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Ionisation constants of ionisable compounds are given as pK values (published in the literature) and refer
to the pKa values at room temperature (~ 15oC to 25oC). Values at other temperatures are given as
superscripts, e.g. pK3 0 for 30oC. Estimated values are entered as pKEst (see Chapter 1, p 32).
The present chapter includes commercially available organic chemicals. Most of the inorganic, metal-organic,
organo- bismuth, boron, phosphorus, selenium, silicon and alkali metal compounds and metal ion salts of
organic acids are in Chapter 5. Naturally occurring commercially available organic compounds for use in
biochemistry, molecular biology and biology are in Chapter 6. Commercially available polymer supported
reagents are indicated with under the appropriate reagent.
Rapid purification procedures are included for commonly used solvents and reagents which make them
suitable for general use in synthetic chemistry.
Abbreviations of titles of periodicals are defined as in the Chemical Abstracts Service Source Index (CASSI)
except that punctuation is deleted. Other abbreviations are self evident.
As a good general rule, all low boiling (<100o) organic liquids should be treated as highly
flammable and toxic (because they can be inhaled in large quantities) and the necessary
precautions should be taken (see Safety precautions associated with the purification of
laboratory chemicals in Chapter 1, p 4).
Benzene has been used as a solvent successfully and extensively in the past for reactions and purification by
chromatography and crystallisation but is now considered a very dangerous substance. It should be used
with extreme care. We emphasise that an alternative solvent to benzene (e.g. toluene, toluene-petroleum ether,
or a petroleum ether to name a few) should be used first. However, if no other solvent system can be found,
then all operations involving benzene (and storage) have to be performed in an efficiently running fumehood,
and precautions must be taken to avoid inhalation and contact with skin and eyes. An asterisk has been inserted
in the text, e.g. *C 6 H6 or *benzene, to remind the user that special precautions should be adopted.
This chapter consists of four sections viz: Aliphatic Compounds, Alicyclic Compounds, Aromatic
Compounds and Heterocyclic Compounds.
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