nd edition) Vol 3 (Bioprocessing) and volume 4 (Measuring Modeling and control) Edited by Rehm and Reed(2003)
3. Bioprocess Technology- fundamentals and applications, S O Enfors & L Hagstrom (1992), RIT, Stockholm

Other Readings

Sr. No. Jouranls atricles as compulsary readings (specific articles, Complete reference)

4 Microbial Fermentations with immobilized cells ;S. V. Ramakrishna and R. S. Prakasham Biochemical and Environmental Engineering, Indian Institute of Chemical
Technology, Hyderabad 500 007, India
5 Recent Developement in Biological Hydrogen Production Processes ; Debrata Das and Namita Khanna

Relevant Websites

Sr. No. Web adress (only if relevant to the courses) Salient Features

6 http://ocw.mit.edu/OcwWeb/Chemical-Engineering/10-445Summer-2005/CourseHom bioseparartion
e/

Detailed Plan For Lectures

Pedagogical tool
Chapters/Sections of
Homework to be Demonstration/case
Week No. Lecture No. Topic Textbook/other
Assigned to students study/images/anmation
reference
ctc. planned

Part 1
Week 1 Lecture 1 Unstructured Models ->Reference :1,7.3

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Part 1
Week 1 Lecture 2 Unstructured Models of growth ->Reference :1,7.3.1

Lecture 3 substrate utilization and product formation ->Reference :1,7.5.1 Term Paper 1 Allocation http://www.exrx.net/Nutrit
ion/Substrates.html

Week 2 Lecture 4 substrate utilization and product formation ->Reference :1,7.5.2 HomeWork 1 Allocation http://www.exrx.net/Nutrit
ion/Substrates.html

Lecture 5 Transient growth Kinetics ->Reference :1,7.3.3

Lecture 6 structured models ->Reference :1,7.4

Week 3 Lecture 7 structure kinetic models of growth and product formation ->Reference :1,7.4.1

Lecture 8 Metabolic Models ->Reference :1,7.4.2 http://en.wikipedia.org/wi

ki/Metabolic_network_m
odelling
Lecture 9 cybernetic models ->Reference :1,7.4.3

Week 4 Lecture 10 cybernetic models ->Reference :1,7.6 HomeWork 1

Submission
Part 2
Week 4 Lecture 11 Bioreactor design and analysis ->Reference :1,9.1 http://www.bioreactordes
ign.org/

Lecture 12 Ideal Bioreactors ->Reference :1,9.1.1

Week 5 Lecture 13 Non ideal reactors ->Reference :1,9.3 Class test based on
homework1

Lecture 14 mixing and residence time ->Reference :1,9.3 HomeWork 2 Allocation http://www.fluent.com/so
->Reference :1,9.3.1-9.3.2 lutions/examples/x93.htm

Lecture 15 distribution studies in bioreactor ->Reference :1,9.3.3-9.3.4

Week 6 Lecture 16 Mass and Heat transfer ->Reference :1,8.1 http://en.wikipedia.org/wi

ki/Mass_transfer

Lecture 17 modeling mass transfer in complex systems ->Reference :1,8.1-8.2

Lecture 18 modeling mass transfer in complex systems ->Reference :1,8.1-8.2

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Part 2
Week 7 Lecture 19 modeling heat transfer in complex systems ->Reference :1,8.10 HomeWork 2
Submission

Lecture 20 modeling heat transfer in complex systems ->Reference :1,8.10 Class test based on
homework2

Lecture 21 determination of KLa ->Reference :1,8.2.1 http://www.scribd.com/d

oc/16171932/Determinatio
n-of-KLa

MID-TERM
Part 3
Week 8 Lecture 22 reactors of specific applications ->Reference :1,9.6

Lecture 23 packed bed, bubble column ->Reference :1,9.6.2-9.6.3 http://www.rpi.edu/dept/c

hem-eng/Biotech-Environ
/IMMOB/packbed.htm
Lecture 24 fluidized bed, trickle bed reactor ->Reference :1,9.6.4-9.6.5 HomeWork 3 Allocation http://www.rpi.edu/dept/c
hem-eng/Biotech-Environ
/IMMOB/fluidized-bed.ht
m

Week 9 Lecture 25 bioreactor for animal cell culture ->Reference :1,9.8

Lecture 26 bioreactor for waste treatment ->Reference :1,14.4 http://ohioline.osu.edu/b

876/index.html

Lecture 27 measurement and control of bioprocess ->Reference :1,10.1

Week 10 Lecture 28 online sensors for process control ->Reference :1,10.2 HomeWork 3
Submission

Lecture 29 offline sensors for process control ->Reference :1,10.3 Class test based on
homework3
Part 4
Week 10 Lecture 30 analysis of cell and media composition ->Reference :1,10.3.2 HomeWork 4 Allocation

Week 11 Lecture 31 data analysis, smoothening, interpolation ->Reference :1,10.5 http://www.modelingandc

ontrol.com/repository/Ph
armMfg0608.pdf
Lecture 32 states and parameters of estimation ->Reference :1,10.5.2

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Part 4
Week 11 Lecture 33 bioprocess control ->Reference :1,10.6

Week 12 Lecture 34 process control, direct regulatory control ->Reference :1,10.6.1 HomeWork 4
Submission

Lecture 35 cascase control of metabolism ->Reference :1,10.6.2 Class test based on Bioprocess\4 - enzyme
homework4 activity model.swf

Lecture 36 Advanced Control strategies ->Reference :1,10.7 Term Paper 1

Submission

Week 13 Lecture 37 optimizing reconbinant protein production ->Reference :1,6.4

Lecture 38 analysing strategies to overcome plasmid instabilty, host and vector ->Reference :1,6.4.1-6.4.3 Bioprocess\5 - NBC2
optimum expression Downstream
Processing.flv
Lecture 39 Feeding strategies, pre and post induction, bottle necks in ->Reference :1,6.4.4-6.4.6
recombinant protein expression

Spill Over
Week 14 Lecture 40 sterilization ->Reference :1,9.4

Lecture 41 fermentation technology ->Reference :1,9.7

Lecture 42 advanced control strategies ->Reference :1,10.7

Week 15 Lecture 43 animal and plant reactor technology ->Reference :1,9.8

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 Details of homework and case studies plan
Nature of homework
Homework No. Topic of the Homework (group/individuals/field work

Homework 1 bioreactor construction and design Group

Homework 2 growth kinetics Group

Homework 3 bioreactor kinetics Group

Homework 4 bioreactor: process control Group

*Normally all the homeworks shall be submitted online but in special courses where homeworks cannot be submited online , the insructor can edit the mode of submission while
entering the IP Details

Scheme for CA:out of 100*

Component Frequency Out of (If any) Marks for each Total Marks

Homework 3 4 7 21

Class test based on homework 3 4 18 54

Term Paper 1 25 25

Total :- 100

* In ENG courses wherever the total exceeds 100, consider x best out of y components of CA, as explained in teacher's guide available on the UMS

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 List of suggested topics for term paper[at least 15] (Student to spend about 15 hrs on any one specified term paper)
Sr. No. Topic
1 Cell Growth Kinetics.
2
Role of Enzymes in Bioprocess Engineering.
3 Enzyme Catalysis.
4 Models Governing Chemical Kinetics.
5 Transport Phenomena in Bioprocess Systems
6 Fluid Rheology in Bioprocess Engineering.
7 Medical Applications of Bioprocess Engineering
8 Bioreactors: Role in Bioprocess Engineering.
9 Recent developments in Bioprocess Engineering.
10 Role of heterogeneous Reaction in Bioprocess Engineering.
11 Cell Death Kinetics
12 Chemical Nature of Enzyme Catalysis
13 Enzyme Inhibition
14 Multi-Substrate Enzyme-Catalyzed Reaction
15 External & Internal Mass Transfer and Reactions and Its Remedies in Bioprocess Engineering.

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 Plan for Tutorial: (Please do not use these time slots for syllabus coverage)

Tutorial No. Topic Type of pedagogical tool(s) planned

(case analysis,problem solving test,role play,business game etc)

Tutorial 1 unstructured models Problem solving

Tutorial 2 product kinetics Problem solving

Tutorial 3 growth kinetics Problem solving

Tutorial 4 structured models Problem solving

Tutorial 5 biorector design Problem solving

Tutorial 6 biorector analysis Problem solving

Tutorial 7 mass, heat transfer Problem solving

After Mid-Term
Tutorial 8 reactor applications Problem solving

Tutorial 9 reactor design for animal cell culture Problem solving

Tutorial 10 process control Problem solving

Tutorial 11 data analysis Problem solving

Tutorial 12 advanced conrol statergies Problem solving

Tutorial 13 recombinant protein production Problem solving

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