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  • Clinical trial peer review and drug information resources

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    This document provides information on drug information resources and medication errors. It outlines primary, secondary, and tertiary sources for drug information including scientific journals, indexes, textbooks, and compendiums. Various compendiums and databases are also described that contain drug monographs and clinical information. Types of medication errors such as prescribing errors, dosing errors, and administration errors are defined. Guidelines for taking certain drugs with food, water, or an empty stomach are also summarized.

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    Drug information sources - PEBC EE preparation

    Original Title

    58 Drug Information Resources

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    This document provides information on drug information resources and medication errors. It outlines primary, secondary, and tertiary sources for drug information including scientific journals, indexes, textbooks, and compendiums. Various compendiums and databases are also described that contain drug monographs and clinical information. Types of medication errors such as prescribing errors, dosing errors, and administration errors are defined. Guidelines for taking certain drugs with food, water, or an empty stomach are also summarized.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    107 views2 pages

    Clinical trial peer review and drug information resources

    Uploaded by

    agent2cat
    This document provides information on drug information resources and medication errors. It outlines primary, secondary, and tertiary sources for drug information including scientific journals, indexes, textbooks, and compendiums. Various compendiums and databases are also described that contain drug monographs and clinical information. Types of medication errors such as prescribing errors, dosing errors, and administration errors are defined. Guidelines for taking certain drugs with food, water, or an empty stomach are also summarized.

    Copyright:

    © All Rights Reserved
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    of 2

    DRUG INFORMATION RESOURCES

    Peer review: assessment of clinical trial by experts for scientific merit, participant safety, ethics

    SOURCES

    Primary Original information about clinical Scientific journals (Pharmacy


    trials/research Connection, Canadian Family
    Most current information keeps up Physician, Canadian Pharmacy Journal)
    with latest developments & research
    in pharmacy
    Source of continuing education
    Does not guarantee article accuracy,
    but good info credibility
    Secondary Info from primary sources compiled Indexes (Clin-Alert, Index Medicus),
    as abstracts and published in bibliography, abstracts, internet
    secondary sources search, Medline/PubMed
    Quick, selective screening of primary
    literature for specific info
    Each indexing service may provide
    specific list of journals, which can limit
    thoroughness of literature search
    Tertiary Obtained from primary/secondary Textbooks, compendia (CPS, US
    sources pharmacopoeia, Martindale, Mother
    Easy, comprehensive topics in 1 book risk, Remington, RxTx, Cochrane
    No recent information database, Health Canada Drug Product
    Database)

    Compendium of Drug monographs, s/e, clinical uses, interactions, contraindications,


    Pharmaceutical Specialty pharmacology, dosing, storage info, drugs containing allergens
    (CPS or RxTx) (peanut, soy, ethanol), immunization schedule
    Compendium of Treatment options (1st line, alternatives)
    Therapeutic Choices (CTC)
    Compendium of Self care, OTC
    Therapeutic Minor
    Ailments (CTMA)
    US approved FDA drugs
    USP-DI Vol 1 Vol 3: Orange book: Approved drug products with therapeutic
    equivalence evaluations
    Cochrane database Evidence-based medicine systematic review
    Health Canada DPD Newly approved drugs
    Medline/Pubmed Off-label drugs
    Martindale Drugs manufactured in foreign countries, off-label drugs
    Handbook of Injectable IV mixture compatibility
    Drugs
    Remington: Science and Pharmaceutics, therapeutics, pharmacy practice, industrial
    Practice of Pharmacy Compounding, buffers, excipients
    Compounding: Remingtons, Merck index Pregnancy, Lactation: Mother Risk
    MEDICATION ERRORS

    Health Canada MedEffect Drug advisories, withdrawals, recalls


    Health Canada Pharmacovigilance ADR in post-marketing surveillance
    Canadian Institute of Health Information (CIHI) Medication incidences in hospital
    Institute of Safe Medication Practices (ISMP) Medication incidences in community
    Canadian Patient Safety Institute (CPSI) Promotes innovative solutions & facilitates
    collaboration among government &
    stakeholders to enhance patient safety

    Drug recalls

    Class/Type I Class/Type II Class/Type III


    Strong likelihood that product May cause temporary but Product not likely to cause
    will cause serious ADR/death reversible adverse; small ADR
    chance of ADR

    Types of medication errors

    Prescribing Wrong dosage form Deterioration


    Omission Wrong Monitoring
    Wrong time administration Compliance
    Unauthorized drug Wrong drug Other
    Improper dose preparation

    Take w/ plenty of water:

    Sulphonamides ( chance of crystalluria)


    Expectorants
    Bulk laxatives
    Irritating drugs (theophylline, K supplements, some antibiotics)

    Take w/food or milk

    NSAIDs, ASA
    Erythromycin
    Nitrofurantoin
    Valproic acid

    Take on empty stomach (1h before or 2-3h after food)

    Levothyroxine
    Ampicillin
    Tetracycline

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